American Oncology Network
- Company typePublic
- Founded2018
- HeadquartersFort Myers, United States
- Headcount501–1,000
- GTM typeB2B
- OfferingServices
American Oncology Network firmographics
Firmographics- Name
- American Oncology Network
- Legal name
- American Oncology Network
- Website
- https://aoncology.com
- Company type
- Public
- Founded year
- 2018
- Operating status
- Operating
- Headcount range
- 501–1,000 employees
- Ownership category
- akta.pro rank
American Oncology Network industry classification
Industry- Product category
- Community Oncology Practice Management Services
- NAICS
- Offices of Physicians (62111), Ambulatory Health Care Services (621), All Other Outpatient Care Centers (621498)
- SIC
- Services-Specialty Outpatient Facilities, Nec (8093), Services-Offices & Clinics Of Doctors Of Medicine (8011), Services-Health Services (8000)
- akta.pro primary industry
- Ambulatory Oncology Centers (Outpatient Chemo/Radiation) (HLAFABAI)
- akta.pro secondary industries
- Medical Oncology (HLAKAFAB), Oncology Remote Symptom Monitoring & Care Navigation (HLALAFAD), Oncology Pathways & Precision Medicine Decision Support (HLACAGAH)
Keywords
Where American Oncology Network is headquartered
LocationHeadquarters
- HQ city
- Fort Myers
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
American Oncology Network business model
Business model- GTM type
- B2B
- Offering type
- Services
- Cost components
- Personnel, Operations, Supply Chain, Technology or R&D, Infrastructure, Marketing or Sales
Revenue model
- Practice Partnership and Management Services: AON generates revenue by partnering with independent community oncology practices, providing administrative ease, practice growth support, technology solutions, and centralized services including pathology, specialty pharmacy, and clinical trial access. Partner practices benefit from better financial outcomes while maintaining physician autonomy.
- Specialty Pharmacy Services: AON operates an in-house specialty pharmacy that provides oral oncolytic pharmacy services to partner practices and patients, generating revenue through prescription fulfillment and pharmacy operations.
- Value-Based Care Contracts: AON participates in CMS's Enhancing Oncology Model (EOM) and other value-based care arrangements, generating revenue through quality-focused interventions and performance-based incentives.
- Clinical Research and Trials: AON generates revenue through clinical trial partnerships with organizations like Sarah Cannon Research Institute, Trial Library, and MiBA, providing access to cutting-edge research for partner practices.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Other | Multi-year contract | Practice partnership model - custom pricing based on practice size and services |
Go-to-market motion2 records
Distribution channels4 records
Marketing channels5 records
American Oncology Network product offering
Product offeringCore offering
American Oncology Network operates as a national network of community oncology practices, providing partner practices with centralized practice management services, in-house specialty pharmacy, pathology and laboratory diagnostics, radiation and radiology services (including radioligand therapies), value-based care program participation, care coordination, behavioral health, and clinical research access. AON enables independent oncology practices to maintain physician autonomy while accessing advanced therapies (CAR T-cell, Bispecific T-cell Engager, radioligand therapies), clinical trials, and operational infrastructure typically only available at larger healthcare systems.
Product overview
American Oncology Network (AON) operates as a national network of community-based oncology practices, functioning as a platform-plus-services model. The core offering is the Practice Success Platform providing administrative ease, patient-centric care, and practice growth resources. This platform is enhanced by integrated service modules including Specialty Pharmacy, Pathology Services (with AI-enhanced karyogram segmentation via CAP-accredited Central Lab), Radiation and Radiology Services (including PET/CT and radioligand therapies), Value-Based Care programs (participating in CMS's Enhancing Oncology Model), and Care Coordination. AON has expanded into advanced immunotherapies including Bispecific T-cell Engager (BiTE) therapies at 40+ clinics and outpatient CAR T-cell therapy programs. The network also integrates behavioral health support through Colla Health partnerships and emotional peer support via CanCare. Research capabilities are powered through American Oncology Research with partnerships enabling AI-driven clinical trial matching (Trial Library), real-time data intelligence (MiBA), and traditional research collaborations (Sarah Cannon Research Institute). The network spans 21 states with over 350 providers and $2B in annual revenue.
Differentiator
Problem solved
Functional benefit
Products and services
- Practice Success Platform Comprehensive partnership platform supporting community oncology practices with patient-centric care, administrative ease, practice growth, value-based care participation (CMS Enhancing Oncology Model), and operational resources.
- Specialty Pharmacy Services
- Pathology Services
- Radiation and Radiology Services
- Value-Based Care Program
- Care Coordination
- CanCare Peer Support Program Partnership with CanCare providing free emotional peer support connecting cancer patients with trained volunteer survivors and caregivers matched by diagnosis or experience, delivered via phone, email, text, or in person.
