Perio Protect LLC

What Perio Protect LLC does

Perio Protect LLC, founded in 2004 by Dr. Duane C. Keller and headquartered at 9701 Green Park Industrial Drive in St. Louis, Missouri, develops and distributes a tray-based drug delivery system for the minimally invasive treatment of periodontal disease. The company's core product is the FDA 510(k)-cleared, patented Perio Tray - a custom-fabricated dental appliance with an internal seal system designed to deliver prescription gel formulations deep below the gum line into periodontal pockets, an area brushing and flossing cannot reach. The system is supported by multiple prescription gels: the original 1.7% hydrogen peroxide PerioGel (~20 years in use), PerioGelX (xylitol-flavored variant released 2020), PerioGelX Neutral (non-mint flavor launched June 2026), and ReminGel (hydroxyapatite-based gel for sensitivity and enamel repair launched October 2025), with a fluoride-based anti-cavity gel listed as forthcoming.

The business operates through a two-sided model. Custom trays are prescribed and fitted by certified dental providers (dentists and hygienists), with dentists taking impressions and the St. Louis lab manufacturing patient-specific trays. Recurring revenue is generated through ongoing prescription gel refills, sold both through providers and via the company's e-commerce site periogel.net for established patients. Pricing is set by individual dental providers rather than Perio Protect directly, and HSA/FSA funds are accepted. The company is privately held, founder-controlled, with no disclosed outside investment, no parent company, and operates exclusively in the United States. Reported scale indicators include tens of thousands of trays shipped annually from the St. Louis lab, 2,220 Google reviews with an excellent rating, and clinical outcomes including 64% reduction in bleeding and 86% patient recommendation rate, applied to an addressable market in which 47% of American adults have chronic periodontal disease.

Name

Perio Protect LLC

Legal name

Perio Protect, LLC

Website

https://perioprotect.com

Company type

Private

Founded year

2004

Operating status

Operating

Headcount range

11–50 employees

Short description

Perio Protect LLC designs and distributes the FDA-cleared Perio Tray and prescription dental gels for the non-invasive treatment of periodontal disease, selling primarily through certified dental providers in the United States.

Ownership category

akta.pro rank

Product category

Dental Medical Devices

NAICS

Dental Equipment and Supplies Manufacturing (339114)

SIC

Dental Equipment & Supplies (3843), Surgical & Medical Instruments & Apparatus (3841)

akta.pro primary industry

Implant Maintenance & Peri-Implantitis Treatment (HLABACAF)

akta.pro secondary industries

Oral Care Products (Toothpaste, Mouthwash, Dental Floss, Whitening) (CRADAMAA), Cosmetic & Esthetic Dentistry (Veneers/Whitening/Bonding) (HLABAAAC)

Keywords

• Periodontal disease treatment
• Dental medicament delivery
• Prescription dental trays
• Oral health products
• Gum disease therapy

Headquarters

HQ city

St Louis

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B and B2C

Offering type

Hardware or Manufacturing

Cost components

Operations, Supply Chain, Personnel, Marketing or Sales, Technology or R&D

Revenue model

1. Prescription Perio Tray System: The company manufactures and sells custom-fitted Perio Trays through certified dental providers. Dentists prescribe the treatment, take impressions, and the company's lab creates customized trays. Treatment includes both the tray system and ongoing prescription gel refills.
2. Dental Gel Refills: Ongoing revenue from prescription gels including PerioGel, PerioGelX, and ReminGel. Available through dental providers and e-commerce at periogel.net for established patients.
3. Provider Certification and Support: The company supports dental providers through training, certification, and a dedicated provider portal (providers.perioprotect.com) for practice implementation.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels8 records

Core offering

Perio Protect LLC manufactures FDA-cleared, custom-fitted Perio Tray™ medical devices and prescription dental gels for minimally invasive gum disease treatment. The patented tray features an internal seal system that delivers 1.7% hydrogen peroxide gel deep into periodontal pockets. The company also produces hydroxyapatite-based ReminGel® for tooth sensitivity and enamel repair, distributed via certified dental providers and patient e-commerce.

Product overview

Perio Protect LLC offers a unified tray-based drug delivery system for minimally invasive gum disease treatment, comprising one FDA-cleared core device — the patented Perio Tray™ — paired with multiple prescription dental gels. The Perio Tray delivers gels deep below the gum line into periodontal pockets. The gel portfolio includes PerioGel™ (original 1.7% hydrogen peroxide gel), PerioGelX™ (xylitol-enhanced mint formulation launched 2020), PerioGelX® Neutral (newly launched June 2026 neutral-flavor variant), and ReminGel® (hydroxyapatite-based enamel repair/sensitivity gel). A fluoride-based anti-cavity gel is listed as forthcoming. All gels use the same custom-fitted Perio Tray, enabling patients to switch or layer gels based on their oral health needs.

