CSafe Global
CSafe Global designs, manufactures, and rents temperature-controlled shipping containers, passive packaging, and cryogenic dewars, plus the CSafe Connect digital monitoring platform, for pharmaceutical manufacturers, freight forwarders, airlines, and cell & gene therapy developers across 185+ countries.
- Company typePrivate
- Founded1979
- HeadquartersDayton, United States
- Headcount101–250
- GTM typeB2B
- OfferingHardware or Manufacturing
What CSafe Global does
CSafe Global is a privately held, PE-backed provider of temperature-controlled shipping solutions for the pharmaceutical and life sciences industries, founded in 1979 and headquartered in Monroe, Ohio (United States). The company designs, manufactures, and rents/leases active ULD containers (RAP, RKN) and passive pallet shippers, parcel solutions, thermal covers, and a growing portfolio of cryogenic dewars for cell and gene therapies, all built around proprietary Vacuum Insulated Panel (VIP) technology originally developed with NASA in the 1990s. CSafe's portfolio also includes the TracSafe family of data loggers and the CSafe Connect cloud portal, which provides real-time shipment visibility, AI-powered analytics, and a Control Tower monitoring service, complemented by Planning, Qualification, and Training (CSafe University) services.
CSafe Global firmographics
Firmographics- Name
- CSafe Global
- Legal name
- CSafe, LLC
- Website
- https://csafeglobal.com
- Company type
- Private
- Founded year
- 1979
- Operating status
- Operating
- Headcount range
- 101–250 employees
- Short description
- CSafe Global designs, manufactures, and rents temperature-controlled shipping containers, passive packaging, and cryogenic dewars, plus the CSafe Connect digital monitoring platform, for pharmaceutical manufacturers, freight forwarders, airlines, and cell & gene therapy developers across 185+ countries.
- Ownership category
- akta.pro rank
CSafe Global industry classification
Industry- Product category
- Pharmaceutical Cold Chain Logistics
- NAICS
- Packaging and Labeling Services (56191), Refrigerated Warehousing and Storage (493120)
- SIC
- Refrigeration & Service Industry Machinery (3580), Public Warehousing & Storage (4220)
- akta.pro primary industry
- Packaging, Insulation & Temperature-Controlled Shippers (Qualified Systems) (HLAGAMAF)
- akta.pro secondary industries
- Cold Chain & Temperature-Controlled Packaging (Insulated Shippers, Gel Packs) (IMALAIAG), Cryogenic & Ultra-Low Temperature Logistics (-80°C, LN2 Dry Shipper) (TLAIAIAK), Cold Chain Packaging, Refrigerants & Thermal Qualification Services (as-a-service) (TLAIAIAL), Cold Chain Monitoring, Data Logging & Chain-of-Custody Services (TLACAMAL), Vaccine & Public Health Immunization Cold Chain Logistics (TLAIAIAD)
Keywords
Where CSafe Global is headquartered
LocationHeadquarters
- HQ city
- Dayton
- HQ country
- United States
- HQ region
- North America
Offices65 records
Markets served
CSafe Global business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Supply Chain, Operations, Infrastructure, Personnel, Marketing or Sales, Technology or R&D
Revenue model
- Active Temperature-Controlled Container Leasing: Rental/leasing of active ULD containers (RAP, RKN) with temperature control capabilities. Includes global network availability, preventive maintenance, real-time tracking, and 24/7 customer support. Proactive maintenance programs and rigorous annual validation testing ensure optimal quality for every lease.
- Passive Temperature-Controlled Packaging Products: Sale of passive temperature-controlled packaging solutions including parcel shippers (Softbox VIP+, Softbox MAX, Softbox ONE, CSafe Advanced), pallet shippers (Silverpod, Silverpod RE, APS Single/Double), thermal covers (Silverskin PH300, PB500, QLT6, QLT19), and specialty containers (AX56L).
- Cell & Gene Therapy Solutions: Specialized shipping solutions for cell and gene therapies including CGT Ultra D (dry ice dewar for <-70°C, 37+ days), CGT Cryo M (multi-use dewar for -150°C), CGT Cryo S (single-use dewar for -150°C, 8+ days), and parcel solutions for <-70°C and <-150°C shipments.
- Professional Services: Comprehensive service offerings including Planning (cold chain strategy, risk assessment, custom logistics solutions, regulatory guidance), Qualification (ISTA-certified testing, thermal qualification services), Monitoring (real-time shipment visibility, automated alerts, Control Tower services), and Training (CSafe University certifications).
