Navidence
Navidence is a private, AI-native health technology company that builds the RWE Sherpa platform — using Computable Operational Definitions (CODefs) to help pharmaceutical, biotechnology, and CRO research teams design reproducible real-world evidence studies against real-world data.
- Company typePrivate
- Founded2022
- HeadquartersAurora, United States
- Headcount1–10
- GTM typeB2B
- OfferingSoftware
What Navidence does
Navidence is a private, AI-native health technology company founded in 2022 and headquartered in Aurora, Colorado, that builds the RWE Sherpa platform for real-world evidence (RWE) study design and real-world data (RWD) assessment. The platform is organized around Computable Operational Definitions (CODefs) — standardized, human- and machine-readable definitions of diseases, treatments, outcomes, and patient cohort criteria that are curated against scientific literature and continuously updated. Its three product modules — Navigate: Code Lists (code list search, comparison, and export), Navigate: CODefs (definition management and stakeholder alignment), and Design Studies (rapid study design and data assessment alignment) — are intended to compress RWE study design from weeks to days and to support reproducibility and regulatory-grade documentation of study definitions.
The underlying technology combines expert-curated CODef libraries with AI-assisted knowledge engineering, most notably Nested Knowledge's AutoLit technology for semi-automated concept extraction and literature validation, and proprietary AI-generated summarization of code list comparisons. Navidence licenses its CODef content through ecosystem partners (Datavant, Panalgo, OneMedNet, Trio Health, Nested Knowledge) and is operationally supported by a strategic equity investment from RTI International. The company is led by a senior team with prior leadership roles at Roche/Genentech, IQVIA, Parexel, Syneos Health, and Health Catalyst.
Navidence sells primarily to enterprise pharmaceutical, biotechnology, and contract research organization (CRO) buyers via a direct field sales motion, with revenue generated through SaaS platform subscriptions, professional services for CODef adoption, and CODef library licensing to data ecosystem partners. Pricing is quote-based with annual enterprise multi-seat subscriptions; no public pricing is disclosed. Distribution is augmented through channel and integration partnerships that embed CODefs into third-party RWD and analytics platforms, allowing the company to reach life sciences analytics users without direct sales coverage.
Navidence firmographics
Firmographics- Name
- Navidence
- Legal name
- Navidence Inc.
- Website
- https://navidence.com
- Company type
- Private
- Founded year
- 2022
- Operating status
- Operating
- Headcount range
- 1–10 employees
- Short description
- Navidence is a private, AI-native health technology company that builds the RWE Sherpa platform — using Computable Operational Definitions (CODefs) to help pharmaceutical, biotechnology, and CRO research teams design reproducible real-world evidence studies against real-world data.
- Ownership category
- akta.pro rank
Navidence industry classification
Industry- Product category
- Real-World Evidence Software
- NAICS
- Software Publishers (5132), Computing Infrastructure Providers, Data Processing, Web Hosting, and Related Services (5182)
- SIC
- Services-Prepackaged Software (7372), Services-Computer Programming, Data Processing, Etc. (7370)
- akta.pro primary industry
- Real-World Data (RWD) / Real-World Evidence (RWE) & Observational Research Platforms (HLACAOAM)
- akta.pro secondary industries
- Real-World Data (RWD) Platforms & Clinical Data Curation (HLACAIAJ), Healthcare Outcomes & Real-World Evidence (RWE) Analytics (BPAHALAN), Data Platform (Unified Data & Analytics) Suites (HDAEABAD)
Keywords
Where Navidence is headquartered
LocationHeadquarters
- HQ city
- Aurora
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Navidence business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Technology or R&D, Personnel, Marketing or Sales, Operations, Infrastructure
Revenue model
- Software Platform Subscription: SaaS platform subscriptions for access to the RWE Sherpa platform, including Navigate: Code Lists, Navigate: CODefs, and Design Studies modules. Revenue is recurring on a subscription basis, likely with enterprise licensing tiers.
- Professional Services: Consulting and implementation services supporting adoption of computable operational definitions within life sciences research programs. Provided alongside the platform to support complex evidence generation engagements.
