What Sente does

Sente is a privately-held medical-grade skincare company founded in 2007 and headquartered in San Diego (Encinitas), California. The company develops, markets, and sells a portfolio of cosmeceutical products built around its patented Heparan Sulfate Analog (HSA) technology — a proprietary molecule designed to replenish heparan sulfate that declines in skin with age and UV damage, thereby supporting the skin's extracellular matrix and cellular repair function. HSA is supplemented by a second patented platform, DECO (Dermatan Sulfate/Chondroitin Sulfate) technology, which the company is positioning for regenerative skincare solutions.

The product portfolio spans cleansers ($36-$46), moisturizers, serums and sunscreens ($75-$198), eye and body care ($98-$110), a vitamin C serum ($165), and bundled kits ranging from $66 to $365. Sente distributes through two channels: direct-to-consumer e-commerce at sentelabs.com — including a subscription service with complimentary shipping and a rewards/referral program — and an authorized physician-dispensed network of dermatologists and aesthetic practitioners. The company cites recommendation by over 500 physicians and operational reach across more than 50 countries. Customer segments include end consumers with skin concerns (redness, hyperpigmentation, sensitive skin, fine lines, dehydration) and the dermatology and aesthetic-professional community that dispenses and recommends the products. Sente's leadership team includes co-founders Kleanthis G. Xanthopoulos, Ph.D. (Executive Chairman) and Marios Fotiadis (Board Member), CEO Zubin Meshginpoosh (promoted from President in April 2026), and Chief Scientific Advisor Richard Gallo, M.D.

In April 2026, Sente closed an undisclosed strategic partnership and equity financing aimed at accelerating growth and expanding its HSA and DECO technologies across physician and e-commerce channels, coinciding with the leadership transition at the CEO and Chairman levels. Revenue is not publicly disclosed; the company has raised approximately $17.9M in disclosed equity across multiple rounds from 2009 through 2017, plus the undisclosed 2026 round.

Name

Sente

Legal name

Sente Inc.

Website

https://sentelabs.com

Company type

Private

Founded year

2007

Operating status

Operating

Headcount range

11–50 employees

Short description

Sente is a privately-held medical-grade skincare company that develops and sells cosmeceutical products built around its patented Heparan Sulfate Analog (HSA) technology, distributed through direct-to-consumer e-commerce and a network of over 500 dermatologists across 50+ countries.

Ownership category

akta.pro rank

Product category

Medical-Grade Skincare (Cosmeceuticals)

NAICS

Soap and Cleaning Compound Manufacturing (32561), Health and Personal Care Retailers (456)

SIC

Perfumes, Cosmetics & Other Toilet Preparations (2844)

akta.pro primary industry

Dermocosmetics & Medical-Grade Skincare (CRABAAAF)

akta.pro secondary industries

Treatment Skincare (Serums, Actives, Acne & Anti-aging) (CRABAAAB), Sensitive Skin & Barrier Repair (CRABAAAG), Professional Skincare & Facial Treatments (CRABALAF)

Keywords

• Medical-grade skincare
• Cosmeceutical products
• Heparan sulfate analog
• Topical skincare formulations
• Physician-dispensed skincare

Headquarters

HQ city

Encinitas

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Marketing or Sales, Personnel, Technology or R&D, Operations

Revenue model

1. Direct-to-Consumer E-commerce: Products sold directly to consumers through sentelabs.com, including one-time purchases and subscription orders with complimentary shipping on subscription orders.
2. Physician-Dispensed Sales: Medical-grade skincare products sold through authorized dermatology and aesthetic practices, reaching patients through professional recommendations.
3. Subscription Service: Automated recurring orders with customizable frequency, offering complimentary shipping and complimentary samples on subsequent orders.

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels7 records

Core offering

Sente develops, manufactures, and sells medical-grade topical skincare products built around its patented Heparan Sulfate Analog (HSA) molecule. The portfolio spans moisturizers, serums, cleansers, treatment masks, sunscreens, and body care, and is sold both directly to consumers via the sentelabs.com e-commerce store and through authorized dermatology and aesthetic practices globally.

Product overview

Sente is a medical-grade skincare company offering a unified portfolio of HSA-powered skincare products. The core offering centers on the proprietary Heparan Sulfate Analog (HSA) technology, which is featured across moisturizers (Dermal Repair Cream, Dermal Repair Ultra-Nourish), serums (Defense C Serum, Bio Complete Serum, HydraFirm Serum, Hydrate+ Serum), treatment products (Pigment & Tone Correcting Mask), and sunscreens (Even Tone Mineral Sunscreen). Supporting products include cleansers (Daily Soothing Cleanser, Exfoliating Cleanser), eye care (Illuminé Eye Cream), and body care (Neck Firming Cream, Dermal Repair Body Cream). The company also offers bundled kits and sets (Dark Spot Defense Trio, Skin Balancing Duo, Daily Repair Essentials Starter Kit, Complete Repair System Kit, Anti-Aging, Hyperpigmentation Duo, Even Skin Tone, Smoother Skin, Calming Duo, Nourishing Ceramides, Ultra-Hydration, Redness Focus) for targeted skincare regimens. All products leverage the patented HSA molecule and are designed to work together as a cohesive skincare routine, from cleansers to moisturizers to sunscreens.

