CRF Health

What CRF Health does

CRF Health, founded in 2000 and headquartered in Lansdale, Pennsylvania, originated as a provider of electronic patient-reported outcomes (ePRO) solutions for the life sciences industry. Through a sequence of growth equity rounds beginning in the early 2000s (3i Group, Nordic Venture Partners, Stratos Ventures) and culminating in a 2018 investment from CPP Investments alongside the acquisition of Bracket, the company evolved into a unified eClinical platform now operating under the Signant Health brand.

Its current product portfolio spans electronic Clinical Outcome Assessment / ePRO (eCOA), Electronic Data Capture (EDC/DDC), Randomization and Trial Supply Management (RTSM), a Clinical Data Repository (CDR System), Electronic Clinician Ratings, Supply Chain Software, and patient engagement modules including a Patient Engagement App, eConsent, and Telemedicine. These capabilities are delivered both as point solutions and as an integrated Unified eClinical Platform supported by PureSignal Analytics for COA data analysis and a Developer Marketplace for third-party integrations. The company also offers Protocol and Study Design consulting staffed by 50+ in-house scientists and clinicians.

CRF Health sells primarily through a direct enterprise field-sales motion targeting large pharmaceutical sponsors, Contract Research Organizations (CROs), biotech and emerging biopharma, medical device, and biologics/vaccine sponsors. Revenue is generated via multi-year, per-study licensing and subscription contracts supplemented by professional services for implementation, training, and protocol consulting. Across approximately 30 years of operations the company reports involvement in thousands of trials and association with 25% of novel FDA and EMA drug approvals from 2021-2024.

Name

CRF Health

Legal name

Signant Health

Website

https://crfhealth.com

Company type

Private

Founded year

1995

Operating status

Operating

Headcount range

251–500 employees

Short description

CRF Health provides electronic patient-reported outcomes (ePRO) and a unified eClinical platform — including eCOA, EDC, RTSM, and patient engagement tools — to pharmaceutical sponsors, CROs, biotech, and medical device companies worldwide.

Ownership category

akta.pro rank

Product category

Clinical Trial Technology (eClinical Solutions)

NAICS

Software Publishers (513210), Other Scientific and Technical Consulting Services (54169)

SIC

Services-Prepackaged Software (7372), Services-Management Consulting Services (8742)

akta.pro primary industry

Patient Recruitment, Site Feasibility & Trial Enablement CROs (HLAGAAAI)

akta.pro secondary industries

Clinical CROs (Phase I–IV) (HLAGAAAA), Clinical Data Management, Biostatistics & Statistical Programming CROs (HLAGAAAF), Specialty Therapeutic-Area CROs (e.g., oncology/rare disease) (HLAGAAAL)

Keywords

• Electronic patient-reported outcomes
• Clinical trial technology
• ECOA data capture
• Life sciences solutions
• Decentralized clinical trials

Headquarters

HQ city

Lansdale

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Marketing or Sales, Operations, Infrastructure

Revenue model

1. eClinical Technology Platform Licensing and Subscription: Signant Health generates revenue primarily through licensing its eClinical technology platform solutions (eCOA, EDC, RTSM, CDR, etc.) to pharmaceutical sponsors and CROs. Given the enterprise sales motion, custom implementation, and protocol-specific nature of the offering, revenue is likely structured as multi-year contracts with subscription or per-study licensing components, supplemented by professional services for implementation, training, and protocol design consulting.

Go-to-market motion2 records

Distribution channels3 records

Marketing channels6 records

Core offering

CRF Health provides electronic patient-reported outcomes (ePRO) solutions for the life sciences industry. The company enables pharmaceutical sponsors, biotech firms, and Contract Research Organizations to capture clinical trial data electronically from patients and sites through a unified eClinical platform supporting both traditional and decentralized clinical trial designs.

Product overview

Signant Health offers a unified eClinical platform architecture that integrates multiple clinical trial solutions. The core product portfolio includes eCOA/ePRO for patient-reported outcomes, EDC/DDC for electronic data capture, RTSM for randomization and supply management, and Electronic Clinician Ratings for clinician-reported outcomes. These solutions are offered both as individual modules and through the Unified eClinical Platform for integrated data collection. Additional capabilities include patient engagement tools (Patient Engagement App, eConsent, Telemedicine), data analytics solutions (COA Data Analytics, Data Aggregation and Intelligence), supply chain software, and clinical consulting services. The platform supports applications across therapeutic areas including CNS, oncology, pediatrics, psychedelics, and vaccines.

Differentiator

Problem solved

Functional benefit

Products and services

• eCOA / ePRO

Quantifiable outcome

• Supported clinical trials associated with 25% of novel drug approvals across FDA (Novel Drug Approval) and EMA (Marketing Authorization for New Active Substance) from 2021-2024
• +1 more outcomes

Segments5 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature12 records

Partnerships

One partnership is on record.

• DSG Inc.coreTechnology or IntegrationSignant Health acquired DSG Inc. in July 2023 to strengthen its eClinical solution offerings and broaden technological capabilities for both traditional and decentralized clinical trials. DSG Inc. is a provider of complementary eClinical technology that enhances Signant Health's ability to serve sponsors and CROs.

Scale indicators5 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• YPrime: Specializes in eCOA, IRT/RTSM, and clinical trial technology for mid-size and large pharma. Direct overlap with Signant's core eCOA and RTSM product lines.
• Medidata Solutions: A Dassault Systèmes company and the leading end-to-end eClinical platform provider (Rave EDC, eCOA, RTSM, CTMS). Direct overlap with Signant across virtually every core product line for pharma and CRO sponsors.
• Clario: Formed via the merger of ERT and Bioclinica, Clario offers eCOA, cardiac safety, imaging, and EDC solutions. Direct competitor in electronic clinical outcome assessments and decentralized trial enablement.
• Veeva Systems: Cloud software provider for life sciences with Vault EDC, Vault CDB, ePRO, and CTMS offerings. Targets the same pharma and CRO buyer base as Signant and competes on unified clinical data management.

Emerging players

• Castor: Cloud-based EDC and eClinical platform targeting academic and commercial trials with a self-service-friendly model. Partially overlaps with Signant's EDC offering, particularly for smaller sponsors.
• Medable: Decentralized clinical trial platform offering eCOA, eConsent, telehealth, and remote data capture. Competes with Signant's DCT-enablement modules and patient engagement app.
• THREAD: Decentralized clinical trial technology provider with eCOA, eConsent, and virtual visit capabilities. Emerging challenger in the same DCT-enablement space as Signant.

Others

• ArisGlobal: Provider of life sciences R&D technology including clinical trial, safety, and regulatory platforms. Adjacent competitor with overlap on data aggregation and clinical trial management functions.

Broad incumbents

• IQVIA: Technology-enabled clinical research services provider offering EDC, eCOA, and DCT platforms alongside its CRO services. Overlaps with Signant on technology and competes with it as a CRO partner for sponsors.
• Oracle Health Sciences: Provides Oracle Clinical One, a broad eClinical platform covering EDC, RTSM, and trial supply. As a broader enterprise software incumbent, it competes with Signant on integrated trial platforms for large pharma sponsors.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat6 records

Key risks5 records

Key highlights6 records

Customer concentration

• Xx.com/CRFhealth
• Facebookfacebook.com/128196243858844
• LinkedInlinkedin.com/company/crf-health

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds8 records

Investors6 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A2 records

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about CRF Health