DrFirst

What DrFirst does

DrFirst is a privately held, Rockville, Maryland-based healthcare IT company founded in 2000 that builds integrated medication management software for hospitals, health systems, EHR/HIT vendors, payers, pharmacies, and pharmaceutical manufacturers. Its platform, anchored by the Rcopia e-prescribing system and a patented clinical-grade AI layer, spans twelve product modules covering e-prescribing (including controlled substances), electronic prior authorization, medication history, prescription renewals, price transparency, real-time prescription benefit checks, population health management, specialty medication access, system migrations, business continuity, and patient prescription engagement (RxInform). The company operates what it describes as the largest integrated medication management network in the United States, connecting 450,000+ prescribers, 71,000 pharmacies, 270+ EHRs, and 2,000+ hospitals, and processes 1.5 billion prescriptions through its ML training pipelines.

The company's revenue model is enterprise SaaS subscription licensing, with quote-based annual contracts sold through direct enterprise field sales to large health systems and payers, and embedded OEM-style distribution via 270+ EHR and health information system partners. Pricing is not publicly disclosed and contracts are negotiated based on integration scope, module breadth, and seat or transaction volume. Customer segments include hospitals and health systems as the primary buyer, EHR/HIT vendors as a key channel partner, plus secondary segments in private practices, payers (notably Humana), and pharmaceutical manufacturers. R&D is concentrated on clinical-grade AI for natural language processing of prescription instructions, missing-medication inference, and ML-driven patient engagement optimization.

Operationally, DrFirst employs 251-500 staff and is led by CEO Laizer Kornwasser with a recently expanded C-suite including a Chief Commercial Officer (Valerie Mondelli, January 2026), Chief Medical Officer, and President of Patient Solutions. The company is privately held, with cumulative disclosed funding of approximately $202 million across rounds led by Goldman Sachs Growth, Sixth Street Growth, and Bregal Sagemount, and has pursued selective M&A including Myndshft Technologies (2024), VisibilityRx (2017), and iPrescribe (2016). Its regulatory posture includes ONC certification for Rcopia4 across 17 criteria and FHIR-based API compliance, positioning it for CMS and ASTP/ONC interoperability mandates.

Name

DrFirst

Legal name

DrFirst.com, Inc.

Website

https://drfirst.com

Company type

Private

Founded year

2000

Operating status

Operating

Headcount range

251–500 employees

Short description

DrFirst is a privately held healthcare IT company that provides integrated medication management software, including e-prescribing, electronic prior authorization, medication history, and AI-driven patient engagement, to 2,000+ hospitals, 450,000+ prescribers, and 270+ EHR vendors across the U.S.

Ownership category

akta.pro rank

Product category

Healthcare IT / Medication Management Software

NAICS

Computer Systems Design and Related Services (54151)

SIC

Services-Prepackaged Software (7372)

akta.pro primary industry

ePrescribing & Medication Workflow Platforms (EPCS, formulary, prior auth, med history) (HLALAIAD)

akta.pro secondary industries

Pharmacy Interoperability, Standards & Integration (FHIR/NCPDP) (HLACAKAO), Specialty Pharmacy & Complex Therapy Management Platforms (HLACAKAG)

Keywords

• Medication management software
• Electronic prescribing platform
• Healthcare interoperability solutions
• Prior authorization automation
• Prescription engagement platform

Headquarters

HQ city

Rockville

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Marketing or Sales, Operations, Infrastructure

Revenue model

1. SaaS / Subscription Licensing: DrFirst provides its medication management solutions (e-prescribing, EPCS, medication history, ePA, RxInform, etc.) to healthcare organizations on a subscription basis. Solutions are integrated into EHR workflows of 270+ connected EHR systems and health information systems. Pricing is enterprise and quote-based, with annual contract commitments.

Pricing tiers

Go-to-market motion3 records

Distribution channels3 records

Marketing channels7 records

Core offering

DrFirst provides an integrated medication management software platform centered on its ONC-certified Rcopia e-prescribing system and clinical-grade AI. Its solutions cover electronic prescribing, controlled substance prescribing, electronic prior authorization, medication history reconciliation, patient prescription engagement, AI-powered prescription renewals, real-time price transparency, and population health management. These capabilities are embedded directly into 270+ EHR and health information system workflows, connecting 450,000+ prescribers, 71,000 pharmacies, and 2,000+ hospitals across the U.S.

