What Medisafe does

Medisafe, founded in 2012 and headquartered in Needham, Massachusetts (with R&D in Israel), is a private AI-driven patient engagement platform purpose-built for the pharmaceutical industry. The company combines behavioral science, machine learning, and omnichannel delivery to help pharmaceutical companies improve medication adherence and persistence across their drug portfolios. Its core technology architecture centers on the proprietary JITI (Just-in-Time Interventions) predictive engine, which is trained on 12+ years of real-world adherence data across 13M+ IQVIA-validated patients and analyzes 130+ behavioral signals per patient to predict non-adherence risk and trigger personalized interventions. The platform is delivered to pharmaceutical companies through Medisafe Maestro, an enterprise orchestration tool that enables pharma teams to design, deploy, and manage personalized patient journeys across brands and markets, complemented by therapy-specific branded Digital Drug Companions, a PATHWAYS web-based care coordination platform for providers, and an AI Voice Agent (VIA) for phone-based patient engagement.

The company generates revenue primarily through multi-year enterprise SaaS subscriptions with pharmaceutical companies for branded digital drug companion deployments, with pricing tied to deployment scope, number of brands, markets, and patient volume. The customer base includes 25+ pharma partners drawn from the top 20 global pharmaceutical companies across therapeutic areas including immunology, inflammatory conditions, mental health, metabolic/GLP-1, neurology, and oncology. A free consumer-facing Medisafe mobile app (4.7-star rating, 150K+ app-store reviews) functions as a freemium acquisition channel and distribution surface for pharma partner programs. Professional services revenue from implementation, configuration, and integration with pharma PSPs and hub services supplements the subscription base. Distribution combines direct enterprise field sales to pharma brand teams and procurement, white-label/OEM licensing through the Maestro SDK, and consumer self-serve app store downloads.

Medisafe's platform is validated through peer-reviewed research with IQVIA, Komodo Health, Vanderbilt University/NIH, and JMIR, and the company holds ISO 27001, ISO 13485 (enabling Software as a Medical Device positioning), HIPAA, SOC 2 Type II, GDPR, and 21 CFR Part 11 certifications. Strategic pharma co-development is anchored by partnerships with Eisai and Biogen on the PATHWAYS platform for Alzheimer's disease patient management, and the company maintains a strategic technology partnership with Amazon Web Services (AWS) for AI infrastructure. Institutional investors include ALIVE Israel HealthTech Fund (lead Series C, board seat), Sanofi Ventures (board seat), Pitango Venture Capital (board seat), Octopus Ventures, 7wire Ventures, Qualcomm Ventures, and M Ventures, with total disclosed funding of approximately $51.5M across rounds from 2012 through 2021.

Name

Medisafe

Legal name

Medisafe Project Ltd.

Website

https://medisafe.com

Company type

Private

Founded year

2012

Operating status

Operating

Headcount range

101–250 employees

Short description

Medisafe is an AI-driven patient engagement platform that helps pharmaceutical companies improve medication adherence through branded digital drug companions, predictive behavioral interventions, and provider care coordination tools, serving 25+ top-20 global pharma partners across 150+ countries.

Ownership category

akta.pro rank

Product category

Pharmaceutical Patient Engagement Software

NAICS

Computer Systems Design and Related Services (54151)

SIC

Services-Prepackaged Software (7372)

akta.pro primary industry

Oncology Remote Symptom Monitoring & Care Navigation (HLALAFAD)

akta.pro secondary industries

Specialty Pharmacy & Complex Therapy Management Platforms (HLACAKAG), Care Management & Coordination Platforms (case/disease management workflows) (HLACAHAD)

Keywords

• Medication adherence software
• Patient engagement platform
• Digital therapeutics
• Pharma patient support
• Healthcare analytics

Headquarters

HQ city

Boston

HQ country

United States

HQ region

North America

Offices4 records

Markets served

GTM type

B2B

Offering type

Software

Cost components

Technology or R&D, Personnel, Marketing or Sales, Infrastructure, Operations

Revenue model

1. Enterprise SaaS Platform Licensing: Pharmaceutical companies license the Medisafe platform to deploy branded digital drug companions for their therapies. Pricing is based on deployment scope, number of brands, markets, and patient volume.
2. Patient App (Freemium): Free medication management app for consumers with premium features available. The app serves as a distribution channel for pharma partner programs and generates indirect revenue through B2B relationships.
3. Professional Services: Implementation, configuration, and customization services for pharma partners deploying branded experiences. Includes onboarding, integration with existing hub/PSP programs, and ongoing support.

