ProNova Solutions
ProNova Solutions is a US medical device manufacturer that develops the SC360, the first and only 360-degree superconducting compact proton therapy system for cancer treatment. It serves hospitals, cancer centers, semiconductor manufacturers, and space/aviation industries with proton therapy systems, AI-enabled QA software, and radiation effects testing services.
- Company typePrivate
- Founded2011
- HeadquartersKnoxville, United States
- Headcount101–250
- GTM typeB2B
- OfferingHardware or Manufacturing
What ProNova Solutions does
ProNova Solutions, LLC is a US medical device manufacturer headquartered in Maryville, Tennessee, that develops and sells the SC360 proton therapy system for cancer treatment. Founded in 2011 by leaders of CTI Molecular Imaging (which was acquired by Siemens for $1 billion), the company has commercialized the SC360, the first and only 360-degree superconducting compact proton therapy system in the world, which has been FDA-approved and treating patients since 2018. The company employs 101-250 people and operates a Radiation Testing Facility in Knoxville, Tennessee.
The SC360 is built on a proprietary Superconducting Isochronous Cyclotron (SCIC) integrated with a 360-degree superconducting gantry operating at 4 Tesla. The platform combines fast-scanning IMPT beam technology (up to 10x faster than competitors), an independent energy selection system enabling millisecond room switching, FLASH radiation therapy capability (up to 600 Gy/s dose rates), integrated dual-energy CBCT imaging, and ProNova SMART AI products for automated beamline tuning and machine QA. The system is offered in single-room, two-room, multi-room, and inline configurations and reduces footprint by up to 52%, weight by 83%, and power consumption by 81% relative to traditional systems. The product portfolio was expanded in September 2024 with the SC360u upright proton therapy system (via partnership with Leo Cancer Care) and in 2025 with the VIRTUE QA software platform, which includes four AI-enabled modules: SynthetIQ (ML-based prediction), DupliQAte (Monte Carlo dose verification), LogIQ (log-file analysis), and smaRT (automated chart review).
ProNova generates revenue through hardware sales of proton therapy systems via direct enterprise field sales to hospitals, cancer treatment centers, and oncology clinics, with quote-based pricing reflecting customized configurations. A secondary revenue stream comes from usage-based hourly radiation testing services at the Knoxville facility, serving semiconductor manufacturers, space industry, and aviation industry customers with a minimum 8-hour daily commitment. The company also holds DFARS 252.204-7012/7019/7020 (NIST SP 800-171 r2) compliance for DoD radiation testing contracts effective August 2024. A future recurring revenue stream is planned from VIRTUE QA software subscriptions, but the platform is not yet FDA-approved and not currently available for sale.
ProNova Solutions firmographics
Firmographics- Name
- ProNova Solutions
- Legal name
- ProNova Solutions, LLC
- Website
- https://pronovasolutions.com
- Company type
- Private
- Founded year
- 2011
- Operating status
- Operating
- Headcount range
- 101–250 employees
- Short description
- ProNova Solutions is a US medical device manufacturer that develops the SC360, the first and only 360-degree superconducting compact proton therapy system for cancer treatment. It serves hospitals, cancer centers, semiconductor manufacturers, and space/aviation industries with proton therapy systems, AI-enabled QA software, and radiation effects testing services.
- Ownership category
- akta.pro rank
ProNova Solutions industry classification
Industry- Product category
- Proton Therapy Systems
- NAICS
- Irradiation Apparatus Manufacturing (334517), Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)
- SIC
- Electromedical & Electrotherapeutic Apparatus (3845), X-Ray Apparatus & Tubes & Related Irradiation Apparatus (3844)
- akta.pro primary industry
- Radiation Oncology (HLAKAFAC)
- akta.pro secondary industries
- Radioisotope Production (Reactor/Cyclotron/Gamma) (HLAIAGAD), Radiation Processing & Sterilization Services (Medical device sterilization, food irradiation, materials modification) (EUAKAIAG)
Keywords
Where ProNova Solutions is headquartered
LocationHeadquarters
- HQ city
- Knoxville
- HQ country
- United States
- HQ region
- North America
Offices2 records
Markets served
ProNova Solutions business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Technology or R&D, Personnel, Operations, Infrastructure, Marketing or Sales
Revenue model
- Proton Therapy Systems (SC360): Sale of SC360 proton therapy systems to healthcare providers, cancer treatment centers, and hospitals. Systems offered in multiple configurations: single-room, two-room, multi-room, and inline configurations. Revenue generated from equipment sale, installation, and commissioning.
- Radiation Testing Services: Proton beam time rental for radiation effects testing. Facility rental charged by the hour with minimum 8 hours daily. Services include beam calibration, technical support, and detailed testing logs. Target customers include semiconductor manufacturers, space industry, and aviation industry.
