What Epicutis does

Epicutis is a U.S.-headquartered, biotech-driven professional skincare brand launched in 2020 as a commercial outgrowth of Signum Biosciences, a Princeton University spin-out founded in 2003 by Dr. Jeffry Stock and Maxwell Stock. The company develops and sells a portfolio of clinical-grade skincare products (serums, cleansers, exfoliating powders, lipid recovery masks, mineral SPF, and body treatments) built around proprietary, patented molecules such as TSC, HYVIA, DSD, QFC, ABSO, AGSE, and TCP, which target barrier repair, inflammation, microbiome balance, and oxidative stress at the signal-transduction level. The Simple System of Oil Cleanser, Lipid Serum, and Hyvia Crème anchors the lineup, with add-on modules including the Arctigenin Brightening Treatment, Hydrobiome Serum and Mist, Lipid Shield SPF 30, and a family of bio-cellulose Lipid Recovery Masks for face, eyes, neck, and décolleté.

Epicutis operates an exclusive professional-channel go-to-market, distributing exclusively through licensed aesthetic professionals, dermatology practices, accredited med-spas, and selected luxury hospitality partners such as The Ritz-Carlton Spa Singapore, while also operating a direct-to-consumer e-commerce storefront at epicutis.com that requires provider code or provider locator selection at checkout. The entire product line is EWG Verified, the first and only such designation exclusive to the professional channel, and the company holds EU and California Proposition 65 compliance. Pricing is at the premium tier, with individual SKUs ranging from approximately $75 (Hydrobiome Mist) to $250 (Lipid Serum), and curated sets priced up to $395 (Luxury Skincare Set).

The company is privately held and is operated under Signum Biosciences, Inc., a New Jersey corporation. Epicutis serves a dual customer base of clinical professionals and premium, skin-health-focused end consumers, with recent expansion into ANZ and broader Asia-Pacific markets via new offices in Sydney and Kyoto, complemented by flagship luxury spa partnerships. Backed by a single insider Series B investor, the company is positioned as a high-growth professional skincare brand built on biotech IP rather than conventional cosmetic chemistry.

Name

Epicutis

Legal name

Signum Biosciences, Inc.

Website

https://epicutis.com

Company type

Private

Founded year

2020

Operating status

Operating

Headcount range

11–50 employees

Short description

Epicutis is a U.S. biotech-driven professional skincare brand that develops patented, clinical-grade formulations (serums, cleansers, masks, SPF) and sells exclusively through licensed dermatologists, med-spas, and luxury hospitality partners, plus a provider-gated DTC e-commerce site.

Ownership category

akta.pro rank

Product category

Professional Skincare

NAICS

Soap and Cleaning Compound Manufacturing (32561)

SIC

Perfumes, Cosmetics & Other Toilet Preparations (2844)

akta.pro primary industry

Dermocosmetics & Medical-Grade Skincare (CRABAAAF)

akta.pro secondary industries

Professional/Backbar Skincare (Esthetician & Spa Use) (CRABAAAK), Professional Skincare & Facial Treatments (CRABALAF)

Keywords

• Professional skincare products
• Biotech skincare formulations
• Clinical grade serums
• Skin barrier treatments
• Licensed aesthetic skincare

Headquarters

HQ city

Boulder

HQ country

United States

HQ region

North America

Offices3 records

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Personnel, Marketing or Sales, Technology or R&D, Operations, Infrastructure

Revenue model

1. Professional Skincare Product Sales: Sale of clinical-grade skincare products through licensed aesthetic professionals, dermatologists, and med-spa partners. Products include serums, creams, cleansers, masks, and SPF products sold as one-time purchases.
2. Direct-to-Consumer E-commerce: Direct sales to consumers through epicutis.com, requiring provider code or selection of a provider partner for checkout.

Pricing tiers

Go-to-market motion3 records

Distribution channels5 records

Marketing channels6 records

Core offering

Epicutis formulates, manufactures, and sells clinical-grade, biotech-driven skincare products—including serums, cleansers, moisturizers, exfoliating powders, lipid recovery masks, brightening treatments, body treatments, and mineral sunscreen—built around proprietary patented ingredients (TSC, HYVIA, DSD, QFC, AGSE, ABSO, TCP) developed through 20+ years of Princeton University research. The company sells primarily through licensed aesthetic professionals, dermatology practices, med-spas, and luxury spa partners, with secondary direct-to-consumer e-commerce.

