Diagonal

What Diagonal does

Diagonal is a European Union Horizon 2020-funded research project (grant agreement No. 953152) that develops and implements safe-by-design tools and guidelines for multicomponent nanomaterials (MCNMs) and High Aspect Ratio Nanoparticles (HARNs). Coordinated by ICCRAM at the University of Burgos, Spain, and operating through a consortium of 22 partners across 14 countries, the project targets gaps in risk assessment, risk management, and risk governance for advanced nanomaterials, with the stated objective of helping industry — particularly SMEs — meet REACH compliance obligations.

Its core technical output is a portfolio of digital tools delivered through the Enalos DIAGONAL Cloud Platform (powered by NovaMechanics) and a standalone Decision Support System. The platform hosts NanoBioAccumulate (Wageningen University–developed model for nanomaterial uptake and bioaccumulation in invertebrates), Zeta-predict (a method for calculating zeta potential from electron microscopy images using DLVO theory and atomistic force-fields), and NanoTube Construct (digital construction of energy-minimized nanotubes with atomistic descriptor calculation). The SSbD Decision Support Tool guides consultants, researchers, industries, and regulators in selecting Safe-and-Sustainable-by-Design strategies for HARNs and MCNMs. Seven industrial demonstrators operationalize SSbD in production environments.

The business model is non-commercial: DIAGONAL is funded by a €6.3 million EU Horizon 2020 grant and distributes its tools and resources free of charge via its website and cloud platform. There is no disclosed pricing model, no paying customers, and no revenue. Go-to-market consists of academic dissemination (publications, conferences such as SETAC, NanoTox, EuroNanoForum), training schools, webinars, social media, and engagement through the EU NanoSafety Cluster and NMBP-16 sister projects (HARMLESS, SUNSHINE). Target audiences are segmented horizontally across SMEs, regulators and policymakers, the research community, and large industrial companies.

Name

Diagonal

Legal name

DIAGONAL

Website

https://diagonalproject.eu

Company type

Private

Founded year

2021

Operating status

Operating

Headcount range

51–100 employees

Short description

Diagonal is an EU Horizon 2020 research project that develops and disseminates free safe-by-design digital tools and guidelines for multicomponent nanomaterials and high aspect ratio nanoparticles, serving SMEs, regulators, researchers, and large industrial companies across 14 countries.

Ownership category

akta.pro rank

Headquarters

HQ city

Burgos

HQ country

Spain

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Others

Distribution channels1 record

Marketing channels8 records

Core offering

Diagonal is a European Union Horizon 2020 funded research project that develops and implements safe-by-design tools and guidelines for multicomponent nanomaterials (MCNMs) and high aspect ratio nanoparticles (HARNs). It delivers cloud-based computational tools (NanoBioAccumulate, Zeta-predict, NanoTube Construct) and an SSbD Decision Support Tool to help industries, regulators, and researchers assess nanomaterial safety and comply with REACH requirements.

Product overview

DIAGONAL is a European Union Horizon 2020 research project (grant agreement No 953152) focused on developing and implementing safe-by-design tools and guidelines for multicomponent nanomaterials and High Aspect Ratio Nanoparticles. The project offers a suite of digital tools centered around the DIAGONAL SSbD Decision Support Tool, which helps select appropriate Safe-and-Sustainable-by-Design strategies. These tools are delivered through the Enalos DIAGONAL Cloud Platform, which hosts specialized applications including NanoBioAccumulate (bioaccumulation modeling), Zeta-predict (zeta potential calculation), and NanoTube Construct (nanotube design and analysis). The portfolio is designed to support nanosafety research, regulatory compliance with REACH requirements, and industrial decision-making for nanomaterial development.

Differentiator

Problem solved

Functional benefit

Brands

• Enalos DIAGONAL Cloud Platform: Cloud-based platform hosting nanoinformatics tools including NanoBioAccumulate, Zeta-predict, and Nanotube Construction Tool.
• SSbD Decision Support Tool

Products and services

• DIAGONAL SSbD Decision Support Tool A digital decision support system that guides consultants, researchers, industries and regulators in selecting the most suitable Safe-and-Sustainable-by-Design (SSbD) strategy for High Aspect Ratio Nanoparticles (HARNs) or Multicomponent Nanomaterials (MCNMs).
• Enalos DIAGONAL Cloud Platform A cloud-based platform powered by Enalos (NovaMechanics) that hosts multiple computational tools for nanomaterial safety assessment, including NanoBioAccumulate, Zeta-predict, and Nanotube Construction Tool.
• NanoBioAccumulate A modeling tool developed by Wageningen University to model the uptake and bioaccumulation of nanomaterials in invertebrate organisms.
• Zeta-predict An alternative method for calculating zeta potential based on electron microscopy images of colloidal dispersions produced by liquid cell and/or cryogenic electron microscopy, DLVO theory, and atomistic force-fields.
• NanoTube Construct A web tool for the digital construction of energy minimized nanotubes of single-layer materials and calculation of their atomistic descriptors, powered by Enalos Cloud Platform. Integrates Safe-and-Sustainable-by-Design (SSbD) principles.

