Brainclinics Foundation

What Brainclinics Foundation does

Brainclinics Foundation, founded in 2001 in Nijmegen, Netherlands, is an independent research institute (Stichting) specializing in applied neuroscience for ADHD, depression, and OCD. Its core scientific thrust is stratified psychiatry — using EEG biomarkers and transcranial magnetic stimulation (TMS) to personalize treatment selection and improve outcomes for treatment-resistant depression, ADHD, and OCD. The institute has produced 316 publications with 14,807 citations and collaborates with 765 co-authors, anchored by Founder and Research Director Martijn Arns, who also serves as a Visiting Scholar at Stanford's Brain Stimulation Lab.

The company's commercial product portfolio straddles hardware, software, data, and education. Core software is the Heart Brain Connect App (iOS), which uses Polar H10 heart-rate sensor data and TMS-induced heart rate changes to identify optimal prefrontal rTMS stimulation targets via its proprietary Heart-Brain Coupling (HBC) method. Supporting hardware includes a customizable rTMS treatment chair, Kendall H124SG/H135SG ECG electrodes, and rTMS educational posters. The TDBRAIN dataset (>1,500 well-phenotyped clinical EEGs, V3.1 released July 2026) is offered as an open-access research resource, and an online EDF/BDF viewer (June 2026) provides local-only EEG/ECG visualization and annotation. Education is delivered through an annual 3-day TMS Masterclass & Certification course accredited by Dutch-Flemish Hersenstimulatie Stichting, FGzPt, and NVvP, using Deymed and MagVenture equipment for hands-on training.

Brainclinics operates an event-driven, multi-stream revenue model: B2C/B2B pricing on consumables and educational materials (e.g., electrodes at ~€97.50/500, posters at €49.99), quote-based pricing on higher-ticket equipment (rTMS chair), quote-based masterclass tuition, and freemium/app-store distribution for the iOS app. As a Dutch foundation with no parent company, funding rounds, or investor backers disclosed, the institute appears self-funded or grant-supported, with commercial product revenue supplementing rather than driving research activities. Marketing is content-led (publications, blogs, LinkedIn) and event-driven (annual Masterclass), targeting psychiatrists, clinical psychologists, neuroscience researchers, and TMS clinics primarily in Europe with growing US research visibility through Stanford and UCLA engagements.

Name

Brainclinics Foundation

Legal name

Brainclinics Foundation

Website

https://brainclinics.com

Company type

Private

Founded year

2001

Operating status

Operating

Headcount range

1–10 employees

Short description

Brainclinics Foundation is an independent Dutch research institute (est. 2001) that develops EEG biomarkers, Heart-Brain Coupling technology, and rTMS targeting methods to personalize treatment for depression, ADHD, and OCD, serving psychiatrists, researchers, and TMS clinics through hardware, software, an open-access EEG dataset, and an annual TMS certification masterclass.

Ownership category

akta.pro rank

Product category

Clinical neuroscience / neuromodulation (rTMS, EEG, and biomarker-guided psychiatry)

NAICS

Research and Development in the Physical, Engineering, and Life Sciences (54171), Research and Development in Biotechnology (except Nanobiotechnology) (541714)

SIC

Electromedical & Electrotherapeutic Apparatus (3845), Services-Commercial Physical & Biological Research (8731), Services-Prepackaged Software (7372)

akta.pro primary industry

Mental Wellness & Stress Management Devices (Biofeedback, Meditation/Neurostimulation Devices) (CRACAQAL)

akta.pro secondary industries

Behavioral Health & Neurocognitive Therapeutics (Digital) (HLACANAI), Psychiatry & Medication Management Platforms (HLALAEAB)

Keywords

• Transcranial magnetic stimulation
• EEG biomarker research
• Precision psychiatry
• Heart-brain coupling
• Clinical neuroscience training

