What Dermophisiologique does

Dermophisiologique is an Italy-based professional cosmetics company founded in 1985 and headquartered in Bollate (Milan), operating as a Società Benefit (Srl SB) since 2015 with B Corp certification. The company develops and distributes professional skincare formulations, nutricosmetics (INSKIN), specialized oncology skincare (ONTHERAPY), and aesthetic devices (MESODERM-PRO), targeting both licensed aesthetic professionals and end consumers.

The company's competitive platform is anchored by the proprietary D4S Method — a diagnostic-to-treatment protocol delivered through training and certification programs to a partner network of aesthetic centers. Underlying formulation technology includes the PeptiHyal-System ingredient platform, and the MESODERM-PRO Mesosonic System represents a hardware extension into device-based aesthetic services. The operating model is dual-channel: business-to-business sales through certified partner clinics and centers in Italy and approximately 20 EMEA countries, alongside direct-to-consumer e-commerce. The DTC site historically supported cross-border orders; international online fulfillment has been suspended since December 2021, concentrating e-commerce activity on the Italian market.

Dermophisiologique generates revenue from product sales (skincare SKUs, supplements) and increasingly from device sales via the Mantis partnership, with no disclosed pricing model or revenue figures. The company operates at SME scale (11–50 employees, €52,000 share capital), is privately held with no recorded outside funding, and has no disclosed M&A or leadership changes. ESG positioning (B Corp, Srl SB, ISO 9001) is a stated element of brand identity but is not separately monetized in the available data.

Name

Dermophisiologique

Legal name

Dermophisiologique Srl SB

Website

https://dermophisiologique.it

Company type

Private

Founded year

1985

Operating status

Operating

Headcount range

11–50 employees

Short description

Dermophisiologique is an Italian professional cosmetics company (founded 1985, Bollate/Milan; B Corp since 2015) that develops and distributes professional skincare, the ONTHERAPY oncology line, INSKIN supplements, and the MESODERM-PRO aesthetic device through partner aesthetic centers in ~20 EMEA countries and Italian DTC e-commerce.

Ownership category

akta.pro rank

Product category

Professional Skincare Cosmetics

NAICS

Cosmetics, Beauty Supplies, and Perfume Retailers (45612)

SIC

Soap, Detergents, Cleang Preparations, Perfumes, Cosmetics (2840)

akta.pro primary industry

Professional Skincare & Facial Treatments (CRABALAF)

akta.pro secondary industries

Professional/Backbar Skincare (Esthetician & Spa Use) (CRABAAAK), Dermocosmetics & Medical-Grade Skincare (CRABAAAF), Body Skincare (Lotions, Creams, Body Oils) (CRABAAAD)

Keywords

• Professional skincare cosmetics
• Dermatological cosmetic products
• Anti-aging skincare lines
• Aesthetic treatment devices
• Beauty food supplements

Headquarters

HQ city

Bollate

HQ country

Italy

HQ region

Europe

Offices2 records

Markets served

GTM type

B2B and B2C

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Personnel, Technology or R&D, Marketing or Sales, Operations

Revenue model

1. Direct-to-Consumer E-commerce Sales: Online sales of professional cosmetics through shop.dermophisiologique.it to end consumers. Products include face care, body care, sun protection, and dietary supplements (Inskin line).
2. B2B Product Sales to Partner Centers: Sales of professional products to partner aesthetic centers, beauty centers and SPAs that use Dermophisiologique methodologies and treatments.
3. Professional Training Services: Training and support services for partner aesthetic professionals through the D4S Method, providing tools to enhance professional skills.

Pricing tiers

Go-to-market motion2 records

Distribution channels4 records

Marketing channels9 records

Core offering

Dermophisiologique researches, develops, manufactures, and distributes professional dermatological cosmetic products and treatment methodologies. The company sells comprehensive skincare and body care product lines (face, body, sun protection, beauty supplements) directly to consumers via its e-commerce platform and through a network of certified partner aesthetic centers, beauty centers and SPAs. It also offers the proprietary Metodo D4S training program and the MESODERM-PRO professional device for aesthetic professionals.

