CryoPen
CryoPen, Inc. is a Texas-based private medical device company that designs, manufactures, and sells the CryoPen Cryosurgical System — a portable cryosurgery device using linear compression cooling that eliminates the need for cryogenic gases — to primary care, OB/GYN, podiatry, dermatology, and family practice physicians.
- Company typePrivate
- Founded2002
- HeadquartersCorpus Christi, United States
- Headcount11–50
- GTM typeB2B
- OfferingHardware or Manufacturing
What CryoPen does
CryoPen, Inc. is a privately held U.S. medical device company headquartered in Corpus Christi, Texas, with a sales office in Dallas. Founded around 2002 and the recipient of an original FDA clearance for its cryosurgical system, the company designs, develops, markets, and sells the CryoPen Cryosurgical System — a portable device that uses linear compression cooling technology to ablate tissue without requiring dangerous cryogenic gases such as liquid nitrogen, CO2, or nitrous oxide. The product line consists of a base refrigeration unit with interchangeable hand-held pen modules (CT 2000 two-pen and CT 1000/1010/1010-A three-pen configurations), reusable applicator tips in 3, 5, 7, and 10mm sizes, a proprietary reservoir solution, and the FDA-cleared GY2 Cervical Attachment for ablation of Cervical Intraepithelial Neoplasia grades 1 and 2.
The company's target customers are office-based physicians across multiple specialties — primary care, family practice, general practice, OB/GYN, podiatry, internal medicine, dermatology, and pediatrics — with named testimonial customers that include Affiliated Podiatrists P.A., Personalized Women's Healthcare, Family Health Association, and Greenwell Medical Clinic. CryoPen generates revenue primarily through direct hardware sales of its systems and consumables (reusable tips and reservoir solution), supported by an established CPT reimbursement pathway. Go-to-market is sales-led, combining a toll-free sales line, the company website (cryopen.com), medical conferences, downloadable clinical resources, and physician testimonials. The company has placed over 1,000 units in doctors' offices and smaller hospitals and has pursued partnerships with the U.S. National Cancer Institute and the George W. Bush Institute's Pink Ribbon Red Ribbon Initiative to address cervical cancer in sub-Saharan Africa. Effective June 15, 2018, CryoPen announced it would no longer offer repair or support services, suggesting a contraction of post-sale operations.
CryoPen firmographics
Firmographics- Name
- CryoPen
- Legal name
- CryoPen, Inc.
- Website
- https://cryopen.com
- Company type
- Private
- Founded year
- 2002
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- CryoPen, Inc. is a Texas-based private medical device company that designs, manufactures, and sells the CryoPen Cryosurgical System — a portable cryosurgery device using linear compression cooling that eliminates the need for cryogenic gases — to primary care, OB/GYN, podiatry, dermatology, and family practice physicians.
- Ownership category
- akta.pro rank
CryoPen industry classification
Industry- Product category
- Cryosurgical Medical Devices
- NAICS
- Electromedical and Electrotherapeutic Apparatus Manufacturing (334510), Surgical Appliance and Supplies Manufacturing (339113)
- SIC
- Surgical & Medical Instruments & Apparatus (3841), Electromedical & Electrotherapeutic Apparatus (3845)
- akta.pro primary industry
- Cold Chain Storage & Cryopreservation Services (LN2/Ultra-low) (HLAGAGAK)
- akta.pro secondary industries
- Cryogenic Logistics (LN2 Dry Shippers, -150°C) (HLAGAMAB), Sample Preparation, Storage & Cryogenics (Freezers, Cryovials, Cryostats) (HLAGAIAJ)
Keywords
Where CryoPen is headquartered
LocationHeadquarters
- HQ city
- Corpus Christi
- HQ country
- United States
- HQ region
- North America
Offices2 records
Markets served
CryoPen business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Supply Chain, Technology or R&D, Personnel, Marketing or Sales, Operations
Revenue model
- CryoPen Cryosurgical System Hardware: Sale of the base cryosurgical unit (CT 1000/1010 and CT 2000 systems) which includes hand-held freeze modules and refrigeration unit. The system is sold directly to physician offices and hospitals.
- Reusable Tips and Accessories: Reusable tips in various sizes (3, 5, 7, 10mm) and accessories including the GY2 cervical attachment for gynecological procedures.
- Consumables - Reservoir Solution: Proprietary reservoir solution required for system operation. Physicians rotate pen cores daily using this solution for cleaning and maintenance.