- VIRTUE QA Software: Radiation therapy quality assurance software platform. Currently not FDA approved and not available for sale. Future revenue stream for clinical QA automation.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Usage-based | Pay-as-you-go | Hourly radiation testing rates with minimum 8-hour daily commitment |
Go-to-market motion1 record
Distribution channels1 record
Marketing channels3 records
ProNova Solutions product offering
Product offeringCore offering
ProNova Solutions develops, manufactures, and sells the SC360 superconducting compact proton therapy system, the first and only 360-degree compact superconducting proton therapy gantry in the world, featuring a proprietary Superconducting Isochronous Cyclotron (SCIC), Fast-Scanning IMPT beam delivery, AI-enhanced SMART products, and FLASH-capable dose rates. The company also sells the SC360u upright positioning variant (via partnership with Leo Cancer Care), the VIRTUE QA clinical software platform for radiation therapy quality assurance, and offers hourly proton beam time rental for radiation effects testing through its Radiation Testing Facility in Knoxville, Tennessee.
Product overview
ProNova Solutions is a US medical device manufacturer providing the SC360 proton therapy system as its core product, which is a superconducting compact proton therapy system with a 360° gantry. The company also offers the SC360u (upright positioning variant through partnership with Leo Cancer Care) and the VIRTUE QA software platform with four integrated modules (SynthetIQ, DupliQAte, LogIQ, smaRT) for radiation therapy quality assurance. Additionally, ProNova provides a Radiation Testing Facility service for semiconductor, space, and aviation industries. The product portfolio spans clinical proton therapy systems for cancer treatment, AI-powered QA software, and specialized radiation testing services.
Differentiator
Problem solved
Functional benefit
Brands
- SC360: First and only 360-degree superconducting compact proton therapy system for cancer treatment
- VIRTUE QA
- SC360u
Products and services
- ProNova SC360 Proton Therapy System Superconducting compact proton therapy system for hospitals, cancer treatment centers, and oncology clinics. Features the proprietary Superconducting Isochronous Cyclotron (SCIC), full 360-degree superconducting gantry, Fast-Scanning IMPT beam delivery, Independent Energy Selection System, FLASH radiation therapy capability, integrated dual-energy CBCT, and ProNova SMART AI products. Offered in single-room, two-room, multi-room, and inline configurations.
- ProNova SC360u Upright Proton Therapy System Upright patient positioning proton therapy system developed through strategic partnership with Leo Cancer Care, integrating CT scanner technology with ProNova's superconducting cyclotron and beam delivery for sustainable future-proof treatment. Available in ultra-compact single-room and multi-room configurations.
- VIRTUE QA Clinical Quality Assurance Software Platform Comprehensive clinical QA software platform for radiation therapy clinics, integrating four modules: SynthetIQ (AI-powered prediction using ML on historical treatment data), DupliQAte (independent dose verification via MCsquare Monte Carlo engine), LogIQ (treatment log file analysis), and SmaRT Chart (automated chart review with cumulative dose tracking). Interfaces with Treatment Planning Systems, Oncology Information Systems, and Treatment Control Systems via DICOM-compliant interfaces.
- ProNova Radiation Testing Facility Proton beam time rental and radiation effects testing service for semiconductor manufacturers, the space industry, and the aviation industry to verify reliability and performance of mission-critical electronic components used in national defense and commercial applications. Facility is located at the Covenant Health Proton Center in Knoxville, TN.
Quantifiable outcome
- Treatment time reduced to under 9 minutes patient-in to patient-out for two-field prostate treatment
- +7 more outcomes
Companies that use ProNova Solutions
Customer profileNamed customers1 record
Segments3 records
Ideal customer profiles2 records
ProNova Solutions technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration4 records
AI capability2 records
Feature8 records
ProNova Solutions partnerships and signals
Strategic signalPartnerships
One partnership is on record.
- Leo Cancer CarecoreStrategic partnership with Leo Cancer Care to enable the SC360u proton therapy system featuring upright patient positioning and CT scanner technology. Leo Cancer Care provides innovative upright patient positioning and imaging solutions for particle therapy, integrated with ProNova's Superconducting Isochronous Cyclotron and advanced beam delivery system capable of ARC and FLASH therapy.
Scale indicators5 records
Recent moves6 records
Expansion highlights6 records
ProNova Solutions competitors and assessment
Company assessmentBroad incumbents
- Varian Medical Systems (Siemens Healthineers): Acquired by Siemens Healthineers in 2021, Varian is the global leader in radiation oncology with the ProBeam proton therapy platform. Directly competes with ProNova in proton therapy while offering a much broader portfolio of linear accelerators and oncology software.
