OneSkin
OneSkin is a San Francisco-based longevity biotech founded in 2016 that sells topical peptide-based skincare products direct-to-consumer through oneskin.co, targeting consumers seeking science-backed solutions that address skin aging at the cellular level.
- Company typePrivate
- Founded2016
- HeadquartersSan Francisco, United States
- Headcount11–50
- GTM typeB2C
- OfferingHardware or Manufacturing
What OneSkin does
OneSkin is a San Francisco-based longevity biotech company founded in 2016 by four Brazilian PhD scientists, developing and commercializing topical skincare products that target skin aging at the cellular level. Its core technology is the proprietary OS-01 Peptide (Decapeptide-52), a senomorphic peptide developed over nine years of R&D that screened more than 900 candidate peptides and is supported by 22 patents and peer-reviewed publications. The proprietary MolClock machine-learning algorithm, trained on 500+ human skin samples and 2,000+ DNA methylation markers, provides the first skin-specific biological age measurement and underpins the company's scientific validation claims.
The product portfolio is anchored by the OS-01 FACE moisturizer at $100 and extends across OS-01 EYE, OS-01 BODY, OS-01 HAIR SCALP SERUM, OS-01 LIP, and SPF variants, with pricing ranging from $26 to $100 per SKU and multi-product bundles up to $332. OneSkin sells almost exclusively direct-to-consumer through its own e-commerce storefront oneskin.co, supported by a subscription model offering 15% recurring savings, celebrity endorsements from Jennifer Aniston, Matthew McConaughey, and Parker Posey, and multi-channel digital marketing across Instagram, TikTok, Facebook, and Pinterest. Distribution is currently United States-only with planned retail expansion in 2027.
The company targets healthspan-oriented consumers, with particular emphasis on perimenopausal women ages 40-60 seeking science-backed alternatives to symptom-treating skincare. OneSkin has raised approximately $32-46 million cumulatively across disclosed rounds including a $20 million Series A led by Prelude Growth Partners in August 2025, and projects $40-50 million in 2025 revenue. The business is led by CEO and co-founder Carolina Reis Oliveira alongside a Brazilian scientific founding team that retains in-house product development.
OneSkin firmographics
Firmographics- Name
- OneSkin
- Legal name
- OneSkin, Inc.
- Website
- https://oneskin.co
- Company type
- Private
- Founded year
- 2016
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- OneSkin is a San Francisco-based longevity biotech founded in 2016 that sells topical peptide-based skincare products direct-to-consumer through oneskin.co, targeting consumers seeking science-backed solutions that address skin aging at the cellular level.
- Ownership category
- akta.pro rank
OneSkin industry classification
Industry- Product category
- Premium Anti-Aging Skincare
- NAICS
- Cosmetics, Beauty Supplies, and Perfume Retailers (45612)
- SIC
- Perfumes, Cosmetics & Other Toilet Preparations (2844)
- akta.pro primary industry
- Treatment Skincare (Serums, Actives, Acne & Anti-aging) (CRABAAAB)
- akta.pro secondary industries
- Dermocosmetics & Medical-Grade Skincare (CRABAAAF), Facial Skincare (Cleansers, Toners, Moisturizers) (CRABAAAA), Sensitive Skin & Barrier Repair (CRABAAAG)
Keywords
Where OneSkin is headquartered
LocationHeadquarters
- HQ city
- San Francisco
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
OneSkin business model
Business model- GTM type
- B2C
- Offering type
- Hardware or Manufacturing
- Cost components
- Technology or R&D, Personnel, Marketing or Sales, Supply Chain, Operations
Revenue model
- Product Sales (DTC): Direct-to-consumer sales of topical skincare products through e-commerce platform. Products include face moisturizers, eye creams, body moisturizers, hair serums, and lip care. Subscription model with 15% recurring discount generates predictable recurring revenue with land-and-expand potential as customers add products to their regimen.
- One-time Product Purchases: Non-subscription one-time purchases of individual products and bundles, with refill options for ongoing customers.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Monthly | OS-01 FACE MOISTURIZER - Daily face moisturizer with OS-01 Peptide |
| Subscription | Monthly | OS-01 BODY MOISTURIZER - Body moisturizer for thin, crepey skin |
| Subscription | Monthly | OS-01 EYE CREAM - Eye cream for periorbital aging |
| Subscription | Pay-as-you-go | OS-01 HAIR SCALP SERUM - Hair serum for thinning and aging scalp |
| Subscription | Monthly | OS-01 LIP MASK - Overnight lip treatment |
| Subscription | Monthly | OS-01 LIP SHIELD SPF 15+ - Lip sunscreen and treatment |
| Subscription | Monthly | OS-01 FACE SPF - Mineral sunscreen with anti-aging benefits |
| Subscription | Monthly | Bundle and Set Options |
Go-to-market motion2 records
Distribution channels2 records
Marketing channels8 records
OneSkin product offering
Product offeringCore offering
OneSkin develops and sells topical peptide-based skincare products powered by its proprietary OS-01 Peptide (Decapeptide-52), targeting cellular senescence to extend skin healthspan. The product line spans face moisturizers, eye cream, body moisturizer, lip mask and SPF, mineral sunscreen, hair and scalp serum, and a facial cleanser, sold directly to consumers through the oneskin.co e-commerce storefront with both one-time purchases and a subscription program offering 15% recurring savings.
