PennMedicine

What PennMedicine does

Penn Medicine, formally the University of Pennsylvania Health System (UPHS), is a non-profit academic health system owned by The Trustees of the University of Pennsylvania and tracing its origins to Pennsylvania Hospital, the nation's first chartered hospital, founded in 1751. The system operates 14+ hospitals and outpatient facilities across Pennsylvania and New Jersey, including the Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Pennsylvania Hospital, Chester County Hospital, Lancaster General Health, Doylestown Health, and Penn Medicine Princeton Medical Center, alongside specialty institutes such as the Abramson Cancer Center and the Penn Cardiovascular Institute. Patient care, biomedical research through the Perelman School of Medicine, and medical education are delivered as an integrated tripartite mission.

The underlying technology stack is anchored by Epic Systems' electronic medical record platform, deployed as MyChart by myPennMedicine across most facilities (with separate MyLGHealth and legacy MyHealthDoylestown portals in regional entities), linked by an Enterprise Master Patient Index (EMPI) that unifies patient records across the acquired regional hospitals. Digital patient-facing infrastructure includes the MyPennMedicine mobile app (developed by Epic) supporting video visits, the PhysicianLink referral portal for outside providers, Health Information Exchange participation, and the Penn Medicine at Home platform providing remote monitoring, infusion, palliative, hospice, and hospital-at-home services (PATH, SNF at Home, Thrive). The system participates in HIE-based automated information sharing and uses Tealium, Google Analytics, and Microsoft Clarity for website analytics under One Trust cookie consent management. AI capabilities are deployed in targeted areas: an AI chatbot on the website, AI tools integrated into Perelman School of Medicine medical education, cryoEM/cryoET computer-vision imaging for molecular biology, and process automation across telemedicine and home-care workflows. Recent research milestones include the world's first personalized CRISPR therapy (May 2025) and CAR T cell therapy expansion into kidney transplant desensitization (June 2026).

Revenue is generated primarily through fee-for-service clinical care billed to patients and insurers, supplemented by negotiated reimbursements from hundreds of insurance partners (Aetna, Cigna, UnitedHealthcare, Independence Blue Cross, Highmark, Horizon BCBS NJ, Geisinger, UPMC, plus Medicare and Medicaid), federal research grants (notably NIH), and ancillary services including the Global Medicine program for international patients. Go-to-market combines direct patient access (phone, MyChart portal, walk-in referrals), provider-to-provider referrals via PhysicianLink, and self-referral for primary care, distributed across a regional acute-care hospital network, specialty centers, and home-based care services. The system is not venture- or private-equity-backed; it operates as a university-affiliated non-profit with academic ties to the Perelman School of Medicine and a separately managed Department of Communications handling media and stakeholder relations.

Name

PennMedicine

Legal name

The Trustees of the University of Pennsylvania

Website

https://pennmedicine.com

Company type

Private

Founded year

1751

Operating status

Operating

Headcount range

11–50 employees

Short description

Penn Medicine (University of Pennsylvania Health System) is a non-profit academic health system operating 14+ hospitals and outpatient facilities across Pennsylvania and New Jersey. Founded in 1751 as America's first chartered hospital, it delivers specialty and primary patient care, conducts biomedical research through the Perelman School of Medicine, and provides home-based and virtual care.

Ownership category

akta.pro rank

Product category

Academic Medical Center / Hospital Services

NAICS

General Medical and Surgical Hospitals (6221), Ambulatory Health Care Services (621), Nursing Care Facilities (Skilled Nursing Facilities) (62311), Offices of Physicians (62111)

SIC

Services-General Medical & Surgical Hospitals, Nec (8062), Services-Hospitals (8060), Services-Home Health Care Services (8082)

akta.pro industry

PRIMARYHLADAFAL

Home-Based Chronic Disease Management (Skilled)

Healthcare & Life Sciences/Elder Care & Long-Term Care/Home Health Care Services (Skilled)

