T&L Biotechnology

What T&L Biotechnology does

T&L Biotechnology is a Carlsbad, California-based private biotechnology supplier that develops and manufactures core raw materials for the Cell and Gene Therapy (CGT) segment. The company's product portfolio spans recombinant proteins (including IL-7, IL-15, TNFα, bFGF, EGF, M-CSF, PDGF-BB, 4-1BB Ligand, and others), monoclonal antibodies (CD3, CD16, CD20, CD28, CD52, CD137), cell separation magnetic beads (proprietary NanoSep 50nm biodegradable nano-magnetic beads available in RUO and GMP grades, plus MaxSortin and ActSep product lines), serum-free media (AMMS series), and complete cell culture kits (AMMS MSC, NK cell, and CIK cell kits). Multiple products hold US FDA Drug Master File (DMF) registrations, including CD3 monoclonal antibody, CD3/CD28 sorting activation magnetic beads, recombinant human IL-7 protein (Cat. No. GMP-TL506), recombinant human IL-15 protein, and CD28 monoclonal antibody (DMF registration number 038820). The company was founded in 2011 and operates with a headcount of approximately 12 employees.

The company operates a direct-to-consumer e-commerce model through tlbiotechnology.com, shipping globally via UPS and FedEx with orders fulfilled within 48 hours and free shipping on orders over $200. Per-unit pricing ranges from $14 (MaxSortin Separation Buffer) to $2,072 (ActCel T Cell Activation Reagent), positioning products for biotech and pharmaceutical research buyers. Beyond catalog sales, T&L offers CRO services including custom magnetic cell sorting, GMP protein expression and purification, GMP formulation, protein characterization, CAR-NK cell therapy development, and gene editing services. The go-to-market combines e-commerce with content marketing (COA documents, FDA DMF files, blog), email newsletters, a 5% commission affiliate program, and selective conference participation including CGT Asia 2024 in Shanghai.

T&L serves two primary customer segments: CGT-focused biotech and pharmaceutical companies requiring GMP-grade raw materials for clinical applications, and academic and private research institutions conducting cell biology, immunology, and biotechnology research. The company operates as an independent private entity with no disclosed external funding, parent company, or public listing, and ships globally from its Carlsbad, California headquarters at 6076 Corte Del Cedro.

Name

T&L Biotechnology

Website

https://tlbiotechnology.com

Company type

Private

Founded year

2019

Operating status

Operating

Headcount range

11–50 employees

Short description

T&L Biotechnology is a Carlsbad, California-based private supplier of cell and gene therapy raw materials, including recombinant proteins, monoclonal antibodies, GMP-grade magnetic beads, serum-free media, and cell culture kits sold via direct e-commerce to biotech and pharmaceutical companies globally.

Ownership category

akta.pro rank

Product category

Cell and Gene Therapy Reagents

NAICS

Biological Product (except Diagnostic) Manufacturing (325414), Research and Development in Biotechnology (except Nanobiotechnology) (541714), Drugs and Druggists' Sundries Merchant Wholesalers (424210)

SIC

Wholesale-Medical, Dental & Hospital Equipment & Supplies (5047), Biological Products, (No Disgnostic Substances) (2836)

akta.pro primary industry

Raw Materials & Critical Reagents Supply (Media/Resins/Cytokines) (HLAGAGAI)

akta.pro secondary industries

Gene Therapy CMC/Process Development Platforms (capsid engineering, producer cell lines, plasmids, upstream/downstream) (HLAAACAN), Analytical Development & QC Testing (Release/Stability/Potency) (HLAGAGAF), Recombinant Protein Therapeutics (enzymes, hormones, growth factors) (HLAAAAAB)

Keywords

• Cell therapy reagents
• Gene therapy raw materials
• Recombinant proteins
• Monoclonal antibodies
• Cell separation magnetic beads

Headquarters

HQ city

Carlsbad

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Technology or R&D, Personnel, Operations, Marketing or Sales

Revenue model

1. Biotech Reagent Product Sales: Sale of recombinant proteins, monoclonal antibodies, cell separation magnetic beads, serum-free media, and cell culture kits through e-commerce platform. One-time purchase model for research reagents.
2. CRO Services: Contract research organization services including custom magnetic cell sorting, GMP protein expression and purification, GMP formulation service, protein characterization service, CAR-NK cell therapies service, and gene editing services.

