What 111Skin does

111SKIN is a London-headquartered luxury clinical skincare company founded in 2012 by Dr. Yannis Alexandrides, a practicing plastic and reconstructive surgeon, and co-founded with Eva Alexandrides. The company's products are built around its proprietary NAC Y²™ complex — a formulation of Vitamin C, Escin, and N-acetylcysteine designed to stimulate glutathione production for skin repair, rejuvenation, and defense against environmental stressors — alongside more recent Exosome technology (derived from Lactobacillus Ferment) and microspicule technology (from hydrolysed freshwater sponge). The portfolio spans 30+ SKUs across Repair, Black Diamond, Cryo, Radiance, and Exosome sub-brands, priced from approximately $50 for entry-level masks to roughly $1,000 for premium Black Diamond products and treatment sets.

The brand operates a hybrid distribution model in which roughly 80% of revenue flows through selective wholesale channels — including Harrods, Nordstrom, Bluemercury, Mandarin Oriental spas, and Four Seasons Hotel Philadelphia — and the remaining ~20% through the brand's own 111skin.com e-commerce platform, which includes a Subscribe & Save subscription tier offering 20% recurring discounts and a V1P loyalty program. Customer mix is anchored to affluent skincare consumers and post-procedure patients, with celebrity-driven earned media (Jessica Alba, Jennifer Aniston, Anne Hathaway, Margot Robbie, Priyanka Chopra) and editorial placement in Vogue, Harper's Bazaar, Forbes, and Elle reinforcing premium positioning.

The company is privately held and has raised successive minority investments from SKKY Partners (January 2025) and The Estée Lauder Companies (April 2026), with Dr. Alexandrides continuing as CEO alongside an expanded management team that includes a COO and an EVP of Strategy & Asia Pacific. Industry sources place annual revenue in the $40–50M range with ~40% of sales in North America, and the brand is actively extending into spa/clinic operations (111CRYO, 111SKIN SPA/CLINIC at The Plaza, treatments at Ritz Carlton Grand Cayman) to support both product demonstration and an emerging services revenue layer.

Name

111Skin

Legal name

111SKIN Ltd

Website

https://111skin.com

Company type

Private

Founded year

2012

Operating status

Operating

Headcount range

101–250 employees

Short description

111SKIN is a London-based luxury clinical skincare brand founded in 2012 by plastic surgeon Dr. Yannis Alexandrides, selling NAC Y2™ complex-based anti-aging products from $50 to $1,000 across 30+ SKUs through luxury retailers (Harrods, Nordstrom, Bluemercury), branded e-commerce, and high-end hotel spas, serving affluent skincare consumers and post-procedure patients worldwide.

Ownership category

akta.pro rank

Product category

Luxury Clinical Skincare

NAICS

Cosmetics, Beauty Supplies, and Perfume Retailers (456120), Health and Personal Care Retailers (4561)

SIC

Perfumes, Cosmetics & Other Toilet Preparations (2844)

akta.pro primary industry

Dermocosmetics & Medical-Grade Skincare (CRABAAAF)

akta.pro secondary industries

Treatment Skincare (Serums, Actives, Acne & Anti-aging) (CRABAAAB), Professional Skincare & Facial Treatments (CRABALAF)

Keywords

• Luxury clinical skincare
• Anti-aging skincare
• Facial treatment masks
• Skincare serums creams
• Premium skincare brand

Headquarters

HQ city

London

HQ country

United Kingdom

HQ region

Europe

Offices1 record

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Marketing or Sales, Personnel, Operations, Technology or R&D

Revenue model

1. Direct-to-Consumer Product Sales: 111Skin sells its skincare products directly to consumers through its e-commerce platform (111skin.com), offering both one-time purchases and a subscription model (Subscribe & Save 20%). Direct-to-consumer comprises approximately 20% of total sales.
2. Wholesale/Retail Distribution: Products are sold through luxury retail partners including Harrods, Nordstrom, and Bluemercury, as well as high-end spa channels such as Mandarin Oriental. This channel represents approximately 80% of total sales.

Pricing tiers

Go-to-market motion1 record

Distribution channels7 records

Marketing channels7 records

Core offering

111Skin develops and sells luxury clinical-grade skincare products, including serums, creams, eye treatments, and facial masks, formulated with proprietary NAC Y²™ technology (a combination of Vitamin C, Escin, and NAC) originally developed by plastic surgeon Dr. Yannis Alexandrides to accelerate post-surgical healing and now marketed for anti-aging, skin repair, and rejuvenation. The portfolio spans the NAC Y²™ Repair line, Black Diamond luxury collection, Cryo energising range, and treatment products, sold to affluent individual consumers globally.