Differentiator

Problem solved

Functional benefit

Products and services

• Dermal Repair Cream Lightweight daily moisturizer formulated with HSA technology for sensitive to combination skin; redness repair cream accepted by the National Rosacea Society; $167 (50mL/30mL).
• Dermal Repair Ultra-Nourish Richer, more intensive HSA moisturizer with ceramides designed for dry, sensitive, or compromised skin barriers; suited to overnight use; $182 (50mL).
• Defense C Serum Brightening Vitamin C serum that provides antioxidant protection; $165.
• Pigment & Tone Correcting Mask Hyperpigmentation mask utilizing cysteamine to improve discoloration and uneven skin tone; $149.
• Bio Complete Serum Retinoid serum formulated for sensitive skin that improves fine lines and skin texture; $122 (30mL).
• Even Tone Retinol Cream Pure retinol cream for anti-aging and evening skin tone; $128.
• HydraFirm Serum Firming serum (Dermal Contour Pressed Serum) targeting skin laxity; $198 (30mL).
• Illuminé Eye Cream Brightening eye cream targeting the delicate eye area; $99 (15mL).
• Even Tone Mineral Sunscreen Mineral sunscreen providing broad spectrum UVA/UVB protection with anti-inflammatory and anti-pigmentation properties, in Light Medium SPF 40 and Medium Dark SPF 36 shades; $75.
• Hydrate+ Serum Hydrating hyaluronic acid serum for deep hydration; $89 (30mL).
• Daily Soothing Cleanser Gentle daily cleanser suitable for all skin types; $36 (163mL).
• Exfoliating Cleanser Chemical exfoliating cleanser for skin renewal; $46.
• Neck Firming Cream Repairing neck cream for firming the neck area; $98.
• Dermal Repair Body Cream Firming body cream for overall body skin repair; $110.
• Dark Spot Defense Trio Three-step routine kit to target dark spots at every stage — cleanse, correct, and restore; $352.
• Skin Balancing Duo Essential daily regimen kit for calm, strong, balanced skin; $238.
• Daily Repair Essentials Starter Kit Four-step starter kit with essentials in travel sizes; $66.
• Complete Repair System Kit Four-step comprehensive repair kit; $99.
• Glow & Guard New bundled skincare solution within the kits/sets assortment targeting skin concerns; $254.
• Smooth & Nourish New bundled skincare solution within the kits/sets assortment targeting skin concerns; $304.
• Defend & Repair New bundled skincare solution within the kits/sets assortment targeting skin concerns; $329.
• Subscription Replenishment Program Automated recurring delivery of Sente products with customizable frequency, complimentary shipping, and complimentary samples on subsequent subscription orders; can skip or cancel anytime.
• Authorized Senté Partner Program Channel partnership for dermatologists, plastic surgeons, and medical aesthetic practices to dispense Sente in-practice; partners receive business development guidance, sales training, educational materials, early product access, and ongoing training.

Quantifiable outcome

• Promotes skin hydration within 2 weeks
• +4 more outcomes

Named customers8 records

Segments3 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature2 records

Scale indicators3 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• SkinCeuticals: L'Oréal-owned medical-grade skincare brand centered on antioxidant and corrective serums (CE Ferulic, etc.) sold through physician channels and DTC. Directly comparable to Sente in physician-dispensed positioning, premium pricing, and serum-led portfolio.
• SkinMedica: AbbVie/Allergan-owned medical-grade skincare line featuring growth-factor and retinoid products distributed primarily through dermatology and plastic surgery practices. Closely comparable to Sente in physician-channel go-to-market, anti-aging portfolio, and clinical credibility.
• Alastin Skincare: Galderma-owned physician-dispensed skincare brand focused on procedure-related skin recovery and anti-aging. Comparable to Sente in physician channel, regenerative/biotech positioning, and procedure-adjacent use cases (e.g., post-treatment skin repair).
• EltaMD: Colgate-Palmolive-owned medical-grade skincare brand anchored by mineral sunscreens and sensitive-skin cleansers sold primarily through physicians. Comparable to Sente in dermatologist-recommended positioning, mineral sunscreen category, and emphasis on sensitive-skin tolerance.
• ZO Skin Health: Founded by Dr. Zein Obagi, ZO is a physician-dispensed medical-grade skincare line covering anti-aging, pigmentation, and corrective treatments. Comparable to Sente in physician channel, premium price points, and pigmentation/anti-aging indications.
• iS Clinical: Innovative Skincare's physician-dispensed cosmeceutical line featuring botanical-actives and treatment serums. Comparable to Sente in clinically-positioned cosmeceuticals, physician channel distribution, and serum/cream-led portfolio.
• Obagi Medical: Long-established medical-grade skincare brand owned by Valeant/Bausch Health, sold through dermatologists and med-spas with a portfolio spanning prescription and OTC regimens. Comparable to Sente in physician channel, hyperpigmentation portfolio, and medical-grade credibility.
• PCA Skin: Colgate-Palmolive-owned professional skincare brand focused on chemical peels, treatment serums, and corrective regimens sold through licensed skincare professionals. Comparable to Sente in professional-channel GTM, treatment-serum portfolio, and clinical positioning.
• Neocutis: Bioactive skincare brand leveraging PSP (Processed Skin Cell Proteins) technology, sold through dermatologists and plastic surgeons for post-procedure recovery and anti-aging. Comparable to Sente in biotech-derived proprietary technology, physician channel, and regenerative positioning.
• Colorescience: Mineral-based skincare and sun protection brand sold through dermatologists and aesthetic practices with an emphasis on sensitive-skin tolerance. Comparable to Sente in mineral sunscreen portfolio, sensitive-skin positioning, and physician-dispensed GTM.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat4 records

Key risks6 records

Key highlights6 records

Customer concentration

• Facebookfacebook.com/SENTEskincare
• Instagraminstagram.com/senteskincare
• TikToktiktok.com/@senteskincare
• Xx.com/senteskincare

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds8 records

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Sente