Product overview
OneSkin is a biotech skincare brand founded in 2016 by four Brazilian scientists, offering a portfolio of topical peptide-based skincare products powered by the proprietary OS-01 Peptide. The product line centers on the OS-01 FACE MOISTURIZER as the hero product, supplemented by OS-01 EYE CREAM for periorbital skin, OS-01 BODY MOISTURIZER for body skin, and OS-01 HAIR SCALP SERUM for hair/scalp health. Sun protection is addressed through OS-01 FACE SPF and OS-01 BODY SPF (both Broad Spectrum SPF 30+), while lip care includes OS-01 LIP SHIELD SPF 15+ and the OS-01 LIP MASK for overnight treatment. The PREP Facial Cleanser supports the regimen. Products are sold individually, as multi-product bundles (Face+Eye+Body Trio, Longevity Defense Sets), and in subscription plans, with the entire line unified by the senolytic/senomorphic OS-01 Peptide technology that aims to reduce cellular senescence at the source.
Differentiator
Problem solved
Functional benefit
Products and services
- OS-01 FACE MOISTURIZER Hero daily face moisturizer formulated with the proprietary OS-01 Peptide (Decapeptide-52) to reduce accumulation of senescent cells, supported by pracaxi oil, andiroba oil, niacinamide, and hyaluronic acid. Clinical results claim 87% reduction in fine lines and wrinkles and 23% increase in epidermal thickness on average. Sold individually or on subscription via oneskin.co.
- OS-01 EYE CREAM Eye cream with the highest concentration of OS-01 Peptide for delicate periorbital skin. A 12-week clinical study reported 32.49% increase in hydration, 25.58% increase in elasticity, 17.33% reduction in transepidermal water loss, and 10.19% improvement in skin firmness.
- OS-01 BODY MOISTURIZER Daily body moisturizer targeting thin, crepey skin using OS-01 Peptide. Clinical results claim up to 41% improvement in skin barrier function. Contains ceramides and tremella mushroom extract among 5 active ingredients.
- OS-01 HAIR SCALP SERUM Daily scalp serum powered by OS-01 Peptide plus Panax Ginseng, Fisetin, and Biotin to support fuller, thicker-looking hair. Clinical data showed 81% of participants achieved +40% improvement in visible hair density after 6 months and 78% showed +43% increase in hair thickness. Available in 1-month, 3-month, and 6-month supplies.
- OS-01 FACE SPF Mineral facial sunscreen with Broad Spectrum SPF 30+ PA+++ containing 17.5% zinc oxide, OS-01 Peptide for cellular aging prevention, and antioxidants including vitamin C and green tea. Available in 4 tints: Light, Light/Medium, Medium/Deep, Deep.
- OS-01 BODY SPF Mineral body sunscreen with Broad Spectrum SPF 30 PA+++ protection; lightweight formula combining UV defense with cellular aging support via OS-01 Peptide.
- OS-01 LIP SHIELD SPF 15+ Mineral lip sunscreen with Broad Spectrum SPF 15+ protection formulated with non-nano zinc oxide, OS-01 Peptide, and 6 antioxidants. Available in tinted (Bare Blush) and untinted formulations.
- OS-01 LIP MASK Overnight lip treatment that targets cellular aging in lip tissue using OS-01 Peptide. Ex vivo testing confirmed improvements in hyaluronic acid, elastin, and collagen biomarkers.
- PREP Facial Cleanser Facial cleanser that gently cleanses and exfoliates without irritation. Designed as part of the 5-minute skin health routine alongside OS-01 EYE and OS-01 FACE.
Quantifiable outcome
- 23% increase in epidermal thickness on average
- +6 more outcomes
Companies that use OneSkin
Customer profileNamed customers3 records
Segments2 records
Ideal customer profiles1 record
OneSkin technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature3 records
OneSkin partnerships and signals
Strategic signalPartnerships
Two partnerships are on record, tiered minor and secondary.
- National Eczema AssociationminorAwarded Seal of Acceptance to all OneSkin products after rigorous evaluation including clinical testing on 100 individuals with zero negative reactions. Validates products as safe for eczema-prone skin.