Product overview

111SKIN is a luxury clinical skincare brand founded in 2012 by plastic surgeon Dr. Yannis Alexandrides, built on its proprietary NAC Y²™ technology (Vitamin C, Escin, and NAC complex) designed to promote glutathione production and skin repair. The product portfolio spans multiple collections: the core Reparative line featuring Repair Serum NAC Y²™, Repair Day/Night Creams, and Eye Lift Gel; the premium Black Diamond collection offering serums, creams, eye treatments, and boosters for advanced anti-aging; the Cryo line with cooling masks and moisturisers; the Radiance collection with brightening treatments; the Exosome line featuring cutting-edge exosome and microspicule technology; and specialty treatments including masks, boosters, cleansers, and body care. The brand operates spa/clinic locations including 111CRYO and the 111SKIN SPA/CLINIC at The Plaza, offering exclusive treatments like the Exosome Regeneration Facial. Products are distributed through luxury retailers (Harrods, Nordstrom, Bluemercury), direct-to-consumer e-commerce, and high-end spa channels. North America represents approximately 40% of sales, with additional presence in China, UK, Europe, and Asia-Pacific.

Differentiator

Problem solved

Functional benefit

Brands

• 111CRYO: Cryotherapy and thermotherapy treatment services
• 111SKIN SPA/CLINIC
• NAC Y²™
• Black Diamond
• Repair
• Cryo
• Radiance
• Exosome

Products and services

• Repair Serum NAC Y²™
• Repair Day Cream NAC Y²™ A daily moisturising cream featuring the NAC Y²™ complex to hydrate, smooth fine lines, and protect skin throughout the day.
• Repair Night Cream NAC Y²™ An overnight recovery cream formulated with NAC Y²™ complex to support skin regeneration and minimise visible signs of aging during sleep.
• Repair Day Cream Light NAC Y²™ A lighter version of the Repair Day Cream offering the same NAC Y²™ benefits in a fluid texture suited to combination or warmer-climate skin.
• Eye Lift Gel NAC Y²™ A targeted eye gel powered by NAC Y²™ to lift, brighten, and reduce the appearance of fine lines and dark circles in the eye area.
• Black Diamond Cream A luxury anti-aging cream in the Black Diamond range that combines diamond powder with peptides to firm, lift, and rejuvenate mature skin.
• Black Diamond Serum A concentrated serum in the Black Diamond collection that uses diamond powder and peptides to address visible signs of advanced aging.
• Black Diamond Eye Cream A rich eye cream in the Black Diamond collection that targets fine lines, dark circles, and loss of firmness around the eye area.
• Celestial Black Diamond Body Cream A luxury body cream from the Black Diamond range designed to firm, smooth, and hydrate the skin on the body.
• Celestial Black Diamond Eye Mask An under-eye treatment mask from the Black Diamond collection that uses diamond powder and actives to firm and brighten the eye area.
• Black Diamond Vitamin C Brightening Booster A Vitamin C booster serum in the Black Diamond range designed to brighten dull skin and even out skin tone.
• Cryo De-Puffing Eye Mask A cooling under-eye mask in the Cryo range designed to de-puff, refresh, and energise tired eyes.
• Cryo Revitalising Moisturiser A daily moisturiser in the Cryo range that uses cooling actives to revitalise, hydrate, and energise the skin.
• Rose Gold Brightening Facial Treatment Mask A brightening facial sheet mask infused with rose gold and actives to even skin tone and impart immediate radiance.
• Hyaluronic Acid Aqua Booster Serum A multi-weight hyaluronic acid serum designed to deliver deep, multi-layer hydration and plump the skin.
• Wrinkle Erasing Retinol Patches Targeted micro-needling patches infused with retinol and hyaluronic acid to reduce the appearance of expression lines and wrinkles.
• Y Theorem Bio Cellulose Facial Mask A bio-cellulose facial mask in the Repair line designed to lock in active ingredients and deliver intensive hydration.
• Sunscreen SPF50 A broad-spectrum SPF50 sunscreen formulated for daily use to protect skin from UVA and UVB damage.
• Dark Spot Correcting Serum A corrective serum formulated to fade hyperpigmentation, dark spots, and post-acne marks for a more even complexion.
• Cleansing Oil A lightweight cleansing oil that dissolves makeup, SPF, and impurities while leaving skin soft and hydrated.
• Anti Blemish Booster A targeted booster serum formulated with clarifying actives to reduce blemishes and prevent new breakouts.
• All Day Radiance Mist A refreshing facial mist that hydrates and boosts radiance for use over makeup throughout the day.
• Exosome Face Lift Treatment Set A two-step at-home treatment set that combines exosome technology with microneedling patches to deliver a 'facelift' effect on the skin.
• Repair & Renew Routine A curated multi-product routine bundle featuring the brand's hero NAC Y²™ Repair products for a complete skin repair and renewal regimen.
• Essential Repair Duo A two-product bundle from the Repair line pairing key NAC Y²™ items for an entry-level skin repair regimen.
• Space Defence Bright Eye Lift Gel NAC Y²™ A brightening and lifting eye gel from the Space Defence sub-line of the Repair collection.
• 111SKIN Exosome Regeneration Facial An in-spa professional facial treatment offered at 111Skin spa and clinic locations that uses the brand's exosome technology to regenerate and rejuvenate the skin.
• 111CRYO Cryotherapy & Thermotherapy Professional in-clinic cryotherapy and thermotherapy treatments that combine cold and hot modalities to stimulate skin rejuvenation, offered at 111Skin spa and clinic locations.
• 111SKIN SPA/CLINIC at The Plaza (Harvey Nichols, Dubai) Physical luxury spa and clinic at The Plaza, Harvey Nichols Dubai that delivers 111Skin's signature facial treatments, exosome regeneration facials, and cryotherapy services to affluent consumers.

