Zytovision

What Zytovision does

ZytoVision GmbH, headquartered in Bremerhaven, Germany and founded in 2004 by Dr. Sven Hauke and Dr. Piere Marggraf-Rogalla, designs, manufactures and distributes in vitro diagnostic (IVD) reagents for molecular tumor and infectious-disease diagnostics based on in situ hybridization. The company operates from a single Bremerhaven headquarters (Fischkai 1) with a workforce of 11–50 employees and is privately held under the ZYTOMICS umbrella, owned by private-equity firm ArchiMed since the January 2021 acquisition of the Zyto Group of Cancer Diagnostics companies. Its current Managing Directors are Bastian Eirich and Claudia Zimmer.

Name

Zytovision

Legal name

ZytoVision GmbH

Website

https://zytovision.com

Company type

Private

Founded year

2004

Operating status

Operating

Headcount range

51–100 employees

Short description

ZytoVision is a German IVD manufacturer that designs FISH and CISH probe kits for cancer and infectious-disease diagnostics, sold globally to certified pathology laboratories through a distributor network across 80+ countries.

Ownership category

akta.pro rank

Product category

Molecular Diagnostics (In Vitro Diagnostics)

NAICS

In-Vitro Diagnostic Substance Manufacturing (325413)

SIC

In Vitro & In Vivo Diagnostic Substances (2835)

akta.pro industry

PRIMARYHLAHAAAM

IVD Reagents, Assay Kits & Consumables (Non-instrument)

Healthcare & Life Sciences/Medical Devices & Diagnostics/In Vitro Diagnostics (IVD) & Laboratory Diagnostics

SECONDARYHLAHAAAE

Anatomic Pathology & Histology/Cytology IVD (Tissue Diagnostics)

Healthcare & Life Sciences/Medical Devices & Diagnostics/In Vitro Diagnostics (IVD) & Laboratory Diagnostics

SECONDARYHLAHAAAI

Genetic, Cytogenetic & Prenatal Screening IVD

Healthcare & Life Sciences/Medical Devices & Diagnostics/In Vitro Diagnostics (IVD) & Laboratory Diagnostics

Keywords

• In situ hybridization diagnostics
• FISH probe products
• CISH detection kits
• Tumor diagnostic reagents
• Molecular pathology tools

Headquarters

HQ city

Bremerhaven

HQ country

Germany

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Personnel, Technology or R&D, Operations, Supply Chain, Marketing or Sales, Infrastructure

Revenue model

1. IVD Diagnostic Products: Sale of in vitro diagnostic products including FISH probes (ZytoLight, FlexISH, ZytoMation), CISH products (ZytoDot 2C, ZytoFast PLUS), and VisionArray chip-based detection systems for tumor diagnostics and pathogen detection.
2. Workshop and Training Services: FISH Expert Evaluation Workshops offered to customers and distributors for training on evaluation techniques.

Go-to-market motion1 record

Distribution channels1 record

Marketing channels4 records

Core offering

ZytoVision designs, develops, and manufactures in vitro diagnostic (IVD) products for tumor and infectious disease diagnostics based on in situ hybridization (FISH and CISH) and DNA microarray technologies. The portfolio includes direct-labeled and automated FISH probes, two-color and rapid CISH detection systems, and VisionArray microarray chips with dedicated software for HPV genotyping, Mycobacteria, and Fungi detection, sold exclusively to certified anatomic pathology and clinical laboratories through a global distributor network.

Product overview

Zytovision is a manufacturer of in vitro diagnostic products for tumor diagnosis based on in situ hybridization techniques (FISH and CISH). The product portfolio consists of six core product lines: (1) ZytoLight® — direct-labeled FISH probes for detecting genetic aberrations (translocations, deletions, amplifications, aneuploidies) in FFPE and cytology specimens; (2) F*lex*ISH® — flexible FISH probes with adaptable 1-day or 2-day hybridization protocols and DistinguISH™ dual-gene detection capability; (3) ZytoMation® — fully automated FISH probes for Leica BOND™ systems; (4) ZytoDot® 2C — two-color CISH for light microscopy detection of genomic alterations; (5) ZytoFast® PLUS — rapid CISH for pathogen virus detection (HPV, EBV, CMV) and lymphocyte clonality; and (6) VisionArray® — microarray-based DNA detection system with chips for HPV genotyping (41 types), Mycobacteria species, and pathogenic Fungi (30 genotypes), each with corresponding PreCise Master Mix reagents, a Detection Kit, and MultiScan/SingleScan analysis software. Supporting accessories include implementation kits, pretreatment reagents, wash buffers, DAPI/DuraTect™ counterstaining solutions, and autofluorescence quenching reagents. The product range covers solid tumor and hematology applications across multiple technique platforms (FISH, CISH, microarray).

Differentiator

Problem solved

Functional benefit

Brands

• ZYTOMICS: Unified brand name for ZytoVision GmbH, Zytomed Systems GmbH, 42 life sciences, and Diagomics following the June 2024 rebranding initiative.