Product overview

Dermophisiologique is an Italian professional cosmetics company with over 40 years of experience in dermatological research. The company offers a comprehensive skincare portfolio organized into distinct product lines for face (AQUALIFE, NUTRICARE, SENSIDERM, SEBOLINE, CHRONO AGE®, D WHITE, RESURFACE, SKIN PERFECTION, OPTYMA, D MAN, ACTIVE AGE, IO) and body care (AQUALIFE, NUTRICARE, CHRONO AGE®, RESURFACE, IO, ADIPEXPERT, BALNEOIL, OSMODERM, XTRA TONE, CELLULHITECH, DREN ACTIVE, SENO 3D, MANIDERM), plus a SOLARI sunscreen line. Specialized sub-brands include ONTHERAPY® for oncology patients and INSKIN for beauty food supplements. Professional offerings include the MESODERM-PRO Mesosonic System (needle-free mesotherapy device with ultrasound) and the patented D4S® Method for aesthetics professionals.

Differentiator

Problem solved

Functional benefit

Brands

• ONTHERAPY®: A skincare line specifically formulated for skin care during and after oncology therapies, including cleansers, emollients, lenitives, anti-desquamation creams, and SPF 50+ sun sticks.
• INSKIN

Products and services

• AQUALIFE Hydration-focused skincare line for dry and dehydrated skin, providing deep moisturization for all skin types.
• NUTRICARE Intensive nourishing line for alipic (oil-deficient) skin, featuring shea butter-based formulas.
• SENSIDERM Skincare line for sensitive, reactive and intolerant skin, including products for erythrosis and couperose.
• SEBOLINE Line for oily and impure skin with comedones, featuring salicylic acid and purifying cleansers.
• CHRONO AGE Anti-aging line for all skin types and signs of aging, particularly during high-stress periods.
• D WHITE Brightening and unifying line targeting brown spots and skin discolorations, with anti-age action and UV protection.
• ACTIVE AGE Pro-aging line featuring exclusive PeptiHyal-System complex for comprehensive personalized aging management.
• ADIPEXPERT Body contouring line targeting localized adiposity with maca extract and pink pepper lipolytic cream.
• DREN ACTIVE Draining line for heavy and swollen legs with refreshing spray and cream formulations.
• CELLULHITECH Anti-cellulite line with melilot and phosphatidylcholine for body remodeling.
• SENO 3D Breast and décolleté firming and remodeling line.
• MANIDERM Hand care line for all skin types with anti-aging and nail treatment products.
• SOLARI Sunscreen Line Sun protection line including SPF 50+ face cream, SPF 50+ body cream, SPF 30 cream, spray oil, and after-sun soothing cream.
• ONTHERAPY Dermo-cosmetic line specifically formulated for oncology patients and those undergoing cancer therapy, including cleanser, lenitivo (soothing), emollient, anti-desquamation, deodorant and SPF 50+ stick.
• INSKIN Food supplement line for skin, hair, and nail wellness, including collagen drinkables (Collagen 50>, VitaCollagen+) and Dr3n draining supplement.
• MESODERM-PRO Mesosonic System 100% Made in Italy professional device combining mesoporation (needle-free mesotherapy) and ultrasound technology with two handpieces for face and body treatments. Developed in partnership with Mantis.
• Metodo D4S Proprietary training method developed to enhance scientific, technical and management skills of aesthetics professionals, aesthetic centers, wellness centers and SPAs.

Quantifiable outcome

• 90% of volunteers reported COMPACT SKIN, 85% REGENERATED SKIN, 90% FIRMED SKIN, 85% SMOOTH AND LEVELED SKIN after using GLOBAL-ACTIVE products for 28 days
• +2 more outcomes

Named customers4 records

Segments5 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration5 records

Feature4 records

Partnerships

Six partnerships are on record, tiered core and minor.