SECONDARYHSABACAA

Medicare-Certified Skilled Nursing Visits (RN/LPN)

Home & Personal Services/Elder Care & In-Home Care Services/Skilled Nursing & Clinical Home Health

SECONDARYHLAFAFAB

Skilled Nursing Facilities (SNF)

Healthcare & Life Sciences/Healthcare Providers & Systems/Post-Acute Care & Rehabilitation Facilities

Keywords

• Academic medical center
• Hospital care services
• Specialty clinical care
• Patient portal access
• Clinical research programs

Headquarters

HQ city

Philadelphia

HQ country

United States

HQ region

North America

Offices9 records

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Technology or R&D, Infrastructure, Supply Chain, Marketing or Sales

Revenue model

1. Patient Care Services: Penn Medicine generates revenue primarily through providing clinical healthcare services across its hospital network including the Hospital of the University of Pennsylvania, Pennsylvania Hospital, Penn Presbyterian Medical Center, and regional hospitals. Services include inpatient, outpatient, emergency, surgical, and diagnostic care billed to patients and insurers.
2. Insurance Contract Reimbursements: Revenue from negotiated contracts with hundreds of insurance providers including Aetna, Cigna, UnitedHealthcare, Blue Cross plans, Medicare, Medicaid, and many regional and specialized health plans listed in the price transparency files.

Pricing tiers

Go-to-market motion1 record

Distribution channels5 records

Marketing channels7 records

Core offering

Penn Medicine operates a multi-hospital academic health system delivering inpatient, outpatient, emergency, surgical, diagnostic, and specialty clinical care across Pennsylvania and New Jersey. Patient access is enabled through the Epic-based MyChart by myPennMedicine portal and a network of regional hospitals. The system also offers home-based care, international patient services, and clinical trials supported by the Perelman School of Medicine.

Product overview

Penn Medicine is a comprehensive academic health system offering patient care, research, and medical education. The organization operates multiple facilities across Pennsylvania, New Jersey, and beyond, providing specialized clinical services alongside digital health tools. The core patient-facing products include MyPennMedicine (MyChart by myPennMedicine) for Penn Medicine, Chester County Hospital, Doylestown Health, and Princeton Medical Center; MyLGHealth for Lancaster General Health patients; and MyHealthDoylestown (transitioning to MyPennMedicine in 2026). These portals provide access to appointments, test results, prescriptions, and video visits. Penn Medicine has expanded into home-based care through Penn Medicine at Home (offering palliative, hospice, infusion, and physical therapy), Thrive (post-discharge support for low-income patients), SNF at Home (skilled nursing at home), and PATH (hospital-at-home for COPD, heart failure, and infections). Clinical specialties include cancer care (Abramson Cancer Center, CAR T therapy, 2-PREVENT program), cardiovascular care, neurology, orthopaedics, primary care, and women's health. The organization conducts research through the Perelman School of Medicine, including cryoEM imaging, organoid platforms, CRISPR therapies, and AI-enhanced medical education, with publications through Penn Medicine Magazine and Benchmarks newsletter.