Products and services

• ZytoLight FISH Probes Direct-labeled fluorescence in situ hybridization (FISH) probes for detecting genetic aberrations including translocations, deletions, amplifications, and chromosomal aneuploidies in FFPE tissue and cytology specimens. Uses proprietary fluorochrome technology that eliminates the need for fluorophore-coupled antibody detection. Designed for certified anatomic pathology laboratories performing cancer diagnostics.
• FlexISH FISH Probes
• ZytoMation Automated FISH Probes Fully automated FISH probes designed for Leica BOND-III, BOND-MAX, and BOND RXm systems to detect genetic aberrations such as translocations and amplifications in FFPE tissue sections. Features a fully automated 5-hour protocol with reduced hands-on time. For clinical pathology laboratories using Leica BOND automation.
• ZytoDot 2C CISH Products Two-color chromogenic in situ hybridization (CISH) products for simultaneous detection of two genomic targets using light microscopy. Differentiates aneuploidies from gene amplifications and detects deletions and translocations in FFPE tissue sections. For cancer diagnostics laboratories.
• ZytoFast PLUS CISH Products Chromogenic in situ hybridization (CISH) products for fast detection and discrimination of human pathogen viruses (HPV, EBV, CMV) and determination of lymphocyte clonality via Ig-\u03ba and Ig-\u03bb light chain RNA detection. Results achievable in 4 hours. For clinical pathology and infectious disease laboratories.
• VisionArray DNA Detection System Array-based DNA detection system using DNA/DNA hybridization on glass chips with a 1-hour protocol and automated evaluation via VisionArray Software. Targets include HPV genotypes, Mycobacteria species, and pathogenic Fungi. System comprises chips, PreCise Master Mix reagents, Detection Kit, and MultiScan/SingleScan software. For clinical laboratories performing pathogen genotyping.

Segments2 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

Feature5 records

Partnerships

Five partnerships are on record, tiered core and secondary.

• BMBF Research NetworkcoreStrategic or Co-development Partner · 18 November 2024Collaboration with BMBF (German Federal Ministry of Education and Research) research network for EDI-4-ALL project to establish methods for early detection of genetic predisposition to acute lymphoblastic leukemia in newborns.
• ZYTOMICS (Parent Brand)coreOthers · 23 June 2024ZytoVision GmbH, Zytomed Systems GmbH, 42 life sciences, and Diagomics have been combined under the brand-new name ZYTOMICS as of June 2024. ZytoVision is a ZYTOMICS company.
• Universitätsklinikum EssensecondaryStrategic or Co-development Partner · 30 October 2020FlexTrack project collaboration with Universitätsklinikum Essen to establish FISH for multiplexed cell tracking in tumor progression.
• Charité BerlinsecondaryStrategic or Co-development Partner · 19 March 2019ALLFISHinFlow project cooperation with Charité Berlin for development of FISH-based flow cytometry applications.
• Leica BiosystemscoreTechnology or IntegrationZytoMation probes are specifically designed for use with Leica BOND systems (BOND-III, BOND-MAX, BOND RXm). The probes require Leica BOND FISH Kit and BOND Enzyme Pretreatment Kit for automated staining protocols. Note: ZytoVision is not affiliated or associated with Leica Biosystems.

Scale indicators3 records

Recent moves7 records

Expansion highlights5 records

Direct peers

• Empire Genomics: US-based FISH probe manufacturer specializing in customized and catalog FISH probes for cancer and constitutional cytogenetics research and diagnostics. Comparable as a FISH-only reagent specialist targeting academic and clinical cytogenetics labs.
• MetaSystems: German manufacturer of automated FISH scanning systems and FISH probes for cytogenetics, hematology, and solid tumor diagnostics. Directly comparable as a mid-sized European FISH reagent and instrument vendor serving the same anatomic pathology and cytogenetic laboratory customers.

Broad incumbents

• Agilent Technologies (Dako): Agilent's Dako pathology business sells FISH probes for HER2, ALK, and other oncology targets alongside IHC reagents and Omnis automation. A broad incumbent with overlapping FISH content and integrated companion-diagnostic capability for pharma partners.
• Roche Diagnostics (Ventana): Roche's diagnostics arm sells FISH probes alongside its Ventana IHC and BenchMark automation platforms, as well as the Foundation Medicine NGS franchise. A broad incumbent that competes in companion diagnostics and integrated pathology workflows where ZytoVision's FISH products are used.
• Hologic: Diagnostics company with the ThinPrep cytology platform and molecular diagnostics franchise (Panther, Aptima) addressing cervical cancer screening and infectious disease - adjacent applications that overlap with VisionArray HPV and ZytoVision's cytology FISH workflow.
• Abbott Molecular (Vysis): Abbott's molecular diagnostics division (including the acquired Vysis FISH probe business and CytoCell) sells FDA-cleared FISH probe panels for ALK, ROS1, HER2, and other oncology biomarkers. A broad incumbent offering overlapping FISH content plus larger molecular diagnostics menu, including PCR and NGS.

Others

• Leica Biosystems: Histopathology and FISH workflow solutions provider, owner of the BOND automated staining platform with which ZytoMation probes integrate. Strategic partner (ZytoVision notes it is not affiliated with Leica) but also a competitor through Kreatech FISH reagents and broader anatomic pathology offerings.
• Bio-Techne: Life science tools and diagnostics company offering proteins, antibodies, and ExoDx molecular diagnostics, with a portfolio spanning research reagents and clinical diagnostics adjacent to ZytoVision's reagent-focused business model.

Emerging players

• Oxford Gene Technology (OGT): UK-based molecular diagnostics company offering FISH probes and NGS-based cytogenetics products for cancer and constitutional genetic disorders. Comparable as a niche molecular cytogenetics specialist with overlapping oncology FISH menu and growing NGS adjacency.

Regional players

• Vitro Master Diagnóstica: Spanish IVD manufacturer distributing FISH and CISH probes for cytogenetics and oncology across Latin America and Southern Europe. Comparable as a regional FISH probe specialist with overlapping product categories but distinct geographic focus from ZytoVision's wider footprint.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/zytovision-gmbh

Compliance4 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Zytovision