Product overview

Epicutis is a science-driven professional skincare brand launched in 2020 as an outgrowth of Signum Biosciences. The company offers a portfolio of skincare products built around three proprietary core ingredients (TSC, HYVIA, and DSD) developed through 20+ years of biotechnology research at Princeton University. The flagship Simple System comprises three products (Oil Cleanser, Lipid Serum, and Hyvia Crème) designed for a twice-daily CLEANSE. TREAT. HYDRATE. routine. The product line extends beyond the core system to include targeted treatments such as Arctigenin Brightening Treatment, Hydrobiome Serum, Hydrobiome Mist, Lipid Shield SPF 30, and a range of Lipid Recovery Masks for different body areas, plus the Lipid Body Treatment for firming/tightening body care. All products are EWG Verified, fragrance-free, and exclusively distributed through licensed aesthetic professionals, dermatology practices, and accredited med-spas.

Differentiator

Problem solved

Functional benefit

Products and services

• Oil Cleanser A botanical-based fatty acid cleanser (3.38 oz / 4 oz, 9 ingredients) featuring Meadowfoam Seed Oil, Sunflower Seed Oil, and HYVIA that creates mild cleansing action when in contact with water, leaving skin soft and cleansed without greasiness. For professional and consumer daily use.
• Lipid Serum An 8-ingredient anti-inflammatory serum (1 oz, $250) delivering therapeutic concentrations of patented TSC for instant relief for inflamed, stressed, sensitive or post-procedure skin while providing proven skin-health benefits over time. For licensed professionals and consumers.
• Hyvia Crème A velvety moisturizer (1.7 oz, 24 ingredients, $195) combining HYVIA (patented moisturizing agent from organic non-GMO chia seed oil) with DSD for environmental protection, shea butter for deep conditioning, and evening primrose extract for brightening.
• Lipid Recovery Mask An ultra-concentrated bio-cellulose mask (set of 5 masks, 0.7 oz each, 10 ingredients) delivering 1% TSC for rapid recovery. Instantly calms skin and reduces appearance of redness in 10–15 minutes. For professional and consumer use.
• Lipid Recovery Mask for Neck + Décolleté Targeted bio-cellulose mask ($140) for the neck and décolleté delivering concentrated TSC for hydration and skin recovery in those areas.
• Arctigenin Brightening Treatment A skin-brightening treatment (1 oz, 19 ingredients) featuring ABSO (arctigenin enriched burdock seed oil) and HYVIA, designed to deliver intense hydration while combating dark spots and uneven tone.
• Lipid Shield SPF 30 A tinted, mineral-based sunscreen (1.7 oz, 39 ingredients, $90, EWG Verified) with non-nano zinc oxide (21%) providing SPF 30 broad-spectrum protection. Features TSC to reduce redness and inflammation from UV exposure.
• Hydrobiome Serum An EWG Verified (pending) microbiome-balancing serum (50 ml / 1.7 fl oz, 10 ingredients, $165) combining TCP (TLR2 modulator) and TPNa (water-soluble Vitamin E) to calm irritation, strengthen the skin barrier, and provide antioxidant protection.
• Hydrobiome Mist A microbiome-balancing treatment mist (1.7 oz, 12 ingredients, $75) featuring Lactobacillus Ferment (postbiotic), AGSE antioxidant protection, and Hinoki Wood Oil for antimicrobial benefits.
• Lipid Body Treatment A body gel (7.4 oz, 19 ingredients, $225) providing hydration paired with firming and tightening benefits, featuring Spilanthes Acmella Flower Extract, Lychee Seed Extract, and Glucosyl Hesperidin.
• Luxury Skincare Set A curated set ($395) combining the Lipid Serum (1 oz, 8 ingredients) and Hyvia Crème (1.7 oz, 24 ingredients), formulated with therapeutic concentrations of TSC for inflamed, stressed, sensitive or post-procedure skin.
• Cleansing Essentials Set A cleansing duo ($105) including Oil Cleanser (3.38 oz, 9 ingredients) and Enzyme Exfoliating Powder (1.1 oz, 7 ingredients) for gentle cleansing and exfoliation using natural enzymes to break down dead skin cells.
• Luxury On-The-Go Care Set A travel-sized set ($175) including Oil Cleanser (5 ml), Lipid Serum (10 ml), Hyvia Crème (15 ml), Travel Lipid Body Treatment, and Lipid Recovery Mask for Face and Eyes.