- CODef Library Licensing: Licensing of proprietary CODef library content to partners such as Datavant for distribution within real-world data ecosystems.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Subscription | Annual | Enterprise multi-seat subscription |
Go-to-market motion3 records
Distribution channels2 records
Marketing channels5 records
Navidence product offering
Product offeringCore offering
Navidence offers an AI-native RWE Design platform (RWE Sherpa / Navidence Platform) that uses Computable Operational Definitions (CODefs) to standardize study elements such as diseases, treatments, outcomes, and patient cohorts for real-world evidence generation. The platform includes three modules—Navigate: Code Lists, Navigate: CODefs, and Design Studies—enabling research teams to move from study concept to data-query-ready design in days. The company also licenses its proprietary CODef libraries to partners such as Datavant for distribution across real-world data ecosystems.
Product overview
Navidence offers a unified AI-native platform (Navidence Platform / RWE Sherpa) with three core modules: Navigate: Code Lists (code list search, comparison, and export), Navigate: CODefs (CODef search, selection, and stakeholder engagement), and Design Studies (rapid study design and data assessment alignment). These modules are built upon AI-assisted, expert-curated CODef Libraries covering diseases, treatments, outcomes, and inclusion/exclusion criteria. The platform enables research teams to move from study concept to data-query-ready design in days rather than weeks, supporting regulatory submissions and real-world evidence generation across the life sciences.
Differentiator
Problem solved
Functional benefit
Brands
- RWE Sherpa: Transformational platform for RWE Design and RWD Assessment using AI-informed, indication-specific libraries of Computable Operational Definitions (CODefs).
- Navigate: Code Lists
- Navigate: CODefs
Products and services
- RWE Sherpa (Navidence Platform) AI-informed SaaS platform for Real-World Evidence (RWE) Design and Real-World Data (RWD) Assessment, providing indication-specific libraries of Computable Operational Definitions (CODefs) to align study design to scientific literature, data science approaches, and existing data assets. Targets pharmaceutical, biotech, and CRO research teams.
- CODef Libraries Expert-curated, indication-specific libraries of Computable Operational Definitions (CODefs) for diseases, treatments, outcomes, and inclusion/exclusion criteria. Standardized, human- and computer-readable definitions pragmatically validated against scientific literature and continuously updated. Licensed separately to partners such as Datavant for distribution across real-world data ecosystems.
Quantifiable outcome
- Weeks of manual definition work replaced by standardized CODef reuse per study
Companies that use Navidence
Customer profileNamed customers1 record
Segments4 records
Ideal customer profiles4 records
Navidence technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration2 records
AI capability5 records
Feature4 records
Navidence partnerships and signals
Strategic signalPartnerships
Six partnerships are on record, tiered major and core.
- RTI InternationalmajorRTI International made a strategic equity investment in Navidence on May 5, 2026, representing a significant vote of confidence from a major research institution. RTI International is a leading independent nonprofit research institute specializing in health, education, and global development, making this partnership strategically aligned with Navidence's mission in real-world evidence.
- PanalgocorePanalgo entered a strategic partnership with Navidence on April 29, 2026. Panalgo provides an analytics platform for life sciences, and the partnership is aimed at integrating Navidence's computable operational definitions into Panalgo's analytics environment to enhance evidence generation capabilities for joint life sciences customers.
- Trio HealthcoreTrio Health entered a strategic partnership with Navidence on April 8, 2026. Trio Health specializes in data-driven healthcare and real-world evidence solutions, making this partnership a natural fit for expanding the use of Navidence's CODef platform within healthcare data and evidence generation programs.
- OneMedNetmajorOneMedNet entered a strategic collaboration with Navidence on March 18, 2026. OneMedNet specializes in real-world data curation and healthcare data exchange, making it a complementary partner for expanding the reach and interoperability of Navidence's CODef libraries across clinical data networks.
- DatavantmajorDatavant partnered with Navidence on March 4, 2026, to license CODef libraries for distribution within the Datavant real-world data ecosystem. This partnership enables standardized computable definitions to be used across Datavant's network of health data partners, expanding the accessibility and adoption of Navidence's proprietary CODef content.
- Nested KnowledgemajorNested Knowledge entered a strategic collaboration with Navidence on April 26, 2024, with a focus on AI-native literature curation and automated knowledge engineering. The partnership integrates Nested Knowledge's capabilities into the RWE Sherpa platform, enabling automated literature synthesis and curation within the evidence generation workflow.
Scale indicators2 records
Recent moves6 records
Expansion highlights5 records
Navidence competitors and assessment
Company assessmentDirect peers
- Panalgo: Panalgo's Instant Health Data (IHD) platform is an analytics environment for life-sciences RWE; Navidence's CODefs are now embedded inside IHD. Direct overlap in target customer (life-sciences biostatisticians) and in the analytics-and-cohort-definition workflow.
