Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF

What Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF does

The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF is a non-commercial academic research center within the University of California, San Francisco, established in 2008 following a $25 million gift from The Eli and Edythe Broad Foundation and headquartered in the purpose-built Ray and Dagmar Dolby Regeneration Medicine Building on the Parnassus campus (opened February 2011 after a further $20 million Dolby gift). It operates as the heart of a 125-lab research program across UCSF, with 25 core labs focused on stem cell and regenerative medicine across reproductive, neural, blood, cardiac/vascular, epithelial, musculoskeletal, and pancreas/liver domains.

The center's core technical platforms include CRISPR-based stem cell genome engineering, lentiviral gene therapy protocols (notably a first-in-human trial for Artemis-deficient SCID that has allowed most treated infants to discontinue immune globulin infusions), patient-derived 3D brain organoid models for neuropsychiatric research, and vascular stem cell identification in developing brains. The strategic vision—'Discover – Engineer – Heal'—positions the center at the translational frontier, with fetal therapy for rare genetic disorders, salivary gland regeneration, glioblastoma stem cell biology, and autism/schizophrenia organoid research as active programs.

Its business model is non-commercial: revenue is a mix of federal grants (NIH BRAIN Initiative contributing up to $100M annually to related consortia), California state funding through CIRM, and philanthropy. The center serves three primary segments—patients with devastating diseases (genetic disorders, cancer, diabetes, neurodegeneration), academic researchers and clinician-scientists, and PhD/postdoctoral/clinical trainees—and is led by Director Tippi C. MacKenzie, MD, with a steering committee covering education, industry partnerships, faculty development, philanthropy, opportunity and outreach, and technology.

Name

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF

Legal name

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF

Website

https://stemcell.ucsf.edu

Company type

Private

Founded year

2008

Operating status

Operating

Headcount range

11–50 employees

Short description

The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF is a non-commercial academic research center within UCSF, housing 25 core labs across a 125-lab program focused on stem cell biology, gene therapy, and organoid modeling for genetic, oncologic, and neurodegenerative diseases, funded by federal grants and philanthropy.

Ownership category

akta.pro rank

Product category

Academic biomedical research

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714), Research and Development in the Physical, Engineering, and Life Sciences (54171)

SIC

Services-Commercial Physical & Biological Research (8731)

akta.pro primary industry

Stem Cell–Based Regenerative Therapies (HLAAAGAA)

akta.pro secondary industries

Stem Cell Therapies (MSC/iPSC/HSC-derived) (HLAAABAE), Cell Therapy Enabling Technologies (gene editing, cell engineering, delivery methods) (HLAAABAL), Neural & Spinal Cord Regeneration (HLAAAGAI)

Keywords

• Stem cell research
• Regenerative medicine
• Gene therapy research
• Genome editing research
• Translational medicine

Headquarters

HQ city

San Francisco

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Infrastructure, Others

Revenue model

1. Philanthropy and Donations: Individual, foundation, and corporate gifts directly support scientists pursuing discoveries. Funds support researchers' time, advanced technologies, genomic sequencing, and data analysis.
2. Research Grants: Federal and state funding including NIH, CIRM, Cancer Grand Challenges awards to support specific research programs and clinical trials

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels5 records

Core offering

The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF is an academic research center conducting basic and translational stem cell and regenerative medicine research. It houses 25 core labs and connects to 125+ labs across UCSF, advancing gene therapy (including a first-in-human lentiviral gene therapy for Artemis-deficient SCID), CRISPR-based genome editing, stem cell-derived organoid modeling, and cell-based therapies targeting genetic diseases, cancer, diabetes, and neurodegenerative disorders. The center also trains PhD students, postdoctoral fellows, and clinical fellows, and operates the Ray and Dagmar Dolby Regeneration Medicine Building on the UCSF Parnassus campus.

Differentiator

Problem solved

Functional benefit

Products and services

• Boardroom Rental at Ray and Dagmar Dolby Regeneration Medicine Building

Quantifiable outcome

• Pioneering gene therapy for Artemis-deficient SCID with exceptional outcomes, allowing most treated infants to discontinue all medications including immune globulin infusions
• +2 more outcomes

Named customers2 records

Segments3 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

Five partnerships are on record, tiered core.

