Cleveland Clinic

What Cleveland Clinic does

Cleveland Clinic is a nonprofit, multispecialty academic medical center founded in 1921, operating 23 hospitals and 300+ outpatient facilities across the United States (Ohio, Florida, Nevada), Canada (Toronto), the United Kingdom (London), the United Arab Emirates (Abu Dhabi), and most recently as the announced anchor institution of the $1.2B Navi Mumbai International MediCity in India. The system recorded nearly 16M patient encounters in 2025 and serves general adult, pediatric, international, employer-sponsored, and member-hospital patient populations through integrated clinical care, an Epic-based MyChart portal, virtual visits, concierge virtual second opinions priced at $1,690-$4,500, and the Cleveland Clinic Connected international membership program (6 international and 3 domestic members).

The organization monetizes primarily through professional services (inpatient/outpatient clinical care, surgical procedures, ancillary services), with additional revenue from technology licensing (e.g., exclusive license of the SirPlux Duo nanoparticle drug-coated balloon to Advanced NanoTherapies), recurring Connected member fees, federal research grants (NIH, AHRQ), and philanthropy (notably a $50M Mandel Foundation gift in 2026). The underlying technology stack is anchored by the first IBM Quantum System One dedicated to healthcare research under a 10-year Discovery Accelerator partnership, proprietary AI models (CMR-CLIP cardiac MRI vision-language framework with 88.5%-99% diagnostic accuracy, EWF-TrimSQD hybrid quantum algorithm simulating 12,635-atom protein complexes, QHDC computing paradigm), and a deployed production AI layer (Ambience AI ambient scribe across 4,000 clinicians, Hippocratic AI Nurse Co-Pilot, Luminai admin automation, AKASA medical coding, Dyania Health Synapsis AI clinical trial matching).

Cleveland Clinic's go-to-market is hybrid — direct-to-patient via 300+ locations, MyChart, and virtual care; enterprise B2B via employer-sponsored virtual second opinions and Connected membership; channel partnerships with international member hospitals; and event-driven sports medicine GTM through PGA TOUR and Cleveland Cavaliers partnerships. The system completed 8,000+ clinical trials since 1921 and participates in Epic Care Everywhere, Carequality, CliniSync, Florida HIE, and TEFCA health information exchange networks. Governance is led by CEO Tomislav Mihaljevic (since January 2018, also an Oracle director as of May 2026) and CIO Sarah Hatchett.

Name

Cleveland Clinic

Legal name

Cleveland Clinic

Website

https://my.clevelandclinic.org

Company type

Private

Founded year

1921

Operating status

Operating

Headcount range

5,001–10,000 employees

Short description

Cleveland Clinic is a 1921-founded nonprofit academic medical center operating 23 hospitals and 300+ outpatient facilities across the U.S., Canada, the U.K., the U.A.E., and planned India, serving nearly 16 million patient encounters annually through integrated clinical care, AI-enabled digital health, and the Cleveland Clinic Connected international hospital membership program.

Ownership category

akta.pro rank

Product category

Academic Medical Center Services

NAICS

Specialty (except Psychiatric and Substance Abuse) Hospitals (6223), Specialty (except Psychiatric and Substance Abuse) Hospitals (62231), Ambulatory Health Care Services (621)

SIC

Services-Hospitals (8060), Services-General Medical & Surgical Hospitals, Nec (8062)

akta.pro primary industry

Hospital-Integrated Cancer Centers (Acute Oncology Programs) (HLAFAAAM)

akta.pro secondary industries

Ambulatory Oncology Centers (Outpatient Chemo/Radiation) (HLAFABAI), Oncology & Cancer Specialty Hospitals (HLAFAHAC), Outpatient Mental Health Clinics & Counseling Centers (HLAFACAA), Outpatient Mental Health & Counseling Clinics (HLAFABAC), Oncology Telemedicine Platforms (HLALAGAH)

Keywords

• Academic medical center
• Hospital care services
• Medical research
• Virtual second opinions
• Healthcare consulting

