Manifest MedEx

What Manifest MedEx does

Manifest MedEx is California's largest nonprofit health information exchange (HIE), operating a shared clinical, claims, behavioral health, and social drivers of health (SDOH) data network that connects 3,800+ healthcare organizations across all 58 California counties — including 180+ hospitals, 21 health plans, 12 county health agencies, and 3,000+ ambulatory providers. Founded in 2017 and headquartered in Riverside, California, the organization exchanges data for 52M+ individual health records and processes approximately 3.3M automated ADT (admission, discharge, transfer) notifications per month.

The platform is organized around three core products: MX Notify (real-time ADT notifications), MX Access (longitudinal patient records accessible via portal or EHR integration), and MX Analyze (population health analytics supporting HEDIS, CalAIM, and health equity reporting). Forthcoming products include MX Engage (whole person care coordination) and a statewide Social Health Information Exchange (SHIE) built on NinePatch technology. Technical infrastructure uses FHIR API-based workflows for bidirectional ADT exchange, with NCQA-validated data feeds and a 7-year HITRUST certification.

Revenue is generated through participation fees from healthcare organizations subscribing to MX Notify, MX Access, and MX Analyze under multi-year contracts with custom quote-based pricing. The organization is a state-designated Qualified Health Information Organization (QHIO) under California's Data Exchange Framework (DxF) and one of the first HIOs nationally to participate in TEFCA. Growth is driven by direct enterprise sales, an HIE affiliate program (SCHIO, OCPH-HIE), and free-tier ADT services that onboard DSA Signatories into the broader paid ecosystem. The customer base spans health plans (Anthem Blue Cross, Blue Shield CA, Inland Empire Health Plan), hospital systems (Adventist Health, Keck Medicine of USC, Children's Hospital of Orange County), IPAs, FQHCs, county health departments, and community-based organizations.

Name

Manifest MedEx

Legal name

Manifest MedEx

Website

https://manifestmedex.org

Company type

Private

Founded year

2017

Operating status

Operating

Headcount range

51–100 employees

Short description

Manifest MedEx is California's largest nonprofit health information exchange, connecting 3,800+ organizations across all 58 counties to exchange 52M+ longitudinal patient records for care coordination, public health, and value-based care.

Ownership category

akta.pro rank

Product category

Health Information Exchange

NAICS

Ambulatory Health Care Services (621)

SIC

Services-Misc Health & Allied Services, Nec (8090)

akta.pro primary industry

Clinical Document & Data Exchange (C-CDA, CCD, Direct Messaging) (HLACABAI)

Keywords

• Health information exchange
• Clinical data sharing
• Population health analytics
• Care coordination platform
• Social health information exchange

Headquarters

HQ city

Riverside

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Infrastructure, Operations, Marketing or Sales

Revenue model

1. Health Data Exchange Services: Manifest MedEx operates as a nonprofit health data utility providing data exchange services to healthcare organizations including hospitals, health plans, IPAs, medical groups, providers, and community-based organizations. Revenue is derived from participant fees for access to MX Notify (ADT notifications), MX Access (longitudinal records), and MX Analyze (analytics). The organization also serves as a designated QHIO under California's Data Exchange Framework, enabling participation in statewide data sharing requirements.

Pricing tiers

Go-to-market motion1 record

Distribution channels4 records

Marketing channels7 records

Core offering

Manifest MedEx operates a nonprofit health information exchange network that securely delivers clinical, claims, behavioral health, and social care data across California. Its core offerings include MX Notify (real-time ADT notifications), MX Access (longitudinal patient records), and MX Analyze (population health analytics), serving hospitals, health plans, IPAs, providers, counties, and community-based organizations. The network covers 180+ hospitals, 21 health plans, and 3,000+ providers across all 58 California counties.

Product overview

Manifest MedEx operates a modular health data exchange platform organized around three core products — MX Notify (real-time ADT notifications), MX Access (longitudinal health records), and MX Analyze (population health analytics) — supplemented by the upcoming MX Engage whole-person care coordination module and a NinePatch-powered Social Health Information Exchange (SHIE) for integrating social care data. The California ADT Network offers no-cost basic ADT notifications to qualifying DSA Signatories. The platform serves as California’s designated QHIO under the Data Exchange Framework and a TEFCA participant, exchanging clinical, claims, behavioral health, and social health data across 180+ hospitals, 21 health plans, 12 county health agencies, and 3,000+ providers.

Differentiator

Problem solved

Functional benefit

Brands

• MX Notify: Real-time ADT (Admission, Discharge, Transfer) notifications for care teams to coordinate care when patients are admitted to or discharged from hospitals.
• MX Access
• MX Analyze
• MX Engage

Products and services

• MX Notify Real-time automated hospital event (ADT) notification system that delivers customizable alerts to care teams when patients are admitted to, discharged from, or transferred across 180+ California hospitals in the MX network. Supports care transitions, readmission reduction, and public health interventions, with notifications accessible via MX web portal, .csv files, and data feeds.
• MX Access Longitudinal health records portal providing instant access to comprehensive patient histories including clinical visits, laboratory results, radiology reports, medications, and claims data. Records are viewable in the MX portal or can be securely connected to EHRs, population health tools, and care coordination systems. Includes medication and allergy history review to reduce adverse drug interactions.
• MX Analyze Population health analytics platform integrating clinical, claims, and SDOH data from the MX network into reports and analytics to identify care gaps, target interventions, evaluate health equity gaps, and support CalAIM. NCQA-validated data feeds designed for seamless ingestion into HEDIS engines.
• Social Health Information Exchange (SHIE) Statewide Social Health Information Exchange platform powered by NinePatch technology, integrating social drivers of health information alongside clinical, behavioral health, and claims data. Provides care assessments, program enrollment, closed-loop referrals, and consent management.
• California ADT Network Basic ADT notification service provided at no cost to Data Sharing Agreement (DSA) Signatory hospitals that both contribute and receive ADT data. Limited to organizations that share data reciprocally.

