Singleron Biotechnologies
Singleron Biotechnologies is an end-to-end single-cell multi-omics platform company that sells kits, automated instruments (notably the FDA-equivalent Class II-approved Matrix NEO), and CRO/bioinformatics services to over 5,000 research, biopharma, and clinical laboratories globally from bases in Germany, Singapore, China, and the US.
- Company typePrivate
- Founded2018
- HeadquartersNanjing, China
- Headcount501–1,000
- GTM typeB2B
- OfferingHardware or Manufacturing
What Singleron Biotechnologies does
Singleron Biotechnologies is a molecular diagnostics company founded in 2018 as a Yale University spinout, headquartered in Cologne, Germany, with operations in Singapore, China, and the United States. The company develops an end-to-end single-cell multi-omics platform built on its proprietary SCOPE-chip microfluidic microwell technology, exclusive-licensed from Professor Rong Fan's laboratory at Yale. Its portfolio spans tissue preservation and dissociation kits (sCelLiVE, PythoN i/Junior), single-cell and single-nucleus RNA sequencing kits (GEXSCOPE family, MobiuSCOPE, FocuSCOPE, DynaSCOPE, ProMoSCOPE, SCircle), automated processing instruments (Matrix NEO, Tensor co-developed with Hamilton Bonaduz AG, Janus magnetic rack), and bioinformatics software (Celescope, Celelens code-free analysis, Synecosys database), alongside a CRO/biopharma services business for fee-for-service single-cell analysis.
The company generates revenue through four streams: one-time sales of sequencing kits and reagents, hardware sales of automated instruments, fee-for-service CRO work for pharmaceutical and academic customers, and subscription-based bioinformatics software. It sells primarily through direct sales teams in Germany, APAC, and North America, supplemented by an exclusive distributor network spanning 20+ countries and certified service providers such as Admera Health (US) and the Garvan Institute (Australia). The customer base includes over 5,000 laboratories, with 1 billion+ single cells processed and 1,000+ scientific publications citing the technology across oncology, immunology, neuroscience, and plant science applications.
Singleron is venture-backed, having raised over $150M cumulatively through five rounds from 2019 to 2022, led successively by Sherpa Healthcare Partners (pre-Series A), Lilly Asia Ventures (Series A), and FirstLight Capital/Lake Bleu Capital (Series B), with additional participation from ARCH Venture Partners, CDH Investments, and Tencent. In March 2022 it acquired Singapore-based Proteona for its multi-omic biomarker capabilities, and in November 2025 the Matrix NEO instrument received the world's first Class II medical device approval for automated single-cell analysis, opening a clinical diagnostics channel beyond the historical research and biopharma focus.
Singleron Biotechnologies firmographics
Firmographics- Name
- Singleron Biotechnologies
- Legal name
- Singleron Biotechnologies GmbH
- Website
- https://singleron.bio
- Company type
- Private
- Founded year
- 2018
- Operating status
- Operating
- Headcount range
- 501–1,000 employees
- Short description
- Singleron Biotechnologies is an end-to-end single-cell multi-omics platform company that sells kits, automated instruments (notably the FDA-equivalent Class II-approved Matrix NEO), and CRO/bioinformatics services to over 5,000 research, biopharma, and clinical laboratories globally from bases in Germany, Singapore, China, and the US.