Go-to-market motion1 record
Distribution channels1 record
Marketing channels7 records
CryoPen product offering
Product offeringCore offering
CryoPen designs, develops, markets, and sells the CryoPen Cryosurgical System, a medical device using linear compression cooling technology that performs cryosurgical tissue ablation without dangerous cryogenic gases or liquids. The company sells base refrigeration units (CT 1000/CT 1010 three-pen and CT 2000 two-pen systems), reusable tips, proprietary reservoir solution consumables, and the FDA-cleared GY2 Cervical Attachment directly to physician offices and smaller hospitals for dermatological, general practice, OB/GYN, podiatry, internal medicine, urology, and pediatric applications.
Product overview
CryoPen offers a modular cryosurgical system architecture consisting of a base refrigeration unit with interchangeable hand-held pen modules and reusable tips. The core CryoPen Cryosurgical System provides dermatological cryosurgery without dangerous cryogenic gases. The product line includes two base unit configurations (CT 2000 two-pen system and CT 1000/CT 1010/CT 1010-A three-pen system), specialized reusable tips in four sizes (3mm, 5mm, 7mm, 10mm), and the GY2 Cervical Attachment module for gynecological applications treating CIN lesions. The system is designed for primary care, dermatology, OB/GYN, podiatry, and internal medicine practices.
Differentiator
Problem solved
Functional benefit
Brands
- CryoPen Cryosurgical System: The primary cryosurgical system using linear compression cooling technology for tissue ablation without dangerous cryogenic gases.
- CryoPen GY2 Cervical Attachment
Products and services
- CryoPen Cryosurgical System The main cryosurgical device using linear compression cooling technology that eliminates the need for dangerous cryogenic gases. Features pen-point precision and consistent freeze temperatures for tissue ablation in dermatological applications. Sold to primary care, family practice, OB/GYN, podiatry, internal medicine, dermatology, urology, and pediatric physicians.
- CryoPen GY2 Cervical Attachment Specialized gynecological attachment for the CryoPen system, delivering treatment at -105 degrees Celsius for ablation of Cervical Intraepithelial Neoplasia (CIN) grades 1 and 2. Enables cervical cryosurgery without liquid nitrogen or nitrous oxide. FDA cleared for gynecology use in August 2012. Targets OB/GYN physicians and cervical cancer treatment in underserved regions.
- CryoPen CT 2000 (2-Pen System) Two-pen configuration of the CryoPen cryosurgical system with hand-held freeze modules, refrigeration unit, and reusable tips. Designed for dermatological and general practice use, providing capacity for practices needing multiple simultaneous treatment modules.
- CryoPen CT 1000 / CT 1010 / CT 1010-A (3-Pen System) Three-pen configuration offering expanded capacity for practices requiring multiple simultaneous freeze modules. Targeted at higher-volume practices performing frequent in-office cryosurgery procedures.
- CryoPen Reusable Tips Reusable tips available in sizes 3mm, 5mm, 7mm, and 10mm that attach to the hand-held CryoPen modules for various treatment applications. Sold as accessories to CryoPen system owners.
Quantifiable outcome
- Over 1,000 units deployed in doctors' offices and smaller hospitals
- +4 more outcomes
Companies that use CryoPen
Customer profileNamed customers8 records
Segments6 records
Ideal customer profiles5 records
CryoPen technology and API
TechnologyTechnology focussed No
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature7 records
CryoPen partnerships and signals
Strategic signalPartnerships
Five partnerships are on record, tiered minor and core.
- U.S. National Cancer InstituteminorWith encouragement from the U.S. National Cancer Institute, CryoPen is refining the current system to more effectively address the needs of cervical cancer treatment in sub-Saharan Africa.
- George W. Bush Institute's Pink Ribbon Red Ribbon InitiativeminorCryoPen is working with the Pink Ribbon Red Ribbon initiative, co-founded by the George W. Bush Institute, to address cervical cancer in developing nations where incidence and mortality are high.
- WBT Innovation Marketplace / Northrup GrummanminorCryoPen was selected to present at the tenth annual WBT Innovation Marketplace presented by Northrup Grumman. WBT alumni have received over $786 million in early and seed stage funding and licensing.
- Startech FoundationminorFeatured in Startech Foundation Annual Report highlighting CryoPen as the biggest innovation in cryosurgery in decades. Startech helped shepherd the technology through development.
- University of Texas – Health Science Center at HoustoncoreCryoPen collaborated with the University of Texas – Health Science Center at Houston which was invaluable in the development of the innovative cryosurgical treatment for cervical cancer. This collaboration was instrumental in the research, design prototyping, and development phases.
Scale indicators4 records
Recent moves6 records
Expansion highlights4 records
CryoPen competitors and assessment
Company assessmentEmerging players
- CSA Medical: Developer of the truFreeze spray cryotherapy system for esophageal and airway indications. Comparable as a specialty cryotherapy device company with novel spray-cooling approaches, though focused on hospital-based endoscopy rather than CryoPen's office-based niche.