Quantifiable outcome

• Repair Serum clinically proven to restore healthy skin in 2 weeks
• +6 more outcomes

Named customers6 records

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

Two partnerships are on record, tiered core and minor.

• 111 Harley Street CliniccoreStrategic or Co-development PartnerDr. Yannis Alexandrides' 111 Harley Street Clinic is the origin of 111Skin, where the brand was originally developed to accelerate patients' healing time following surgical procedures. This clinic serves as the brand's R&D foundation and ongoing innovation source.
• Four Seasons Hotel PhiladelphiaminorStrategic or Co-development PartnerFour Seasons Hotel Philadelphia launched 111SKIN clinically-inspired skincare products at its spa for facial treatments and retail. This partnership provides luxury service environments for product demonstration and premium customer access.

Scale indicators6 records

Recent moves5 records

Expansion highlights5 records

Direct peers

• ZO Skin Health: Dr. Zein Obagi-founded clinical skincare brand focused on physician-dispensed corrective and anti-aging protocols. Comparable surgeon-founder heritage and clinical efficacy positioning, with a similar bridge between in-clinic procedures and at-home regimens.
• iS Clinical: Physician-dispensed clinical skincare brand with botanical-pharmaceutical formulations and strong spa/medical-spa channel presence. Comparable clinical efficacy narrative and distribution across luxury spa and medical aesthetics channels.
• SkinMedica: Allergan/AbbVie-owned clinical skincare brand with TNS growth factor technology and a strong post-procedure / anti-aging positioning. Comparable as a physician-backed line bridging aesthetic procedures and daily skincare routines.
• Alastin Skincare: Procedure-focused clinical skincare brand (acquired by Galderma) specializing in post-procedure skin recovery and TriHex Technology®. Directly comparable to 111Skin's clinic-to-home positioning and surgeon-channel distribution model.
• Augustinus Bader: Luxury clinical skincare brand co-founded by a biomedical scientist (Professor Augustinus Bader) with proprietary TFC8® technology and a similar surgeon/scientist-led clinical narrative. Competes head-to-head in the prestige anti-aging segment with comparable price points and selective luxury retail distribution.
• Dr. Barbara Sturm: Surgeon-founded luxury skincare brand built around proprietary 'Vampire Facial' / plasma-based aesthetics heritage. Closely mirrors 111Skin's positioning at the intersection of medical aesthetics and prestige beauty, with comparable price ladder and celebrity-driven marketing.
• SkinCeuticals: Physician-dispensed clinical skincare brand (L'Oréal-owned) anchored in antioxidant and post-procedure science. Directly comparable as a clinical/dermatologist-grade skincare line positioned adjacent to aesthetic procedures with similar efficacy-claim-driven messaging.

Broad incumbents

• La Mer: Iconic ultra-luxury skincare brand (Estée Lauder-owned) with Miracle Broth™ proprietary technology. Competes with 111Skin at the top of the prestige skincare price ladder but as part of ELC's broader portfolio rather than a focused clinical-skincare specialist.
• Drunk Elephant: Biocompatible clinical-skincare brand (Shiseido-owned) with a strong clean-clinical positioning. Comparable efficacy-led marketing but distributed more through specialty beauty (Sephora) than the luxury department-store/spa channel 111Skin prioritizes.

Emerging players

• Tata Harper: Luxury natural-clinical skincare brand focused on high-performance, non-toxic formulations at premium price points. Comparable as a prestige skincare competitor targeting affluent efficacy-driven consumers, though differentiated by its natural/botanical positioning versus 111Skin's surgeon-clinical angle.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/111SKIN
• Instagraminstagram.com/111SKIN
• TikToktiktok.com/@111SKIN

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds3 records

Investors3 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about 111Skin