- Silverskin RE Rental Program: Rental model for Silverskin RE reusable thermal covers including full lifecycle management, inspection, cleaning, and return logistics after each use.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Multi-year contract | Container and packaging rental/lease model with per-shipment or contract pricing |
Go-to-market motion2 records
Distribution channels3 records
Marketing channels5 records
CSafe Global product offering
Product offeringCore offering
CSafe Global manufactures and leases temperature-controlled shipping containers, passive thermal packaging, thermal covers, and cryogenic dewars for pharmaceutical, biotech, and cell and gene therapy companies. Its portfolio combines active ULD containers (RAP, RKN) and passive parcel/pallet shippers (Softbox, Silverpod, CSafe Advanced, APS) with proprietary Vacuum Insulated Panel insulation and Phase Change Material coolants, complemented by the CSafe Connect digital platform and TracSafe data loggers for real-time shipment visibility. Supporting professional services cover cold chain planning, ISTA-certified thermal qualification, 24/7 Control Tower monitoring, and GDP-compliance training through CSafe University.
Product overview
CSafe Global provides end-to-end temperature-controlled shipping solutions for the life sciences industry, offering both active and passive temperature-controlled shipping products. The portfolio includes: Active containers (RAP, RKN) for bulk air cargo with built-in cooling and real-time monitoring; Passive pallet shippers (APS Single/Double, Silverpod family) featuring VIP insulation and phase-change materials; Parcel solutions (CSafe Advanced, Softbox VIP+, Softbox MAX, Softbox ONE) for various temperature ranges and duration requirements; Thermal covers (Silverskin, Silverskin RE) for protection between risk points; Specialty products (AX56L) for military-grade last-mile delivery; and Digital solutions (TracSafe data loggers PRO/MAX/RLT, CSafe Connect platform) providing real-time tracking, AI-powered analytics, and predictive insights. Services include planning, qualification testing, monitoring/Control Tower, and training through CSafe University. The company serves pharma manufacturers across R&D, clinical trials, and commercial distribution, as well as logistics partners including freight forwarders and airlines.
Differentiator
Problem solved
Functional benefit
Brands
- Softbox: Passive parcel shipping solutions brand including Softbox VIP+, Softbox MAX, Softbox ONE, and Softbox VIP product lines
- Silverskin
- Silverpod
- CSafe Connect
- TracSafe
- CSafe University
Products and services
- Active RAP Multi-pallet active ULD temperature-controlled container for air cargo featuring superior VIP insulation, integrated real-time data logger, user-selectable temperature set points from +4°C to +25°C, and an air recirculation system for precise temperature control under extreme ambient conditions (-30°C to +54°C). Targeted at pharmaceutical manufacturers, freight forwarders, and airlines moving bulk biologics and vaccines.
- Active RKN Single-pallet active ULD temperature-controlled container for air cargo featuring superior VIP insulation and integrated real-time data logger, providing end-to-end supply chain visibility. Targeted at pharmaceutical manufacturers and airlines for air freight shipments requiring active refrigeration.
- Advanced Passive Pallet – S (APS Single) Advanced passive single-pallet shipper featuring superior VIP insulation and integrated data logger, qualified to ISTA 7D with 120+ hour duration for +2°C to +8°C, +15°C to +25°C, and <-20°C temperature ranges. Targeted at pharmaceutical manufacturers needing qualified passive pallet protection with real-time visibility.
- Advanced Passive Pallet – D (APS Double) Advanced passive double-pallet shipper featuring superior VIP insulation and integrated data logger for real-time shipment visibility of larger pharmaceutical payload volumes.
- Silverpod Passive Pallet Shippers Patented passive pallet shippers available in multiple sizes and temperature ranges with single-use and multi-use shipment options. Features patented fold-flat coolant sleeves and interlocking design for cost-effective pharma pallet shipping.
- Silverpod MAX RE Reusable PCM pallet shipper with real-time tracking, representing the latest evolution of the Silverpod product line designed with sustainability in mind and utilizing enhanced PCM technology.
- Silverskin Thermal Covers Thermal covers providing thermal protection between risk points in pharmaceutical shipment. Reflect solar radiation, protect therapeutics from light exposure, and provide water resistance with tamper-evident security barrier. Available in PH300, PB500, QLT6, and QLT19 grades.