- Colla Health Behavioral Health Services Partnership with Colla Health providing personalized behavioral health support through telehealth and phone services, including therapeutic interventions and psychiatric oversight for cancer patients.
- Clinical Research (American Oncology Research)
- Bispecific T-cell Engager (BiTE) Therapies Administration of bispecific antibody therapies in outpatient community oncology settings across 40+ clinics, with standardized protocols, staff training, and patient education materials for at-home monitoring.
- Outpatient CAR T-cell Therapy Program FDA-approved CAR T-cell therapy administration in outpatient community oncology settings, enabling advanced immunotherapy access closer to patients' homes; The Center for Cancer and Blood Disorders became one of the first community oncology practices in the U.S. to offer CAR T-cell therapy outside a hospital setting.
- Radioligand Therapies Advanced radiopharmaceutical treatments including Pluvicto (metastatic prostate cancer), Lutathera (neuroendocrine tumors), and Xofigo (bone metastases), offering targeted radiation delivery. Over 300 treatments delivered to nearly 70 patients across six partner practices.
Quantifiable outcome
- AON posted $2B annual revenue with 40% growth in 2025
- +3 more outcomes
Companies that use American Oncology Network
Customer profileNamed customers6 records
Segments2 records
Ideal customer profiles1 record
American Oncology Network technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration7 records
AI capability7 records
Feature4 records
American Oncology Network partnerships and signals
Strategic signalPartnerships
Eleven partnerships are on record, tiered core, flagship and minor.
- CanCare, Inc.corePartnership to provide whole-person cancer care combining advanced medical treatment with emotional peer support from trained cancer survivors and caregivers. CanCare volunteers are matched with patients based on diagnosis or life experience and provide support by phone, email, text, or in person. The partnership builds on successful pilot programs at four AON partner practices and will expand nationwide.
- Colla HealthcorePartnership to expand behavioral health services for cancer patients in community oncology settings. The collaboration addresses emotional and psychological challenges accompanying cancer diagnosis, treatment, and survivorship through telehealth and phone-based services. Launches with two AON partner practices and expands to all practices nationwide by end of 2026.
- The Ohio State University Comprehensive Cancer Center – James Cancer HospitalflagshipZangmeister Cancer Center became an affiliate of The Ohio State University Comprehensive Cancer Center through The James Cancer Network. The affiliation increases clinical trial availability and access to advanced therapies including CAR T-cell therapy and proton therapy for central Ohio patients.
- MiBA (Meaningful Insights Biotech Analytics)coreStrategic alliance to integrate AI-enhanced data intelligence into community oncology clinical research. The alliance embeds real-time data workflows to reduce timelines between site selection and patient enrollment while improving trial accessibility and helping meet Diversity Action Plan requirements through data-driven inclusive enrollment strategies.
- Evolent HealthcoreInnovative partnership model to improve cancer care while eliminating prior authorization burden. The collaboration introduces quality-focused interventions, drives clinical insights through data and analytics platform, and rewards providers for high-quality care.
- Thyme CarecoreCollaboration developing data-driven, patient-centered, value-based oncology care. Presented nine research abstracts at ASCO Quality 2025 focusing on improving care models, policy implications, patient outcomes, and health equity based on real-world data from AON's clinical network.
- Trial LibrarycorePartnership to expand patient access to cancer clinical trials as a care option. Trial Library uses AI-enabled platform for clinical trial matching and patient navigation. The partnership integrates clinical research into standard care delivery across AON's network of 320+ clinics and 1,500+ providers.
- Vantage Health TechnologiescorePartnership to improve cancer patient outcomes with AI-enabled value-based care platform. Collaboration focuses on enhancing cancer care delivery through data-driven insights and value-based care optimization.
- Sarah Cannon Research InstitutecoreCancer research collaboration expanding patient access to community-based clinical trials. AON and Sarah Cannon offer clinical trial options to patients across several locations within AON's network, with strategic research sites including Hematology Oncology Clinic and Messino Cancer Centers.
- Dignitana ABminorMaster contract for THOR light therapy scalp cooling technology. The Center for Cancer and Blood Disorders became the first medical oncology network in the United States to offer THOR light therapy.
- AmerisourceBergencoreContinuing strategic relationship with global healthcare solutions leader AmerisourceBergen for pharmaceutical distribution and supply chain services.
