Infertility Center of St. Louis

What Infertility Center of St. Louis does

The Infertility Center of St. Louis is a private, founder-owned reproductive medicine practice established in 1985 and directed by Dr. Sherman J. Silber, one of the world's most recognized infertility specialists. The center provides a comprehensive range of fertility treatments including IVF, Mini-IVF, ICSI, pre-implantation genetic diagnosis, GIFT, vitrification-based egg/embryo/sperm freezing, ovarian tissue freezing, ovary transplantation, microscopic vasectomy reversal, tubal ligation reversal, sperm aspiration, adenomyomectomy, and fertility preservation for cancer patients. It operates from St. Luke's Hospital in suburban St. Louis, Missouri, and in 2026 expanded to a new ultra-modern IVF laboratory approximately one mile from the main facility. Patients travel to St. Louis from every US state and from Europe, South America, the Middle East, Asia, and Africa.

The center's clinical technology stack is built around an IVF laboratory operational since 1985, supported by what the practice describes as among the most technically respected embryology teams in the country. Differentiated technical capabilities include exclusive US use of Piezo ICSI, vitrification brought from Japan to the United States, the Matcher chain-of-custody system for IVF process safeguarding, and the Tomorrow Machine for secure embryo and egg storage. Dr. Silber pioneered most modern infertility treatments now used worldwide, including microsurgical vasectomy reversal (1970s), the first US ICSI procedure (1990s), vitrification introduction (2000s), and the world's first ovary transplant (2010s), and has authored over 250 peer-reviewed scientific papers and ten textbooks and layman books.

The business model is fee-for-service revenue from fertility treatment cycles, microsurgical procedures, and preservation services, with acquisition driven by free initial telemedicine (Zoom/video) consultations that allow patient evaluation globally before travel. Pricing is not publicly disclosed; a dedicated financial guidance page and insurance-information contact form indicate some payor-mix activity, but international and out-of-network patients are core to the demand profile. Marketing relies heavily on PR-driven demand from television appearances (Discovery Channel, TODAY Show, Netflix), Dr. Silber's published books including "How to Get Pregnant" (over 400,000 copies sold), patient testimonials, and a multi-platform social media presence on YouTube, Instagram, Facebook, and TikTok. The practice is founder-owned with no venture capital or private equity involvement indicated in the source data.

Name

Infertility Center of St. Louis

Legal name

Infertility Center of St. Louis

Website

https://infertile.com

Company type

Private

Founded year

1985

Operating status

Operating

Headcount range

1–10 employees

Short description

The Infertility Center of St. Louis is a private reproductive medicine practice in St. Louis, Missouri, directed by Dr. Sherman Silber. Founded in 1985, it provides IVF, Mini-IVF, ICSI, fertility preservation, and microsurgical procedures to infertile couples and cancer patients traveling from across the US and internationally.

Ownership category

akta.pro rank

Product category

Reproductive Medicine and Fertility Treatment Services

NAICS

Offices of Physicians (except Mental Health Specialists) (621111)

SIC

Services-Offices & Clinics Of Doctors Of Medicine (8011)

akta.pro industry

PRIMARYHLAFAJAD

Fertility, Reproductive Endocrinology & IVF Centers

Healthcare & Life Sciences/Healthcare Providers & Systems/Women’s & Children’s Health Providers

SECONDARYHLAKAJAC

Reproductive Endocrinology & Infertility (IVF/Fertility)

Healthcare & Life Sciences/Specialist Medical Practice/Obstetrics & Gynecology (OB/GYN)

Keywords

• Fertility treatments
• In vitro fertilization
• Reproductive medicine
• Egg freezing services
• Male infertility treatment

Headquarters

HQ city

Saint Louis

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. IVF and Fertility Treatment Services: Core medical services including IVF, Mini-IVF, ICSI, egg/embryo freezing, fertility preservation, microsurgery procedures, and consultations