- Ownership category
- akta.pro rank
Singleron Biotechnologies industry classification
Industry- Product category
- Single-Cell Genomics Tools
- NAICS
- Analytical Laboratory Instrument Manufacturing (334516), Scientific Research and Development Services (5417), Research and Development in Biotechnology (except Nanobiotechnology) (541714), Medical and Diagnostic Laboratories (62151), Research and Development in the Physical, Engineering, and Life Sciences (54171)
- SIC
- Laboratory Analytical Instruments (3826), Services-Commercial Physical & Biological Research (8731), In Vitro & In Vivo Diagnostic Substances (2835), Services-Medical Laboratories (8071)
- akta.pro primary industry
- Single-Cell & Spatial Omics Discovery Platforms (target ID/validation, functional profiling) (HLAAAIAF)
- akta.pro secondary industries
- Bioinformatics & Multi-omics Analysis Software (HLAGAJAD), Bioinformatics, Multi-Omics Data Analysis & Interpretation Services (HLAGANAI), Single-Cell & Spatial Omics Services (HLAGANAC)
Keywords
Where Singleron Biotechnologies is headquartered
LocationHeadquarters
- HQ city
- Nanjing
- HQ country
- China
- HQ region
- Asia
Offices7 records
Markets served
Singleron Biotechnologies business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Technology or R&D, Personnel, Supply Chain, Marketing or Sales, Operations
Revenue model
- Single Cell Sequencing Kits and Reagents: Sale of proprietary kits including GEXSCOPE, FocuSCOPE, MobiuSCOPE, DynaSCOPE, ProMoSCOPE, CLindex, and AccuraCode products for single cell and bulk RNA sequencing
- Instruments and Devices: Sale of automated instruments including Matrix NEO, PythoN, PythoN Junior, Tensor, and Janus Magnetic Rack for tissue dissociation and single cell processing
- CRO/Biopharma Services: Fee-for-service single cell analysis services including tissue dissociation, library preparation, sequencing, and bioinformatics for pharmaceutical companies and research institutions
- Bioinformatics Software: Software solutions for sequencing data processing, analysis, and database services
Go-to-market motion1 record
Distribution channels8 records
Marketing channels10 records
Singleron Biotechnologies product offering
Product offeringCore offering
Singleron Biotechnologies develops and commercializes an end-to-end single-cell multi-omics platform for research and clinical diagnostics. The offering includes microfluidic-based reagent kits (GEXSCOPE, MobiuSCOPE, FocuSCOPE, DynaSCOPE, ProMoSCOPE, SCircle, CLindex, AccuraCode, sCelLiVE), automated instruments (PythoN i/Junior tissue dissociators, Matrix NEO single cell processor, Tensor library processing system, Janus magnetic rack), bioinformatics software (CelESCOPE, Celelens, SyneCosys), and CRO/biopharma services for tissue dissociation, library preparation, sequencing, and data analysis.
Product overview
Singleron Biotechnologies offers an end-to-end single cell multi-omics platform comprising instruments, reagents/kits, bioinformatics software, and laboratory services. The portfolio is organized around three main pillars: (1) Kits & Solutions including GEXSCOPE family for single cell/nucleus RNA sequencing, MobiuSCOPE for full-length transcriptomics, SCircle for immune profiling, FocuSCOPE for targeted variant detection, DynaSCOPE for RNA dynamics, ProMoSCOPE for glycosylation, CLindex for multiplexing, AccuraCode/AccuraSCOPE for bulk and multi-omics analysis, and sCelLiVE for tissue preservation; (2) Instruments including PythoN i/Junior automated tissue dissociators, Matrix NEO single cell processing system (Class II medical device), Tensor high-throughput automated library processing system (with Hamilton), and Janus magnetic rack; and (3) Services covering single cell/nucleus sequencing, immune profiling, multi-omics, ATAC-seq, bulk mRNA-seq, bioinformatics, eQTL analysis, and CRO/biopharma partnerships. The proprietary microfluidic microwell SCOPE-chip technology underpins the platform, enabling the complete workflow from tissue preservation to single-cell partitioning, barcoding, library preparation, and bioinformatic analysis.
Differentiator
Problem solved
Functional benefit
Brands
- GEXSCOPE: Single cell RNA sequencing and single nucleus RNA sequencing kits for whole transcriptome profiling
- RetroSCOPE
- MobiuSCOPE
- FocuSCOPE
- DynaSCOPE
- ProMoSCOPE
- SCircle
- CLindex
- PythoN
- PythoN Junior
- Matrix NEO
- Tensor
- CelLiVE
- CelESCOPE
- Celelens
- Synecosys
- AccuraCode
- SCOPE-chip
- AD-Omics
Products and services
- GEXSCOPE Single Cell RNA Sequencing Kit Microfluidic microwell-based kit for highly parallel single-cell separation and RNA sequencing library preparation, enabling whole-transcriptome profiling at single-cell resolution. Used by researchers in oncology, immunology, and neuroscience.
- GEXSCOPE Single Nucleus RNA Sequencing Kit Kit for single nucleus transcriptomic analysis from frozen or complex tissues where nucleus extraction is preferred over whole-cell processing.
- GEXSCOPE FFPE / RetroSCOPE FFPE Single Nucleus Transcriptome Library Kit Kit enabling recovery of comprehensive single-nucleus transcriptomic data from formalin-fixed paraffin-embedded (FFPE) tissues and paraformaldehyde-fixed samples for archived sample analysis.
