What US Oncology does

The US Oncology Network is the largest national network of independent community-based oncology practices in the United States, operating as a wholly-owned subsidiary of McKesson Corporation (NYSE: MCK). Founded in 1992 and headquartered in The Woodlands, Texas, the Network supports over 3,300 affiliated providers across 750+ sites of care, treating more than 2 million patients annually and reaching approximately 45% of the U.S. population within a 20-mile radius of a member practice. Member practices maintain clinical independence while accessing centralized infrastructure, capital, and operational support through Comprehensive Strategic Alliance (CSA) and Radiation Joint Venture (JV) affiliation models. The Network operates an integrated practice management technology stack including the iKnowMed electronic health record (FHIR-enabled) and Practice Insights, a CMS-designated Qualified Clinical Data Registry (QCDR) offering nine oncology-specific quality measures, both powered by McKesson's Ontada data business.

The business model centers on a Management Services Organization (MSO) structure delivering practice management, revenue cycle management, value-based care contracting, and clinical research operations to member practices. Revenue is generated through MSO service fees, Unity Group Purchasing Organization (GPO) rebates (averaging 26% growth since 2019), performance-based payments under value-based care arrangements (including the Enhancing Oncology Model, which delivered $88 million in gross Medicare savings), and clinical trial revenue through the Sarah Cannon Research Institute joint venture with HCA Healthcare. The Network committed $114 million in capital investments in 2025 alone to expand member practice capabilities.

Technology and AI deployments are increasingly central to operations. DeepScribe ambient AI documentation serves over 1,000 providers and saves 2-3 hours per week per clinician. The Precision Care Companion program, launched in April 2025, extends into biomarker-directed precision oncology across 12 practices. AI-driven prior authorization automation, NLP-based digital quality measurement, and EMR-integrated liquid biopsy results delivery represent the active technology surface. Sarah Cannon Research Institute operates 500+ active oncology trials across the Network, with 88,000+ patients cumulatively enrolled and contributions to 100 FDA-approved cancer therapies. Customer acquisition occurs through physician-led referral networks, industry events (ASCO, COA, McKesson Accelerate), and direct enterprise outreach to independent practices seeking infrastructure support.

Name

US Oncology

Legal name

The US Oncology Network

Website

https://usoncology.com

Company type

Private

Founded year

1998

Operating status

Operating

Headcount range

5,001–10,000 employees

Short description

The US Oncology Network is a McKesson-owned network of 750+ community oncology practice sites and 3,300+ affiliated providers serving 2M+ patients annually. It operates as an MSO delivering practice management, Unity GPO purchasing, value-based care contracting, and Sarah Cannon clinical trial access to independent oncology practices across the United States.

Ownership category

akta.pro rank

Product category

Oncology Practice Management Services

NAICS

Specialty (except Psychiatric and Substance Abuse) Hospitals (622310)

SIC

Services-Health Services (8000), Services-Offices & Clinics Of Doctors Of Medicine (8011)

akta.pro primary industry

Oncology Remote Symptom Monitoring & Care Navigation (HLALAFAD)

akta.pro secondary industry

Hospital-Integrated Cancer Centers (Acute Oncology Programs) (HLAFAAAM)

Keywords

• Oncology practice management
• Community cancer care
• Clinical research services
• Specialty drug purchasing
• Value-based oncology care

Headquarters

HQ city

The Woodlands

HQ country

United States

HQ region

North America

Offices3 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Marketing or Sales, Infrastructure

Revenue model

1. Management Services Organization (MSO) Fees: The Network operates as an MSO providing practice management, administrative, and operational support to independent oncology practices. Practices pay for access to infrastructure, purchasing power, technology, and support services while maintaining independence.
2. Unity Group Purchasing Organization (GPO): Through Unity GPO, practices gain access to competitive pricing on drugs and services. The GPO generates revenue through strategic contracting and rebate programs. Since 2019, practices have seen average rebate growth of 26%.
3. Value-Based Care Contracts: Practices participate in value-based care arrangements including Enhancing Oncology Model (EOM). Network delivers $88 million in gross savings for Medicare compared to benchmark. Practices earn performance-based payments through managed care contracts.
4. Clinical Research Operations: Through partnership with Sarah Cannon Research Institute, practices offer clinical trials. The Network simplifies research through centralized operational support, staffing optimization, and advanced technology.
5. Capital Investment Returns: The Network provides capital investments to practices for infrastructure upgrades, service line expansion, and geographic growth. Practices benefit from lower cost of capital compared to prime rate.