Headquarters

HQ city

Cleveland

HQ country

United States

HQ region

North America

Offices12 records

Markets served

GTM type

B2B and B2C

Offering type

Services

Revenue model

1. Healthcare Services Delivery: Primary revenue from inpatient and outpatient clinical care across 23 hospitals and 300 outpatient facilities; nearly 16 million patient encounters recorded in 2025; revenue from surgical procedures, hospital stays, physician services, and ancillary services across specialties.
2. Concierge Virtual Second Opinions: Self-pay concierge service priced at $1,690 for written report only and $1,990 for report plus virtual visit; $4,500 for international patients; not covered by Medicare or commercial insurance; available to employers and health plans as a benefits offering.
3. Technology Licensing & Royalties: Licensing of proprietary medical technologies including the nanoparticle drug-coated balloon platform exclusively licensed to Advanced NanoTherapies for coronary and peripheral artery disease applications (FDA Breakthrough Device designation).
4. Cleveland Clinic Connected Member Fees: Long-term consultative partnerships offering advisory services, clinical assessments, and training to member hospitals while they retain ownership; current six international and three domestic members including Radiochirurgia Zagreb and Central Asian University.
5. Research Grants & Sponsored Research: Major NIH and federal grants including $14.2M for atrial fibrillation research, $7.9M for Radiation Oncology-Biology Integration Network, $3.14M for digital twin health disparities, $2.5M for pneumonia antibiotic trial; over 8,000 clinical trials completed since 1921.
6. Philanthropy & Donations: Major gifts including $50M from Jack, Joseph and Morton Mandel Supporting Foundation for AI Digital Front Door; $2.5M Second Harvest partnership; $3M Akron-Canton Regional Foodbank commitment; $1M Clorox Public Health Research Fund.

Pricing tiers

Go-to-market motion4 records

Distribution channels7 records

Marketing channels10 records

Core offering

Cleveland Clinic is a nonprofit, multispecialty academic medical center operating 23 hospitals and 300+ outpatient facilities across Ohio, Florida, Nevada, Toronto, London, and Abu Dhabi. It delivers inpatient and outpatient clinical care, specialty institutes, research, and medical education, supplemented by digital health services including MyChart, virtual visits, and concierge virtual second opinions, and by the Cleveland Clinic Connected membership program for partner hospitals.

Product overview

Cleveland Clinic operates as a globally integrated, multispecialty academic healthcare system delivering care across Ohio (Main Campus, Akron General, Fairview, and 300+ locations), Florida (Weston and Martin Health), Nevada, Canada (Toronto), London, and Abu Dhabi, alongside a broad portfolio of digital health products and research platforms. Its core consumer-facing product is the Epic-based MyChart patient portal, supplemented by Virtual Visits and Virtual Second Opinions telehealth services delivered through the MyClevelandClinic app. Layered on top, Cleveland Clinic deploys an integrated stack of AI and automation modules — Ambience AI ambient scribe and Chart Chat for Nursing, Hippocratic AI Nurse Co-Pilot and AI Front Door, AKASA generative AI medical coding, Dyania Health Synapsis AI for clinical trial matching, Luminai for administrative automation, and the internally developed CMR-CLIP cardiac MRI vision-language AI — that collectively transform clinical, nursing, research, and revenue-cycle workflows. The Discovery Accelerator partnership with IBM anchors a research platform featuring the IBM Quantum System One, powering the Quantum Innovation Catalyzer Program and recent breakthroughs such as the 12,635-atom protein simulation. Cleveland Clinic Connected, the Pediatric Partial Hospitalization Program, the Pediatric Precision Oncology Program, the Endorobotics Collaborative, Global MedConnect (with Global Guardian), and the consumer-facing Cleveland Clinic Diet App and Health Essentials Podcast round out a portfolio that bridges direct care delivery, member-hospital partnerships, and externally deployed technology collaborations.

Differentiator

Problem solved

Functional benefit

Brands

• MyClevelandClinic: Cleveland Clinic's branded mobile and online patient platform (app and website) used to access MyChart and virtual visit services.
• Cleveland Clinic Connected
• Cleveland Clinic Diet
• Cleveland Clinic Global MedConnect