- MobiuSCOPE Full-Length Single Cell RNA Sequencing Kit Full-length single cell RNA sequencing kit enabling discovery of complete transcriptome information including isoform and variant information with short-read sequencing instruments.
- SCircle Full-Length TCR/BCR Profiling Kit Solution for full-length T-cell receptor (TCR) and B-cell receptor (BCR) profiling to analyze immune repertoire diversity and composition.
- FocuSCOPE Single Cell Targeted Capture Kit Targeted variant detection kit enabling customizable detection of specific variants such as SNVs, fusion genes, viral genes, and the whole transcriptome from the same single cells.
- DynaSCOPE Time-Resolved RNA Library Kit Kit for time-resolved RNA sequencing that delineates nascent RNA from long-lasting transcripts, enabling analysis of RNA dynamics.
- ProMoSCOPE Glycosylation Discovery Kit Kit for glycosylation analysis at the single-cell level, enabling discovery of glycosylation patterns and their role in cellular function.
- CLindex Sample Multiplexing Kit Sample multiplexing kit enabling combination of up to 16 samples per run to boost throughput and reduce per-sample cost.
- AccuraCode mRNA Sequencing Kit High-throughput bulk RNA-Seq kit for mRNA sequencing including project consultation, RNA extraction, library generation, sequencing, and data analysis.
- AccuraCode TCR Library Construction Kit Bulk TCR profiling kit for analyzing T-cell receptor diversity and composition through end-to-end bulk TCR profiling.
- AccuraSCOPE Transcriptome & Genome Analysis Kit Multi-omics kit combining genome and transcriptome analysis at the single-cell level for combined genomic and transcriptomic profiling.
- sCelLiVE Tissue Preservation and Dissociation Kit (Skin) All-in-one kit combining 72-hour tissue preservation and efficient dissociation for streamlined single-cell sample preparation, with skin-specific protocol.
- PythoN i Automated Tissue Dissociation System Advanced automated tissue processing system with eight independent channels, combining tissue dissociation and nuclei extraction functions for different sample types.
- PythoN Junior Tissue Dissociation System Compact tissue dissociation system optimized to handle challenging tissue types and produce consistent single-cell suspensions.
- Matrix NEO Single Cell Processing System Automated single-cell processing system, the world's first Class II medical device approved for automated single-cell analysis, enabling clinical diagnostics applications.
- Tensor High Throughput Single Cell & Library Processing System Fully automated high-throughput single-cell library processing system developed in partnership with Hamilton Bonaduz AG, setting new standards in single-cell sequencing automation.
- Janus Magnetic Rack Magnetic rack for daily lab work supporting magnetic bead-based workflows in single-cell analysis protocols.
- CelESCOPE Sequencing Data Processing Software Bioinformatics software pipeline for processing and analyzing single-cell sequencing data through automated analysis workflows.
- SyneCosys Single Cell Database Single-cell knowledge base platform providing access to curated single-cell datasets and analysis tools for data storage and exploration.
- Celelens Code-free Data Analysis Platform Code-free bioinformatics platform enabling researchers to analyze single-cell data without programming expertise through a user-friendly interface.
- Single Cell & Single Nucleus Sequencing Service End-to-end service where Singleron's lab team processes customer samples and delivers publication-ready single-cell data, covering tissue dissociation, library preparation, and sequencing.
- Immune Profiling Service Service offering including V(D)J immune profiling, TCR/BCR sequencing, and surface protein expression analysis for comprehensive immune cell characterization.
- Multi-Omics Service Combined single-cell analysis services delivering multiple data layers including transcriptomics and additional modalities from the same single cells.
- Single Cell ATAC-seq Service Service for transposase-accessible chromatin analysis with high-throughput bulk sequencing to identify open chromatin regions within the genome.
- Bulk mRNA Sequencing Service Large-scale RNA sequencing service using AccuraCode technology including project consultation, RNA extraction, library generation, sequencing, and data analysis.
- Bioinformatics Service Advanced bioinformatics support including project planning, automated cell annotation, batch correction, differential gene expression analysis, pathway analysis, cell-cell communication analysis, CNV analysis, biomarker discovery, survival analysis, and interpretable machine learning for treatment response prediction.
- eQTL Analysis Service Bioinformatic pipeline for single-cell expression quantitative trait locus (eQTL) analysis to investigate genetic variants affecting gene expression.