- GlycanAgesecondaryClinical research partnership to measure effects of OS-01 BODY product. Collaboration supports scientific validation of products' effects on biological aging markers.
Scale indicators7 records
Recent moves6 records
Expansion highlights5 records
OneSkin competitors and assessment
Company assessmentDirect peers
- Drunk Elephant: Premium, science-led, ingredient-focused skincare brand with a strong DTC and Sephora presence. Comparable to OneSkin in positioning around active-ingredient skincare backed by clinical claims, premium pricing, and a regimen-based product architecture.
- The Ordinary: Active-ingredient skincare brand built around science-driven, low-cost single-actives. Comparable to OneSkin in the science-led actives category, though positioned at a much lower price point, targeting similar ingredient-savvy consumers.
- Augustinus Bader: Luxury skincare brand built around proprietary cell-signaling technology (TFC8) with peer-reviewed science, premium pricing, and DTC-first distribution. Highly comparable on the science-led longevity/cellular mechanism positioning that OneSkin uses with OS-01.
- Allies of Skin: Premium science-backed skincare brand with a small SKU portfolio and clinical-efficacy claims. Comparable to OneSkin in category (premium actives-led skincare), DTC distribution model, and clinical/peer-reviewed-led brand narrative.
- SkinMedica: Clinical-grade skincare brand owned by AbbVie/Allergan, sold through dermatologists and select retailers. Comparable to OneSkin in clinical-efficacy positioning and anti-aging claims, though distributed through professional channels rather than pure DTC.
- Paula's Choice: Science-led, ingredient-driven skincare brand with strong DTC and third-party retail presence. Comparable to OneSkin on clinically validated claims, regimen architecture, and an educated consumer target — though at a lower entry price point.
Broad incumbents
- La Roche-Posay: L'Oréal-owned dermocosmetics brand with strong sensitive-skin and eczema positioning. Comparable to OneSkin in the dermatology-adjacent claims space, NEA-equivalent validations, and barrier-repair focus — though distributed primarily through pharmacy and dermatologist channels.
- CeraVe: L'Oréal-owned mass-dermocosmetics brand and category leader in barrier-repair skincare. Comparable to OneSkin on the sensitive-skin/eczema credentialing and barrier-repair positioning, though at mass price points and broad retailer distribution.
- Eucerin: Beiersdorf-owned dermocosmetics brand with strong clinical/dermatologist credibility. Comparable to OneSkin in the medical-grade and sensitive-skin positioning, though Eucerin operates as a broad incumbent across body and face SKUs in mass retail.
Emerging players
- iS Clinical: Clinical skincare brand with physician-dispensed and DTC channels, focused on anti-aging and active-ingredient formulations. Comparable to OneSkin on the clinical-efficacy and anti-aging positioning, though distributed primarily through professional channels.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
OneSkin social profiles
Digital presenceOneSkin compliance and trust
Trust signalCompliance4 records
OneSkin financial estimates
Financial estimateRevenue estimate
Valuation estimate
OneSkin leadership team
Management profileNumber of profiles
Profiles5 records
OneSkin funding detail
Funding detailFunding overview
Funding rounds6 records
Investors10 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
OneSkin M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about OneSkin
What does OneSkin do?
OneSkin develops and sells topical peptide-based skincare products powered by its proprietary OS-01 Peptide (Decapeptide-52), targeting cellular senescence to extend skin healthspan. The product line spans face moisturizers, eye cream, body moisturizer, lip mask and SPF, mineral sunscreen, hair and scalp serum, and a facial cleanser, sold directly to consumers through the oneskin.co e-commerce storefront with both one-time purchases and a subscription program offering 15% recurring savings.
Is OneSkin a public or private company?
OneSkin is a private company. It is classified as venture growth investor backed and is currently operating.
When was OneSkin founded?
OneSkin was founded in 2016. It employs 11 to 50 people.
Where is OneSkin based?
OneSkin is headquartered in San Francisco, United States, in the North America region.
How does OneSkin make money?
Two revenue lines are on record. Product Sales (DTC) is the primary driver. The others are one-time Product Purchases.
Who are OneSkin's main competitors?
Direct peers on record are Drunk Elephant, The Ordinary, Augustinus Bader, Allies of Skin, SkinMedica and Paula's Choice. Broad incumbents are La Roche-Posay, CeraVe and Eucerin. iS Clinical is listed as an emerging player.
Does OneSkin have an API?
No public API is recorded for OneSkin.
What industry is OneSkin in?
OneSkin's product category is Premium Anti-Aging Skincare. Its primary akta.pro industry code is CRABAAAB, Treatment Skincare (Serums, Actives, Acne & Anti-aging), with a secondary code of CRABAAAF, Dermocosmetics & Medical-Grade Skincare. Its NAICS code is 45612 and its SIC code is 2844.