Advarra

What Advarra does

Advarra is a Columbia, Maryland-based clinical research technology company serving sponsors, CROs, academic medical centers, and investigator sites across the drug development lifecycle. Founded in 1993 and operating with 501-1,000 employees, it provides AAHRPP-accredited central IRB review services (CIRBI), enterprise CTMS platforms (OnCore for academic medical centers, Clinical Conductor for sites), an investigator community covering 50,000+ investigators, complementary offerings in IBC review, eSource, eRegulatory, DMC oversight, and GxP services, plus the Study Collaboration protocol site-portal product (formerly Longboat). The company reports 3,500+ institutions on its networks, 12,000+ open protocols annually, 3M+ patient visits, and $4B+ in trial invoice value flowing through its systems, with claimed penetration of 88% of NCI-designated cancer centers and 100% of top-10 pharma sponsors and CROs for IRB services.

Revenue mechanics combine multi-year subscription licenses for CTMS and Study Collaboration, per-protocol IRB and IBC review fees, ancillary compliance services, and enterprise contracts with major sponsors and CROs. Recent commercial activity in 2025-2026 — including the launch of the Braid AI and analytics platform and an AI-powered Study Design product, the appointment of a CTO, the addition of five eClinical partner integrations, an EHR-to-EDC interoperability partnership with IgniteData, and a site-network partnership with ICON plc — points to an explicit strategy to extend Advarra from review and workflow systems into an AI-enabled data and protocol design layer for the broader clinical research stack.

Name

Advarra

Legal name

Advarra, Inc.

Website

https://advarra.com

Company type

Private

Founded year

1993

Operating status

Operating

Headcount range

501–1,000 employees

Short description

Advarra is a Columbia, Maryland-based clinical research technology company providing central IRB review, enterprise CTMS (OnCore, Clinical Conductor), and the Study Collaboration site platform for pharma sponsors, CROs, and 3,500+ academic and research institutions worldwide.

Ownership category

akta.pro rank

Product category

Clinical Trial Management Software

NAICS

Custom Computer Programming Services (541511)

SIC

Services-Prepackaged Software (7372), Services-Computer Programming Services (7371)

akta.pro primary industry

Clinical CROs (Phase I–IV) (HLAGAAAA)

akta.pro secondary industries

Patient Recruitment, Site Feasibility & Trial Enablement CROs (HLAGAAAI), Electronic Data Capture (EDC) Platforms (HLACAOAA)

Keywords

• Clinical trial management
• IRB review services
• Clinical research software
• EClinical platform
• Institutional review board

Headquarters

HQ city

Columbia

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

1. CTMS Platform Subscriptions: Annual or multi-year subscription licensing for OnCore and Clinical Conductor CTMS platforms, typically sold as enterprise agreements to research sites, academic medical centers, and health systems.
2. Study Collaboration Platform: Subscription-based access to connected site network and eClinical integrations for sponsors and CROs, with per-seat or site-based licensing models.
3. IRB Review Services: Regulatory review services for clinical trials, providing independent oversight with speed and transparency. Revenue from review fees and service agreements.
4. AI and Data Platform (Braid): AI-powered insights and operational intelligence services, likely bundled with platform subscriptions or offered as add-on capabilities.
5. Professional Services: Consulting and professional services including study startup, coverage analysis, budget negotiation, and CTMS configuration services.

Go-to-market motion2 records

Distribution channels4 records

Marketing channels9 records

Core offering

Advarra provides clinical research technology and regulatory oversight products, including IRB review services through its CIRBI platform, enterprise CTMS solutions (OnCore and Clinical Conductor), eSource and eRegulatory document systems for research sites, and a Study Collaboration platform that connects sponsors, CROs, and sites via single sign-on to integrated eClinical technologies. Its Braid AI and data engine adds operational intelligence across the protocol lifecycle.

Product overview

Advarra is a clinical research technology platform combining IRB oversight, operational intelligence, and collaborative trial management. The core offerings include CIRBI for IRB services and the Braid AI and data engine platform. For research sites, Advarra provides OnCore (enterprise CTMS for academic medical centers and cancer centers) and Clinical Conductor (CTMS for sites, networks, and health systems), along with eReg (regulatory document management) and eSource (electronic data capture). For sponsors and CROs, the Study Collaboration platform integrates AI-powered Study Design, Site Identification & Feasibility, Study Startup, Site Collaboration & Training, and Enrollment Planning & Tracking. Additional offerings include IBC, DMC, and GxP compliance services. The Braid platform weaves operational intelligence from Advarra's IRB and clinical trial systems throughout the entire protocol lifecycle.