- Elekta: Swedish leader in linear accelerators and stereotactic radiosurgery (Gamma Knife, Versa HD). Competes with ProNova in the broader radiation oncology capital equipment market even though Elekta does not sell proton therapy systems directly.
Direct peers
- IBA (Ion Beam Applications): Belgian proton therapy pioneer and the largest pure-play proton therapy equipment vendor worldwide. Competes head-to-head with ProNova in single-room and multi-room proton therapy installations, especially in academic and large cancer centers.
- Hitachi (Hitachi High-Tech, Proton Therapy): Operates one of the most established proton and heavy-ion therapy businesses globally, with strong presence in Asia and the US. Competes with ProNova on multi-room proton systems and synchrotron-based installations.
- Mevion Medical Systems: Closest direct competitor in compact single-room proton therapy, marketing the MEVION S250i/HYPERSCAN. Targets the same mid-sized cancer center segment as ProNova's SC360 with a smaller-footprint, lower-cost value proposition.
Emerging players
- Accuray: Maker of CyberKnife and TomoTherapy systems focused on robotic and image-guided radiotherapy. Competes for hospital capital budgets and patient referrals in advanced radiation oncology, particularly for SBRT cases where ProNova also competes.
- ViewRay: Developer of MR-guided radiation therapy systems (MRIdian), combining real-time MRI with linear accelerators. Represents an adjacent advanced radiation therapy modality competing for similar oncology capital equipment customers.
- Leo Cancer Care: Upright patient positioning and CT imaging technology partner for particle therapy. Strategic partner of ProNova for the SC360u, and could overlap competitively as it seeks other proton therapy OEM partners.
- Advanced Oncotherapy: UK-based developer of a compact linear proton therapy system (LIGHT). Competes in the same compact/affordable proton therapy segment as ProNova, targeting community hospitals and emerging markets.
- RefleXion Medical: Developer of biology-guided radiotherapy (BgRT) combining PET-guided targeting with LINAC delivery. Competes for innovative radiation oncology capital budgets in advanced community cancer centers.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat5 records
Key risks6 records
Key highlights7 records
Customer concentration
ProNova Solutions social profiles
Digital presenceProNova Solutions compliance and trust
Trust signalCompliance4 records
ProNova Solutions financial estimates
Financial estimateRevenue estimate
Valuation estimate
ProNova Solutions leadership team
Management profileNumber of profiles
Profiles3 records
ProNova Solutions funding detail
Funding detailFunding overview
Funding rounds3 records
Investors
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
ProNova Solutions M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about ProNova Solutions
What does ProNova Solutions do?
ProNova Solutions develops, manufactures, and sells the SC360 superconducting compact proton therapy system, the first and only 360-degree compact superconducting proton therapy gantry in the world, featuring a proprietary Superconducting Isochronous Cyclotron (SCIC), Fast-Scanning IMPT beam delivery, AI-enhanced SMART products, and FLASH-capable dose rates. The company also sells the SC360u upright positioning variant (via partnership with Leo Cancer Care), the VIRTUE QA clinical software platform for radiation therapy quality assurance, and offers hourly proton beam time rental for radiation effects testing through its Radiation Testing Facility in Knoxville, Tennessee.
Is ProNova Solutions a public or private company?
ProNova Solutions is a private company. It is classified as founder individual operated bootstrapped and is currently operating.
When was ProNova Solutions founded?
ProNova Solutions was founded in 2011. It employs 101 to 250 people.
Where is ProNova Solutions based?
ProNova Solutions is headquartered in Knoxville, United States, in the North America region.
How does ProNova Solutions make money?
Three revenue lines are on record. Proton Therapy Systems (SC360) is the primary driver. The others are radiation Testing Services and VIRTUE QA Software.
Who are ProNova Solutions's main competitors?
Broad incumbents on record are Varian Medical Systems (Siemens Healthineers) and Elekta. Direct peers are IBA (Ion Beam Applications), Hitachi (Hitachi High-Tech, Proton Therapy) and Mevion Medical Systems. Emerging players are Accuray, ViewRay, Leo Cancer Care, Advanced Oncotherapy and RefleXion Medical.
Does ProNova Solutions have an API?
No public API is recorded for ProNova Solutions.
What industry is ProNova Solutions in?
ProNova Solutions's product category is Proton Therapy Systems. Its primary akta.pro industry code is HLAKAFAC, Radiation Oncology, with a secondary code of HLAIAGAD, Radioisotope Production (Reactor/Cyclotron/Gamma). Its NAICS code is 334517 and its SIC code is 3845.