What DefenAge does

DefenAge is a prestige skincare brand operated by Progenitor Biologics LLC, a Nevada limited liability company that is itself a wholly-owned subsidiary of Medicell Technologies LLC. The company develops and sells a portfolio of anti-aging skincare, haircare, body, and men's products built around its proprietary Age-Repair Defensins technology — bioidentical synthetic peptides (Alpha-Defensin 5 and Beta-Defensin 3) that activate LGR6+ master cells to regenerate skin, a mechanism distinct from retinol-based anti-aging approaches. The line spans facial skincare (flagship Clinical Power Trio, 8-in-1 BioSerum, 24/7 Barrier Balance Cream), targeted treatments for eyes, neck, lips, hands/body, and nails, a patented 150K Hair Follicle Serum for hair thinning, and dedicated men's formulations.

The business model is primarily direct-to-consumer e-commerce through defenage.com, with prices ranging from a $19 trial kit to a $398 Morning & Night Routine, supported by a free Skin Club loyalty program, Rakuten-managed affiliate marketing, and email/SMS marketing. A second go-to-market is a controlled professional channel of authorized dermatologists, plastic surgeons, medspas, and medically-directed retailers, including a PRO Exclusive Line available only through practitioners. DefenAge enforces restricted distribution, declining to authorize resellers such as Amazon or eBay, and operates internationally with shipping to Canada and additional countries.

The technology is protected by three US patents (11,260,013; 11,491,096; 11,020,452) and the trademarked "Age-Repair Defensins" brand, with more than 30 published clinical and consumer studies including a multi-center, double-blind, vehicle-controlled trial in the Journal of Drugs in Dermatology (2018). The company has accumulated multiple industry awards from 2018 through 2026 (Aesthetic Awards, Good Housekeeping, Allure, NewBeauty, BeautyMatter NEXT, Skincare Anarchy) and an endorsement network of board-certified dermatologists and plastic surgeons who recommend the products in clinical practice. DefenAge is headquartered in Carlsbad, California.

Name

DefenAge

Legal name

Progenitor Biologics LLC

Website

https://defenage.com

Company type

Private

Founded year

2014

Operating status

Operating

Headcount range

11–50 employees

Short description

DefenAge is a privately held prestige skincare brand that sells anti-aging products built on patented bioidentical defensin peptides, distributed via defenage.com and a controlled network of dermatologists, plastic surgeons, and medically-directed retailers across the US and internationally.

Ownership category

akta.pro rank

Product category

Anti-Aging Skincare

NAICS

Cosmetics, Beauty Supplies, and Perfume Retailers (45612), Health and Personal Care Retailers (456), Health and Personal Care Retailers (4561)

SIC

Perfumes, Cosmetics & Other Toilet Preparations (2844), Soap, Detergents, Cleang Preparations, Perfumes, Cosmetics (2840)

akta.pro primary industry

Treatment Skincare (Serums, Actives, Acne & Anti-aging) (CRABAAAB)

akta.pro secondary industries

Dermocosmetics & Medical-Grade Skincare (CRABAAAF), Professional/Backbar Skincare (Esthetician & Spa Use) (CRABAAAK), Men’s Facial Skincare (Cleansers, Moisturizers, Anti-aging) (CRABAGAD)

Keywords

• Anti-aging skincare
• Defensin peptide technology
• Professional skincare distribution
• Clinical skincare products
• Stem cell skincare

Headquarters

HQ city

Carlsbad

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Operations, Marketing or Sales, Personnel, Technology or R&D, Supply Chain

Revenue model

1. Direct Product Sales (D2C): Primary revenue stream through direct-to-consumer e-commerce sales via defenage.com. Products sold at various price points from $19 starter kits to $398 complete routines. One-time purchase model with optional subscription through Skin Club rewards program.
2. Professional Channel Sales: Sales through authorized medical and aesthetic practices. Products sold to dermatologists, plastic surgeons, and medspas who recommend or dispense to patients. PRO Exclusive Line available only through professional channel with enhanced defensin concentrations.
3. Skin Club Rewards Program: Free loyalty program where customers earn points on purchases redeemable for discounts. Points expire 12 months after most recent purchase. Membership tiers with increasing benefits drive retention and repeat purchases.

