Rosetta Commons
- Company typePrivate
- Founded-
- HeadquartersBerkeley, United States
- Headcount1–10
- GTM typeB2B
- OfferingSoftware
Rosetta Commons firmographics
Firmographics- Name
- Rosetta Commons
- Legal name
- Rosetta Commons
- Website
- https://rosettacommons.org
- Company type
- Private
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Ownership category
- akta.pro rank
Rosetta Commons industry classification
Industry- Product category
- Computational Biology Software
- NAICS
- Software Publishers (5132), Scientific Research and Development Services (5417)
- SIC
- Services-Prepackaged Software (7372)
- akta.pro primary industry
- Bioinformatics & Multi-omics Analysis Software (HLAGAJAD)
- akta.pro secondary industry
- Cheminformatics & Molecular Modeling / CADD (HLAGAJAE)
Keywords
Where Rosetta Commons is headquartered
LocationHeadquarters
- HQ city
- Berkeley
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Rosetta Commons business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Technology or R&D, Personnel, Operations, Marketing or Sales, Infrastructure
Revenue model
- Commercial Software Licensing: Rosetta source code is freely available for academic and nonprofit research, but commercial entities must pay annual licensing fees. Revenue is managed by University of Washington's CoMotion office and reinvested to support the Rosetta Commons community including conferences, workshops, developer salaries, and infrastructure.
- Commercial Research License: Annual license allowing commercial entities to use Rosetta for research purposes and develop derivative products. Explicitly forbids repackaging, redistribution, or relicensing.
- Levitate-Rosetta Cloud License: Levitate offers cloud-based Rosetta access to customers with active Rosetta licenses (commercial or academic). Rosetta Commons Foundation owns Levitate and receives royalties from UW.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Freemium | Others | Academic/Nonprofit/Government - Free access |
| Subscription | Annual | Commercial Research License - Annual paid license |
| Subscription | Annual | Company Contributor License Agreement |
Go-to-market motion1 record
Distribution channels6 records
Marketing channels7 records
Rosetta Commons product offering
Product offeringCore offering
Rosetta Commons develops and maintains the Rosetta software suite, a comprehensive C++ software package for macromolecular structure modeling, prediction, and design. The suite enables protein design, enzyme engineering, ligand docking, antibody engineering, vaccine design, and structure prediction, integrating physics-based methods with deep learning tools like RoseTTAFold, RFdiffusion, and MPNN. Software is distributed freely to academic and nonprofit users, while commercial entities purchase annual licenses through University of Washington's CoMotion office.
Product overview
Rosetta Commons is a global consortium of over 100 research laboratories that develops and maintains an integrated software ecosystem for computational protein modeling and design. The core offering is the Rosetta software suite (C++ with Python interface via PyRosetta), which provides physics-based modeling capabilities alongside AI-powered tools including RoseTTAFold, RFdiffusion, and MPNN. The portfolio centers on de novo protein design, structure prediction, enzyme design, and antibody engineering. Key products include the core Rosetta framework, PyRosetta for Python scripting, Foldit for citizen science engagement, and the Foundry platform bundling deep learning tools. Educational programs (REU, RaMP, workshops, bootcamps) support workforce development, while the community maintains a GitHub-based distribution model with academic free access and commercial licensing through UW CoMotion.
Differentiator
Problem solved
Functional benefit
Brands
- Rosetta: A C++ software suite for modeling macromolecular structures including structure prediction, design, and remodeling of proteins and nucleic acids.
- PyRosetta
- Foldit
- RoseTTAFold
- RFdiffusion
Products and services
- Rosetta Software Suite
- PyRosetta
- Foldit
- Foundry
- RoseTTAFold
- RoseTTAFold3 (RF3)
- RFdiffusion / RFdiffusion2 / RFdiffusion3
- MPNN (Message Passing Neural Network)
- DeepAb
- RFantibody
- ProteinGenerator
- RFDpoly
- HBDesigner
- MaSIF (Molecular Surface Interaction Fingerprints)
- ROSIE (Rosetta Online Server)
- Robetta Server
- Commercial Research License (Rosetta)
- Company Contributor License Agreement
Quantifiable outcome
- First accurate solutions to de novo structure prediction problem
- +2 more outcomes
Companies that use Rosetta Commons
Customer profileNamed customers13 records
Segments4 records
Ideal customer profiles3 records
Rosetta Commons technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration3 records
AI capability6 records
Feature10 records
Rosetta Commons partnerships and signals
Strategic signalPartnerships
Six partnerships are on record, tiered core, major and minor.