- CRO / Biopharma Services Contract research organization services for pharmaceutical and biotech companies including customized single-cell analysis solutions and dedicated project management.
Quantifiable outcome
- 1000+ scientific publications supported by Singleron technology
- +4 more outcomes
Companies that use Singleron Biotechnologies
Customer profileNamed customers14 records
Segments6 records
Ideal customer profiles3 records
Singleron Biotechnologies technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Feature9 records
Singleron Biotechnologies partnerships and signals
Strategic signalPartnerships
18 partnerships are on record, tiered core, strategic, flagship and minor.
- Garvan Institute of Medical ResearchcoreAustralia certified service provider and strategic research partner. Garvan utilizes Singleron's cutting-edge products to deliver single-cell multi-omics solutions to academic and biopharmaceutical clients.
- DKSHcoreExclusive distributor partnership covering Australia and New Zealand, marking third collaboration after South Korea and Thailand. DKSH provides distribution, marketing, and local expertise for Singleron's single-cell solutions.
- Institute for Healthier Living Abu Dhabi (IHLAD)strategicJoint venture to launch AD-Omics, a center dedicated to advancing precision medicine in the Middle East. IHLAD is the world's first specialized Healthy Longevity Medicine Center.
- Hamilton Bonaduz AGcoreStrategic partnership to develop Tensor High Throughput Single Cell Library Processing System - a fully automated instrument for single-cell processing, officially launched in April 2025.
- TOMY Digital Biology Co., Ltd.coreExclusive distributor for Japan providing access to Singleron's comprehensive range of single-cell analysis products and services, covering tissue preservation, dissociation, library preparation, and data analysis software.
- Bioscreen (India)strategicStrategic partnership to enhance access to single-cell multi-omics solutions for India researchers through Bioscreen's distribution network.
- Human Cell Atlas (HCA)flagshipPartnership with international scientific consortium aiming to map all human cell types. Singleron contributes to enhancing access to single-cell analysis globally and advancing the atlas-building mission.
- Admera HealthcoreCertified US service provider partnership announced at Festival of Genomics & Biodata in Boston. Admera delivers curated single-cell multi-omic solutions using Singleron's products and platform.
- ProteonacoreSingleron acquired Singapore-based Proteona to expand global presence and technological capabilities. The acquisition included Proteona's network across Asia, Europe, US, and Canada, plus access to multi-omic analysis tools and AI bioinformatics expertise for precision medicine.
- XtalPi Inc.strategicAI-driven drug discovery partnership combining Singleron's single-cell analysis with XtalPi's AI and robotics platforms for intelligent drug discovery development.
- Agilent TechnologiesstrategicCollaboration to accelerate the development and application of single cell sequencing technology through combined expertise in genomics solutions.
- CERTAINTY ProjectstrategicEU-funded initiative developing virtual twin for personalized cancer treatment, particularly focusing on CAR T cell therapy. Led by Fraunhofer Institute, funded with EUR 10 million over 4.5 years under Digital Europe Programme.
- B2B-RAREminorInitiative developing innovative treatments for rare neuromuscular diseases using patient-derived skin cells and omics technologies for diagnostic and therapeutic procedures.
- Macrogen EuropestrategicStrategic alliance combining Singleron's single-cell solutions with Macrogen's sequencing services to serve European researchers.
- Berry GenomicsstrategicStrategic alliance in single-cell sequencing area aimed at promoting clinical applications of single-cell technology.
- PhileKorea, Inc.minorDistributor for South Korea market alongside DKSH Korea.
- Bio3 Scientific Sdn BhdminorDistributor for Malaysia market.
- AdOmicsminorDistributor for Middle East region.
Scale indicators14 records
Recent moves7 records
Expansion highlights6 records
Singleron Biotechnologies competitors and assessment
Company assessmentDirect peers
- BD (Becton, Dickinson and Company): BD Biosciences offers the Rhapsody single-cell analysis platform, directly competing with Singleron in microwell-based single-cell partitioning and in instrumentation for genomics workflows.
- 10x Genomics: The dominant single-cell sequencing platform company (Chromium, Visium spatial, Xenium). Most directly comparable competitor to Singleron across instruments, kits, and software for scRNA-seq and multi-omics.
- Takara Bio: Provides SMART-seq single-cell RNA-seq kits and instruments, directly competing with Singleron's GEXSCOPE and MobiuSCOPE chemistry offerings in research and translational labs.
