Health Technology Innovations

What Health Technology Innovations does

Health Technology Innovations, Inc. (HTI) is a Portland, Oregon-based company founded in 2017 by former Intel engineers that develops AI/ML-powered cryo-electron microscopy (cryo-EM) automation for structure-based drug discovery. The company's core software products are CryoFAST™, an AI Data Automation Software for cryo-EM sample screening and data collection that reduces scientist screening time from six hours to five minutes and delivers 4X throughput via multi-shot imaging, and CryoDiscovery™, a machine learning platform that automates 2D and 3D class selection in the cryo-EM image processing workflow. Both products are patent-pending and integrate directly with cryo-EM instruments and acquisition software from Gatan, JEOL, Thermo Fisher Scientific, SerialEM, EPU, and Latitude. Underlying machine learning uses deep learning models trained on proprietary and public cryo-EM datasets.

HTI operates a two-stream revenue model. The first stream is professional services: full-service cryo-EM structure determination engagements for pharma and biotech clients, spanning protein production and analysis, sample optimization, AI/ML grid processing, optimized data collection, AI/ML-based 2D/3D class selection, 3D atomic structure determination, and training and project consultation, delivered by an enterprise field sales team with assigned customer project managers. The second stream is software licensing of CryoFAST, available with a 30-day complimentary evaluation license. Distribution combines direct enterprise sales, scientific conference presence (Microscopy & Microanalysis, American Crystallographic Association), and a verified provider listing on the Science Exchange marketplace. Named enterprise customers include ADRXpharma, Flare Therapeutics, Ideaya Biosciences, Nimbus Therapeutics, ADRx, BASF, and PATH.

The company has been funded primarily through non-dilutive grants, totaling approximately $1.1M across NSF SBIR Phase I (~$225K, 2020), NSF SBIR Phase II ($1M, 2022), and multiple Oregon Innovation Council awards. Capital is complemented by deep strategic relationships with OHSU's Pacific Northwest Cryo-EM Center, the Beckman Cryo-EM Center at University of Washington, NVIDIA Inception, Intel AI Builders, and a 2024 collaboration with KanPro Research for protein production integration.

Name

Health Technology Innovations

Legal name

Health Technology Innovations, Inc.

Website

https://hti.ai

Company type

Private

Founded year

2017

Operating status

Operating

Headcount range

1–10 employees

Short description

Health Technology Innovations (HTI) builds AI/ML software (CryoFAST, CryoDiscovery) and provides cryo-electron microscopy services that automate structure-based drug discovery for pharmaceutical and biotechnology clients.

Ownership category

akta.pro rank

Product category

Cryo-EM Software & Drug Discovery Services

NAICS

Research and Development in Biotechnology (except Nanobiotechnology) (541714), Scientific Research and Development Services (5417), Analytical Laboratory Instrument Manufacturing (334516)

SIC

Services-Commercial Physical & Biological Research (8731), Laboratory Analytical Instruments (3826)

akta.pro industry

PRIMARYHLAAAIAH

Protein Interaction & Structural Biology Platforms (cryo-EM, X-ray, NMR, biophysics)

Healthcare & Life Sciences/Biotechnology & Biologics/Biologic Drug Discovery Platforms (screening, antibody engineering, synthetic biology)

Keywords

• Cryo-EM software
• AI drug discovery
• Structural biology services
• Protein structure determination
• Machine learning imaging

Headquarters

HQ city

Portland

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Cryo-EM Structure Determination Services: Full-service cryo-EM services from protein purification to structure determination including: Custom Protein Production & Analysis, Cryo-EM Sample Optimization, Qualitative Sample Check, Real-time AI/ML Grid Processing, Optimized Data Collection, AI/ML based 2D/3D Class Selection, 3D Atomic Structure Determination, Training & Project Consultation.
2. CryoFAST AI Software Licensing: CryoFAST AI Data Automation Software available with 30-day complimentary evaluation license for labs interested in trialing the solution.

Pricing tiers

Go-to-market motion3 records

Distribution channels2 records

Marketing channels6 records

Core offering

Health Technology Innovations develops and licenses proprietary AI/ML software (CryoFAST and CryoDiscovery) that automates cryo-electron microscopy (cryo-EM) sample screening and image processing, and delivers full-service cryo-EM structure determination for pharmaceutical and biotechnology drug discovery programs. The offerings span custom protein production, sample optimization, AI/ML-based 2D/3D class selection, and 3D atomic structure determination, accessed via direct enterprise engagement or the Science Exchange marketplace.