Differentiator

Problem solved

Functional benefit

Brands

• PerioGel: Prescription hydrogen peroxide-based gel (1.7%) for gum disease treatment, combating gingivitis and periodontitis below the gum line.
• PerioGelX
• PerioGelX Neutral
• ReminGel
• Perio Tray

Products and services

• Perio Tray™ FDA-cleared, custom-fitted dental tray with a patented internal seal designed to deliver prescription medication deep below the gum line into periodontal pockets. Worn 10–15 minutes daily at home; the only customized periodontal medicament carrier with FDA clearance.
• PerioGel™ Original prescription hydrogen peroxide-based gel (1.7% concentration) used with the Perio Tray to break down bacteria cell walls in periodontal pockets, reduce bleeding, and whiten teeth. Soft mint flavor; 3oz tube.
• PerioGelX™ Prescription hydrogen peroxide gel formulation with xylitol added as a sugar-free flavoring agent. Effervescent mint flavor; clinically equivalent to original PerioGel.
• PerioGelX® Neutral Neutral-flavor variant of PerioGelX designed for patients who prefer non-mint or milder flavor options while using the same hydrogen peroxide and xylitol formula with the Perio Tray.
• ReminGel® Hydroxyapatite-based prescription gel for tooth sensitivity relief and enamel repair. Fluoride-free, fills exposed dentin tubules, reduces white spot lesions. Safe for children and adults; 3–15 minute daily sessions via custom trays.

Quantifiable outcome

• 64% reduction in bleeding among Perio Protect patients
• +5 more outcomes

Named customers4 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Scale indicators4 records

Recent moves5 records

Expansion highlights4 records

Direct peers

• OraPharma: OraPharma (a Bausch Health franchise) markets ATRIDOX, a doxycycline gel placed directly into periodontal pockets. It is the closest direct therapeutic competitor to Perio Protect, addressing the same patient population with a prescription pharmacologic approach to gum disease, though delivered in-office rather than via a custom take-home tray.
• DenMat: DenMat manufactures and distributes a broad portfolio of professional dental products including restorative materials, hygiene products, and periodontal solutions sold through dental practices. Comparable to Perio Protect as a specialty dental products company selling through the same dentist-prescribed channel.
• Ultradent Products: Ultradent makes prescription and professional dental products, including periodontal therapies, desensitizers, and whitening gels, distributed via dental offices. Comparable to Perio Protect as a privately held dental products manufacturer selling prescription-grade oral care through dental providers.
• Premier Dental Products: Premier Dental manufactures preventive and periodontal products, instruments, and hygiene supplies sold through dental distributors and directly to practices. Comparable to Perio Protect as a specialty dental products manufacturer serving the same hygienist and dentist customer base with overlapping prevention-focused offerings.

Broad incumbents

• Dentsply Sirona: Dentsply Sirona is the largest global manufacturer of dental equipment, instruments, and consumables, including preventive and periodontal product lines. Comparable as a broad incumbent in the same dental supply ecosystem into which Perio Protect sells, with far greater scale and product breadth.
• Kerr Dental (Envista): Kerr Dental, part of Envista, manufactures preventive, restorative, and endodontic products used in dental offices. Comparable to Perio Protect as a dental consumables manufacturer within a larger dental platform, serving the same professional channel with adjacent product categories.
• 3M Oral Care: 3M's Oral Care division offers preventive, orthodontic, and restorative products sold through dental professionals. Comparable as a broad incumbent in the dental professional channel with the scale and R&D resources that Perio Protect lacks.
• Sunstar (GUM): Sunstar's GUM brand makes toothbrushes, interdental, and chemotherapeutic oral care products for both professional and consumer channels. Comparable as a broader oral care incumbent addressing gum health, though primarily through mechanical and rinse-based products rather than prescription tray therapy.
• Colgate-Palmolive (Colgate Professional): Colgate-Palmolive operates the Colgate Professional division, selling prescription and OTC oral care products to dental offices and patients. Comparable as the dominant oral care incumbent with the marketing scale and dentist relationships that could be redirected to compete directly with Perio Protect's prescription gel platform.
• Water Pik (Church & Dwight): Water Pik, owned by Church & Dwight, makes water flossers and other interdental cleaning devices recommended by dental professionals for at-home gum care. Comparable as a consumer-facing, dentist-recommended home oral care solution that competes for the same patient mindshare and dental recommendation.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks7 records

Key highlights7 records

Customer concentration

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Perio Protect LLC