Direct peers
- Brymill Cryogenic Systems: Leading US/UK manufacturer of medical cryosurgery equipment used by dermatologists and primary care physicians. Directly comparable as another specialist maker of physician-office cryosurgical devices, though Brymill's systems rely on liquid nitrogen rather than CryoPen's gas-free cooling.
- OraSure Technologies (Histofreezer): Markets the Histofreezer portable cryosurgery system used by primary care physicians and podiatrists for wart and lesion treatment. Directly comparable on portable, physician-office cryosurgery positioning, though Histofreezer uses a cryogen-based disposable cartridge approach.
- Wallach Surgical Devices (CooperSurgical): Now part of CooperSurgical, Wallach is a long-established maker of physician-office cryosurgery devices including the Quantifi system. Closely comparable on product category (cryosurgery hardware for office use), customer (OB/GYN, dermatology, primary care), and indication set (CIN lesions, skin lesions).
- Erbe Elektromedizin: German manufacturer of electrosurgery and cryosurgery equipment for hospitals and specialty practices. Comparable as a specialist device maker serving overlapping physician specialties with cryosurgical instruments, with strong European distribution.
Broad incumbents
- Boston Scientific (Galil Medical): Acquired Galil Medical, a specialist in cryoablation technology for prostate, kidney, and other indications. Comparable as a broad incumbent with significant cryotherapy device offerings, though oriented toward hospital/hospital-based procedural use rather than CryoPen's office-based niche.
- CooperSurgical: Large women's health and medical device company with cryosurgery products (via Wallach acquisition) and a broad OB/GYN portfolio. Comparable as a broader incumbent competing for the same OB/GYN and primary care customers that CryoPen targets with the GY2 cervical attachment.
- Hologic: Diversified women's health company that acquired Sanarus Technologies and its cryoablation technology for breast and other indications. Comparable as a major incumbent with physician-channel cryotherapy products overlapping CryoPen's clinical use cases.
- Medtronic: Global medical device leader whose cryoablation portfolio (e.g., Arctic Front for atrial fibrillation) competes in adjacent cryotherapy applications. Comparable as a broad incumbent with deep R&D and clinical evidence capabilities that dwarf a small specialty device maker.
- AtriCure: Public medical device company specializing in cardiac surgical ablation, including cryoablation products. Comparable as an incumbent cryotherapy device maker with substantial clinical evidence infrastructure and sales coverage that a small specialist like CryoPen cannot match.
Market position
Strengths4 records
Weaknesses4 records
Competitive moat4 records
Key risks5 records
Key highlights6 records
Customer concentration
CryoPen social profiles
Digital presenceCryoPen compliance and trust
Trust signalCompliance1 record
CryoPen financial estimates
Financial estimateRevenue estimate
Valuation estimate
CryoPen leadership team
Management profileNumber of profiles
Profiles1 record
CryoPen funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
CryoPen M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about CryoPen
What does CryoPen do?
CryoPen designs, develops, markets, and sells the CryoPen Cryosurgical System, a medical device using linear compression cooling technology that performs cryosurgical tissue ablation without dangerous cryogenic gases or liquids. The company sells base refrigeration units (CT 1000/CT 1010 three-pen and CT 2000 two-pen systems), reusable tips, proprietary reservoir solution consumables, and the FDA-cleared GY2 Cervical Attachment directly to physician offices and smaller hospitals for dermatological, general practice, OB/GYN, podiatry, internal medicine, urology, and pediatric applications.
Is CryoPen a public or private company?
CryoPen is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was CryoPen founded?
CryoPen was founded in 2002. It employs 11 to 50 people.
Where is CryoPen based?
CryoPen is headquartered in Corpus Christi, United States, in the North America region.
How does CryoPen make money?
Three revenue lines are on record. CryoPen Cryosurgical System Hardware is the primary driver. The others are reusable Tips and Accessories and consumables - Reservoir Solution.
Who are CryoPen's main competitors?
CSA Medical is listed as an emerging player. Direct peers are Brymill Cryogenic Systems, OraSure Technologies (Histofreezer), Wallach Surgical Devices (CooperSurgical) and Erbe Elektromedizin. Broad incumbents are Boston Scientific (Galil Medical), CooperSurgical, Hologic, Medtronic and AtriCure.
Does CryoPen have an API?
No public API is recorded for CryoPen.
What industry is CryoPen in?
CryoPen's product category is Cryosurgical Medical Devices. Its primary akta.pro industry code is HLAGAGAK, Cold Chain Storage & Cryopreservation Services (LN2/Ultra-low), with a secondary code of HLAGAMAB, Cryogenic Logistics (LN2 Dry Shippers, -150°C). Its NAICS code is 334510 and its SIC code is 3841.