Product overview

DrFirst offers a unified medication management platform with Rcopia as the core e-prescribing system and Clinical-Grade AI as the foundational intelligence layer. The platform comprises 12 integrated modules: EPCS (controlled substance prescribing), ePA (prior authorization automation), Medication History (comprehensive prescription data), RxInform (patient engagement), Population Health Management, Prescription Renewals/SmartRenewal (AI-powered sig translation), Price Transparency, System Migrations, Specialty Medications, and Business Continuity. The ecosystem connects providers, pharmacies, payers, and patients through the nation's largest integrated medication management network, supporting over 450,000 prescribers, 71,000 pharmacies, 270 EHRs, and 2,000+ hospitals. Advanced capabilities include the Gadget prescription orchestration platform and NewRx Insights for payer-provider collaboration.

Differentiator

Problem solved

Functional benefit

Products and services

• Rcopia E-Prescribing ONC-certified e-prescribing platform enabling integrated medication prescribing workflows for hospitals, health systems, and physician practices. Supports regulatory mandates and reduces staff burden through electronic prescription transmission to pharmacies.
• Electronic Prescribing for Controlled Substances (EPCS) Controlled substance prescribing solution with in-workflow visibility into PDMP (Prescription Drug Monitoring Program) data to minimize overprescribing risks. Supports multi-factor authentication per ONC certification criteria for EPCS signing and transmission.
• Electronic Prior Authorization (ePA) End-to-end electronic prior authorization automation that speeds access to specialty drugs. Reduces clinician time on prescription data entry by up to 80% and lowers specialty pharmacy operational costs by 30%. Complies with FHIR APIs and CMS/ONC interoperability standards.
• Medication History Comprehensive medication history solution powered by the largest medication management network in the U.S., aggregating prescription fill data from national and local pharmacies (including independent pharmacies). Used for medication reconciliation at admission, transitions of care, and discharge.
• RxInform (Prescription Engagement) Real-time prescription engagement platform using machine learning to send personalized clinical messages to patients minutes after a prescription is sent. Achieves 88% engagement rate and 98% patient satisfaction, improving medication adherence and reducing hospital readmissions.
• Population Health Management Solution enabling proactive identification of high-risk patients to keep them on track with treatments, using prescription fill data to calculate adherence metrics (such as PDC) and identify gaps across patient populations.
• SmartRenewal (Prescription Renewals) AI-powered prescription renewal solution that translates prescription instructions (sigs) directly into discrete EHR fields using machine learning, eliminating manual sig-mapping tables. Achieves 93% clean sig import rate and saves hundreds of thousands of clicks for large health systems.
• Price Transparency (Real-Time Benefit Check) Real-time prescription benefit information displayed at the point of prescribing, enabling providers and patients to view patient-specific coverage, costs, and therapeutic alternatives to reduce cost-related prescription abandonment.
• System Migrations AI-powered solution for transitioning data easily from one healthcare system to another, supporting healthcare organizations during EHR migrations by translating legacy medication data into structured fields.
• Specialty Medications Solution streamlining prior authorization processes and improving patient access to complex specialty therapies, addressing the complexity of managing specialty medications under both medical and pharmacy benefits.
• Business Continuity Solution maintaining access to prescribing and medication history capabilities when the primary EHR system experiences downtime, ensuring continuous patient care and uninterrupted medication management.
• Clinical-Grade AI Patented artificial intelligence technology that normalizes prescription instructions (sigs) into consistent terms, safely infers missing medication details, and codifies free-text information into discrete data elements. Reduces manual data entry, prevents medication errors, and pre-populates EHRs with structured medication data.
• Gadget Prescription Orchestration Platform Prescription orchestration platform enabling payer-provider communication within e-prescribing workflows, supporting NewRx Insights and other clinical collaboration programs aligned with NCPDP SCRIPT standards.
• NewRx Insights Payer-to-provider communication platform within the Gadget prescription orchestration system, delivering prescription recommendations and care gap alerts at the point of prescribing in alignment with NCPDP SCRIPT standards. Co-developed with Humana to eliminate fax-based payer-provider communication.