Products and services

• MyChart Patient Portal Secure online patient portal (licensed from Epic Systems) connecting Cleveland Clinic patients to their electronic medical record for viewing test results, secure messaging with physicians, scheduling, prescription refills, and bill payment.
• Virtual Visits Telehealth Telehealth service delivered via the MyClevelandClinic app offering Express Care on-demand visits, scheduled virtual specialist visits, and Virtual Primary Care for common conditions, follow-ups, and pediatric care in Ohio and Florida.
• Concierge Virtual Second Opinions Self-pay concierge remote consultation service providing written expert reports or written report plus physician video review from Cleveland Clinic specialists across cancer, cardiology, orthopaedics, neurology, and other specialty areas; available to U.S. and international patients.
• Cleveland Clinic Connected Membership Program Long-term consultative membership program providing advisory services, clinical assessments, training, and best-practices knowledge transfer to member hospitals worldwide; currently has six international and three domestic member institutions.
• Cleveland Clinic Global MedConnect Program integrating Cleveland Clinic physicians with Global Guardian's global security operations to provide clients with 24/7 access to physicians, coordinated medical and security support, evacuation services, and crisis management for international travelers.
• Cleveland Clinic Children's Pediatric Partial Hospitalization Program Pediatric mental health program at Cleveland Clinic Children's Hospital for Rehabilitation featuring virtual reality exposure therapy, AI-assisted emotional regulation therapy, and frequency-specific microcurrent therapy; opening Fall 2026.
• Cleveland Clinic Pediatric Precision Oncology Program Pediatric and young adult cancer program integrating molecular diagnostics, next-generation sequencing, advanced tumor profiling, and multidisciplinary review into standard care.
• Cleveland Clinic Diet App Mobile nutrition app launched in partnership with FitNow Inc. combining AI personalization with evidence-based nutrition programs.
• Community Bridge to Care Initiative with AI Digital Front Door Community care access program featuring an AI-enabled Digital Front Door system designed to guide patients to the most appropriate care setting, supported by a Level I trauma center on main campus.
• Cleveland Clinic Health Library Online medical reference covering body systems, diseases and conditions, treatments, procedures, drugs, devices, supplements, diagnostics, and symptoms; serves as a 24/7 patient and consumer health information resource.

Quantifiable outcome

• 14 minutes saved per day per clinician with ambient AI scribes; 2 minutes saved per appointment
• +11 more outcomes

Named customers12 records

Segments8 records

Technology focussed No

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration12 records

AI capability24 records

Feature10 records

Partnerships

20 partnerships are on record, tiered core, minor and flagship.