Differentiator

Problem solved

Functional benefit

Products and services

• MyChart by myPennMedicine Patient Portal Secure online portal for patients of Penn Medicine, Chester County Hospital, Doylestown Health, and Princeton Medical Center that enables appointment scheduling, access to test results and health records, prescription renewals, bill payment, provider messaging, and video visits.
• MyLGHealth Patient Portal Patient portal for Lancaster General Health patients providing access to health records, appointments, and care team messaging through the MyChart platform.
• Penn Medicine Cancer Care Comprehensive cancer care including medical oncology, radiation oncology, surgical oncology, and access to clinical trials such as CAR T cell therapy and the 2-PREVENT breast cancer program, delivered through the Abramson Cancer Center and Penn Medicine facilities.
• Penn Medicine Heart and Vascular Care Cardiovascular care services for the prevention, diagnosis, and treatment of heart and vascular conditions, delivered through Penn Medicine facilities.
• Penn Medicine Neurology Neurological care services including the diagnosis and treatment of brain, spine, and nervous system conditions.
• Penn Medicine Orthopaedics Orthopaedic care including joint replacement, sports medicine, and treatment of musculoskeletal conditions.
• Penn Medicine Primary Care Primary care services for individuals and families, available across Penn Medicine's regional locations in Pennsylvania, New Jersey, and beyond.
• Penn Medicine Women's Health Women's health services including obstetrics, gynecology, and specialized care for women across all life stages.
• Penn Medicine at Home Home-based health care services for Penn Medicine patients, offering palliative care, hospice, infusion therapy, physical therapy, and remote vital sign monitoring coordinated through a single electronic health record.
• PATH (Practical Alternatives to Hospitalization) Hospital-at-home program enabling patients with COPD, heart failure, and infections to avoid emergency department admission or inpatient stay through virtual and in-person care delivered at home.
• SNF at Home (Skilled Nursing Facility at Home) Program providing skilled nursing facility-level care in patients' homes following major operations or strokes, including physical therapy, occupational therapy, daily nurse visits, and virtual case management.
• Thrive Program Post-discharge support program for low-income patients providing virtual teams including discharging providers, virtual care managers, home care nurses, and social workers to reduce hospital readmissions by addressing socioeconomic barriers.
• Penn Medicine Virtual Care 24/7 virtual care service providing patients with remote access to primary care while offloading on-call duties from physicians.
• Global Medicine Program International patient services providing medical consultations, treatment coordination, travel assistance, and cultural support for patients seeking specialty care from outside the United States.
• PhysicianLink Referrals Secure provider-facing portal enabling referring physicians to access patient information, submit referrals, and communicate with Penn Medicine specialists.
• Penn Medicine Transplant Services Organ transplant services including living organ donation, supported by research on CAR T cell therapy-based desensitization for previously ineligible kidney transplant candidates.

Named customers1 record

Segments3 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration6 records

AI capability7 records

Feature4 records

Partnerships

14 partnerships are on record, tiered core, regional and minor.

• Children's Hospital of Philadelphia (CHOP)coreStrategic or Co-development PartnerCHOP handles pediatric care for Penn Medicine patients. Referrals and specialized pediatric services are coordinated between the two institutions. Contact: 800-283-3055. CHOP Public Relations: 267-426-6050 for media inquiries about Penn Medicine Department of Pediatrics.
• Epic Systems CorporationcoreTechnology or IntegrationEpic provides the MyChart patient portal and electronic medical record infrastructure powering Penn Medicine's unified health information system across all facilities. The myPennMedicine app is developed by Epic.
• AetnacoreOthersMajor insurance partner with multiple plan types including commercial HMO/PPO, Medicare Advantage, and CAR-T managed care. Contract rate names include Aetna Commercial, Aetna HMO, Aetna Medicare HMO, Coventry Advantra Medicare, and others.
• CignacoreOthersInsurance partner offering commercial plans, Medicare, dental, and specialized CAR-T and transplant network options. Includes Cigna, CIGNA Existing, Cigna Lifesource, and Cigna HealthSpring.
• UnitedHealthcarecoreOthersMajor insurance partner covering commercial plans, Medicaid, Medicare Advantage, and student health. Includes UnitedHealthcare Community, UnitedHealthcare Non Options, United Healthcare Medicare Advantage.
• Independence Blue Cross (IBC)coreOthersRegional insurance partner for southeastern Pennsylvania offering PPO, HMO, Traditional, and Medicare plans. Includes Personal Choice, Keystone Health Plan East, and IBC Medicare products.
• HighmarkcoreOthersRegional insurance partner in Pennsylvania offering ACA Exchange, BCBS, PPO, HMO, and Medicaid plans including Highmark Freedom Blue and Gateway Health Plan products.
• Horizon Blue Cross of New JerseycoreOthersPrimary insurance partner for New Jersey operations including Princeton Medical Center. Plans include Horizon PPO, HMO POS, Direct Access, Medicare HMO, and NJ Health Medicaid products.
• Geisinger Health PlanregionalOthersRegional insurance partner offering commercial and government plans in Pennsylvania including Geisinger Gold Medicare Advantage, Geisinger HMO/PPO, and Geisinger Medicaid.
• UPMC Health PlanregionalOthersRegional insurance partner in Pennsylvania offering commercial plans, UPMC for Kids Medicaid, UPMC for Life Medicare, and UPMC Medicaid products.
• Lancaster Radiology AssociatesminorOthersIndependent radiology group providing services at Lancaster General Health locations. Contact: 717-394-6028. Separate billing from Penn Medicine.
• MRI GroupminorOthersIndependent MRI services provider at Lancaster General Health locations. Contact: 717-291-1016. Separate billing from Penn Medicine.
• Lancaster Emergency AssociatesminorOthersIndependent emergency medicine group providing services at Lancaster General Health. Contact: 855-690-9890. Separate billing from Penn Medicine.
• Deeply Rooted Community PartnerscoreStrategic or Co-development PartnerCommunity partnership established in 2022 focused on planting trees, greening vacant lots, and funding grassroots programs to advance health justice. Includes partnership with Men of 52K group on Kingessing Avenue for urban gardening and youth education.