Pricing tiers

Go-to-market motion1 record

Distribution channels3 records

Marketing channels6 records

Core offering

The Infertility Center of St. Louis is a private reproductive medicine practice that provides a full range of fertility diagnosis and treatments, including IVF, Mini-IVF, ICSI, PGD, GIFT, egg/embryo/sperm and ovarian tissue cryopreservation via vitrification, ovary transplantation, cancer-patient fertility preservation, microscopic vasectomy reversal, tubal ligation reversal, sperm aspiration, donor egg and gestational surrogacy services, and adenomyomectomy. Treatment is anchored at St. Luke's Hospital in suburban St. Louis with a separate ultra-modern IVF laboratory nearby, supported by telemedicine and Zoom consultations that allow patient evaluation globally.

Product overview

The Infertility Center of St. Louis is a medical practice offering a comprehensive range of fertility treatments and reproductive medicine services. The center provides both surgical and non-surgical treatments including IVF (In-Vitro Fertilization), Mini-IVF (minimal stimulation IVF), ICSI (Intra Cytoplasmic Sperm Injection), Pre-implantation Genetic Diagnosis (PGD), GIFT, egg/embryo/sperm freezing via vitrification, ovarian tissue freezing and transplantation, fertility preservation for cancer patients, microscopic vasectomy reversal, tubal ligation reversal, sperm aspiration for ICSI, donor eggs and gestational surrogacy, and adenomyosis/fibroids treatment. The center emphasizes its pioneering techniques and cost-effective approaches, with Dr. Sherman Silber having developed many of the modern infertility treatments used worldwide.

Differentiator

Problem solved

Functional benefit

Products and services

• IVF (In-Vitro Fertilization) In-vitro fertilization procedure in which the husband's sperm fertilize the wife's eggs outside the body (in a test tube or culture dish), and the resulting embryos are returned to her uterus. Offered to couples seeking assisted conception.
• Mini-IVF Minimal Stimulation IVF technique designed to recruit fewer but high-quality eggs, avoiding the risks of ovarian hyperstimulation, reducing the number of injections, and dramatically reducing cost relative to conventional IVF.
• ICSI (Intra Cytoplasmic Sperm Injection) Procedure in which a single sperm is injected directly into the egg, solving most or all cases of male infertility. At this center it is performed using Piezo ICSI technology, the only U.S. site employing this method, which avoids egg damage.
• PGD (Pre-implantation Genetic Diagnosis) Genetic analysis performed on a single cell from an 8-cell embryo to determine whether the embryo is genetically normal before transfer, used to screen for chromosomal and single-gene disorders in IVF embryos.
• GIFT (Gamete Intra-Fallopian Transfer) Procedure in which eggs and sperm are transferred directly into the fallopian tube so that fertilization occurs naturally within the body, offered as an alternative to standard IVF for select patients.
• Egg, Embryo, and Sperm Freezing (Vitrification) Cryopreservation of eggs, embryos, and sperm using vitrification, a technique that avoids intracellular ice crystal formation and the resulting cellular damage, offered to patients seeking fertility preservation.
• Ovarian Tissue Freezing Outpatient procedure in which a thin cortex of the ovary is extracted and frozen for later re-grafting to restore fertility, used primarily for cancer patients or others needing urgent fertility preservation.
• Ovary Transplantation Transplantation of previously frozen ovarian tissue to restore or preserve fertility using advanced cryogenic technology. The center states it is the only center in the world that can transplant ovary tissue reliably.
• Antral Follicle Counting Brief, painless ultrasound procedure used to determine precisely where a woman is on her biological clock and how long her natural fertility is expected to last, provided for women seeking fertility assessment.
• Fertility Preservation for Cancer Patients Specialized fertility preservation program for patients whose cancer treatment (chemotherapy or radiation) may affect reproductive capacity, combining egg, embryo, sperm, and ovarian tissue freezing options.
• Microscopic Vasectomy Reversal (MVR) Microsurgical repair of the vas deferens under high-powered magnification to restore fertility in men who previously underwent vasectomy, with reported success rates above 95%.
• Tubal Ligation Reversal Microsurgical reversal of tubal ligation via a small incision, restoring fertility for women who previously underwent the procedure, typically with one day of hospitalization.
• Sperm Aspiration for ICSI Direct retrieval of sperm from the testicle or epididymis (including TESE/micro-TESE techniques) for use with ICSI, effectively eliminating male factor infertility even when little or no sperm is present in the ejaculate.
• Donor Eggs & Gestational Surrogacy Coordinated donor egg and gestational surrogacy services for couples requiring third-party reproduction to achieve pregnancy.
• Adenomyomectomy (Fibroids and Adenomyosis Treatment) Surgical procedure to remove adenomyosis while preserving the uterus and maintaining fertility, performed using the Osada procedure pioneered in Japan, offered to women with previously considered inoperable adenomyosis or large fibroids.

