Tennessee Memory Disorders Foundation (tmdf)

What Tennessee Memory Disorders Foundation (tmdf) does

Tennessee Memory Disorders Foundation (TMDF) is a Knoxville, Tennessee-based 501(c)(3) nonprofit specialty clinic that diagnoses and treats Alzheimer's disease and related neurodegenerative dementias in adults across East Tennessee and the broader Southeast. Founded in 2017 by Dr. Monica Crane as the Genesis Neuroscience Clinic and converted to a board-governed nonprofit in 2020, TMDF operates from a single site at 1400 Dowell Springs Blvd Suite 340 and serves 6,500+ active patients out of a cumulative 9,000+ treated since opening.

The clinical platform integrates comprehensive neurocognitive testing (MMSE, MoCA), physical examination, and diagnostic follow-up visits with multi-modal brain imaging coordinated through Provision and Abercrombie radiology partners, blood-based biomarker testing (p-tau217, amyloid, tau) routed through Quest Diagnostics, Labcorp, and C2N Diagnostics/Precivity, and lumbar puncture procedures. TMDF also operates an active clinical research program running six Phase 3 Alzheimer's trials in parallel with sponsors including Hoffmann-La Roche, Bristol Myers Squibb, Eli Lilly, and AriBio, and participates in the Alzheimer's Association-sponsored ALZ-NET registry. A distinctive undergraduate clinical internship program delivers hands-on geriatric and cognitive-assessment experience, and the foundation runs CME courses with ETSU Quillen College of Medicine plus community outreach, podcasts, and donor programs.

TMDF's revenue model combines three streams: insurance reimbursement for patient services (the clinic accepts only insured patients under credentialed plans and does not accept cash payments, with billing outsourced to Cornerstone Healthcare Solutions), pharmaceutical-sponsored clinical trial payments, and tax-deductible donations, grants, and legacy gifts. Distribution is referral-based — patients must be referred by a PCP or neurologist — and growth is supported by thought-leadership content from Dr. Crane across Instagram (@heydrcrane), LinkedIn, Facebook, X, podcast appearances, and CME presentations.

Name

Tennessee Memory Disorders Foundation (tmdf)

Legal name

Tennessee Memory Disorders Foundation

Website

https://tmdf.org

Company type

Private

Founded year

2017

Operating status

Operating

Headcount range

11–50 employees

Short description

Tennessee Memory Disorders Foundation is a Knoxville-based 501(c)(3) nonprofit specialty clinic that diagnoses and treats Alzheimer's disease and related dementias in adults across East Tennessee and the Southeast, while operating an active Phase 3 clinical trial program and an undergraduate internship pipeline.

Ownership category

akta.pro rank

Product category

Geriatric Memory Care Healthcare Services

NAICS

Services for the Elderly and Persons with Disabilities (624120), Services for the Elderly and Persons with Disabilities (62412)

SIC

Services-Offices & Clinics Of Doctors Of Medicine (8011), Services-Specialty Outpatient Facilities, Nec (8093)

akta.pro primary industry

Memory Care Care Management & Navigation (Dementia Care Coordination) (HLADACAJ)

Keywords

• Memory disorder diagnosis
• Dementia care services
• Alzheimer treatment
• Clinical trials research
• Geriatric medicine

Headquarters

HQ city

Knoxville

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Marketing or Sales, Technology or R&D, Infrastructure, Supply Chain

Revenue model

1. Patient Services (Insurance Reimbursement): Clinical care services billed to insurance companies. TMDF only accepts patients with insurance plans they are credentialed with. Cash payments are not accepted for patient services including copays and visit-related charges. Billing handled by Cornerstone Healthcare Solutions LLC.
2. Donations and Grants: Tax-deductible donations from individuals, corporate donors, and foundation grants. Federal tax ID 85-1051195. General donations, intern sponsorship, memorial/honor gifts accepted. Overhead and operational expenses covered by insured patients.
3. Clinical Trial Sponsorships: Participation in clinical trials sponsored by pharmaceutical companies (Roche, Bristol Myers Squibb, Eli Lilly, AriBio, Novo Nordisk) providing research funding and patient access to experimental treatments