- Silverskin RE Reusable thermal cover with weather-resistant cleanable exterior, zip-closure door, integrated tracking, adjustable straps for US and EU pallets, and patent-pending air security belts and buckles for high tension and tamper resistance. Available for +2°C to +8°C and +15°C to +25°C ranges with rental or purchase model.
- CSafe Advanced Reusable parcel shipper combining VIP panels and PCMs for reliable temperature control with 72-hour performance against ISTA 7D standards. Reduces cost, complexity, and environmental impact relative to single-use parcel shippers. Available in 2L, 8L, 35L, and 50L sizes.
- Softbox VIP+ High-performance single and multi-use parcel shipper featuring superior VIP insulation and optional data logger integration for shipment visibility. Temperature ranges from -25°C to +8°C for pharmaceutical parcel shipments.
- Softbox MAX Premium parcel shipper delivering reliable thermal protection in extreme conditions with advanced PCM and Thermal Insulating Foil (TIF) technology, positioned between standard and premium passive parcel systems.
- Softbox ONE Cost-effective single-use parcel shipper for low-risk pharmaceutical shipping lanes, qualified for both summer and winter temperature profiles.
- AX56L Military-Grade Container Versatile military-grade container for transporting and storing temperature-sensitive products in extreme conditions, featuring 56.6L payload capacity, dual temperature modes (+4°C Cool and -22°C Freeze), VIP insulation technology, and 78-hour duration. Targeted at government, military, and humanitarian aid customers for last-mile delivery.
- CGT Ultra D Multi-use dry ice dewar built for advanced therapeutic medical products (ATMPs), maintaining temperatures below -70°C for 37+ days with integrated real-time tracking. Targeted at cell and gene therapy developers needing long-duration cryogenic transport.
- CGT Cryo M Multi-use cryogenic dewar capable of maintaining -150°C or colder to transport cell and gene therapies with integrated real-time tracking. Targeted at CGT manufacturers needing long-duration cryogenic transport.
- CGT Cryo S Single-use cryogenic dewar providing 8+ days of thermal protection at -150°C or colder with integrated real-time tracking for cell and gene therapy shipments.
- TracSafe PRO Cost-effective single-use shipment data logger tracking payload temperature via USB connection for pharmaceutical parcel shipments requiring post-shipment temperature verification.
- TracSafe MAX Multi-use Bluetooth-enabled data logger with optional dry ice probe, tracking ambient temperature, shock events, light events, tilt events, and location for reusable temperature monitoring.
- TracSafe RLT Reusable real-time 4G/5G data logger for extreme temperatures, providing global location tracking and continuous monitoring for high-value and cryogenic pharmaceutical shipments.
- CSafe Connect Cloud-based customer portal integrating product ordering, tracking, reporting, and customer support under a single login. Provides real-time shipment data, predictive insights, AI-powered analytics, automated alerts, lane risk analysis, and load optimization tools for pharmaceutical shipments.
- Control Tower Monitoring Service White-glove shipment monitoring service provided through CSafe Connect, where a global team monitors shipments around the clock in real-time, handles all setup, and provides shipment reports upon delivery for pharmaceutical manufacturers.
- Cold Chain Planning Services End-to-end cold chain planning services including cold chain strategy development, risk assessment and mitigation, custom logistics solutions, regulatory and compliance guidance, and pre-conditioning services for pharmaceutical companies.
- Thermal Qualification Services ISTA-certified thermal qualification testing services including Design Qualification (DQ), Operational Qualification (OQ), and Performance Qualification (PQ), conducted in state-of-the-art environmental test chambers covering temperature ranges from -70°C to +80°C.
- Training / CSafe University Training and certification program for cold chain employees and service providers working with CSafe packaging solutions, ensuring compliance with Good Distribution Practices (GDP) and service provider competence on proper container handling.
Quantifiable outcome
- Reduce freight costs by up to 25%
- +6 more outcomes
Companies that use CSafe Global
Customer profileNamed customers9 records
Segments5 records
Ideal customer profiles5 records
CSafe Global technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability4 records
Feature9 records
CSafe Global partnerships and signals
Strategic signalPartnerships
22 partnerships are on record, tiered core and minor.
- DHL Global ForwardingcoreGlobal logistics partnership with DHL for temperature-controlled pharmaceutical shipments. DHL is a key player in CSafe's global logistics network supporting freight forwarding operations.