Pricing tiers

Go-to-market motion3 records

Distribution channels4 records

Marketing channels7 records

Core offering

DefenAge develops, manufactures, and sells a comprehensive line of anti-aging skincare products formulated around its proprietary Age-Repair Defensins technology (Alpha-Defensin 5 and Beta-Defensin 3 bioidentical peptides). The portfolio includes facial serums, creams, masques, eye, neck, lip, body, nail, and hair/scalp treatments, plus trial kits and bundled regimens, sold direct-to-consumer and through authorized medical and aesthetic practices.

Product overview

DefenAge is a prestige skincare brand offering a comprehensive anti-aging product portfolio built around its proprietary Age-Repair Defensins technology. The core lineup centers on the Clinical Power Trio (2-Minute Reveal Masque, 24/7 Barrier Balance Cream, and 8-in-1 BioSerum), which is the regimen used in landmark clinical studies. The brand extends beyond facial skincare to include targeted treatments for the eyes (3D Eye Radiance Cream), neck (6-Week Perfection Neck Tightening Cream), lips (12-Factor Revitalizing Lip Enhancer), body (10 Luxe Hand and Body Cream), nails (360-Rejuvenation Nail Root Serum), and hair/scalp (150K Hair Follicle Serum). A dedicated men's line includes the Men's Edition of the Barrier Balance Cream and Hair Follicle Serum, plus bundled routines. The product ecosystem also includes trial kits (24-Hour Fast Starter Kit, Fly Kit), a loyalty rewards program (Skin Club), and gift cards. All products are fragrance-free, vegan, and cruelty-free, formulated without parabens, sulfates, and other common irritants.

Differentiator

Problem solved

Functional benefit

Products and services

• 8-in-1 BioSerum A multitasking anti-aging serum containing the highest concentration of defensin molecules in the DefenAge line; used as the final skincare step to deliver visible improvements in skin quality. Priced at $198 for 1.5 fl oz mega size.
• 24/7 Barrier Balance Cream A daily moisturizer providing barrier protection and hydration with an inflammation-controlling system and antioxidants, suitable for all skin types including a dedicated Men's Formula version.
• 3D Eye Radiance Cream An ophthalmologist- and dermatologist-tested eye cream clinically proven in five studies to visibly reduce puffiness, dark circles, and fine lines; safe for contact lens wearers.
• 6-Week Perfection Neck Tightening Cream A neck and décolleté cream formulated for thinner, more delicate skin, with visible tightening and texture improvements typically within six weeks. Priced at $98.
• 12-Factor Revitalizing Lip Enhancer A multi-benefit lip treatment designed to enhance lip appearance and health. Recognized as 'Best Age-Defying Lip Serum' in 2024.
• 10 Luxe Hand and Body Cream A body moisturizer targeting crepey skin on arms, legs, hands, elbows, and knees; improves skin thickness, firmness, and elasticity. Priced at $138.
• 360-Rejuvenation Nail Root Serum A serum delivering defensin molecules directly to the nail root to smooth the nail plate, reduce ridges and lines, and improve nail strength and hydration. Recognized with a Best Nail Serum Award in 2023.
• 150K Hair Follicle Serum A scalp serum using patented defensin technology with 48 clinically active ingredients, clinically shown to reduce visible hair shedding by 90% and increase hair fullness by 67%. Available in 1-month and 3-month dispensers, priced $99-$106, plus a Men's Edition.
• 2-Minute Reveal Masque An exfoliating masque with mild crystals designed to accelerate visible results by clearing old skin cells; used once or twice weekly after cleansing.
• 1-Step Multi-Cleanse An ophthalmologist-tested facial cleanser safe for use around the eye area, suitable for all skin types.
• 7X Calming Complex A calming and soothing complex formulated to support the skin's barrier, ideal for sensitive skin, post-procedure recovery, or when skin needs additional calming support. Recognized as the 2026 #1 Anti-Aging Sensation three-time award winner.
• Clinical Power Trio The signature three-step regimen consisting of the 2-Minute Reveal Masque, 24/7 Barrier Balance Cream, and 8-in-1 BioSerum; the core treatment used in landmark clinical studies and the Aesthetic Award 2018. Priced $295-$328 for full-size (6-8 week supply).
• 24-Hour Fast Starter Kit A trial-size version of the Clinical Power Trio providing a 2-3 day supply, covered by U.S. Patents No. 11,491,096 and 11,020,452. Priced at $19.
• Fly Kit A two-week supply of the Clinical Power Trio providing enough product to begin seeing initial results and assess skin response.
• Morning & Night Routine A complete daily skincare routine bundle designed for twice-daily use (morning and evening), containing products for the full DefenAge regimen. Priced at $398.
• 24/7 Barrier Balance Cream Men's Edition A daily moisturizer specifically formulated for men's skin with an inflammation-controlling system, barrier protection, and antioxidants tailored to male skin.
• Men's Skin Booster A complete daily regimen kit designed around men's skincare needs.
• Men's Skin Provision A complete daily regimen kit for men including the 24/7 Barrier Balance Cream Men's Edition.
• 150K Hair Follicle Serum Men's Edition A version of the 150K Hair Follicle Serum with dedicated beard application instructions for men.
• 100% Silk Pillowcase A silk pillowcase accessory designed to complement the skincare and haircare regimen by reducing friction and supporting skin and hair health during sleep.