Go-to-market motion1 record

Distribution channels3 records

Marketing channels9 records

Core offering

Tennessee Memory Disorders Foundation delivers specialty clinical care for adults with memory disorders and neurodegenerative dementias, including Alzheimer's disease. The clinic provides comprehensive evaluation and diagnosis through neurocognitive testing, brain imaging coordination, blood-based biomarker testing, and lumbar puncture, followed by ongoing treatment management and participation in Phase 3 clinical trials sponsored by major pharmaceutical companies. Beyond clinical services, the foundation runs a clinical internship program for undergraduate students and delivers community education, CME courses, and caregiver support resources through its Knoxville, Tennessee nonprofit operations.

Product overview

Tennessee Memory Disorders Foundation (TMDF) operates as a nonprofit healthcare organization offering a unified clinical care model for memory disorders and neurodegenerative dementias. The organization provides integrated services including evaluation and diagnosis of Alzheimer's disease and related conditions, diagnostic imaging coordination, an active clinical trials program with multiple Phase 3 studies, community outreach and education, a clinical internship program for undergraduate students, and patient/caregiver support services. The core offering is comprehensive memory disorder care combining clinical services with research and education initiatives.

Differentiator

Problem solved

Functional benefit

Products and services

• Memory Disorder Evaluation and Diagnosis Comprehensive evaluation and diagnosis services for neurodegenerative dementia syndromes, including Alzheimer's disease, memory loss, and other cognitive concerns. Involves neurocognitive testing (MMSE, MoCA), physical exams, medical history review, and diagnostic follow-up visits with Dr. Monica Crane. Target users are adults experiencing memory problems, cognitive decline, or diagnosed with Alzheimer's disease and related dementias, referred by PCPs or neurologists.
• Diagnostic Imaging Services Brain imaging services including MRI, CT scans, PET/CT scans, amyloid PET scans, and lumbar puncture procedures coordinated through partner imaging facilities to support the diagnosis of memory disorders and Alzheimer's disease.
• Clinical Trials Program Research studies providing patients access to ethical clinical research for Alzheimer's disease and related dementias, with screening and eligibility determination, longitudinal study visits, and access to experimental treatments sponsored by Roche, Bristol Myers Squibb, Eli Lilly, AriBio, and Novo Nordisk.
• Community Outreach and Education Educational programs, CME-accredited courses, podcasts, and community presentations on Alzheimer's disease, brain health, and dementia care. Includes collaboration with ETSU Quillen College of Medicine on AMA PRA Category 1 accredited courses and appearances on Living Our Best With Memory Loss, Aging Starts Now, and Your Fantastic Mind podcasts.
• Clinical Internship Program Undergraduate student internship program providing hands-on experience in geriatric medicine, cognitive assessments (MMSE, MoCA), clinical documentation, and mentorship from fellowship-trained geriatricians and nurse practitioners. Target users are undergraduate pre-medical students, particularly those from groups underrepresented in healthcare.
• Blood-Based Biomarker Testing Non-invasive blood tests measuring proteins linked to Alzheimer's disease including amyloid and tau proteins, p-tau217 markers, and other neurodegeneration indicators to support diagnosis and treatment decisions. Coordinated with Quest Diagnostics, Labcorp, and C2N Diagnostics/Precivity.
• Caregiver Support and Resources Patient paperwork assistance, referral coordination, billing support through Cornerstone Healthcare Solutions, and connections to community resources including the Alzheimer's Association, Knoxville Office on Aging, and ETHRA. Designed for caregivers and families of patients with memory disorders.
• Donation Programs Philanthropic giving programs including general donations, internship sponsorships, memorial and honor gifts, the Dearest Friends membership program, and the Dr. John Dougherty Legacy Giving Program for planned estate gifts. Federal tax ID 85-1051195 makes donations tax-deductible.

Quantifiable outcome

• Over 9,000 patients treated since opening in 2017
• +2 more outcomes

Named customers3 records

Segments4 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration6 records

Feature4 records

Partnerships

Five partnerships are on record, tiered core and minor.