Scale indicators8 records
Recent moves8 records
Expansion highlights6 records
American Oncology Network competitors and assessment
Company assessmentDirect peers
- OneOncology: Private equity-backed national network of independent community oncology practices, founded by former US Oncology executives. Direct competitor to AON in aggregating independent oncology practices and providing practice management, pharmacy, and value-based care services.
- The US Oncology Network: Subsidiary of McKesson; one of the largest community oncology networks in the US, providing practice management, technology, and clinical research support to independent oncology practices. AON's primary direct competitor and a target competitor for practice affiliation.
- Florida Cancer Specialists & Research Institute: Large independent community oncology and hematology practice in Florida with significant clinical research operations. Comparable as a high-volume community oncology provider offering advanced therapies and clinical trials outside academic centers.
- Texas Oncology: One of the largest community-based oncology practices in the US, affiliated with US Oncology Network. Operates a multi-state network of community oncology clinics with advanced therapy offerings comparable to AON's footprint.
- Tennessee Oncology / Astera Cancer Care: Large independent community oncology practice serving Tennessee and surrounding states, including OneOncology-affiliated sites. Comparable to AON in scale, advanced therapy delivery, and clinical research integration in community settings.
Broad incumbents
- Sarah Cannon Research Institute: Cancer research institute within HCA Healthcare that partners with community oncology networks (including AON) for clinical trial delivery. Adjacent rather than direct competitor, but a critical ecosystem player for community-based oncology research.
- McKesson: Parent of The US Oncology Network and a major pharmaceutical distributor (including AmerisourceBergen, an AON partner). As the incumbent aggregator in community oncology, McKesson is both a competitor (via US Oncology) and a strategic partner/distributor to AON.
- City of Hope: Major NCI-designated academic cancer center expanding community oncology affiliations (including acquisitions of community oncology groups in California). Represents the incumbent academic-system expansion that competes with AON for advanced therapy referrals and physician talent.
Emerging players
- Thyme Care: Value-based cancer care enabler partnering with AON and community oncology networks to deliver oncology navigation, care management, and risk-bearing arrangements with payers. Comparable in the value-based oncology services layer where AON is positioning.
- Pearl Health: Emerging risk-bearing primary and specialty care enablement company expanding into oncology value-based arrangements. Represents the broader shift toward risk-bearing care models that affect AON's specialty positioning.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat6 records
Key risks6 records
Key highlights7 records
Customer concentration
American Oncology Network social profiles
Digital presenceAmerican Oncology Network compliance and trust
Trust signalCompliance4 records
American Oncology Network financial estimates
Financial estimateRevenue estimate
Valuation estimate
American Oncology Network leadership team
Management profileNumber of profiles
Profiles14 records
American Oncology Network subsidiaries and ownership
Company hierarchySubsidiaries2 records
American Oncology Network funding detail
Funding detailFunding overview
Funding rounds
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
American Oncology Network M&A and investment
M&A and investmentM&A1 record
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about American Oncology Network
What does American Oncology Network do?
American Oncology Network operates as a national network of community oncology practices, providing partner practices with centralized practice management services, in-house specialty pharmacy, pathology and laboratory diagnostics, radiation and radiology services (including radioligand therapies), value-based care program participation, care coordination, behavioral health, and clinical research access. AON enables independent oncology practices to maintain physician autonomy while accessing advanced therapies (CAR T-cell, Bispecific T-cell Engager, radioligand therapies), clinical trials, and operational infrastructure typically only available at larger healthcare systems.
Is American Oncology Network a public or private company?
American Oncology Network is a public company. It is classified as public and is currently operating.
When was American Oncology Network founded?
American Oncology Network was founded in 2018. It employs 501 to 1,000 people.
Where is American Oncology Network based?
American Oncology Network is headquartered in Fort Myers, United States, in the North America region.
How does American Oncology Network make money?
Four revenue lines are on record. Practice Partnership and Management Services are the primary driver. The others are specialty Pharmacy Services, value-Based Care Contracts and clinical Research and Trials.
Who are American Oncology Network's main competitors?
Direct peers on record are OneOncology, The US Oncology Network, Florida Cancer Specialists & Research Institute, Texas Oncology and Tennessee Oncology / Astera Cancer Care. Broad incumbents are Sarah Cannon Research Institute, McKesson and City of Hope. Emerging players are Thyme Care and Pearl Health.
Does American Oncology Network have an API?
No public API is recorded for American Oncology Network.
What industry is American Oncology Network in?
American Oncology Network's product category is Community Oncology Practice Management Services. Its primary akta.pro industry code is HLAFABAI, Ambulatory Oncology Centers (Outpatient Chemo/Radiation), with a secondary code of HLAKAFAB, Medical Oncology. Its NAICS code is 62111 and its SIC code is 8093.