UsAgainstAlzheimer's

What UsAgainstAlzheimer's does

UsAgainstAlzheimer's (UsA2) is a 501(c)(3) nonprofit founded in 2010 and headquartered in Washington, DC, focused on catalyzing change in the Alzheimer's and dementia health ecosystem through prevention, early detection, and access to treatments, with a particular emphasis on health equity for women and communities of color. The organization operates a portfolio of digital platforms, including BrainGuide / MyBrainGuide (a confidential memory questionnaire available online or by phone in English and Spanish, with tailored education and a clinical trial connector), the A-LIST patient- and caregiver-led research network, the AD-PACE engagement initiative, the Brain Health Academy for healthcare professionals (with CME/CE credits), and the National Alzheimer's Disease Index (NADEX), a Medicare-data analytics tool for health-equity research. MyBrainGuide's 2026 expansion integrates Synapticure and Isaac Health for direct specialist access across all 50 states.

Its business model is donor- and member-supported: it generates revenue through tax-deductible individual donations, three membership tiers ($25/year Member, $100/year Ally, $10/month Champion), corporate sponsorships (Biogen, Bristol Myers Squibb, Eisai, Eli Lilly, Johnson & Johnson as Summit sponsors), and a CDC cooperative agreement supporting the Center for Brain Health Equity. All core programs are provided free to the public. The organization also convenes a portfolio of large cross-sector consortiums — the LEAD Coalition (now 280+ member organizations, 3M+ individuals reachable), the Global CEO Initiative on Alzheimer's Disease (CEOi), the Davos Alzheimer's Collaborative, and the Global Alliance on Women's Brain Health — that constitute its primary structural and competitive assets. In 2026, the organization is undergoing a leadership transition: Russ Paulsen was named President and COO in February 2026, followed by Co-Founder and Chairman George Vradenburg's announced transition in April 2026.

Name

UsAgainstAlzheimer's

Legal name

UsAgainstAlzheimer's

Website

https://usagainstalzheimers.org

Company type

Private

Founded year

2010

Operating status

Operating

Headcount range

11–50 employees

Short description

UsAgainstAlzheimer's is a 501(c)(3) nonprofit that runs digital brain-health platforms (BrainGuide, A-LIST, NADEX), convenes major Alzheimer's coalitions and consortiums, and advocates for prevention, early detection, and treatment access, with a focus on health equity for women and communities of color.

Ownership category

akta.pro rank

Product category

Alzheimer's Advocacy and Brain Health Nonprofit Services

NAICS

Services for the Elderly and Persons with Disabilities (624120), Other Individual and Family Services (624190)

SIC

Services-Home Health Care Services (8082)

akta.pro primary industry

Dementia/Alzheimer’s Care Management & Behavioral Support (HLADALAF)

akta.pro secondary industries

Memory Care Care Management & Navigation (Dementia Care Coordination) (HLADACAJ), Dementia Care Coordination & Care Planning (HSABAEAJ), Cognitive Stimulation & Reminiscence Therapy (Non-Clinical) (HSABAEAH)

Keywords

• Alzheimer's advocacy
• Brain health education
• Dementia early detection
• Patient research networks
• Health equity programs

Headquarters

HQ city

Washington

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Marketing or Sales, Operations, Technology or R&D, Others

Revenue model

1. Donations and Membership Program: The organization generates revenue through tax-deductible donations from individuals, membership program fees (starting at $25/year for Member level, $100/year for Ally level, and $10/month for Champion level), and other giving mechanisms including matching gifts, stocks and securities, donor advised funds, and legacy gifts.

Pricing tiers

Go-to-market motion1 record

Distribution channels4 records

Marketing channels10 records

Core offering

UsAgainstAlzheimer's is a 501(c)(3) nonprofit that delivers free brain health education, early detection tools, patient and caregiver engagement programs, and policy advocacy to stop Alzheimer's. Its flagship offering is BrainGuide/MyBrainGuide, a confidential memory questionnaire platform available online and by phone in English and Spanish that provides tailored brain health resources and connects users to dementia specialists. The organization also operates the A-LIST research network, Brain Health Academy courses for healthcare professionals, the National Alzheimer's Disease Index data tool, and convenes major coalitions including the LEAD Coalition and Global CEO Initiative on Alzheimer's Disease.