Product overview

Health Technology Innovations offers a unified platform combining proprietary AI/ML software products with cryo-EM structure determination services. The core software portfolio includes CryoFAST™ (AI-driven automation for sample screening and data collection) and CryoDiscovery™ (machine learning software for automated 2D/3D class selection in image processing). Both products are integrated into HTI's cryo-EM service offerings, enabling structure-based drug discovery through a network of image acquisition sites with high-end cryo-EM instruments including Krios and Glacios microscopes. Services range from protein purification through 3D atomic structure determination, with deep cryo-EM expertise and AI/ML automation to accelerate workflows for pharma and biotech clients.

Differentiator

Problem solved

Functional benefit

Brands

• CryoDiscovery: AI/ML-based software platform for automated cryo-EM image processing, 2D and 3D class selection for structure-based drug discovery.
• CryoFAST

Products and services

• CryoFAST AI Data Automation Software for cryo-electron microscopy that automates sample screening and data collection through deep learning models. Reduces sample screening time from 6 hours to 5 minutes, supports automated grid swapping for up to twelve grids in a single run, and delivers 4X data throughput via multi-shot imaging. Designed for cryo-EM labs running structure-based drug discovery on instruments from Gatan, JEOL, and Thermo Fisher Scientific.
• CryoDiscovery Proprietary machine learning software that automates 2D and 3D class selection in single particle cryo-EM image processing. Uses ML models trained on proprietary and public datasets to recognize and classify particles with repeatable accuracy, integrates with popular open source and commercial image processing packages, and reduces new-user training time. Designed for cryo-EM researchers needing to accelerate image processing pipelines.
• Cryo-EM Structure Determination Services Full-service cryo-EM structure determination services for pharmaceutical and biotechnology drug discovery programs, spanning custom protein production and analysis, cryo-EM sample optimization, qualitative sample check, real-time AI/ML grid processing, optimized data collection, AI/ML-based 2D/3D class selection, 3D atomic structure determination, and training and project consultation. Delivered through a network of image acquisition sites equipped with high-end cryo-EM instruments.

Quantifiable outcome

• Reduces sample screening time from 6 hours to 5 minutes
• +4 more outcomes

Named customers7 records

Segments2 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration6 records

AI capability5 records

Feature3 records

Partnerships

Twelve partnerships are on record, tiered core and minor.

• KanPro Research, Inc.coreStrategic or Co-development Partner · 29 July 2024Deep collaboration to integrate KanPro protein production and analysis into HTI Cryo-EM service delivery. Provides new levels of efficiency for protein production, analysis and cryo-EM services. KanPro, a protein production CRO headquartered at Kansas University Innovation Park, delivers optimized protein samples for cryo-EM structure determination with time and cost savings.
• Oregon Health & Science University (OHSU)coreStrategic or Co-development PartnerPartnership with OHSU's Pacific Northwest Cryo-EM Center (PNCC), one of three national cryo-EM centers funded by NIH. Dr. Craig Yoshioka serves as Co-Director of PNCC and Senior Advisor to HTI. Collaboration on cryo-EM research and development.
• Kollman Lab, University of WashingtoncoreStrategic or Co-development PartnerDr. Justin M. Kollman serves as Chair of HTI's Science & Technology Advisory Board. Dr. Kollman is Director at Arnold and Mabel Beckman Cryo-EM Center at University of Washington with deep expertise in cryo-EM structural biology.
• NVIDIAcoreTechnology or IntegrationHTI is a member of NVIDIA's Inception accelerator program for AI startups, providing access to GPU technology and resources for cryo-EM AI/ML development.
• IntelcoreTechnology or IntegrationHTI is a member of Intel's AI Builders program. Former Intel engineers founded HTI bringing deep technology industry experience.
• Pacific Northwest Cryo-EM Center (PNCC)coreStrategic or Co-development PartnerNIH-funded national cryo-EM center jointly operated by OHSU. Dr. Craig Yoshioka serves as Co-Director. Research supported by NIH grant U24GM129547 performed at PNCC.
• Kansas UniversityminorStrategic or Co-development PartnerPartnership for protein production collaboration through KanPro Research located at KU Innovation Park on University of Kansas west campus.
• GatancoreTechnology or IntegrationCryoFAST software integrates with Gatan cryo-EM solutions. Collaboration to harden the solution for broad deployment in labs.
• JEOLcoreTechnology or IntegrationCryoFAST integrated into JEOL CryoARM solution. Dr. Jacob Brink, TEM Product Manager at JEOL, provided endorsement for the collaboration.
• Thermo Fisher ScientificcoreTechnology or IntegrationCryoFAST integrates with Thermo Fisher Scientific cryo-EM solutions. Collaboration with industry leaders including Thermo Fisher Scientific hardened the solution.
• National Science FoundationcoreOthersNSF awarded Phase I STTR and Phase II SBIR grants totaling $1M+ for CryoDiscovery cryo-EM automation platform development. Primary research partner Dr. Craig Yoshioka of OHSU/PNCC.
• Oregon Innovation CouncilcoreOthersMultiple innovation and matching grant awards including Enhanced Phase 0 Program Award (2019), Enhanced Innovation Award (2020), and SBIR Phase I Matching Grant Award (2020) totaling $65,600+ to develop, test and commercialize CryoDiscovery AI platform.