Headquarters

HQ city

Nijmegen

HQ country

Netherlands

HQ region

Europe

Offices1 record

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure, Supply Chain

Revenue model

1. Education and Certification Programs: Annual TMS Masterclass & Certification Course offering professional accreditation points (Dutch-Flemish Hersenstimulatie Stichting, FGzPt, NVvP). Participants pay for comprehensive 3-day training with world-renowned speakers and hands-on equipment sessions.
2. Medical Hardware Products: Sale of specialized medical equipment including rTMS chairs (customizable stainless steel, adjustable design for TMS positioning), ECG electrodes (Kendall H124SG and H135SG models), and rTMS posters for clinical settings.
3. Mobile Application: Heart Brain Connect app available on iOS App Store, used for heart rate variability measurement and breathing training, with Polar H10 Heart Rate Sensor integration.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels4 records

Core offering

Brainclinics Foundation develops and sells neuroscience-based products and services for clinicians treating ADHD, depression, and OCD. Its commercial portfolio centers on the Heart Brain Connect mobile app (rTMS target guidance via heart-brain coupling), a customizable rTMS treatment chair, Kendall ECG electrodes, and an rTMS educational poster, alongside an annual accredited TMS Masterclass & Certification course. Foundational research assets include the open-access TDBRAIN EEG dataset (>1,500 recordings) and an online EDF/BDF viewer that anchor the foundation's stratified psychiatry and TMS target-engagement methodology.

Product overview

Brainclinics Foundation operates as an independent research institute (founded 2001) specializing in applied neuroscience for ADHD, Depression, and OCD treatment. The company's portfolio centers on the Heart Brain Connect App as its core software product, which uses heart-brain coupling measurement for rTMS target engagement. Supporting hardware products include the rTMS Chair, ECG Electrodes, and rTMS Poster. Data offerings comprise the TDBRAIN Dataset (>1500 EEGs) and Brainclinics EDF/BDF Viewer for EEG/ECG analysis. Educational services include the annual TMS Masterclass certification course. The company applies EEG biomarker-based stratified psychiatry approaches for treatment personalization, with published research demonstrating predictive analytics capabilities for antidepressant and neurofeedback treatment selection.

Differentiator

Problem solved

Functional benefit

Brands

• Heart Brain Connect App: Mobile application for measuring heart rate and heart rate variability for non-medical purposes and biofeedback exercising, developed to assist clinicians in pinpointing the optimal location for rTMS treatment
• TDBRAIN Dataset
• Brainclinics EDF/BDF Viewer
• rTMS Chair
• rTMS Poster
• ECG Electrodes

Products and services

• Heart Brain Connect App iOS mobile application that measures heart-brain coupling during TMS stimulation by detecting heart rate changes and supports resonant breathing biofeedback training to assist clinicians in pinpointing the optimal prefrontal location for rTMS treatment of depression and OCD.
• rTMS Chair Ergonomically designed treatment chair customized for rTMS procedures, featuring a fully adjustable stainless steel neck-support base, support pillow, and durable antimicrobial synthetic leather upholstery for patient positioning during brain stimulation sessions.
• ECG Electrodes Kendall Arbo H124SG (24 mm) and H135SG (35 mm) ECG electrodes with conductive solid gel, strong adhesion, and silver/silver chloride sensors designed for high-quality ECG signal acquisition during rTMS and Heart-Brain Coupling assessments.
• rTMS Poster Scientifically accurate educational poster (70 cm x 50 cm) for clinical settings showing rTMS application locations for OCD and MDD treatment, featuring an updated Homunculus figure and rTMS protocol examples, printed on 250gsm glossy paper.
• TDBRAIN Dataset Open-access clinical EEG dataset with more than 1,500 recordings and accompanying descriptive clinical and treatment outcome data, distributed in lossless 24-bit BDF format for biomarker validation, AI/ML model training, and external reproducibility studies.
• Brainclinics EDF/BDF Viewer Online viewer for EEG and ECG files that allows users to open EDF/BDF files, apply filters, change montages, identify PQRST components in ECG data, and export annotated EDF+/BDF+ files, with all processing performed locally so no data is stored externally.
• TMS Masterclass & Certification Course Annual three-day in-person training covering foundations through advanced applications of TMS and brain stimulation, including connectomic-based stimulation, pharmaco-TMS, accelerated protocols, and TMS-induced Heart-Brain Coupling, with hands-on equipment sessions and accreditation by Dutch-Flemish Hersenstimulatie Stichting, FGzPt, and NVvP.