- Parse Biosciences: Evercode single-cell technology using combinatorial barcoding without microfluidics or instruments. Competes with Singleron for scale and flexibility in single-cell transcriptomics.
- Standard BioTools (formerly Fluidigm): Pioneer in mass cytometry and microfluidic single-cell technology (now Standard BioTools). Competes in single-cell genomics workflows through its Hyperion imaging and Biomark HD platforms.
Others
- Hamilton Bonaduz AG: Laboratory automation partner that co-developed Singleron's Tensor instrument. Adjacent technology partner rather than direct competitor, but its automation platforms are comparable instruments in adjacent genomics labs.
Broad incumbents
- Illumina: Sequencing platform incumbent whose NovaSeq/NextSeq systems are used downstream of Singleron's kits. Overlaps through its own single-cell initiatives (e.g., partnerships and DRAGEN bio-IT) and is a critical ecosystem participant.
- Bio-Techne: Through its R&D Systems and ProteinSimple brands, Bio-Techne supplies reagents, antibodies, and analytical instruments used in single-cell workflows, including its own spatial biology offering (RNAscope).
- NanoString Technologies: Spatial omics company offering GeoMx and CosMx platforms. Comparable to Singleron in driving the broader multi-omics and spatial biology market, though focused on imaging rather than dissociation-based workflows.
Emerging players
- Mission Bio: Single-cell DNA sequencing and multi-omics platform (Tapestri). Partial overlap with Singleron's FocuSCOPE targeted variant detection and AccuraSCOPE genome+transcriptome offerings.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
Singleron Biotechnologies social profiles
Digital presenceSingleron Biotechnologies financial estimates
Financial estimateRevenue estimate
Valuation estimate
Singleron Biotechnologies leadership team
Management profileNumber of profiles
Profiles5 records
Singleron Biotechnologies subsidiaries and ownership
Company hierarchySubsidiaries1 record
Singleron Biotechnologies funding detail
Funding detailFunding overview
Funding rounds3 records
Investors16 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Singleron Biotechnologies M&A and investment
M&A and investmentM&A1 record
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Singleron Biotechnologies
What does Singleron Biotechnologies do?
Singleron Biotechnologies develops and commercializes an end-to-end single-cell multi-omics platform for research and clinical diagnostics. The offering includes microfluidic-based reagent kits (GEXSCOPE, MobiuSCOPE, FocuSCOPE, DynaSCOPE, ProMoSCOPE, SCircle, CLindex, AccuraCode, sCelLiVE), automated instruments (PythoN i/Junior tissue dissociators, Matrix NEO single cell processor, Tensor library processing system, Janus magnetic rack), bioinformatics software (CelESCOPE, Celelens, SyneCosys), and CRO/biopharma services for tissue dissociation, library preparation, sequencing, and data analysis.
Is Singleron Biotechnologies a public or private company?
Singleron Biotechnologies is a private company. It is classified as venture growth investor backed and is currently operating.
When was Singleron Biotechnologies founded?
Singleron Biotechnologies was founded in 2018. It employs 501 to 1,000 people.
Where is Singleron Biotechnologies based?
Singleron Biotechnologies is headquartered in Nanjing, China, in the Asia region.
How does Singleron Biotechnologies make money?
Four revenue lines are on record. Single Cell Sequencing Kits and Reagents are the primary driver. The others are instruments and Devices, CRO/Biopharma Services and bioinformatics Software.
Who are Singleron Biotechnologies's main competitors?
Direct peers on record are BD (Becton, Dickinson and Company), 10x Genomics, Takara Bio, Parse Biosciences and Standard BioTools (formerly Fluidigm). Hamilton Bonaduz AG is listed as an others. Broad incumbents are Illumina, Bio-Techne and NanoString Technologies. Mission Bio is listed as an emerging player.
Does Singleron Biotechnologies have an API?
No public API is recorded for Singleron Biotechnologies.
What industry is Singleron Biotechnologies in?
Singleron Biotechnologies's product category is Single-Cell Genomics Tools. Its primary akta.pro industry code is HLAAAIAF, Single-Cell & Spatial Omics Discovery Platforms (target ID/validation, functional profiling), with a secondary code of HLAGAJAD, Bioinformatics & Multi-omics Analysis Software. Its NAICS code is 334516 and its SIC code is 3826.