Quantifiable outcome

• 3.3 million ADT notifications delivered per month across the network
• +3 more outcomes

Named customers16 records

Segments6 records

Ideal customer profiles7 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

Feature6 records

Partnerships

Six partnerships are on record, tiered core.

• Orange County Partners in Health (OCPH) HIEcoreChannel Partner/ Reseller/ Distributor · 7 April 2026Strategic affiliation with OCPH-HIE, a DxF QHIO and part of the Coalition of Orange County Community Health Centers. OCPH-HIE participants onboard to MX’s best-in-class technology to exchange data and support connectivity and care coordination across Orange County, continuing to meet DxF data sharing requirements.
• California Mental Health Services Authority (CalMHSA)coreTechnology or Integration · 16 December 2025Bi-directional ADT exchange between MX and CalMHSA for inpatient and emergency department encounters involving individuals overseen by county behavioral health organizations. MX sends ADT messages for patients with established relationships with shared DxF participants; CalMHSA returns ADT messages for patients it serves who are also known to MX. Uses FHIR API-based matching workflow for accurate notification routing. Advances behavioral health data sharing under DxF and CalAIM.
• NinePatchcoreTechnology or Integration · 11 December 2025Exclusive partnership to launch a statewide social health information exchange (SHIE) platform powered by NinePatch technology. Integrates clinical, behavioral health, administrative, and social data including SDOH needs assessments, program enrollment, closed-loop referrals, and consent management with MX’s 50M+ longitudinal health records. Targets CalAIM’s Enhanced Care Management and Community Supports services. One large Central Valley county is the first implementation site, with planned deployment across county departments and contracted CBOs in 2026.
• FindhelpcoreTechnology or Integration · 2 December 2025Data-sharing partnership connecting Findhelp’s social care referral platform with MX’s HIE. Organizations using Findhelp can opt in to securely share SDOH data with MX; MX users gain access to verified social care data within longitudinal health records portal. Advances California’s DxF by integrating social care data with clinical records under a consent-driven model.
• Santa Cruz Health Information Organization (SCHIO)coreChannel Partner/ Reseller/ Distributor · 22 October 2025SCHIO, a nonprofit DxF QHIO based in Santa Cruz, became a MX affiliate. SCHIO’s participants onboard to MX’s technology to exchange data and support connectivity across the Bay Area and statewide. SCHIO’s affiliate status helps build the MX network by providing front-line support in connecting regional participants and guiding future direction to meet local needs.
• California State Government (SB 660)coreOthers · 8 October 2025Manifest MedEx applauded Governor Newsom for signing SB 660 to strengthen California’s Data Exchange Framework. MX played an advocacy role in shaping this legislation that enhances governance and enforcement for secure, real-time health data sharing across the state.

Scale indicators12 records

Recent moves9 records

Expansion highlights7 records

Direct peers

• CRISP (Chesapeake Regional Information System for our Patients): A nonprofit health information exchange serving Maryland, DC, West Virginia, and surrounding regions. CRISP is the closest direct peer — same nonprofit HIE model, state-level infrastructure for ADT notifications, longitudinal records, and public health reporting.
• Health Gorilla: A clinical data exchange network operating across multiple U.S. states, providing longitudinal records, ADT notifications, and interoperability services to health plans, providers, and HIEs — direct overlap with MX Notify and MX Access.
• Indiana Health Information Exchange (IHIE): One of the largest nonprofit HIEs in the U.S., operating the Indiana Network for Patient Care. Member of the Consortium for State and Regional Interoperability (CSRI) alongside Manifest MedEx, with comparable population-health and clinical-data exchange services.
• CyncHealth: A nonprofit HIE serving Nebraska, Iowa, and adjacent states. CSRI member alongside MX, offering ADT alerts, longitudinal records, and public health data exchange with similar nonprofit governance and QHIO-equivalent designations.
• New York eHealth Collaborative (NYeC): The state-designated nonprofit HIE for New York, operating the SHIN-NY. CSRI peer of Manifest MedEx with analogous role as statewide HIE backbone for hospitals, plans, and providers under state regulatory frameworks.
• Wisconsin Statewide Health Information Network (WISHIN): A nonprofit statewide HIE in Wisconsin delivering ADT notifications, longitudinal records, and analytics to providers, plans, and public health agencies — closely comparable operating model and customer mix to Manifest MedEx.
• Oregon's Reliance eHealth Collaborative: A nonprofit community-based HIE serving Oregon and southwest Washington, providing clinical data exchange, ADT notifications, and HEDIS reporting — comparable scale and customer segments to Manifest MedEx.
• Arizona Health Information Exchange (AzHIE): A nonprofit HIE serving Arizona healthcare organizations with ADT notifications, longitudinal records, and public health data sharing — same nonprofit operating model and comparable service portfolio.

Emerging players

• Bamboo Health (formerly Collective Medical): A care coordination and ADT notification platform widely deployed across U.S. hospitals and post-acute providers. Directly competitive with MX Notify in the ADT and care transitions segment, with national footprint that exceeds MX's California-only reach.
• Particle Health: An API-based clinical data exchange platform serving payers, providers, and digital health companies. Competes with MX on payer-facing longitudinal record retrieval via a national, FHIR-native API model rather than a regional HIE model.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/ManifestMedEx

Compliance4 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles7 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Manifest MedEx