Gleam
Gleam builds a browser-based AI assistant that helps clinical research sites move data from source documents into EDC Case Report Forms with audit traceability, serving independent sites, academic medical centers, and site networks through a direct sales-assisted SaaS model.
- Company typePrivate
- Founded2023
- HeadquartersSan Francisco, United States
- Headcount11–50
- GTM typeB2B
- OfferingSoftware
What Gleam does
Gleam (legal entity: Gleam Care, Inc.) is a San Francisco-based healthcare technology company founded in 2023 that builds a browser-based AI assistant for clinical research site data entry. The product is a single unified SaaS tool delivered as a browser extension, designed to move data from any source document (browser-based eSource systems today, with paper and PDF support announced as forthcoming) into any Electronic Data Capture (EDC) system's Case Report Forms (CRFs). Its core workflow consists of four sequential steps: Learn (the system learns each CRF's structure and tracks protocol amendments), Fetch (it captures source data from eSource systems and flags uncertain fields), Fill (it auto-populates CRF fields with matched source data, supporting batch and one-click repeat use), and Trace (every EDC value can be clicked through to its source document, supporting quality control and audit readiness). The product is validated to 21 CFR Part 11 with a human-in-the-loop design: the system drafts and links values but a trained coordinator reviews and submits every entry, and the product is positioned outside the scope of FDA's January 2025 draft guidance on AI in regulatory decision-making. It works alongside existing eSource and EDC systems in the browser, requiring no installation, integrations, or sponsor approval to deploy.
The company contracts directly with clinical research sites rather than through sponsors or CROs, targeting independent sites, academic medical centers, hospital-based research sites, and site networks as a horizontal segment. Its go-to-market is sales-assisted: pricing is not publicly disclosed, and all customer acquisition flows through a demo request form on joingleam.com. Sponsors and CROs are referenced as a secondary segment served via compliance documentation rather than direct contracting. Distribution is direct (self-serve sign-up via app.joingleam.com or sales-assisted for enterprise), with content marketing through the Gleam Stream blog, podcast appearances (Note to File), and LinkedIn serving as the primary top-of-funnel channels. The company is founder-led by Oliver Keh (Founder & CEO), who previously founded Slope Clinical, and operates with a small team of 1-10 employees. It participated in Y Combinator in 2023 with backing from Liquid 2 Ventures and focal.
Gleam firmographics
Firmographics- Name
- Gleam
- Legal name
- Gleam Care, Inc.
- Website
- https://joingleam.com
- Company type
- Private
- Founded year
- 2023
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- Gleam builds a browser-based AI assistant that helps clinical research sites move data from source documents into EDC Case Report Forms with audit traceability, serving independent sites, academic medical centers, and site networks through a direct sales-assisted SaaS model.
- Ownership category
- akta.pro rank
Gleam industry classification
Industry- Product category
- Clinical Trial EDC Data Entry Software
- NAICS
- Software Publishers (513210)
- SIC
- Services-Prepackaged Software (7372), Services-Computer Processing & Data Preparation (7374)
- akta.pro primary industry
- Site & Investigator Platforms (Site Payments, Feasibility, Activation) (HLACAOAJ)
Keywords
Where Gleam is headquartered
LocationHeadquarters
- HQ city
- San Francisco
- HQ country
- United States
- HQ region
- North America
Markets served
Gleam business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Marketing or Sales, Infrastructure, Operations
Revenue model
- SaaS Subscription (implied): Gleam operates as a browser-based SaaS tool accessed through app.joingleam.com. Pricing is not publicly disclosed; customers request a demo to get started, indicating a sales-assisted subscription model rather than self-serve pricing.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Other | Monthly | No public pricing tiers available |
Go-to-market motion1 record
Distribution channels2 records
Marketing channels5 records
Gleam product offering
Product offeringCore offering
Gleam is a browser-based AI data-entry assistant for clinical research sites that reads source documents (eSource, with paper/PDF coming soon), drafts Electronic Data Capture (EDC) Case Report Form (CRF) entries, and provides a full audit trail linking every value back to its source. Delivered as a SaaS browser extension with a four-step Learn-Fetch-Fill-Trace workflow, it requires no integrations or sponsor approval and is validated to 21 CFR Part 11 with a human-in-the-loop design.
Product overview
Gleam is a single, unified SaaS product delivered as a browser extension. It is not a modular platform — all capabilities (Learn, Fetch, Fill, Trace) are built into one product designed specifically for clinical research sites. The workflow consists of four sequential steps: Learn (teaches the system CRF structure), Fetch (captures source data from eSource), Fill (auto-populates CRF fields), and Trace (shows source provenance for each entry). No installation, custom integrations, or sponsor approval is required. The product supports browser-based eSource and EDC systems, with paper/PDF source support announced as coming soon.