Pricing tiers

Go-to-market motion3 records

Distribution channels4 records

Marketing channels5 records

Core offering

Medisafe operates a behavior-driven patient engagement platform combining the Medisafe Maestro enterprise orchestration suite, the JITI predictive AI engine, and therapy-specific Digital Drug Companions that pharmaceutical companies license to deploy branded patient support across brands and markets. The platform is complemented by a free consumer mobile app for medication management, the PATHWAYS web-based care coordination tool for healthcare providers, and an AI Voice Agent (VIA) for conversational patient outreach.

Product overview

Medisafe is a modular patient engagement platform architecture consisting of three core engines: Medisafe Maestro (enterprise orchestration platform for pharma teams), Digital Drug Companion (therapy-specific patient experiences), and JITI Predictive Engine (behavioral intelligence layer). The platform serves pharmaceutical companies, healthcare providers, and patients directly, offering solutions for Hub & PSP acceleration, drug launch support, portfolio-wide orchestration, and clinical trial support. Additional offerings include the Medisafe consumer app for medication management, AI Voice Agent (VIA) for conversational support, and PATHWAYS for provider care coordination. The platform is validated through IQVIA, Vanderbilt University, NIH, and Komodo Health research.

Differentiator

Problem solved

Functional benefit

Brands

• JITI (Just-in-Time Intervention): Proprietary AI-driven behavioral prediction engine that identifies patient non-adherence risk and triggers personalized just-in-time interventions.
• Medisafe Maestro
• PATHWAYS
• Medisafe VIA
• Rapid Release

Products and services

• Medisafe Maestro Enterprise orchestration platform serving as the command center for pharma patient engagement programs. Enables pharmaceutical brand teams to design, deploy, and manage personalized patient journeys across brands and markets without engineering resources, with visual journey builder, multi-brand/multi-market campaign management, real-time analytics, configurable intervention rules, and enterprise SSO/audit logging.
• Digital Drug Companion Therapy-specific branded patient experiences that extend pharmaceutical support beyond the prescription, tailored to each therapy's adherence challenges, side-effect profile, and patient population. Includes personalized medication reminders, therapy-specific education, caregiver coordination, progress tracking, white-label branding, and omnichannel engagement across web, app, text, and voice.
• JITI Predictive Engine Behavioral intelligence layer built on 12+ years of real-world patient data that uses machine learning to predict patient risk and trigger just-in-time interventions. Features predictive non-adherence risk scoring, intervention triggers based on 130+ behavioral signals per patient, personalization engine, continuous learning, and privacy-first architecture with de-identified behavioral models.
• Medisafe App Free medication management mobile app helping millions of patients track medications, appointments, and measurements. Features smart reminders, drug interaction alerts, caregiver support via Medfriend, progress reports, and integration with Apple HealthKit, Samsung S-Health, and Google Fit.
• PATHWAYS Web-based care coordination platform for healthcare providers, HCPs, infusion centers, and clinical teams managing patients on chronic and specialty therapies. Offers at-a-glance patient and disease care dashboards, multi-site care coordination, and care plan tracking, recognized as Best Care Coordination Platform in 2025 MedTech Breakthrough Awards.
• Medisafe AI Voice Agent (VIA) Conversational AI voice agent that proactively engages patients via phone to log doses, check symptoms, and deliver personalized support. Extends reach across digital literacy levels and age groups, especially for populations less engaged with apps or digital interfaces.

Quantifiable outcome

• 15% increase in medication adherence
• +8 more outcomes

Named customers5 records

Segments4 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

AI capability7 records

Feature6 records

Partnerships

Seven partnerships are on record, tiered core and flagship.