• MantiscoreStrategic or Co-development PartnerCollaboration with Mantis for the development of MESODERM-PRO Mesosonic System. Mantis contributes expertise in continuous research for new performing and cutting-edge technologies in the aesthetic field. The resulting product is 100% Made in Italy.
• AssobenefitminorOthersMember of Assobenefit, the association of Italian benefit companies. Collaborates with other B Corps and industry groups for research, training, sustainable innovation and knowledge sharing.
• B Beauty CoalitionminorOthersParticipates in B Beauty Coalition along with other B Corp companies for collective impact initiatives in the beauty industry.
• TNT ( TNT Italy)minorOthersShipping partner for domestic (Italy) and international (EMEA) deliveries. Standard shipping within 72 hours.
• Facebook, Inc.minorGTM or Marketing PartnerFacebook Ads conversion tracking service for measuring advertising performance and campaign effectiveness.
• Google LLCminorGTM or Marketing PartnerGoogle AdWords conversion tracking service for measuring advertising performance from Google advertising network.

Scale indicators4 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• Mesoestetic Pharma Group: Spanish professional skincare and dermo-cosmetic company serving aesthetic centers and medical-aesthetic clinics with both products and professional devices. Comparable on professional channel, dermatological R&D emphasis, and integrated device-plus-skincare offering.
• Collistar: Italian professional cosmetics brand sold through both DTC e-commerce and a network of beauty centers/beauty advisors. Closely comparable business model: professional skincare, hybrid DTC + B2B partner network, Italy-headquartered with international reach.
• Germaine de Cappuccini: Spanish professional skincare company operating through a partner-center network of aesthetic institutes and spas with proprietary treatment protocols. Closely comparable on professional B2B partner model and European cross-border distribution.
• Sothys: French family-owned professional skincare brand with a global network of partner aesthetic institutes and spas selling its products and protocols. Comparable on partner-center business model, professional training programs, and Made-in-Europe heritage.
• Institut Esthederm (NAOS): French professional dermo-cosmetic brand sold through aesthetic centers, spas, and selective retail with a physiology-led skincare philosophy. Comparable on professional-channel distribution, dermatological positioning, and physiology-respectful product narrative.
• Comfort Zone (Davines Group): Italian B Corp-certified professional skincare brand with a partner-spa/aesthetic center network and a strong sustainability positioning. Directly comparable to Dermophisiologique on B2B channel model, B Corp certification, and Made-in-Italy professional heritage.

Emerging players

• Medik8: British professional skincare brand combining clinical actives (vitamin C, retinoids, peptides) with a professional partner-network and DTC e-commerce. Comparable on professional-channel skincare with clinical efficacy positioning, though at a different scale stage.
• iS Clinical (Innovative Skincare): American professional skincare brand distributed through medical spas, physicians, and aesthetic centers with clinically tested formulations. Comparable on professional-spa distribution model and clinical efficacy-led marketing, serving a similar professional channel.
• Caudalie: French natural dermocosmetic brand with a pharmacy and spa distribution presence and an emphasis on natural/physiological active ingredients. Comparable on the natural physiology-led skincare narrative and European multi-channel distribution.

Broad incumbents

• Bioderma (NAOS): Large French dermocosmetic brand sold through pharmacies and professional channels, focused on skin biology and physiology-led formulations. Comparable on dermatological/physiology positioning but operates at significantly larger scale across broader retail channels.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

• YouTubeyoutube.com/channel/UC
• Instagraminstagram.com/dermophisiologique
• Xx.com/dermoPH_Italia
• Facebookfacebook.com/dermophisiologique
• LinkedInlinkedin.com/company/dermophisiologique-cosmetics

Compliance5 records

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Dermophisiologique