• 10x GenomicscoreStrategic or Co-development Partner · 1 June 2026Multi-year research collaboration focused on bladder cancer diagnostics using 10x's Flex Apex, Xenium, and Atera single cell and spatial analysis platforms. Will examine tumor samples from patients with advanced bladder cancer undergoing antibody-drug conjugate and immunotherapy treatments, aiming to identify biomarkers that predict treatment response and generate comprehensive multimodal datasets linking molecular data with clinical outcomes across oncology.
• Samsung MedisonminorChannel Partner/ Reseller/ Distributor · 1 June 2026Supply agreement providing Samsung Medison's R20 radiology ultrasound systems to Cleveland Clinic-affiliated hospitals as part of the medical device subsidiary's expansion in the North American premium ultrasound market (revenue grew from 16.4 billion won in 2023 to 27.7 billion won in 2025).
• Advanced NanoTherapiescoreOEM/ Whitelabel/ Licensing Partner · 1 June 2026Exclusive license from Cleveland Clinic for SirPlux Duo nanoparticle drug-coated balloon platform combining paclitaxel and sirolimus for coronary and peripheral artery disease indications. FDA Breakthrough Device designation; first-in-human data from 28 patients in Australia, Dominican Republic, and New Zealand demonstrated no new treatment failures over two years. Advanced NanoTherapies raised $31M Series B to advance U.S. IDE approval.
• Government of Maharashtra, Brookfield Asset Management, Arodhan Health CityflagshipStrategic or Co-development Partner · 1 June 2026Memorandum of Understanding to develop Navi Mumbai International MediCity, a 250-acre healthcare, research and education ecosystem near Navi Mumbai International Airport. Project involves ~$1.2 billion investment, expected to generate over 10,000 direct jobs. Cleveland Clinic serves as anchor institution. LNMIIT Jaipur will collaborate on healthcare innovation, translational research, AI, and precision medicine initiatives. Aligns with India's 'Heal in India' vision.
• Aspira Women's HealthcoreStrategic or Co-development Partner · 1 May 2026Master Collaboration and License Agreement for AI-powered diagnostics for ovarian cancer and endometriosis. Combines Cleveland Clinic's translational research expertise with Aspira's AI-enabled multiomic platform for biomarker discovery, data generation, translational development, IP collaboration, and clinical research. Aspira CEO Mike Buhle described as 'inflection point for building category-defining women's health diagnostics platform'.
• LuminaicoreTechnology or Integration · 1 May 2026Partnership to automate core hospital administrative operations starting with referral management workflows. Luminai's platform processes each incoming fax in under a minute, identifying referrals, assessing urgency, extracting patient data, and routing cases into scheduling systems or EMRs. Plans to evaluate expanding automation into eligibility checks, revenue cycle processes, and supply chain workflows across 23 hospitals and 300 outpatient facilities.
• PGA TOURcoreGTM or Marketing Partner · 1 May 2026Multi-year partnership making Cleveland Clinic the tour's official health, wellness, and performance partner. Will provide professional athletes with multidisciplinary care, performance evaluation, and data analysis services, with Cleveland Clinic clinicians traveling with the PGA TOUR throughout the season. Data gathered from athletes will advance sports medicine insights beyond professional sports to everyday populations.
• Cleveland CavalierscoreStrategic or Co-development Partner · 1 May 2026Earlier partnership for the Cleveland Clinic Global Peak Performance Center opening in 2027, providing athletes with multidisciplinary care and performance services alongside PGA TOUR partnership.
• Global GuardiancoreStrategic or Co-development Partner · 1 May 2026Collaboration to integrate Cleveland Clinic's medical expertise with Global Guardian's global security infrastructure through the Global MedConnect program. Provides Global Guardian clients 24/7 access to Cleveland Clinic physicians, coordinated medical and security support, evacuation services, and crisis management for international travelers. Extends Cleveland Clinic's medical reach beyond traditional healthcare settings.
• Bridge to Life LtdminorStrategic or Co-development Partner · 1 May 2026Clinical research collaboration for VitaSmart Hypothermic Oxygenated Perfusion (HOPE) system for marginal donor livers, presented at ILTS 2026 Congress in Geneva. Cleveland Clinic Foundation studies demonstrated HOPE achieves outcomes comparable to standard cold storage with lower 90-day mortality, and validated Flavinmononucleotide (FMN) as biomarker for pre-transplant organ viability assessment.
• Moleculin BiotechminorImplementation/ SI/ Consulting Partner · 1 May 2026Independent Cleveland Clinic cardio-oncology review of pooled data from 90 patients across five trials showed no clinically significant cardiotoxicity with Annamycin at cumulative doses exceeding conventional anthracycline exposure limits. Findings published at European Hematology Association 2026 Congress and ASCO 2026 support broader clinical positioning in relapsed/refractory AML.
• IceCure MedicalminorStrategic or Co-development Partner · 1 May 2026Symposium featuring breast surgeons from Cleveland Clinic and other institutions at American Society of Breast Surgeons 2026 Annual Meeting on ProSense cryoablation system; ASBrS Resource Guide now recommends cryoablation for select low-risk, early-stage breast cancer patients.
• Second Harvest Food Bank of North Central OhioOthers · 1 May 2026
• Hippocratic AIcoreTechnology or Integration · 1 April 2026Co-development partnership for AI Front Door voice agent and Nurse Co-Pilot AI voice assistant for inpatient nurses, alongside Cincinnati Children's Hospital Medical Center and OhioHealth. Tools operate on Polaris safety architecture with 180 million patient interactions and 99.90% correct clinical advice; Nurse Co-Pilot saves 1-4 hours per nurse per shift across admission education, patient education, caregiver engagement, and medication adherence workflows.
• Anixa BiosciencescoreStrategic or Co-development Partner · 1 April 2026Joint development of ovarian cancer CAR-T therapy lira-cel (Phase 1 positive survival observations) and breast cancer vaccine targeting human α-lactalbumin (Phase 1 completed with 74% immune response). Patents secured in U.S. (No. 12,357,593), Mexico (No. 432748 through 2040), Canada (Notice of Allowance), and Korea. Anixa presenting at New York Academy of Sciences symposium June 22-23, 2026.
• Algorithmiq (via Wellcome Leap Q4Bio Challenge)coreStrategic or Co-development Partner · 1 April 2026Algorithmiq won the $2M Phase III prize of Wellcome Leap's $50M Q4Bio Challenge in collaboration with Cleveland Clinic and IBM for demonstrating scalable quantum algorithms on up to 100 qubits to simulate photodynamic therapy processes for cancer treatment. First successful experimental realization meeting program criteria for quantum advantage on therapeutic applications. Earlier prize funding from Wellcome Leap also supported the collaboration.
• Akron-Canton Regional FoodbankminorOthers · 1 April 2026Cleveland Clinic received Guiding Partner Award for contributions helping provide nearly 500,000 meals last year; announced new $3 million commitment to expand hunger relief services across Summit, Stark, Portage, Medina, Tuscarawas and surrounding counties in Northeast Ohio.
• Ambience HealthcarecoreTechnology or Integration · 1 January 2025Selected after a 2024 pilot with 250 physicians evaluating five ambient AI scribe products; Ambience was chosen for accuracy and user experience. Rolled out to US-based clinicians in spring 2025; adopted by 4,000 clinicians within 15 weeks and documented 1 million patient encounters by August 2025, reducing note time by 2 minutes per appointment and 14 minutes per day. Also launching Chart Chat for Nursing product at Cleveland Clinic.
• Clorox CompanyminorStrategic or Co-development Partner · 1 May 2021$1 million donation from Clorox established the Clorox Public Health Research Fund supporting innovative research, training, education, and healthcare innovations with initial focus on COVID-19, virus-fighting products, and health protocols.
• IBMflagshipStrategic or Co-development Partner · 1 January 202110-year Discovery Accelerator partnership between Cleveland Clinic and IBM hosting the world's first IBM Quantum System One dedicated to healthcare research at Cleveland Clinic Main Campus. Supports 50+ research projects with peer-reviewed publications at the intersection of AI and quantum computing. Recent milestones include simulating 12,635-atom protein complexes (largest on quantum hardware) with 40x scale and 210x accuracy improvements, the Cleveland Clinic Quantum Catalyzer Program, and the 2026 Global Quantum + AI Challenge with $200,000 prize pool.