Scale indicators3 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• NYU Langone Health: NYU Langone is a New York-based academic medical system combining hospital care, research, and medical education. It directly competes with Penn for specialty referrals and talent in the densely competitive Northeast healthcare market.
• Northwestern Medicine: Northwestern Medicine is a Chicago-based integrated academic health system affiliated with the Feinberg School of Medicine. It offers a comparable mix of quaternary care, research, and multi-site integrated delivery, though at slightly smaller scale than Penn.
• UCSF Health: UCSF Health is the academic medical center of UC San Francisco, offering comparable quaternary specialty care, research enterprise, and graduate medical education. Both operate as top-tier AMCs with substantial NIH research portfolios.
• UCLA Health: UCLA Health operates an academic medical center with multiple hospitals, a medical school, and significant research activity. It is comparable to Penn Medicine in scale, complexity of case mix, and reliance on academic medical center economics.
• Stanford Health Care: Stanford Health Care is the adult hospital component of Stanford Medicine, combining quaternary clinical care with a leading research university. Both are comparable in scope, patient mix, and innovation focus.
• Mount Sinai Health System: Mount Sinai is a multi-hospital academic health system in New York City affiliated with the Icahn School of Medicine. It is comparable in scale, specialty mix, and integrated delivery model to Penn Medicine, and competes for patient referrals in the Northeast corridor.
• Mass General Brigham: Mass General Brigham is the largest hospital-based research enterprise in the US and a direct peer to Penn Medicine in scale, quaternary care mix, and academic affiliation. Both compete for complex specialty referrals and NIH research funding.
• Cedars-Sinai Medical Center: Cedars-Sinai is a large, research-intensive academic medical center in Los Angeles with a comparable specialty care mix and significant NIH-funded research. Both compete for complex case referrals and physician talent at the top of the US hospital market.
• NewYork-Presbyterian Hospital: NewYork-Presbyterian is the academic medical center of Columbia and Cornell, operating a similar multi-hospital integrated delivery model in the Northeast. Both function as destination centers for complex specialty care and are anchored by Ivy League medical schools.
• Johns Hopkins Medicine: Johns Hopkins is a peer academic medical center with comparable scope: multiple hospitals, an integrated medical school, and a leading research enterprise. Both operate as flagship AMCs combining quaternary care, research, and education in the Mid-Atlantic/Atlantic corridor.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• Xx.com/PennMedBench
• YouTubeyoutube.com/playlist?list=PLRGEsZTjjo8mJFYrC_CsXoIgXzoYFBnxH
• LinkedInlinkedin.com/company/pennmedicine

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles8 records

Subsidiaries10 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about PennMedicine