- Kuehne+NagelcorePartnership with Kuehne+Nagel for cold chain logistics services. Kuehne+Nagel is one of the world's leading logistics providers specializing in sea freight, airfreight, and contract logistics.
- DSVcorePartnership with DSV for global logistics and cold chain solutions. DSV is a global transport and logistics company offering services across air, sea, and road freight.
- DB SchenkercorePartnership with DB Schenker for temperature-controlled pharmaceutical logistics. DB Schenker is the logistics division of Deutsche Bahn AG.
- Expeditors InternationalcorePartnership with Expeditors for global logistics services. CSafe case study demonstrates zero temperature excursions shipping medical supplies from U.S. to Europe and China.
- FedExcorePartnership with FedEx for global freight and logistics services in CSafe's partner network.
- UPScorePartnership with UPS for global freight and logistics services in CSafe's partner network.
- Lufthansa CargocoreStrategic airline partnership with Lufthansa Cargo for temperature-controlled air cargo solutions. Lufthansa is one of Europe's largest airlines with significant cargo operations.
- Emirates SkyCargocoreAirline partnership with Emirates for pharmaceutical cargo transportation. Emirates operates one of the largest freighter networks globally.
- Singapore Airlines CargocoreAirline partnership with Singapore Airlines Cargo for global temperature-controlled cargo solutions.
- Cathay CargocorePartnership with Cathay Cargo for temperature-controlled pharmaceutical shipments across Asia-Pacific network.
- CargoluxcorePartnership with Cargolux, a dedicated cargo airline specializing in pharmaceutical logistics with temperature-controlled capabilities.
- Air France KLM CargocoreJoint airline partnership with Air France KLM for cold chain cargo solutions across European and global networks.
- Qatar Airways CargocorePartnership with Qatar Airways Cargo for pharmaceutical cold chain transportation via Doha hub.
- United CargocorePartnership with United Cargo. Quote from Managing Director Specialty Products: 'It is not just ordering a container, it is a logistics process made easy & business friendly.'
- American Airlines CargocorePartnership with American Airlines Cargo for temperature-controlled pharmaceutical shipments across Americas network.
- Delta CargocorePartnership with Delta Cargo for cold chain pharmaceutical logistics across Delta's global network.
- Korean Air CargocorePartnership with Korean Air Cargo for temperature-controlled cargo in Asia-Pacific region.
- World CouriercorePartnership with World Courier, a specialty logistics company focused on the pharmaceutical and biotech industries.
- MarkencorePartnership with Marken, a global clinical trial logistics provider serving the pharmaceutical industry.
- Softbox SystemscoreAcquired by CSafe in 2021, Softbox Systems is now an integral part of CSafe's passive parcel product line including Softbox VIP+, Softbox MAX, and Softbox ONE.
- NASAminorPartnership in the 1990s with NASA to develop insulated units for Space Shuttle program, contributing to VIP technology development.
Scale indicators8 records
Recent moves12 records
Expansion highlights6 records
CSafe Global competitors and assessment
Company assessmentDirect peers
- Cryoport Systems: Cryoport specializes in temperature-controlled logistics for cell and gene therapies, reproductive medicine, and biobanking, with cryogenic capabilities directly comparable to CSafe's CGT product line. Both serve pharmaceutical/biotech customers requiring ultra-low temperature shipping.
- Pelican BioThermal: Pelican BioThermal provides passive and reusable temperature-controlled shipping containers for the pharmaceutical and life sciences industries, directly competing with CSafe's parcel and pallet shipper portfolio. Strong overlap in clinical trial logistics and biologics distribution.
- va-Q-tec: va-Q-tec is a German-based provider of high-performance VIP (Vacuum Insulated Panel) thermal packaging solutions for pharmaceuticals and life sciences, directly competing with CSafe's VIP-based passive products. Both companies leverage proprietary VIP technology as a core differentiator.
- Envirotainer: Envirotainer is the global market leader in active temperature-controlled ULD container rentals for pharmaceuticals, directly competing with CSafe's RAP and RKN fleet across airlines and freight forwarders. Identified alongside CSafe as the two key players in the cold chain packaging pooling market.
- Sonoco ThermoSafe: Sonoco ThermoSafe is a major provider of passive temperature-controlled packaging solutions for the pharma and life sciences industry, directly competing with CSafe's Silverpod, APS, and Softbox product lines. Both companies target pharmaceutical manufacturers and clinical trial logistics customers.