Pricing tiers

Go-to-market motion1 record

Distribution channels1 record

Marketing channels5 records

Core offering

T&L Biotechnology researches, develops, and manufactures core raw materials for the Cell and Gene Therapy (CGT) segment, including recombinant proteins, monoclonal antibodies, cell separation magnetic beads, serum-free media, and cell culture kits. The company also provides CRO services such as custom magnetic cell sorting, GMP protein expression and purification, GMP formulation, protein characterization, CAR-NK cell therapy development, and gene editing. Products are sold directly through the company's e-commerce platform with FDA DMF filings for key CGT raw materials.

Product overview

T&L Biotechnology is a biotechnology company focusing on the R&D and production of core raw materials for the Cell and Gene Therapy (CGT) segment. The company offers a comprehensive portfolio of products including Recombinant Proteins (such as TNFα, bFGF, EGF, IL-15, IL-7, and 4-1BB Ligand), Monoclonal Antibodies (CD3, CD16, CD20, CD28, CD52, CD137), Cell Separation Magnetic Beads (including NanoSep nano-magnetic beads and MaxSortin CD3/CD4/CD8/CD14/CD138 isolation kits), Serum-Free Medium (AMMS series), and Cell Culture Kits (AMMS MSC and NK cell culture kits). Services include Custom Magnetic Cell Sorting, GMP Protein Expression & Purification, GMP Formulation, Protein Characterization, CAR-NK Cell Therapies, and Gene Editing Services. The company operates an e-commerce platform for direct product sales and has received FDA DMF filings for key CGT raw materials.

Differentiator

Problem solved

Functional benefit

Brands

• AMMS: Cell culture kit and serum-free medium product line
• MaxSortin
• ActSep
• ActCel

Products and services

• Recombinant Proteins Recombinant proteins for cell culture and research applications, including TNFα, bFGF, EGF, M-CSF, PDGF-BB, Fibronectin, FLT3 Ligand, IL-3, LIF, SCF, Vitronectin, IL-15, IL-7, IFN-γ, Activin A, and 4-1BB Ligand proteins. Intended for biotech and pharmaceutical researchers working on cell and gene therapy applications.
• Monoclonal Antibodies Monoclonal antibodies including Anti-Human CD137 mAb, Anti-Human CD16 mAb, Anti-Human CD20 mAb, Anti-Human CD28 mAb, Anti-Human CD3 mAb, and Anti-Human CD52 mAb for research and cell therapy applications.
• NanoSep Cell Separation Nano-Magnetic Beads 50nm biodegradable nano-magnetic beads for cell separation with high safety, stability, and separation efficiency. Available in RUO and GMP grades. Includes CD3, CD4, CD8, CD14, CD138 beads and isolation kits under the MaxSortin brand.
• ActSep CD3/CD28 Separation and Activation Magnetic Beads T cell activation and expansion reagents for in vitro T cell activation, particularly for T cell therapy production. Used in cell therapy manufacturing workflows.
• ActCel T Cell Activation Reagent T cell activation reagent designed for the activation and expansion of T cells in vitro, particularly in the production of T cell therapies.
• Serum-Free Medium Serum-free media including AMMS Matrix for Organoid Culture, AMMS HEK293 serum-free medium, Cell Cryopreservation Solution, and Lymphocyte Separation Medium for cell culture applications.
• AMMS Cell Culture Kits Complete cell culture kits for MSC, NK cell, CIK cell, and pluripotent stem cell expansion. Includes AMMS MSC Cell Culture Kit 2.0, AMMS NK Cell Culture Kit 2.0/2.0 Plus/3.0, and AMMS CIK Cell Expansion Reagent and Medium Kit.
• OK432 Lyophilized devitalized bacterium used to activate neutrophils for killing IFN-γ or TNF-α treated cancer cells, inducing neutrophil-killing effect on autologous tumor cells through CD11b/CD18 and ICAM-1 binding.
• Custom Magnetic Cell Sorting Service Custom magnetic cell sorting services for specialized separation needs. Targeted at biotech and pharmaceutical clients with bespoke separation requirements.
• GMP Protein Expression and Purification Service Good Manufacturing Practice (GMP) protein expression and purification services for clients requiring regulatory-grade protein production.
• GMP Formulation Service GMP formulation services for cell therapy products. Targeted at clients requiring regulatory-compliant formulation development.
• Protein Characterization Service Protein characterization services for quality analysis. Targeted at biotech and pharmaceutical clients needing protein analytics.
• CAR-NK Cell Therapies Service CAR-NK cell therapies development services for biotech clients developing cell-based immunotherapies.
• Gene Editing Services Gene editing services for cell therapy applications, supporting clients developing gene-modified cell therapies.