Go-to-market motion3 records

Distribution channels3 records

Marketing channels7 records

Core offering

The US Oncology Network operates as a Management Services Organization that supports a national network of more than 3,300 affiliated providers across 750+ community oncology sites, supplying independent practices with practice management infrastructure, group purchasing through Unity GPO, clinical research access via the Sarah Cannon Research Institute joint venture, revenue cycle management, value-based care program participation, and proprietary technology such as the iKnowMed EHR and Practice Insights QCDR analytics platform.

Product overview

The US Oncology Network is a national network of independent community oncology practices supported by McKesson, providing practice management, technology solutions, and clinical support. The core technology stack includes iKnowMed EHR for clinical documentation and Practice Insights QCDR for quality reporting and analytics. Key supporting services include Unity Group Purchasing Organization for drug procurement, Revenue Cycle Management for billing, and Sarah Cannon Research Institute for clinical trials. The Network has launched Precision Care Companion for precision medicine and deployed DeepScribe AI for ambient documentation. McKesson Accelerate serves as the annual industry conference.

Differentiator

Problem solved

Functional benefit

Brands

• Unity Group Purchasing Organization: A leading GPO dedicated to community oncology practices offering competitive pricing on essential drugs and services.
• Unity GPO
• US Oncology Research
• Precision Care Companion

Products and services

• Practice Insights (QCDR) Performance analytics tool powered by Ontada that serves as a Qualified Clinical Data Registry for MIPS reporting, collecting and reporting clinical data for clinicians using the iKnowMed EHR. Offers nine oncology-specific QCDR measures to drive improvements in quality and cost of care.
• iKnowMed Electronic Health Record Oncology-specific electronic health record system used by network practices for clinical documentation, scheduling, and patient management. Provides structured data enabling AI-powered quality measures and supports FHIR interoperability standards for clinical data exchange.
• Precision Care Companion A precision medicine initiative integrating education, clinical support, technology, data analytics, and best practices to advance personalized biomarker-directed cancer care in community oncology settings. Addresses clinical challenges and administrative burden in precision oncology.
• Unity Group Purchasing Organization (GPO) Group purchasing organization providing community oncology practices with competitive pricing on drugs and services through strategic contracting, data-driven purchasing tools, pharmacy support teams, and real-time contract updates. Practices have seen average rebate growth of 26% since 2019.
• Sarah Cannon Research Institute (SCRI) Clinical Trials Clinical research organization joint venture providing access to more than 500 active oncology clinical trials across the network at any given time, with 2,000+ cancer clinical trials offered and 88,000+ patients enrolled in communities. Has contributed to 100 FDA-approved cancer therapies.
• Revenue Cycle Management (RCM) Services Comprehensive billing and reimbursement services covering claims submission, denial management, and regulatory compliance using automation, analytics, and compliance tools to support independent oncology practice revenue operations.
• DeepScribe AI Ambient Documentation Ambient AI noting technology that captures clinical conversations and automatically generates documentation, helping reduce provider documentation time by 2-3 hours per week and addressing provider burnout across network practices.
• McKesson Accelerate Conference Premier annual conference for community oncology practices at Wynn Las Vegas bringing together more than 1,000 physicians, clinicians, practice leaders and industry experts for leadership sessions, networking, and peer-to-peer learning.

Quantifiable outcome

• $88 million in gross savings for Medicare compared to benchmark through Enhancing Oncology Model (EOM) periods 1 & 2
• +8 more outcomes

Named customers13 records

Segments3 records

Ideal customer profiles1 record

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

AI capability6 records

Feature6 records

Partnerships

Five partnerships are on record, tiered core and minor.