• UCLA and UC Santa Cruz Genomics InstitutecoreStrategic or Co-development Partner · 31 January 2025Multi-institution collaboration including UCSF Broad Stem Cell Center, UCLA, and UC Santa Cruz Genomics Institute to develop new stem cell-based treatments for neuropsychiatric disorders, studying how metabolism influences brain development.
• Stanford UniversitycoreStrategic or Co-development PartnerCollaborative research partnerships between UCSF and Stanford for psychiatric neurodevelopmental disorders research, including the CIRM ReMIND Program projects.
• QB3 (California Institute for Quantitative Biosciences)coreStrategic or Co-development PartnerQB3 helped form multidisciplinary teams including investigators from UCSF, UC Berkeley, and UC Santa Cruz for autism spectrum disorder research using 3D brain organoid models and AI analysis.
• Salk InstitutecoreStrategic or Co-development PartnerScientists from UCSF, Stanford, and Salk Institute received grant funding to study glioblastoma stem cells - the most aggressive form of brain cancer.
• UCLA Broad Stem Cell Research CentercoreStrategic or Co-development PartnerCollaborative effort to accelerate development of transformative treatments; UCLA advancing a gene therapy trial targeting ADA-deficient SCID while UCSF advances Artemis-deficient SCID therapy.

Scale indicators8 records

Recent moves8 records

Expansion highlights5 records

Broad incumbents

• Whitehead Institute for Biomedical Research: Affiliated with MIT, Whitehead conducts foundational research in stem cell biology, cancer, and regenerative medicine. It is a broader incumbent biomedical research institute with overlapping basic-science capabilities rather than a stem-cell-only specialty, comparable in scale and prestige to UCSF Broad.
• Koch Institute for Integrative Cancer Research at MIT: Major academic cancer research institute with programs in cancer stem cells, regenerative medicine-adjacent technologies, and Cancer Grand Challenges-funded teams. It is a broader incumbent in cancer biology and engineering rather than a stem cell-only institution, comparable in translational orientation.

Direct peers

• Gladstone Institutes: Independent nonprofit biomedical research institute physically affiliated with UCSF, with overlapping programs in regenerative medicine, stem cell biology, cardiovascular and neurological disease. Gladstone serves as a closely adjacent peer institution with shared faculty, shared trainees, and complementary research infrastructure.
• Harvard Stem Cell Institute: One of the largest and most prominent academic stem cell research programs in the United States. HSCI pursues a comparable portfolio spanning basic stem cell biology, regenerative medicine, and clinical translation across a multi-faculty, multi-hospital academic structure similar to UCSF Broad's 25-lab core model.
• Allen Institute for Cell Science: Nonprofit research division focused on understanding cell behavior using stem cell-derived models, including genome-edited iPSC lines and 3D organoid-like models. Overlaps with UCSF Broad's stem cell genome engineering and brain organoid programs in methodology and translational orientation.
• Salk Institute for Biological Studies: Direct peer and named scientific collaborator on glioblastoma stem cell research. Salk operates major programs in stem cell biology, cancer, and neuroscience with comparable basic-to-translational scope and similarly competes for the same pool of NIH, CIRM, and major-foundation funding.
• Stanford Institute for Stem Cell Biology and Regenerative Medicine: Direct peer in stem cell and regenerative medicine research at a major Bay-area academic medical center. Stanford's institute pursues overlapping programs in stem cell genome engineering, organoid biology, and neuropsychiatric/neurodegenerative disease modeling, and collaborates with UCSF Broad on CIRM ReMIND-funded psychiatric neurodevelopmental disorder research.
• UCLA Broad Stem Cell Research Center: Direct peer and named collaborator with UCSF Broad. UCLA operates a parallel comprehensive stem cell and regenerative medicine research program, is jointly advancing SCID gene therapy trials (UCLA on ADA-deficient, UCSF on Artemis-deficient), and shares a similar basic-to-translational science mission housed within a major UC-system research university.
• New York Stem Cell Foundation (NYSCF) Research Institute: Independent stem cell research organization that runs the NYSCF Robertson Investigator Program, which has included UCSF Broad-affiliated researchers. NYSCF pursues an overlapping portfolio in stem cell biology, disease modeling, and automation of cell engineering, with similar translational ambitions.

Emerging players

• Cincinnati Children's Center for Stem Cell & Organoid Medicine: Pediatric hospital-anchored stem cell and organoid research program with overlapping focus areas in pediatric genetic disease modeling and regenerative medicine. Smaller in scale than UCSF Broad but pursues comparable organoid-based disease modeling and translational stem cell pipelines.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/UCSFstemcell
• YouTubeyoutube.com/@UCSFBroadStemCell
• Facebookfacebook.com/UCSFBroadStemCell
• LinkedInlinkedin.com/school/ucsf-stem-cell
• Instagraminstagram.com/ucsfstemcell

Revenue estimate

Valuation estimate

Number of profiles

Profiles11 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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