Product overview

UsAgainstAlzheimer's is an advocacy organization offering a portfolio of digital products and programs centered on prevention, early detection, and access to treatments for Alzheimer's disease. The core digital product is BrainGuide/MyBrainGuide, a first-of-its-kind brain health platform featuring a confidential memory questionnaire available over the phone or online in English or Spanish, with tailored education and resources. The platform connects users to dementia specialists through integrations with Synapticure and Isaac Health, and includes a clinical trial connector. Complementary programs include the A-LIST patient/caregiver research network, AD-PACE engagement initiative, and Brain Health Academy educational courses. Major convened initiatives include the Global CEO Initiative on Alzheimer's Disease (CEOi), LEAD Coalition of over 90 organizations, and Davos Alzheimer's Collaborative. The Center for Brain Health Equity and Advancing Women's Brain Health Initiative address health disparities affecting women and people of color. Additional offerings include the BrainStorm podcast, National Alzheimer's Summit, Women's Leadership Council, National Alzheimer's Disease Index data tool, and Brain Health Equity Nurse Fellowship.

Differentiator

Problem solved

Functional benefit

Brands

• BrainGuide: A first-of-its-kind platform to help people understand and manage their brain health, featuring a confidential memory questionnaire available in English and Spanish.
• BrainStorm
• Be Brain Powerful
• Global Alzheimer's Platform Foundation
• LEAD Coalition
• Davos Alzheimer's Collaborative

Products and services

• BrainGuide
• MyBrainGuide
• A-LIST
• Brain Health Academy
• National Alzheimer's Disease Index (NADEX)
• Center for Brain Health Equity
• Brain Health Equity Nurse Fellowship
• BrainStorm Podcast
• National Alzheimer's Summit
• Global CEO Initiative on Alzheimer's Disease (CEOi)
• LEAD Coalition (Leaders Engaged on Alzheimer's Disease)
• Davos Alzheimer's Collaborative
• Advancing Women's Brain Health Initiative

Quantifiable outcome

• Reached 700,000 Black and Latino individuals with tailored brain health messaging in year one of Center for Brain Health Equity
• +4 more outcomes

Named customers3 records

Segments5 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

Feature5 records

Partnerships

14 partnerships are on record, tiered core and minor.

• Centers for Disease Control and Prevention (CDC)coreStrategic or Co-development PartnerFederal agency partner through CDC's Healthy Brain Initiative cooperative agreement enabling the Center for Brain Health Equity work. CDC provides funding and collaboration for brain health public health strategies.
• National Association of Hispanic Nurses (NAHN)coreStrategic or Co-development PartnerKey partner in Center for Brain Health Equity collaboration, working to educate and mobilize minority serving health providers and promote culturally tailored brain health messaging.
• National Black Nurses Association (NBNA)coreStrategic or Co-development PartnerKey partner in Center for Brain Health Equity collaboration, working on brain health equity initiatives and nurse fellowship programs.
• Alzheimer's Los AngelescoreStrategic or Co-development PartnerPartner in Center for Brain Health Equity collaboration, contributing to culturally tailored brain health resources and education.
• SynapticurecoreStrategic or Co-development PartnerVirtual neurology care practice collaboration with MyBrainGuide to help individuals and families connect more quickly with dementia specialists. Provides rapid access to dementia assessment, diagnosis, and treatment planning across all 50 states.
• Isaac HealthcoreStrategic or Co-development PartnerVirtual-first memory and brain health clinic collaboration with MyBrainGuide providing rapid access to cognitive specialists and personalized care across all 50 states.
• Mayo ClinicminorStrategic or Co-development PartnerResearch partner on A-LIST, collaborating to study lucid episodes among individuals with dementia.
• Dana FoundationminorStrategic or Co-development PartnerPartner for Brain Health Awareness Week, collaborating on brain health awareness initiatives.
• Global Alzheimer's Platform (GAP) FoundationcoreStrategic or Co-development PartnerIncubated initiative building the first global trial-ready platform for Alzheimer's drug development to reduce time, cost, and risk of bringing innovative medicines to market.
• Davos Alzheimer's CollaborativecoreStrategic or Co-development PartnerGlobal initiative led by CEOi and World Economic Forum developing a global cohort to identify treatment targets, clinical trial platform, and healthcare system readiness.
• LEAD CoalitioncoreStrategic or Co-development PartnerLeaders Engaged on Alzheimer's Disease - the largest nationwide coalition of Alzheimer's organizations with over 90 member organizations reaching more than 3 million individuals. UsAgainstAlzheimer's created and convenes this coalition.
• Global CEO Initiative on Alzheimer's Disease (CEOi)coreStrategic or Co-development PartnerConvened consortium bringing together top private-sector leaders to collaborate with government and researchers to overcome barriers to Alzheimer's treatments.
• United for CuresminorStrategic or Co-development PartnerCollaborative network of patient advocacy organizations dedicated to protecting and strengthening federal medical research funding.
• Home InsteadminorStrategic or Co-development PartnerResearch partner supporting A-LIST initiative and Alzheimer's caregiving research.