Scale indicators7 records

Recent moves6 records

Expansion highlights7 records

Broad incumbents

• Gatan (AMETEK): Gatan (owned by AMETEK) supplies cryo-EM detectors and DigitalMicrograph / EPU acquisition software, and is one of HTI's named integration partners. Comparable as a broad incumbent with overlapping capabilities in cryo-EM software and a much larger portfolio and installed base.
• JEOL: JEOL manufactures cryo-EM instruments including the CryoARM series with its own control software stack. Comparable as a broad cryo-EM instrument incumbent and a named HTI integration partner; could ship native AI automation features.
• Schrödinger: Schrödinger is a leading computational chemistry and structure-based drug discovery platform serving pharma/biotech. Comparable as a broad computational drug-discovery incumbent that also invests heavily in cryo-EM integration; HTI's advisor Dr. Leah Frye is a former Schrödinger VP.
• Crelux (WuXi AppTec): Crelux, part of WuXi AppTec, offers protein production, crystallization and structure determination services to pharma — adjacent to HTI's services but with a much broader CRO portfolio and global footprint.
• Thermo Fisher Scientific: Thermo Fisher Scientific manufactures the dominant Krios and Glacios cryo-EM microscopes and bundles EPU acquisition software. As a cryo-EM instrument incumbent, it has the leverage to ship competing AI automation in EPU and is a named HTI integration partner.

Emerging players

• Refeyn: Refeyn develops mass photometry instruments for characterizing biomolecules, with overlap into single-molecule and structural biology workflows. Comparable as an emerging adjacent player in bioanalytical instrumentation, and employs HTI advisor Dr. Gabriella Kiss.
• Atomwise: Atomwise applies AI/ML to small-molecule drug discovery, partnering with major pharma. Comparable as an emerging AI-for-drug-discovery company addressing the same customer base as HTI but on the small-molecule side rather than cryo-EM structural biology.

Direct peers

• Structura Biotechnology (CryoSPARC): Structura Biotechnology develops CryoSPARC, the dominant commercial cryo-EM image processing software used by most pharma and academic cryo-EM labs. Most directly comparable to HTI's CryoDiscovery product, competing head-to-head for 2D/3D class selection and reconstruction workflows.
• Creative Biostructure: Creative Biostructure provides cryo-EM services for protein structure determination including single particle analysis — directly comparable to HTI's cryo-EM services for pharma and biotech customers.
• NanoImaging Services: NanoImaging Services is a CRO providing cryo-EM sample preparation, imaging, and structure determination services to pharma and biotech — directly overlapping with HTI's Cryo-EM Structure Determination Services offering for drug discovery clients.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• Facebookfacebook.com/HealthTechnologyInnovations
• LinkedInlinkedin.com/company/health-technology-innovations

Revenue estimate

Valuation estimate

Number of profiles

Profiles12 records

Funding overview

Funding rounds2 records

Investors1 record

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M&A

Investments

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Frequently asked questions about Health Technology Innovations