Quantifiable outcome

• Medication adherence increases by up to 10 percentage points across all therapeutic classes (DrFirst data)
• +7 more outcomes

Named customers10 records

Segments5 records

Ideal customer profiles5 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration6 records

AI capability7 records

Feature6 records

Partnerships

Two partnerships are on record, tiered core / flagship and core.

• Humanacore / flagshipStrategic or Co-development Partner · 16 June 2026DrFirst and Humana co-developed NewRx Insights, a program embedded in the DrFirst Gadget prescription orchestration platform that enables bidirectional, real-time payer-to-provider communication within e-prescribing workflows. The program delivers prescribing recommendations and care gap alerts directly in provider EHR workflows, eliminating fax-based outreach. Eliminated over 70,000 faxes, achieving ~20% clinician response rate vs. 7-9% via fax. Collaboration built on a decade-long track record including the 2015 introduction of the first real-time prescription benefit tool.
• TebracoreTechnology or Integration · 10 December 2025Tebra integrated RxInform, DrFirst's prescription notification solution, into the Tebra EHR+ platform. The integrated solution combines automated outreach with secure educational resources to improve treatment follow-through, clinical outcomes, and reduce administrative work for independent practices.

Scale indicators10 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Surescripts: Surescripts operates the dominant U.S. electronic prescribing network connecting physicians, pharmacies, payers, and pharmacy benefit managers. Directly comparable to DrFirst as both compete in e-prescribing, medication history, and prior authorization across the same healthcare provider and pharmacy customers.
• CoverMyMeds: CoverMyMeds (owned by McKesson) provides electronic prior authorization, medication adherence, and price transparency solutions. Direct competitor to DrFirst's ePA, RxInform, and Price Transparency products, serving the same health system, provider, and pharmacy markets.

Broad incumbents

• Epic Systems: Epic is the dominant EHR vendor for large U.S. health systems and has built medication management capabilities including e-prescribing and medication history. While Epic is a channel partner for DrFirst, it represents the primary competitive threat if it chooses to displace third-party medication management solutions.
• Oracle Health (Cerner): Oracle Health (formerly Cerner) provides EHR and medication management solutions to health systems globally. Comparable to DrFirst as a broad healthcare IT incumbent with overlapping capabilities in e-prescribing and clinical decision support, serving similar large hospital and health system customers.
• Veradigm (formerly Allscripts): Veradigm provides EHR, practice management, and clinical solutions to hospitals and physician practices. Comparable to DrFirst as a broad healthcare IT incumbent with overlapping capabilities in e-prescribing, medication management, and clinical decision support.

Emerging players

• Bamboo Health (formerly Appriss Insights): Bamboo Health provides prescription drug monitoring program (PDMP) data and substance use disorder solutions, intersecting with DrFirst's EPCS and controlled substance prescribing capabilities. Comparable as a healthcare data and clinical workflow company serving similar provider and health system customers.
• Arrive Health (formerly RxRevu): Arrive Health provides real-time prescription benefit and price transparency tools at the point of prescribing. Directly comparable to DrFirst's Price Transparency product, serving similar provider and health system customers with overlapping functionality.
• Phreesia: Phreesia provides patient intake, engagement, and payment solutions integrated with EHRs. Comparable to DrFirst's patient engagement capabilities (RxInform) as both serve healthcare providers with workflow automation and patient communication tools embedded in clinical workflows.

Regional players

• Tebra Technologies: Tebra provides an EHR+ platform for independent practices with integrated patient engagement and billing tools. DrFirst's RxInform is integrated into Tebra's platform, making Tebra both a channel partner and a comparable player in the independent practice market.

Others

• LexisNexis Risk Solutions (Health Care): LexisNexis Risk Solutions provides clinical data connectivity and healthcare analytics, including medication history and clinical decision support. Comparable as a data infrastructure provider in the healthcare ecosystem that overlaps with DrFirst's medication history aggregation capabilities.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/DrFirst
• Facebookfacebook.com/DrFirstInc
• LinkedInlinkedin.com/company/drfirst

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles6 records

Funding overview

Funding rounds9 records

Investors5 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A5 records

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about DrFirst