Quantifiable outcome

• DMF filed products enable customers to reference DMF registration numbers in FDA submissions, reducing product review time and simplifying IND application process

Segments2 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration6 records

Feature3 records

Scale indicators2 records

Recent moves6 records

Expansion highlights4 records

Broad incumbents

• Cytiva (Danaher): Large life-science supplier providing cell-therapy processing instruments, media, and process development services. Adjacent comparator for T&L's full-stack CGT positioning and CRO services offering.
• Lonza: Global CDMO and raw materials supplier offering cell and gene therapy manufacturing services plus media/reagent products. Represents both an upstream competitor (instruments, media) and a downstream partner opportunity for T&L's CRO services.
• Thermo Fisher Scientific (Gibco/Life Technologies): Global life-science leader with Gibco brand covering cell culture media, sera, and recombinant proteins used in CGT manufacturing. Sets the enterprise default against which T&L competes for sponsor-qualified vendor status.
• PeproTech (Thermo Fisher): Recombinant cytokine specialist (now part of Thermo Fisher) producing EGF, IL-2, IL-7, IL-15 and other CGT-relevant cytokines. Direct overlap with T&L's recombinant protein catalog in the same buyer workflows.

Direct peers

• STEMCELL Technologies: Canadian supplier of cell isolation reagents (EasySep magnetic beads), serum-free media, and cell culture kits for research and clinical cell-therapy workflows. Direct overlap with T&L's MaxSortin, AMMS, and cell-therapy reagent lines.
• CellGenix: German supplier of GMP-grade raw materials (cytokines, media, cell separation reagents) for cell and gene therapy manufacturing. Closely comparable to T&L in target customers (CGT sponsors) and GMP/DMF-focused product strategy.
• ACROBiosystems: Supplier of recombinant proteins, magnetic beads (Magbeads), GMP cytokines, and cell-therapy reagents with strong Asia-Pacific presence. Competes head-to-head with T&L across recombinant proteins and magnetic bead categories.
• Miltenyi Biotec: German manufacturer of magnetic cell separation beads (MACS), GMP cytokines, and cell-therapy processing reagents. Most direct competitor to T&L's NanoSep bead and recombinant protein portfolio serving CGT developers globally.
• Sino Biological: China-based manufacturer of recombinant proteins, antibodies, and GMP-grade reagents serving biotech and CGT customers. Highly comparable catalog overlap with T&L's recombinant protein and antibody lines, especially in APAC.

Emerging players

• BioLegend (Revvity): Manufacturer of recombinant proteins and antibodies for immunology and cell therapy research (now part of Revvity). Comparable catalog positioning to T&L's antibody and recombinant protein lines, especially on the research-use side.

Market position

Strengths1 record

Weaknesses5 records

Competitive moat3 records

Key risks5 records

Key highlights6 records

Customer concentration

• LinkedInlinkedin.com/company/tlbiotechnology

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about T&L Biotechnology