TwelveStone Health Partners

What TwelveStone Health Partners does

TwelveStone Health Partners operates an integrated specialty pharmacy and outpatient infusion therapy platform serving patients with chronic autoimmune, neurological, inflammatory, oncologic, and other complex conditions across the southeastern United States. The company delivers care through three primary sites of service: 30+ private-suite infusion centers across Tennessee, Kentucky, Georgia, Mississippi, and Virginia; home-based infusion services staffed by registered nurses; and physician-office-based infusions offered through its Cornerstone program. It also operates a specialty pharmacy that sources, prepares, and dispenses 62 specialty medications including biologics such as Remicade, Entyvio, and Ocrevus. The technology layer includes VirtueScript, a digital prescription and medication management platform launched in 2019, supported by the January 2026 Tennr partnership for referral and intake automation. Clinical operations are run by PharmD-led teams with continuous RN monitoring during infusions, and the company maintains URAC Specialty Pharmacy and ACHC Gold Seal accreditations. Supporting services include insurance navigation and prior authorization, the TailorMed financial assistance program, peer advocate support, and a corporate chaplaincy program.

The business model is reimbursement-driven: TwelveStone bills Medicare, Medicaid, and commercial payers for administered drugs and infusion services, with revenue tied to treatment volume, drug mix, and site-of-care economics. The GTM motion is a hybrid of physician referral-based patient acquisition (targeting neurologists, rheumatologists, gastroenterologists, oncologists, and pediatric specialists) and enterprise field sales to health systems, long-term care facilities, and specialty physician practices. Customers are split between individual patients with chronic conditions and institutional partners (Stones River Manor, Tennova Healthcare, Cookeville Regional Medical Center, Cedarcroft Home, Knollwood Manor, GoodWorks Unlimited, Quality Home Health), with named case studies covering both long-term care and acute-care hospital relationships. CEO Shane Reeves (also a Tennessee State Senator) has led the company since joining the family business in 1994; President Jay McKnight joined in September 2024 from Varsity Healthcare Partners. The company is privately held, headquartered in Murfreesboro, Tennessee, and was previously operated as Reeves-Sain before rebranding in 2022 following the Claritas Capital venture round (2017), Siena Healthcare Finance $12M debt funding (2021), and Heritage Group growth equity investment (2022). The Inc. 5000 has recognized the company for six consecutive years from 2020 through 2025.

Name

TwelveStone Health Partners

Legal name

TwelveStone Health Partners

Website

https://12stonehealth.com

Company type

Private

Founded year

1980

Operating status

Operating

Headcount range

101–250 employees

Short description

TwelveStone Health Partners is a privately held specialty pharmacy and outpatient infusion therapy operator running 30+ private-suite infusion centers across the southeastern U.S., serving patients with chronic autoimmune, neurological, oncologic, and other complex conditions referred by specialist physicians, and dispensing 62 specialty medications including biologics.

Ownership category

akta.pro rank

Product category

Specialty Infusion Therapy Services

NAICS

Ambulatory Health Care Services (621)

SIC

Services-Specialty Outpatient Facilities, Nec (8093), Services-Home Health Care Services (8082), Services-Health Services (8000)

akta.pro primary industry

Infusion & Home Infusion Pharmacy Services (HLAFALAG)

akta.pro secondary industries

Infusion Therapy Centers (Outpatient) (HLAFABAF), Home Infusion Therapy Providers (HLAFAEAE), Specialty Pharmacy & Complex Therapy Management Platforms (HLACAKAG), Home Infusion Therapy & IV Nursing Services (HLADAFAG)

Keywords

• Specialty infusion therapy
• Specialty pharmacy services
• Home infusion services
• Chronic care management
• Infusion center services

Headquarters

HQ city

Murfreesboro

HQ country

United States

HQ region

North America

Offices25 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Supply Chain, Infrastructure, Technology or R&D, Marketing or Sales

Revenue model

1. Infusion Therapy Services: Revenue generated from administering IV and subcutaneous medications in outpatient infusion centers. Services are billed to insurance including Medicare, Medicaid, and commercial payers. The company handles insurance authorization and benefits verification on behalf of patients.
2. Specialty Pharmacy: Specialty pharmacy services managing and dispensing 62 specialty medications including biologics. The pharmacy handles medication sourcing, preparation, and delivery for infusion treatments.
3. Home Infusion Services: Home-based infusion care for eligible patients requiring nursing support at their residence. RNs with infusion expertise deliver medications in patient homes.

Pricing tiers

Go-to-market motion2 records

Distribution channels4 records

Marketing channels7 records

Core offering

TwelveStone Health Partners operates a specialty infusion therapy and chronic care medication management platform, delivering outpatient IV and subcutaneous medication administration across 30+ private-suite infusion centers in Tennessee, Kentucky, Georgia, Mississippi, and Virginia. The company also provides home-based infusion care delivered by experienced RNs, specialty pharmacy services managing 62 specialty medications, and physician office infusion solutions through the Cornerstone program. PharmD-led clinical teams handle insurance authorization, benefits verification, and continuous nursing monitoring during treatments for patients with complex chronic and autoimmune conditions.