Quantifiable outcome

• 77% improvement in overall skin appearance in 8-week clinical study (n=48) with zero reported irritation
• +3 more outcomes

Named customers4 records

Segments4 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature7 records

Partnerships

Five partnerships are on record, tiered core, flagship and minor.

• LPG AmericacoreGTM or Marketing Partner · 10 November 2025LPG America partnered with Epicutis to deliver an educational webinar for licensed professionals on combining endermologie cellular stimulation techniques with Epicutis biotechnology formulations to support skin barrier function and improve recovery from aesthetic procedures.
• The Ritz-Carlton Spa SingaporeflagshipChannel Partner/ Reseller/ Distributor · 6 November 2025The Ritz-Carlton Spa Singapore became the first luxury spa in Southeast Asia to feature Epicutis products, designated as the brand's flagship property in the region. The spa offers facials and treatments featuring patented ingredients including TSC, Hyvia, and DSD.
• Rohto PharmaceuticalcoreStrategic or Co-development PartnerRohto Pharmaceutical is a corporate partner of Signum Biosciences, with their top formulator Masanori Tamura (developer of Japan's #1 moisturizer Hada Labo) joining the Signum team as head formulator and director of Product Development.
• CHICMAX (Shang Mei)minorStrategic or Co-development PartnerCorporate partner of Signum Biosciences listed on Signum partner page.
• Elizabeth ArdenminorStrategic or Co-development PartnerCorporate partner of Signum Biosciences listed on Signum partner page.

Scale indicators7 records

Recent moves7 records

Expansion highlights6 records

Direct peers

• SkinCeuticals: L'Oréal-owned medical-grade professional skincare brand sold through physicians and licensed skincare professionals with patented antioxidant and corrective formulations — a direct competitor in the dermocosmetics channel that Epicutis targets.
• SkinMedica: Allergan Aesthetics/AbbVie professional skincare line sold through physician channels with growth-factor and TNS-based formulations — direct competitor in the medical-grade professional skincare segment.
• Alastin Skincare: Galderma-owned medical-grade skincare brand developed by dermatologists for pre/post-procedure care, sold through physicians and med-spas — a direct professional-channel competitor with patented TriHex technology.
• iS Clinical: Innovative Skincare clinical skincare line sold through licensed physicians, spas, and medical professionals with pharmaceutical-grade botanical formulations — direct peer in professional skincare distribution.
• Obagi Medical: Long-established medical-grade skincare brand distributed through physicians and skincare professionals with patented ingredient systems (e.g., Penetrating Therapeutic Technology) — direct competitor in physician-dispensed skincare.
• PCA Skin: Colgate-Palmolive-owned professional skincare brand sold exclusively through licensed professionals, with chemically formulated corrective treatments — direct competitor in the professional-channel aesthetic skincare category.
• EltaMD: Colgate-Palmolive-owned medical-grade sunscreen and skincare brand sold through dermatologists, plastic surgeons, and med-spas — a direct peer in professional-channel skincare with strong SPF positioning overlapping Epicutis's Lipid Shield SPF 30.
• Colorescience: Mineral-based professional skincare and SPF brand sold through dermatologists and licensed professionals with patented EnviroScreen technology — comparable professional-channel positioning in mineral sun and skincare.

Broad incumbents

• Dermalogica: Unilever-owned professional skincare brand sold through licensed skin therapists and spas globally, with broader skin and body portfolio — broader incumbent in the professional skincare channel that overlaps with Epicutis's spa/esthetician positioning.

Emerging players

• Dr. Barbara Sturm: Premium doctor-founded molecular cosmetics brand with biotech-positioned 'vampire' and anti-inflammatory skincare lines sold DTC and through luxury spa partners — an emerging player in luxury biotech skincare overlapping Epicutis's high-end positioning.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/epicutis
• YouTubeyoutube.com/@epicutisskincare
• Facebookfacebook.com/epicutis
• Instagraminstagram.com/epicutis
• TikToktiktok.com/@epicutis

Compliance4 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Funding overview

Funding rounds3 records

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Epicutis