Differentiator
Problem solved
Functional benefit
Products and services
- Gleam Browser-based AI data-entry assistant delivered as a SaaS tool and browser extension that learns EDC CRF structures, fetches source data from eSource systems, auto-fills EDC fields, and traces every entry back to its source document. Built exclusively for clinical research sites (independent sites, academic medical centers, hospital sites, and site networks), requires no integrations or sponsor approval, and is validated to 21 CFR Part 11 with human-in-the-loop review.
Quantifiable outcome
- Site Director at Yuma Clinical Trials reports saving hours every week using Gleam
Companies that use Gleam
Customer profileNamed customers1 record
Segments3 records
Ideal customer profiles3 records
Gleam technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability4 records
Feature5 records
Gleam partnerships and signals
Strategic signalRecent moves6 records
Expansion highlights4 records
Gleam competitors and assessment
Company assessmentDirect peers
- Florence Healthcare: Florence builds workflow and eRegulatory/eSource tools specifically for clinical research sites, including document management and remote monitoring workflows. It addresses the same site-operations pain points Gleam targets and serves a similar buyer.
- Castor EDC: Castor offers a cloud-based EDC and ePRO platform widely adopted by independent clinical research sites and academic medical centers. It overlaps directly with Gleam's site-level data entry workflow, though it is an integrated EDC rather than a browser-extension assist layer.
- OpenClinica: OpenClinica provides open-source and enterprise EDC platforms used by research sites, AMCs, and CROs. It competes in the same EDC data capture category where Gleam operates, particularly for cost-sensitive site networks.
- RealTime Software Solutions: RealTime Software Solutions offers CTMS, eRegulatory, and eSource/ePay tools specifically built for clinical research sites and site networks. It targets the same site-operations buyer with overlapping workflow functionality.
- Prelude Dynamics: Prelude Dynamics provides the eClinicalOS EDC platform with strong penetration among independent sites and AMCs. It directly competes for the same site-level data capture buyer Gleam serves.
Emerging players
- Mendel: Mendel applies AI/LLM technology to structure clinical trial data and operational workflows, including patient cohort and document understanding. It is an emerging AI-native competitor in adjacent clinical-trial data workflows.
Broad incumbents
- Medidata (Dassault Systèmes): Medidata Rave is one of the largest EDC platforms used by sponsors and CROs globally. As an incumbent with deep sponsor relationships and R&D scale, it represents the primary bundled-competition threat to standalone site tools like Gleam.
- Medrio: Medrio provides cloud-based EDC and eClinical solutions for sponsors, CROs, and sites, with a focus on Phase I–III trials. It competes in the same EDC and clinical data capture category Gleam addresses.
- Veeva Systems (Vault EDC): Veeva Vault EDC is a dominant sponsor-grade EDC platform in large pharma trials. It is a broader incumbent that could bundle AI-assisted entry features competitive to Gleam's workflow inside its sponsor-facing platform.
- Advarra: Advarra provides IRB, technology, and site-centric clinical trial services including eRegulatory and eSource platforms. It serves the same site ecosystem and could expand its technology portfolio to overlap with Gleam's offering.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat3 records
Key risks5 records
Key highlights6 records
Customer concentration
Gleam social profiles
Digital presenceGleam compliance and trust
Trust signalCompliance1 record
Gleam financial estimates
Financial estimateRevenue estimate
Valuation estimate
Gleam leadership team
Management profileNumber of profiles
Profiles2 records
Gleam funding detail
Funding detailFunding overview
Funding rounds1 record
Investors3 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Gleam M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Gleam
What does Gleam do?
Gleam is a browser-based AI data-entry assistant for clinical research sites that reads source documents (eSource, with paper/PDF coming soon), drafts Electronic Data Capture (EDC) Case Report Form (CRF) entries, and provides a full audit trail linking every value back to its source. Delivered as a SaaS browser extension with a four-step Learn-Fetch-Fill-Trace workflow, it requires no integrations or sponsor approval and is validated to 21 CFR Part 11 with a human-in-the-loop design.
Is Gleam a public or private company?
Gleam is a private company. It is classified as venture growth investor backed and is currently operating.
When was Gleam founded?
Gleam was founded in 2023. It employs 11 to 50 people.
Where is Gleam based?
Gleam is headquartered in San Francisco, United States, in the North America region.
How does Gleam make money?
One revenue line is on record: saaS Subscription (implied).
Who are Gleam's main competitors?
Direct peers on record are Florence Healthcare, Castor EDC, OpenClinica, RealTime Software Solutions and Prelude Dynamics. Mendel is listed as an emerging player. Broad incumbents are Medidata (Dassault Systèmes), Medrio, Veeva Systems (Vault EDC) and Advarra.
Does Gleam have an API?
No public API is recorded for Gleam.
What industry is Gleam in?
Gleam's product category is Clinical Trial EDC Data Entry Software. Its primary akta.pro industry code is HLACAOAJ, Site & Investigator Platforms (Site Payments, Feasibility, Activation). Its NAICS code is 513210 and its SIC code is 7372.