Scale indicators16 records

Recent moves15 records

Expansion highlights7 records

Direct peers

• Mayo Clinic: Non-profit multispecialty academic medical center founded in the late 1800s with flagship campuses in Rochester, MN and major sites in Arizona and Florida. Closest comparable to Cleveland Clinic in scale, brand, research intensity, and multi-state footprint, and operates the same 'destination medicine' model with concierge services and international patient programs.
• Johns Hopkins Medicine: Non-profit academic medical center anchored by The Johns Hopkins Hospital in Baltimore, with a regional health system, extensive NIH-funded research portfolio, and a globally recognized brand in specialty care. Directly comparable to Cleveland Clinic as a top-tier U.S. academic medical center competing for complex tertiary referrals and research talent.
• Mass General Brigham: Non-profit integrated academic health system centered on Massachusetts General Hospital and Brigham and Women's Hospital in Boston. Comparable to Cleveland Clinic in research output, tertiary/quaternary case mix, and academic affiliation, with overlapping specialty institutes in heart, cancer, and neurosciences.
• NewYork-Presbyterian Hospital: Non-profit academic medical center affiliated with Columbia and Cornell in New York City, with multiple hospitals across the metropolitan region. Comparable to Cleveland Clinic as a multi-campus academic system serving as a destination center for complex cases, with similar brand-driven domestic and international patient pipelines.
• Cedars-Sinai Medical Center: Non-profit academic medical center in Los Angeles with a large research enterprise and a strong consumer brand in cardiology and specialty care. Comparable to Cleveland Clinic as a destination academic center competing for West Coast and international patient flows, particularly in cardiology and orthopedics.
• Stanford Health Care: Non-profit academic health system anchored by Stanford Hospital in Palo Alto, CA, with significant NIH-funded research and a growing ambulatory network. Comparable to Cleveland Clinic in academic standing, technology adoption (Epic, ambient AI scribes), and ability to attract complex referrals from a multi-state catchment.
• Mount Sinai Health System: Non-profit integrated academic health system in New York City comprising eight hospital campuses and a large medical school. Comparable to Cleveland Clinic in urban-tertiary care delivery, research portfolio, and concierge/employer virtual-care services to large patient populations.
• CommonSpirit Health: One of the largest non-profit health systems in the U.S., formed from the merger of Catholic Health Initiatives and Dignity Health, operating 140+ hospitals across 20+ states. Comparable to Cleveland Clinic in non-profit academic and community hospital footprint, but with a much broader geographic and ambulatory footprint and a less concentrated specialty brand.

Broad incumbents

• HCA Healthcare: Largest for-profit hospital operator in the U.S. with 180+ hospitals and 2,400+ sites of care across 20 states and the UK. Comparable to Cleveland Clinic as a major U.S. health system but differs in for-profit status, broader community/general hospital mix rather than destination academic specialty care, and access to public capital markets.
• Tenet Healthcare: For-profit hospital and ambulatory operator with hospitals, USPI ambulatory surgery centers, and Conifer revenue cycle services. Comparable to Cleveland Clinic as a large multi-state health system with significant ambulatory expansion, but structurally different as a publicly traded investor-owned operator versus Cleveland Clinic's non-profit academic model.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat7 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/ClevelandClinic
• YouTubeyoutube.com/user/clevelandclinic
• Facebookfacebook.com/info
• LinkedInlinkedin.com/company/cleveland-clinic
• Instagraminstagram.com/clevelandclinic
• Pinterestpinterest.com/clevelandclinic

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Subsidiaries5 records

Funding overview

Funding rounds20 records

Investors11 records

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M&A2 records

Investments27 records

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Frequently asked questions about Cleveland Clinic