Differentiator

Problem solved

Functional benefit

Brands

• CIRBI: IRB platform for managing institutional review board submissions and reviews
• OnCore
• Clinical Conductor
• Braid
• Study Collaboration
• eReg
• eSource
• IBC Services
• DMC Services

Products and services

• CIRBI (Center for IRB Intelligence) Advarra's IRB platform providing independent, rigorous oversight with speed, expertise and transparency for ethical review of clinical research protocols, used by 100% of the top 10 pharmaceutical sponsors and CROs.
• Braid Advarra's AI and data engine platform that weaves operational intelligence into the protocol lifecycle, powering Study Collaboration and providing actionable insights for smarter study design, faster decisions, and AI-automated workflows.
• OnCore Enterprise CTMS designed for academic medical centers and cancer centers, managing all operational aspects of clinical trials from study startup to closeout. Used by 88% of NCI-designated cancer centers.
• Clinical Conductor CTMS for research sites, site networks, hospitals, and health systems to manage research operations, study conduct, financial management, billing, and regulatory compliance.
• eReg Electronic regulatory document management and exchange system for efficient regulatory compliance at research sites.
• eSource Integrated data capture and oversight system enabling electronic source documentation for clinical trials.
• Study Collaboration (formerly Longboat) Study collaboration solution providing sponsors, CROs, and research sites a single access point for clinical trial systems with single sign-on, credential management, and integrated eClinical technology partners.
• IBC (Institutional Biosafety Committee) Services Review and audit services for institutional biosafety committee oversight of gene therapy, cell therapy, and biologics research.
• DMC (Data Monitoring Committee) Services Data monitoring committee services providing independent oversight of clinical trial safety data.
• GxP Compliance Intelligence Compliance intelligence services for GxP regulatory requirements in clinical research.

Quantifiable outcome

• 88% of NCI-designated cancer centers use Advarra technology
• +6 more outcomes

Named customers8 records

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration13 records

AI capability6 records

Feature8 records

Partnerships

Seven partnerships are on record, tiered core and secondary.

• ICON plccoreStrategic or Co-development Partner · 24 March 2026Definitive partnership to introduce a 'research-ready' connected site network model for clinical trials globally. Integration of ICON's global clinical trial solutions with Advarra's site CTMSs, eISF, and eSource systems used by 50,000+ investigators. Aims to reduce administrative friction, accelerate study startup, and increase clinical trial participation.
• YPrimesecondaryTechnology or Integration · 10 December 2025eClinical technology partner integrated into Advarra's Study Collaboration solution. YPrime provides clinical trial technology solutions and is part of the expanded partner network providing single sign-on access through Advarra's platform.
• ScoutsecondaryTechnology or Integration · 10 December 2025eClinical technology partner integrated into Advarra's Study Collaboration solution. Scout's technology is accessible through single sign-on within Advarra's platform ecosystem.
• SuvodasecondaryTechnology or Integration · 10 December 2025eClinical technology partner integrated into Advarra's Study Collaboration solution. Suvoda's solutions are accessible through single sign-on within Advarra's platform.
• DatacubedsecondaryTechnology or Integration · 10 December 2025eClinical technology partner integrated into Advarra's Study Collaboration solution. Datacubed's technology is accessible through single sign-on within Advarra's platform.
• EndpointsecondaryTechnology or Integration · 10 December 2025eClinical technology partner integrated into Advarra's Study Collaboration solution. Endpoint's technology is accessible through single sign-on within Advarra's platform.
• IgniteDatacoreTechnology or Integration · 12 November 2025Partnership to enhance clinical trial data transfer between research sites' EHR systems, Advarra's eSource and EDC systems, and sponsor EDC systems. Collaboration aims to improve data accuracy, reduce administrative burden, and accelerate clinical trial conduct.

Scale indicators8 records

Recent moves8 records

Expansion highlights5 records

Direct peers

• Veeva Systems: Veeva provides CTMS, eTMF, Vault Clinical, and a broad clinical operations suite for pharma sponsors and CROs, competing directly with Advarra's Study Collaboration and CTMS offerings for sponsor-side wallet share.
• Medidata (Dassault Systèmes): Medidata's Rave EDC, CTMS, eCOA, and RTSM platform competes with Advarra's eSource, Clinical Conductor, and integrated eClinical partners across sponsor and CRO customers.
• WCG (WIRB-Copernicus Group): WCG is Advarra's most direct IRB services competitor, providing independent review boards and clinical services to sponsors, CROs, and research sites across all therapeutic areas.
• Clario (formerly ERT): Clario provides eCOA, cardiac safety, respiratory, and imaging solutions integrated into clinical trials, directly competing with Advarra's eClinical partner ecosystem for sponsor eClinical spend.
• Signant Health: Signant Health offers eCOA, eConsent, RTSM, patient engagement, and clinical supply technology, overlapping with Advarra's Study Collaboration partner integrations and eSource offerings.

Broad incumbents

• Oracle Health Sciences (Clinical One): Oracle's Clinical One platform unifies EDC, RTSM, CTMS, and ePRO, competing with Advarra's integrated eClinical vision for large enterprise pharma customers.
• IQVIA Technologies: IQVIA combines CRO services with proprietary clinical trial technology (e.g., IQVIA Technologies, Digital Trial Solutions), positioning as a broader incumbent that overlaps with Advarra's sponsor-side offerings.

Emerging players

• Florence Healthcare: Florence provides eISF and site-focused clinical trial technology that directly competes with Advarra's eReg, eISF, and site CTMS offerings for academic and community research sites.
• Castor: Castor offers an EDC and eClinical platform with strong adoption among academic medical centers and emerging sponsors, competing with Advarra's Clinical Conductor and eSource offerings in the site segment.

Others

• ICON plc: ICON is both Advarra's strategic partner (connected site network) and a global CRO with proprietary technology. As a distribution partner, ICON extends Advarra's reach; as a CRO with competing site technology, it represents a complex peer relationship.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xtwitter.com/advarra
• LinkedInlinkedin.com/company/advarra

Compliance7 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles9 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A6 records

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Advarra