- University of WashingtoncoreLead institution of Rosetta Commons; exclusively manages licensing through CoMotion office; hosts Summer RosettaCon annually
- Levitate-RosettacoreCloud-based Rosetta platform owned by Rosetta Commons Foundation through which they receive royalties from UW; commits significant code to Rosetta codebase and recruits new Rosetta customers
- Rosetta Design GroupmajorOfficial liaison between Rosetta Commons and industry participants; performs in-house and contract R&D; offers on-site training in Rosetta software; David Nannemann serves as Industry Chair on Rosetta Commons Board
- Cyrus BiotechnologyminorCommercial Rosetta licensee and spin-out; David Baker and Jeffrey Gray have financial interest in Cyrus; provides cloud Rosetta access to customers
- Open Molecular Software Foundation (OMSF)majorProvides technical infrastructure support including documentation writing, software best practices, and community coordination; Hope Woods serves as Technical Product Lead and Julia Koehler Leman as Documentation Writer
- HuggingFacemajorHosts Rosetta Data Bazaar collection of molecular datasets for training and evaluating structure prediction and design methods; enables community data sharing
Scale indicators3 records
Recent moves6 records
Expansion highlights6 records
Rosetta Commons competitors and assessment
Company assessmentEmerging players
- EvolutionaryScale: Early-stage AI company developing large protein language models (ESM series) for protein design and prediction. Competes with Rosetta's MPNN/RFdiffusion-class tools using a foundation-model approach.
Direct peers
- Cyrus Biotechnology: Commercial Rosetta spin-out providing cloud-based Rosetta access and protein engineering services. Founded by Rosetta community members (David Baker, Jeffrey Gray) and offers a commercialized layer over the Rosetta codebase.
- Generate Biomedicines: Flagship AI protein design startup using generative AI to create novel therapeutic proteins. Directly comparable to Rosetta Commons as a competing platform for de novo protein design, with named researcher Gevorg Grigoryan affiliated with both organizations.
- Manifold Bio: AI-native drug discovery startup focused on in vivo protein design and antibody therapeutics. A Diamond sponsor at Summer RosettaCon 2026 and a direct competitor in AI-driven protein design for pharma.
- Arzeda: Computational enzyme and protein design company that uses Rosetta and related methods. A Rosetta licensee applying protein design to industrial enzyme engineering, with named scientist Jim Havranek using Rosetta internally.
- Absci: AI-driven biologics design platform using generative AI for antibody and protein design. A Diamond sponsor at Summer RosettaCon 2026 and a competing AI protein design platform for therapeutic applications.
- Profluent: AI protein design company developing large protein language models for de novo protein generation. A Diamond sponsor at Summer RosettaCon 2026 and a direct competitor in the AI protein design space.
Broad incumbents
- DeepMind: Google DeepMind division that developed AlphaFold and AlphaFold 3. The most prominent direct competitor in AI protein structure prediction with vastly greater compute resources and a structural-advantage head start.
- Schrödinger, Inc. Established computational chemistry and molecular simulation platform serving pharma R&D with physics-based software. Overlaps with Rosetta's physics-based modeling capabilities but operates as a broader commercial drug discovery software incumbent.
- Isomorphic Labs: Alphabet-owned commercial drug discovery spin-out of DeepMind focused on AI-driven protein structure prediction and drug design. A well-capitalized incumbent competitor to Rosetta, leveraging AlphaFold and adjacent AI methods.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat6 records
Key risks6 records
Key highlights7 records
Customer concentration
Rosetta Commons social profiles
Digital presenceRosetta Commons financial estimates
Financial estimateRevenue estimate
Valuation estimate
Rosetta Commons leadership team
Management profileNumber of profiles
Profiles2 records
Rosetta Commons subsidiaries and ownership
Company hierarchySubsidiaries1 record
Rosetta Commons funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Rosetta Commons M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Rosetta Commons
What does Rosetta Commons do?
Rosetta Commons develops and maintains the Rosetta software suite, a comprehensive C++ software package for macromolecular structure modeling, prediction, and design. The suite enables protein design, enzyme engineering, ligand docking, antibody engineering, vaccine design, and structure prediction, integrating physics-based methods with deep learning tools like RoseTTAFold, RFdiffusion, and MPNN. Software is distributed freely to academic and nonprofit users, while commercial entities purchase annual licenses through University of Washington's CoMotion office.
Is Rosetta Commons a public or private company?
Rosetta Commons is a private company. It is classified as nonprofit foundation owned and is currently operating.
When was Rosetta Commons founded?
Rosetta Commons was founded in -1. It employs 1 to 10 people.
Where is Rosetta Commons based?
Rosetta Commons is headquartered in Berkeley, United States, in the North America region.
How does Rosetta Commons make money?
Three revenue lines are on record. Commercial Software Licensing is the primary driver. The others are commercial Research License and levitate-Rosetta Cloud License.
Who are Rosetta Commons's main competitors?
EvolutionaryScale is listed as an emerging player. Direct peers are Cyrus Biotechnology, Generate Biomedicines, Manifold Bio, Arzeda, Absci and Profluent. Broad incumbents are DeepMind, Schrödinger, Inc. and Isomorphic Labs.
Does Rosetta Commons have an API?
No public API is recorded for Rosetta Commons.
What industry is Rosetta Commons in?
Rosetta Commons's product category is Computational Biology Software. Its primary akta.pro industry code is HLAGAJAD, Bioinformatics & Multi-omics Analysis Software, with a secondary code of HLAGAJAE, Cheminformatics & Molecular Modeling / CADD. Its NAICS code is 5132 and its SIC code is 7372.