• Sarah Cannon Research Institute (SCRI)coreStrategic or Co-development Partner · 31 October 2022Joint venture between McKesson and HCA Healthcare combining US Oncology Research and Sarah Cannon Research Institute. Creates fully integrated oncology research organization expanding clinical research, accelerating drug development, and increasing availability of clinical trials for community oncology providers and patients.
• OntadacoreTechnology or IntegrationMcKesson's real-world oncology data and insights business. Powers Practice Insights QCDR with performance analytics. Provides iKnowMed EHR integration and FHIR interoperability standards for clinical data exchange.
• Unity Group Purchasing Organization (GPO)coreStrategic or Co-development PartnerLeading GPO dedicated to community oncology practices. By joining The Network, practices join Unity GPO and gain access to savings on drugs and services, strategic partnerships, and comprehensive support. Central to The Network's financial strategy.
• HCA HealthcarecoreStrategic or Co-development PartnerJoint venture partner with McKesson in Sarah Cannon Research Institute. Combines clinical research capabilities to expand access to clinical trials for community oncology providers and patients, including those in underserved communities.
• American Society of Clinical Oncology (ASCO)minorOthersThe Network presents research at ASCO Annual Meeting. Dr. Debra Patt serves as COA President and discusses oncology topics. Network participates in ASCO quality improvement initiatives and educational sessions.

Scale indicators17 records

Recent moves7 records

Expansion highlights8 records

Direct peers

• Sarah Cannon Research Institute: Sarah Cannon is the joint-venture clinical research organization combining US Oncology Research with HCA's research arm — directly comparable as a community-based oncology clinical trials network, and now structurally integrated with The Network.
• Flatiron Health: Flatiron Health, a Roche subsidiary, provides oncology-specific EHR, real-world data, and clinical trial technology — directly comparable to The Network's iKnowMed EHR, Practice Insights QCDR, and Ontada real-world data capabilities, and competes for oncology data and technology contracts.
• Florida Cancer Specialists & Research Institute: FCS is one of the largest independent community oncology practices in the US, recently joined The Network, but historically operated its own large-scale clinical trials and practice management — comparable as a direct peer representing the type of large independent practice The Network competes to attract.
• Regional Cancer Care Associates (RCCA): RCCA is one of the largest physician-led community oncology networks in the US, offering multi-specialty oncology care, clinical trials, and value-based care programs — comparable to The Network as a competing regional/national community oncology practice platform.
• OneOncology: OneOncology is a national network of independent community oncology practices offering practice management, GPO, clinical trials, and value-based care support — the closest direct competitor to The US Oncology Network's MSO model, often competing head-to-head for the same independent practice recruits.

Broad incumbents

• HCA Healthcare: HCA Healthcare is a large national hospital system and Sarah Cannon JV partner, operating oncology programs across its facilities — comparable as a broad incumbent that combines hospital-based oncology with the Sarah Cannon clinical trials network overlapping with The Network.
• McKesson Corporation: McKesson is the parent company and a Fortune 9 diversified healthcare services firm that owns The Network and provides infrastructure, capital, specialty drug distribution, and Ontada — a broader incumbent providing oncology distribution, practice management, and technology at scale across the US.
• Cardinal Health: Cardinal Health operates specialty pharmaceutical distribution and has oncology practice services (Navista) supporting community oncology — comparable as a broad incumbent with overlapping specialty drug distribution and oncology practice support capabilities.
• Cencora (formerly AmerisourceBergen): Cencora is a leading pharmaceutical distributor with specialty/oncology distribution and practice support services (ION Solutions / Specialty Provider Services) — comparable as a broad incumbent that competes with McKesson and Unity GPO in serving community oncology practices.
• City of Hope: City of Hope is a leading specialty cancer hospital and research center that has acquired community oncology practices including Cancer Treatment Centers of America — comparable as a broad incumbent oncology provider combining academic-grade specialty care with community reach.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat7 records

Customer concentration

• Xx.com/theusonetwork
• YouTubeyoutube.com/channel/UCllQZ0OLFbed9P7JVVQKQmw
• Facebookfacebook.com/theusoncologynetwork
• LinkedInlinkedin.com/company/us-oncology

Revenue estimate

Valuation estimate

Number of profiles

Profiles10 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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Frequently asked questions about US Oncology