Quantifiable outcome

• Visible improvement in 22 measures of skin quality within 6 weeks (JDD 2018 study)
• +4 more outcomes

Named customers8 records

Segments5 records

Ideal customer profiles1 record

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration7 records

Feature4 records

Partnerships

One partnership is on record.

• Rakuten Advertising (Linksynergy)minorGTM or Marketing PartnerDefenAge participates in the Rakuten affiliate marketing network through Linksynergy, enabling affiliate publishers to promote DefenAge products in exchange for commissions. Affiliates receive exclusive codes, early access to new products, and generous commissions.

Scale indicators4 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• SkinMedica: Allergan Aesthetics-owned medical-grade skincare brand sold primarily through dermatologists and plastic surgeons. Highly comparable to DefenAge in distribution model (PRO channel + D2C), anti-aging positioning, and clinical-validation marketing.
• Alastin Skincare: Galderma-owned professional skincare brand focused on procedure-enhancing and anti-aging products sold through aesthetic practices. Directly comparable to DefenAge's medical-channel strategy and post-procedure use cases.
• ZO Skin Health: Dr. Zein Obagi's physician-dispensed skincare brand with a strong D2C and medical-professional channel. Comparable to DefenAge in physician-dispensed anti-aging positioning, premium pricing, and clinical-results messaging.
• EltaMD: Colgate-Palmolive-owned skincare brand with strong dermatologist endorsement and clinical positioning. Comparable to DefenAge in physician-channel distribution and trusted-brand marketing, though broader portfolio.
• SkinCeuticals: L'Oréal-owned medical-grade skincare brand sold through dermatologists, medspas, and authorized retailers. Directly comparable to DefenAge on clinical anti-aging positioning, professional-channel DNA, and prestige pricing.
• iS Clinical: Innovative Skincare brand sold through physicians, medspas, and D2C with clinically validated anti-aging and post-procedure products. Comparable to DefenAge in physician-channel + D2C mix and clinical evidence emphasis.
• Neocutis: Medical-grade skincare brand using proprietary peptide and growth-factor technologies, sold through dermatologists and plastic surgeons. Closely comparable to DefenAge in biotech-derived peptide technology and PRO channel exclusivity.
• Revision Skincare: Physician-dispensed anti-aging brand with peptide-based formulations sold through dermatologists and plastic surgeons. Comparable to DefenAge in PRO-channel positioning, peptide technology, and clinical-results marketing.

Emerging players

• Dr. Dennis Gross Skincare: DTC and Sephora-distributed clinical skincare brand with dermatologist credibility. Comparable to DefenAge on clinical positioning and D2C strength, but more retail-channel exposure rather than medical exclusivity.

Broad incumbents

• Allergan Aesthetics (AbbVie): Parent of SkinMedica and CoolSculpting, with broad aesthetics portfolio including Botox, fillers, and medical-grade skincare. Comparable to DefenAge as a strategic acquirer archetype and competitive threat in the medical aesthetics space.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat4 records

Key risks4 records

Key highlights6 records

Customer concentration

• Xx.com/DefenAge
• YouTubeyoutube.com/channel/UCUNgakIU09qBQ4x1ulfc0jQ
• Facebookfacebook.com/DefenAge
• Instagraminstagram.com/defenageskincare

Compliance5 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about DefenAge