Product overview

TwelveStone Health Partners operates as an integrated infusion care platform offering multiple sites of care across the southeastern United States. The core offering consists of Infusion Center Services (30+ private-suite outpatient locations across TN, KY, GA, MS, AL, and VA), Home Infusion Services (RN-delivered in-home care), Specialty Pharmacy (62 specialty medications), and specialty programs including Oncology Infusion Treatment, Pediatric Infusion Therapy, Cornerstone Physician Office Solutions, and RX4Him. These are unified through shared clinical oversight (PharmD-led teams), insurance navigation support, and patient-centered services including Peer Advocate Support, Chaplain Services, and TailorMed financial assistance. The company delivers a simplified care model with one trusted partner, one point of contact, and one simplified bill. Founded in 1980 as Reeves-Powell Drug Store and rebranded to TwelveStone Health Partners, the company has 35+ years of experience in community-based care and specialty pharmacy services.

Differentiator

Problem solved

Functional benefit

Brands

• Cornerstone: Physician Office Solutions - infusion services offered at physician offices
• VirtueScript
• MEDIpack
• RX4Him

Products and services

• Infusion Center Services
• Home Infusion Services
• Oncology Infusion Treatment
• Pediatric Infusion Therapy
• Specialty Pharmacy
• Chronic Condition Management
• Cornerstone Physician Office Solutions
• RX4Him
• VirtueScript

Quantifiable outcome

• Reduced medication error rate from 4% to nearly 0.004% at partner long-term care facilities over a decade
• +3 more outcomes

Named customers7 records

Segments6 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Partnerships

Two partnerships are on record, tiered core.

• TennrcoreTechnology or Integration · 6 January 2026TwelveStone partnered with healthcare technology company Tennr to automate and streamline patient referral processing. Tennr handles fax management, referral intake, eligibility verification, and patient qualification against payer criteria. The partnership aims to reduce delays and resubmissions while enabling TwelveStone to focus on complex, high-touch referrals.
• TailorMedcoreStrategic or Co-development Partner · 22 August 2023TailorMed joined forces with TwelveStone Health Partners to improve medication access and affordability for patients. The partnership focuses on helping patients navigate financial assistance programs and reduce out-of-pocket costs for specialty medications.

Scale indicators6 records

Recent moves18 records

Expansion highlights6 records

Direct peers

• Option Care Health: Largest independent U.S. provider of home and alternate-site infusion therapy plus specialty pharmacy, with national coverage. TwelveStone competes for the same prescribing specialists and payer contracts across Tennessee, Kentucky, Georgia, and Virginia on a smaller geographic scale.
• IVX Health: Outpatient infusion-center operator focused on biologics for autoimmune and immune-mediated conditions across multiple U.S. states. Competes with TwelveStone for specialty rheumatology, GI, and neurology referrals with a similar private-suite, hospitality-oriented delivery model.
• Soleo Health: Specialty infusion provider and home-infusion pharmacy delivering IVIG, biologics, and complex therapies nationally. Direct peer in the integrated specialty pharmacy + alternate-site infusion model that TwelveStone's 62-medication formulary mirrors.
• Vivo Infusion: Outpatient infusion-therapy network administering specialty biologics for autoimmune, neurological, and rheumatologic conditions. Directly comparable to TwelveStone's private-suite outpatient infusion centers in terms of patient population, formulary, and revenue-per-chair economics.
• BioPlus Specialty Pharmacy: Specialty pharmacy focused on complex therapies and patient access, now part of CarelonRx (Elevance Health). Competes with TwelveStone on specialty medication dispensing, prior-authorization support, and adherence programs for the same autoimmune/oncology patient pool.
• Shields Health Solutions: Specialty pharmacy integrated inside hospital systems to manage complex-condition patients on high-cost biologics. Direct peer to TwelveStone's specialty-pharmacy arm and Cornerstone physician-office infusion model on health-system partnerships and care-coordination economics.

Broad incumbents

• Accredo (Evernia/Express Scripts): One of the largest U.S. specialty pharmacies for high-cost biologics, owned by Express Scripts/Evernia. Represents the broad-incumbent PBM-aligned version of TwelveStone's specialty pharmacy offering for patients on autoimmune, oncology, and rare-disease therapies.
• Coram (CVS Health): CVS Health's home-infusion pharmacy serving patients nationwide. Broad-incumbent peer to TwelveStone's home-infusion service line and represents the integrated-payor-and-provider approach that regional infusion operators must defend against.
• Optum Infusion (UnitedHealth Group): Home and alternate-site infusion pharmacy operated by Optum/UnitedHealth Group. A scaled, vertically integrated incumbent competing with TwelveStone on payer relationships and across the same chronic-disease biologics administered in the Southeast.

Emerging players

• Medix Infusion: Specialty infusion provider operating community-based centers in Tennessee and surrounding states. Closest geographic overlap to TwelveStone in the Mid-South and serves the same neurology/rheumatology referral base.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat6 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xx.com/12stonehealth
• YouTubeyoutube.com/channel/UCZg1OWczCKzdyoGZl4QCUYA
• Facebookfacebook.com/12stonehealth
• LinkedInlinkedin.com/company/twelvestone-health-partners

Compliance5 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles12 records

Funding overview

Funding rounds4 records

Investors3 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about TwelveStone Health Partners