Quantifiable outcome

• 86% accuracy in identifying sgACC-anticorrelated stimulation sites using HBC method
• +4 more outcomes

Named customers3 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration1 record

AI capability4 records

Feature4 records

Partnerships

Four partnerships are on record, tiered core and minor.

• Dutch-Flemish Hersenstimulatie StichtingcoreStrategic or Co-development PartnerProfessional accreditation body for TMS certification in the Netherlands and Belgium. Complete 3-day Masterclass fulfills TMS Certification requirements (20 points) and Masterclass (Day 2 & 3) accredited for 13 continuing education points.
• Shan Siddiqi (Collaborating Researcher)coreStrategic or Co-development PartnerCollaboration on fMRI validation study confirming that HBC identifies sites functionally connected to the sgACC, achieving 86% accuracy in 14 participants.
• UCLAminorStrategic or Co-development PartnerPresentation engagement at UCLA on alpha frequency and heart-brain coupling as biomarkers for personalized TMS treatment.
• Stanford Brain Stimulation LabcoreStrategic or Co-development PartnerMartijn Arns serves as Visiting Scholar, maintaining ongoing research collaboration with Stanford University's brain stimulation research program.

Scale indicators5 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• MagVenture: MagVenture is a leading Danish manufacturer of TMS coils and systems used in clinical depression treatment. As a hands-on training equipment partner for Brainclinics' TMS Masterclass, MagVenture is directly comparable as a provider of TMS technology serving the same psychiatric practitioner base.
• ANT Neuro: ANT Neuro is a Dutch-headquartered manufacturer of EEG systems, TMS-compatible EEG equipment, and clinical neurophysiology software. Direct peer as it supplies both EEG and integrated EEG-TMS technology to the same neuroscience research and clinical practitioners that Brainclinics targets.
• Deymed Diagnostic: Deymed manufactures TMS devices (including the Duomag XT used in Brainclinics' Masterclass) as well as EEG and clinical neurophysiology equipment. Direct overlap with Brainclinics across both TMS hardware and clinical neurotechnology products targeting the same psychiatric and neurology practices.

Emerging players

• Mendi Innovations: Mendi produces a consumer neurofeedback headband for brain training with biofeedback via an app. Comparable as an emerging player in the heart-brain coupling / neurofeedback consumer product space, though focused on consumer wellness rather than clinical TMS targeting.
• Wave Neuroscience (PFC Boulder): Wave Neuroscience (formerly Personal Frequency Carriers) provides EEG-guided neurostimulation and brain mapping services. Comparable as an emerging player using EEG biomarkers for personalized treatment — a similar value proposition to Brainclinics' precision psychiatry/stratified psychiatry approach.
• Soterix Medical: Soterix Medical develops non-invasive neuromodulation technologies including transcranial direct current stimulation (tDCS) and high-definition tDCS, with overlapping research and clinical applications in depression and psychiatry. Comparable as an emerging player in the neuromodulation technology ecosystem adjacent to Brainclinics' TMS focus.
• Mente (Mente Autism / AAT Research): Mente develops wearable neurofeedback devices targeting autism and ADHD using heart-brain coupling concepts. Comparable as a smaller emerging player combining heart-rate variability / biofeedback with neurotherapy in adjacent indications to Brainclinics' Heart Brain Connect approach.

Broad incumbents

• Neuronetics (NeuroStar): Neuronetics is the publicly-traded market leader in TMS therapy with its NeuroStar system for treatment-resistant depression, the first FDA-cleared TMS device. As a broad incumbent it operates at a much larger commercial scale than Brainclinics, but serves the same psychiatrist and TMS clinic customer base.
• Brainsway: Brainsway develops deep transcranial magnetic stimulation (dTMS) systems for depression, OCD, and smoking addiction, with FDA-cleared H-coil technology. It is a broad incumbent in the same clinical TMS space and competes for the same psychiatrist customers Brainclinics serves.
• Compumedics Limited: Compumedics is an Australia-based medical device company specializing in EEG, sleep diagnostics, and brain monitoring. Comparable to Brainclinics in the EEG dataset, viewer, and clinical neurophysiology product space, but at a much larger commercial scale.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/research-institute-brainclinics-nijmegen

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Brainclinics Foundation