Quantifiable outcome

• Over 95% success rate for microsurgical vasectomy reversal
• +2 more outcomes

Named customers2 records

Segments5 records

Ideal customer profiles5 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Scale indicators7 records

Recent moves8 records

Expansion highlights4 records

Direct peers

• CCRM (Colorado Center for Reproductive Medicine): National fertility network operating own IVF labs and offering IVF, ICSI, PGD, egg freezing, and male infertility services. Competes for the same complex-case, premium patient segment as the Infertility Center of St. Louis with a multi-site, technology-marketed model.
• Boston IVF: Multi-site US fertility practice offering the full range of ART services including IVF, ICSI, PGD, egg/embryo freezing, and donor services. Directly comparable clinical offering with academic affiliations, competing for complex infertility referrals.
• CNY Fertility: Fertility clinic known for low-cost IVF pricing and global medical-tourism patient flow. Directly competes with the Infertility Center of St. Louis for cost-sensitive and travel-in patients seeking affordable IVF.
• New Hope Fertility Center: NYC-based fertility clinic well known for pioneering Mini-IVF (minimal stimulation), the same protocol the Infertility Center of St. Louis promotes. Closest direct competitor on the cost-efficient Mini-IVF positioning and global inbound patient model.
• Shady Grove Fertility (now part of US Fertility): One of the largest US fertility clinic networks offering IVF, ICSI, egg freezing, and fertility preservation across multiple states. Directly comparable full-service reproductive medicine offering, but with vastly greater scale and geographic footprint than the Infertility Center of St. Louis.
• Reproductive Medicine Associates (RMA Network): Large multi-site US fertility network with strong R&D programs, IVF, ICSI, PGT, and fertility preservation services. Comparable full-service reproductive medicine offering backed by significant clinical research output.

Emerging players

• Kindbody: Tech-forward, venture-backed fertility clinic operator with employer-benefit partnerships and growing multi-site footprint. Comparable IVF/IUI/egg-freezing services but positioned to disrupt traditional boutique clinics on price and employer-channel distribution.
• Extend Fertility: Specialty egg-freezing and fertility preservation clinic with a tech-driven, direct-to-consumer marketing model. Comparable only in the egg-freezing segment the Infertility Center of St. Louis also serves, but focused narrowly on elective preservation.

Broad incumbents

• Prelude Fertility: Multi-site fertility network offering IVF, egg freezing, and fertility preservation with employer-benefit partnerships. Comparable service portfolio but more distributed, employer-channel-focused model versus the St. Louis boutique approach.

Others

• Genea Biomedx: Developer and supplier of assisted reproductive technology instruments and lab consumables (e.g., Gavi vitrification system). Not a clinical peer but an adjacent technology provider whose vitrification and lab automation competes with/relates to the Infertility Center of St. Louis's proprietary freezing and chain-of-custody technologies.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights7 records

Customer concentration

• YouTubeyoutube.com/channel/UCfmqNkEnhy098JF-nW9SAZQ
• Facebookfacebook.com/InfertilityCenterSt.Louis
• Instagraminstagram.com/silberinfertility
• TikToktiktok.com/@silberinfertility
• LinkedInlinkedin.com/company/infertility-center-of-st.-louis

Revenue estimate

Valuation estimate

Number of profiles

Profiles3 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Infertility Center of St. Louis