• Amazon Web Services (AWS)coreTechnology or IntegrationStrategic partnership announced in 2023 combining Medisafe's 10+ years of healthcare data and experience with AWS's AI capabilities to build the future of connected health with technology advancements and regulatory achievements.
• EHR Systems (Integration)coreTechnology or IntegrationOpen APIs enable integration with Electronic Health Records, CRM systems, and pharma's existing digital infrastructures for seamless patient journeys and consistent brand experience.
• EisaiflagshipStrategic or Co-development PartnerCo-developed PATHWAYS platform for Alzheimer's disease patient care coordination. Eisai and Biogen partnered with Medisafe to deploy the web-based tool for FDA-approved monoclonal antibody treatments.
• BiogenflagshipStrategic or Co-development PartnerCo-developed PATHWAYS platform for Alzheimer's disease patient care coordination. PATHWAYS is recognized as Best Care Coordination Platform in 2025 MedTech Breakthrough Awards.
• IQVIAcoreStrategic or Co-development PartnerResearch partnership conducting validation studies on medication adherence. IQVIA published peer-reviewed research demonstrating Medisafe's impact on HIV and hypertension patient adherence outcomes.
• Komodo HealthcoreStrategic or Co-development PartnerHealthcare data partnership for real-world evidence. Komodo Health study of 1600 patients over 52 weeks demonstrated 22% incremental persistence lift and 2.1 additional Rxs per patient for Medisafe users.
• Vanderbilt University / NIHcoreStrategic or Co-development PartnerAcademic research partnership contributing to NIH-published research validating Medisafe's platform efficacy and patient outcomes.

Scale indicators13 records

Recent moves6 records

Expansion highlights3 records

Direct peers

• Welldoc: Digital health platform focused on chronic disease management with FDA-cleared SaMD products and pharma partnerships (e.g., AstraZeneca). Operates a similar B2B2C model serving payers, providers, and pharma — directly comparable to Medisafe's Maestro + JITI architecture.
• Click Therapeutics: Prescription digital therapeutics company with pharma partnerships (Otsuka for depression adjunct, Boehringer Ingelheim). Pursues the same enterprise pharma licensing model and FDA-regulated digital therapeutic pathway that Medisafe targets via ISO 13485 SaMD positioning.
• AdhereHealth: Medication adherence management platform combining predictive analytics with human outreach for payers, health systems, and pharma. Competes with Medisafe on the payer-sponsored adherence layer and predictive non-adherence risk scoring use case.
• RxAnte: Medication adherence analytics platform using predictive models to identify at-risk patients for payers and PBMs. Overlaps with Medisafe's JITI predictive engine and pharma/payer GTM motion.
• emocha Health: Digital medication adherence platform featuring directly observed therapy via video and asynchronous chat. Competes with Medisafe's patient engagement offering, particularly in public health, infectious disease, and specialty therapy adherence.
• OptimizeRx: Provider-patient engagement and messaging platform that connects pharma brand messaging into the EHR workflow. Targets the same pharma brand team buyers as Medisafe and represents a competing approach to in-workflow digital engagement.
• Akili Interactive: Digital therapeutics company with FDA-cleared prescription cognitive treatments, monetized via consumer subscription and potential pharma channels. Operates in the adjacent digital therapeutics category with the same pharma-licensing thesis.

Emerging players

• Virta Health: Digital health company focused on metabolic disease reversal (type 2 diabetes, prediabetes) with strong outcomes evidence and payer/employer contracts. Overlaps with Medisafe in the metabolic/GLP-1 therapeutic area and chronic-condition patient engagement.
• Omada Health: Virtual-first chronic care platform for diabetes, hypertension, and mental health sold primarily to employers and payers. Overlaps with Medisafe in chronic-condition management and GLP-1/musculoskeletal therapeutic engagement.

Broad incumbents

• Veeva Systems: Pharma commercial cloud platform offering CRM, content management, and patient engagement modules. Represents the larger incumbent that pharma procurement may consolidate toward, potentially squeezing specialized vendors like Medisafe into narrower niches.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/MedisafeApp
• Facebookfacebook.com/MedisafeProject
• LinkedInlinkedin.com/company/medisafe-project

Compliance6 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds5 records

Investors17 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Medisafe