- TriNetX: TriNetX operates a global real-world data and analytics network for clinical research, serving pharma, biotech, and CROs with patient cohort feasibility and protocol design. Overlaps with Navidence on RWD access and study design support.
- Aetion: Aetion provides a regulatory-grade RWE analytics platform used by pharma, biotech, and regulators (including FDA collaborations). Like Navidence, it focuses on real-world evidence generation for life sciences, but emphasizes outcome studies rather than upstream study design and definition standardization.
Broad incumbents
- Datavant: Datavant is the largest health-data connectivity ecosystem for de-identification and linking. Navigence licenses its CODef libraries into Datavant's ecosystem — they are simultaneously a partner and an incumbent with potential to develop overlapping definition tooling.
- Medidata (Dassault Systèmes): Medidata provides the leading clinical trials technology platform (Rave, eCOA, EDC) and increasingly RWE capabilities via the Dassault 3DEXPERIENCE platform. Competes for the same pharma technology budget on study design and clinical data.
- Health Catalyst: Health Catalyst is a healthcare data and analytics platform serving providers and life sciences. Navigence's CSO previously led clinical informatics at Health Catalyst; competes for analytics-driven healthcare data insights and life-sciences RWE.
- ConcertAI: ConcertAI is an oncology-focused real-world evidence and AI company serving pharma and providers. Overlaps with Navidence in life-sciences RWE tooling, but operates at significantly larger scale with its own data assets.
- Flatiron Health: Flatiron Health (owned by Roche) is a leading real-world evidence company focused on oncology EHR data and RWE studies. Competes with Navidence for oncology RWE budgets, though Flatiron also provides proprietary data assets Navigence does not own.
- IQVIA: IQVIA is the largest life-sciences technology and services incumbent, offering end-to-end RWE, RWD, clinical operations, and analytics. Multiple Navidence executives previously worked at IQVIA; competes broadly across the same pharma/biotech accounts.
Emerging players
- Tempus AI: Tempus AI combines multimodal real-world data (clinical, molecular, imaging) with AI for life sciences R&D and clinical decision support. An emerging player with growing overlap in real-world data curation for pharma, though its primary focus is precision medicine rather than study definition standardization.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat6 records
Key risks6 records
Key highlights6 records
Customer concentration
Navidence social profiles
Digital presenceNavidence financial estimates
Financial estimateRevenue estimate
Valuation estimate
Navidence leadership team
Management profileNumber of profiles
Profiles5 records
Navidence funding detail
Funding detailFunding overview
Funding rounds2 records
Investors3 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Navidence M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Navidence
What does Navidence do?
Navidence offers an AI-native RWE Design platform (RWE Sherpa / Navidence Platform) that uses Computable Operational Definitions (CODefs) to standardize study elements such as diseases, treatments, outcomes, and patient cohorts for real-world evidence generation. The platform includes three modules—Navigate: Code Lists, Navigate: CODefs, and Design Studies—enabling research teams to move from study concept to data-query-ready design in days. The company also licenses its proprietary CODef libraries to partners such as Datavant for distribution across real-world data ecosystems.
Is Navidence a public or private company?
Navidence is a private company. It is classified as venture growth investor backed and is currently operating.
When was Navidence founded?
Navidence was founded in 2022. It employs 1 to 10 people.
Where is Navidence based?
Navidence is headquartered in Aurora, United States, in the North America region.
How does Navidence make money?
Three revenue lines are on record. Software Platform Subscription is the primary driver. The others are professional Services and CODef Library Licensing.
Who are Navidence's main competitors?
Direct peers on record are Panalgo, TriNetX and Aetion. Broad incumbents are Datavant, Medidata (Dassault Systèmes), Health Catalyst, ConcertAI, Flatiron Health and IQVIA. Tempus AI is listed as an emerging player.
Does Navidence have an API?
No public API is recorded for Navidence.
What industry is Navidence in?
Navidence's product category is Real-World Evidence Software. Its primary akta.pro industry code is HLACAOAM, Real-World Data (RWD) / Real-World Evidence (RWE) & Observational Research Platforms, with a secondary code of HLACAIAJ, Real-World Data (RWD) Platforms & Clinical Data Curation. Its NAICS code is 5132 and its SIC code is 7372.