Quantifiable outcome

• Seven industrial demonstrators operational to showcase SSbD implementation

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

19 partnerships are on record, tiered core and flagship.

• ICCRAM (University of Burgos)coreStrategic or Co-development Partner · 1 January 2021International Research Center in Critical Raw Materials for Advanced Industrial Technologies. Coordinator of the DIAGONAL project. Conducts research on synthesis of nanomaterials, computational simulation, nanosafety and sustainability. Hosts project headquarters and consortium meetings.
• NovaMechanics Ltd.coreStrategic or Co-development Partner · 1 January 2021Developed NanoTube Construct tool and powers the Enalos DIAGONAL Cloud Platform. Part of the computational materials modelling team. Received funding from EU's Horizon 2020 through DIAGONAL project.
• University of BirminghamcoreStrategic or Co-development Partner · 1 January 2021Contributes expertise in nanosafety, specifically involved in NanoTube Construct development (Dr. Iseult Lynch co-author). Part of the NanoSafety Cluster community.
• BioNanoNet (BNN)coreStrategic or Co-development Partner · 1 January 2021Austrian association that organizes events, training schools, and coordinates stakeholder engagement activities for DIAGONAL. Responsible for communication, dissemination, and NanoSafety Training School organization.
• Wageningen UniversitycoreStrategic or Co-development Partner · 1 January 2021Developed the NanoBioAccumulate model for uptake and bioaccumulation of nanomaterials in invertebrate organisms. Subject to TRAAC framework evaluation for regulatory readiness.
• HARMLESS ProjectflagshipStrategic or Co-development Partner · 1 January 2021NMBP-16 sister project focusing on safe-by-design from science to regulation for multicomponent nanomaterials. Regular joint meetings, shared task forces, and collaborative publications.
• SUNSHINE ProjectflagshipStrategic or Co-development Partner · 1 January 2021NMBP-16 sister project addressing safe-by-design for multicomponent nanomaterials. Co-organizes training schools, ambassador meetings, and joint events with DIAGONAL.
• EU NanoSafety ClustercoreStrategic or Co-development Partner · 1 January 2021DIAGONAL is a member of the NanoSafety Cluster, collaborating with 15+ other nanosafety projects on shared methodologies, training, and research alignment.
• European Commission (JRC)coreStrategic or Co-development Partner · 1 January 2021Joint Research Centre provides the SSbD framework that DIAGONAL tests and implements. Regular engagement through stakeholder workshops on SSbD case studies.
• OECDcoreStrategic or Co-development Partner · 1 January 2021DIAGONAL contributes to OECD work on safe-by-design approaches and test guidelines for nanomaterials through project outputs and expert participation.
• MonolithoscoreStrategic or Co-development Partner · 1 January 2021Greek partner functioning as an industrial demonstrator. Site visits conducted for exposure monitoring campaigns in Athens.
• Creative NanocoreStrategic or Co-development Partner · 1 January 2021Greek partner hosting site visits for exposure monitoring. Works with partners ITENE, LIST, and ISQ on nanoparticles and microparticles monitoring.
• DTI (Danish Technological Institute)coreStrategic or Co-development Partner · 1 January 2021Functions as an industrial demonstrator within DIAGONAL, presenting company activities and role at the Conference on Sustainability.
• LIST (Luxembourg Institute of Science and Technology)coreStrategic or Co-development Partner · 1 January 2021Contributes to sustainability assessment frameworks and participated in site visits for exposure monitoring with ITENE and ISQ.
• ISQ (Instituto de Soldadura e Qualidade)coreStrategic or Co-development Partner · 1 January 2021Portuguese partner that presented DIAGONAL at sustainable manufacturing conferences and participated in exposure monitoring site visits.
• ITENEcoreStrategic or Co-development Partner · 1 January 2021Spanish packaging, transport and logistics research center participating in exposure monitoring campaigns and WP4 activities.
• NANOTEC (Thailand)coreStrategic or Co-development Partner · 1 January 2021National Nanotechnology Center of Thailand represented on DIAGONAL's international Advisory Board, providing feedback on standardization and harmonization activities.
• ECHA (European Chemicals Agency)coreStrategic or Co-development Partner · 1 January 2021DIAGONAL's NanoTube Construct was featured in ECHA Nanopinion, demonstrating regulatory engagement and contribution to nanomaterial safety discussions.
• QSAR LabcoreStrategic or Co-development Partner · 1 January 2021Polish partner contributing to joint publications on multicomponent nanomaterials and similarity assessment for safe-by-design context. Co-chaired nanoSAFE sessions.

Scale indicators3 records

Recent moves6 records

Expansion highlights5 records

Market position

Strengths4 records

Competitive moat3 records

Key risks6 records

Key highlights6 records

Customer concentration

• Xx.com/DIAGONALproject
• LinkedInlinkedin.com/company/diagonalproject

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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Frequently asked questions about Diagonal