• East Tennessee State University (ETSU) Quillen College of MedicinecoreStrategic or Co-development PartnerCollaboration for Continuing Medical Education (CME) course on Alzheimer's Disease Diagnosis, Treatment and Hope. Dr. Crane's presentation approved for AMA PRA Category 1 Credits (0.75 hours). Partnership provides CME opportunities for health professionals.
• University of Tennessee, Knoxville and Graduate School of MedicinecoreStrategic or Co-development PartnerAcademic partnership integrated into unique care model. Dr. Crane serves as Clinical Assistant Professor at UT Graduate School of Medicine. Supports mentorship and research collaboration.
• Knox County Health DepartmentminorStrategic or Co-development PartnerTMDF Clinical Coordinator Eduardo Chacon completed Applied Practice Experience (APEx) with KCHD Emergency Preparedness & Epidemiology Division developing EMERION framework.
• Cornerstone Healthcare Solutions LLCminorOthersBilling services partner handling patient billing inquiries and revenue cycle management. Phone: (877) 501-1247 for billing questions.
• Alzheimer's Association (ALZ-NET Sponsor)coreStrategic or Co-development PartnerSponsor of ALZ-NET (Alzheimer's Network for Treatment & Diagnostics) managed by American College of Radiology. TMDF participates in this network for treatment and diagnostics.

Scale indicators5 records

Recent moves7 records

Expansion highlights5 records

Others

• C2N Diagnostics: Diagnostics company offering the Precivity blood-based biomarker (p-tau217) tests used by TMDF. Not a clinical competitor but an enabling technology vendor whose products underpin TMDF's biomarker-based diagnostic workflow.
• Alzheimer's Association: National nonprofit providing caregiver support, education, and ALZ-NET clinical infrastructure in which TMDF participates. Comparable nonprofit mission around dementia care and a partner in TMDF's service ecosystem rather than a direct clinical competitor.

Direct peers

• Penn Memory Center: Academic-affiliated specialty memory disorders clinic at the University of Pennsylvania providing diagnosis, treatment, and clinical trials for Alzheimer's and related dementias. Directly comparable in mission, multimodal diagnostics, and clinical trial participation.
• Banner Alzheimer's Institute: Specialty Alzheimer's and dementia clinic combining clinical care, biomarker-based diagnostics, and an extensive Phase 2/3 clinical trial portfolio. Comparable as a physician-led outpatient specialty practice that integrates research with patient care.
• Cleveland Clinic Lou Ruvo Center for Brain Health: Specialty outpatient clinic providing cognitive evaluation, diagnosis, and treatment for Alzheimer's and related dementias, with active clinical trials. Highly comparable operating model, including physician-led specialty consult practice with multi-modal diagnostics and trial enrollment.
• Dent Neurologic Institute: Independent specialty neurology practice offering cognitive assessment, neuroimaging, and clinical trial participation. Comparable as a multi-specialty neurology group providing outpatient memory disorder evaluation and treatment.
• Compass Memory Center: Specialty memory and cognitive disorder clinic providing diagnostic workup, treatment, and clinical trial access. Comparable outpatient specialty care delivery model for dementia patients.
• Alzheimer's Research and Treatment Center (Texas): Independent outpatient specialty clinic focused on Alzheimer's diagnosis, biomarker testing, and clinical trial enrollment. Comparable private-practice specialty model with similar reliance on referrals and pharma-sponsored trials.

Broad incumbents

• Massachusetts General Hospital Memory Disorders Unit: Academic specialty unit within a major hospital system providing evaluation and treatment of Alzheimer's and related dementias, with a clinical trials portfolio. Comparable specialty scope but embedded in a much larger health system.
• Mayo Clinic Alzheimer's Disease Research Center: Large academic medical center specialty program for Alzheimer's diagnosis, treatment, and clinical trials. Comparable in clinical trial activity and multi-modal diagnostics but operates at significantly greater scale within a major health system.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xtwitter.com/tmdf
• Facebookfacebook.com/tennesseememorydisordersfoundation
• LinkedInlinkedin.com/company/tennessee-memory-disorders-foundation
• Instagraminstagram.com/heydrcrane

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Tennessee Memory Disorders Foundation (tmdf)