Scale indicators8 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• BrightFocus Foundation: Nonprofit funding research on Alzheimer's, macular degeneration, and glaucoma, plus public education. Comparable to UsA2 as a disease-focused nonprofit combining research grants with public brain/eye health education.
• Alzheimer's Association: The largest U.S. Alzheimer's disease nonprofit; runs the 24/7 Helpline, care and support programs, research funding, and federal advocacy. Directly comparable to UsAgainstAlzheimer's as a national Alzheimer's advocacy, research-funding, and care-support organization, but with much larger reach and budget.
• Alzheimer's Drug Discovery Foundation: Nonprofit that funds drug discovery and translational research for Alzheimer's and related dementias. Comparable to UsA2 in mission focus on accelerating treatments, but with a more direct biomedical-research-grant-making model rather than advocacy/convening.
• Cure Alzheimer's Fund: Nonprofit that funds high-potential Alzheimer's research with a venture-philanthropy approach. Comparable to UsA2's research-funding advocacy function, though smaller and more narrowly focused on biomedical research grants.

Emerging players

• Synapticure: Virtual neurology care practice providing dementia assessment, diagnosis, and treatment across all 50 states. Comparable to UsA2 as a MyBrainGuide integration partner addressing the same patient journey; an emerging specialty care delivery player in the dementia space.
• Davos Alzheimer's Collaborative: Global initiative co-launched by UsA2 (via CEOi) and the World Economic Forum building a global cohort, clinical trial platform, and healthcare system readiness for Alzheimer's. Comparable as a convening entity in the same ecosystem, partially incubated and co-led by UsA2.

Regional players

• Alzheimer's Research UK: U.K.-based dementia research charity with global research funding and public-facing brain health campaigns. Comparable in mission to UsA2's advocacy and research-funding model, but primarily serving the U.K. and Europe rather than the U.S.

Broad incumbents

• Mayo Clinic: Large academic medical center with significant Alzheimer's research, clinical trials, and the Alzheimer's Disease Research Center network. Comparable to UsA2 as a clinical-research partner on A-LIST and as a major player in the same patient/caregiver engagement ecosystem.
• National Institute on Aging (NIA): Lead U.S. federal agency for Alzheimer's and aging research, distributing the majority of federal dementia research dollars UsA2 helped scale to $3.1B in FY2021. Comparable as the primary research-funding incumbent whose budget UsA2's advocacy directly influences.

Others

• Home Instead: Largest in-home personal care network focused on aging seniors, including Alzheimer's and dementia care. Comparable to UsA2 through the Home Instead board presence (Paul Hogan, co-founder) and A-LIST caregiving research partnership; represents the in-home caregiver delivery side of the same mission.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks5 records

Key highlights7 records

Customer concentration

• Xtwitter.com/usagainstalz
• YouTubeyoutube.com/user/USAgainstAlz
• Facebookfacebook.com/UsAgainstAlz
• Instagraminstagram.com/usagainstalz/?hl=en

Revenue estimate

Valuation estimate

Number of profiles

Profiles16 records

Funding overview

Funding rounds

Investors

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M&A

Investments

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Frequently asked questions about UsAgainstAlzheimer's