Broad incumbents
- World Courier: World Courier (Cencora subsidiary) is a specialty logistics provider focused on pharmaceutical and biotech industries, offering temperature-controlled transport and storage as part of a broader clinical trial logistics and commercialization services portfolio. Listed as a CSafe partner but also serves as indirect competitor.
- DHL Global Forwarding Life Sciences: DHL's Life Sciences division offers integrated cold chain logistics including temperature-controlled air freight, warehousing, and packaging solutions. While a CSafe partner, DHL also develops proprietary solutions that compete for the same pharma logistics wallet.
- Marken: Marken (UPS Healthcare subsidiary) is a global clinical trial logistics provider serving pharmaceutical manufacturers, offering temperature-controlled supply chain solutions that overlap with CSafe's clinical trial segment. Listed as a CSafe partner but also competes in pharma logistics.
- Thermo Fisher Scientific (Patheon/CDMO logistics): Thermo Fisher Scientific's clinical trials logistics and pharma services division offers temperature-controlled shipping and storage as part of a much broader life sciences tools and CDMO portfolio. Indirect competitor in pharma cold chain services for clinical trials.
Others
- Softbox Systems (legacy): Softbox Systems was an independent passive temperature-controlled packaging specialist prior to being acquired by CSafe in 2021; the legacy brand is now integrated into CSafe's product portfolio (Softbox VIP+, MAX, ONE). Included for historical context on CSafe's M&A-driven portfolio expansion.
Market position
Strengths5 records
Weaknesses3 records
Competitive moat6 records
Key risks6 records
Key highlights7 records
Customer concentration
CSafe Global social profiles
Digital presenceCSafe Global compliance and trust
Trust signalCompliance7 records
CSafe Global financial estimates
Financial estimateRevenue estimate
Valuation estimate
CSafe Global leadership team
Management profileNumber of profiles
Profiles9 records
CSafe Global subsidiaries and ownership
Company hierarchySubsidiaries3 records
CSafe Global funding detail
Funding detailFunding overview
Funding rounds1 record
Investors2 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
CSafe Global M&A and investment
M&A and investmentM&A2 records
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about CSafe Global
What does CSafe Global do?
CSafe Global manufactures and leases temperature-controlled shipping containers, passive thermal packaging, thermal covers, and cryogenic dewars for pharmaceutical, biotech, and cell and gene therapy companies. Its portfolio combines active ULD containers (RAP, RKN) and passive parcel/pallet shippers (Softbox, Silverpod, CSafe Advanced, APS) with proprietary Vacuum Insulated Panel insulation and Phase Change Material coolants, complemented by the CSafe Connect digital platform and TracSafe data loggers for real-time shipment visibility. Supporting professional services cover cold chain planning, ISTA-certified thermal qualification, 24/7 Control Tower monitoring, and GDP-compliance training through CSafe University.
Is CSafe Global a public or private company?
CSafe Global is a private company. It is classified as private equity controlled and is currently operating.
When was CSafe Global founded?
CSafe Global was founded in 1979. It employs 101 to 250 people.
Where is CSafe Global based?
CSafe Global is headquartered in Dayton, United States, in the North America region.
How does CSafe Global make money?
Five revenue lines are on record. Active Temperature-Controlled Container Leasing is the primary driver. The others are passive Temperature-Controlled Packaging Products, cell & Gene Therapy Solutions, professional Services and silverskin RE Rental Program.
Who are CSafe Global's main competitors?
Direct peers on record are Cryoport Systems, Pelican BioThermal, va-Q-tec, Envirotainer and Sonoco ThermoSafe. Broad incumbents are World Courier, DHL Global Forwarding Life Sciences, Marken and Thermo Fisher Scientific (Patheon/CDMO logistics). Softbox Systems (legacy) is listed as an others.
Does CSafe Global have an API?
No public API is recorded for CSafe Global.
What industry is CSafe Global in?
CSafe Global's product category is Pharmaceutical Cold Chain Logistics. Its primary akta.pro industry code is HLAGAMAF, Packaging, Insulation & Temperature-Controlled Shippers (Qualified Systems), with a secondary code of IMALAIAG, Cold Chain & Temperature-Controlled Packaging (Insulated Shippers, Gel Packs). Its NAICS code is 56191 and its SIC code is 3580.