Laboratoire De Rhumatologie Appliquee

What Laboratoire De Rhumatologie Appliquee does

Laboratoire De Rhumatologie Appliquee (Labrha) is a French private SAS company founded in 2005 and headquartered in Lyon, France. The company develops and markets a portfolio of natural-phytotherapy products for joint health, organized in three categories: dietary supplements (Cuivramine, Cuivragène, Ainat, Tenofort, Chondrofon, Fibro Classique/Forte, Nutros), topical gels (Gel Capsaïne, Tenofort Gel), and CE-marked viscosupplements (HAppyMini, HAppycross, HAppyvisc) based on a patented cross-linked hyaluronic acid technology enabling single-injection administration. Products are listed in VIDAL (France's authoritative pharmaceutical reference) and the company has held the 'fabricant de qualité' certification from ASFA since 2005.

Labrha operates a direct-to-consumer e-commerce business primarily through its French website (laboratoire-labrha.fr), supplemented by a toll-free phone order line and a bilingual French/English storefront. The viscosupplement line is distributed via a physician-prescription channel, with bundled packs pairing injectable devices with oral supplements to drive cross-category uptake. Supporting channels include a content-marketing blog, an online self-service diagnostic tool, free 15-minute personalized advisory appointments, and an acerola-based loyalty/subscription program.

The company sells to French consumers experiencing osteoarthritis, joint pain, tendon disorders, fibromyalgia, and bone-health concerns. Unit prices range from €11.80 (Chondrofon) to €382.00 (Pack HAppycross & Cuivramine 2-pack). Ownership is private with €70,000 share capital (RCS LYON 482 062 684); no parent company, institutional investors, or venture funding are disclosed. Patrick Sac-Epée is identified as Publication Director. Customer ratings stand at 4.6/5 on Avis Vérifiés.

Name

Laboratoire De Rhumatologie Appliquee

Legal name

Laboratoire de Rhumatologie Appliquée

Website

https://laboratoire-labrha.fr

Company type

Private

Founded year

2005

Operating status

Operating

Headcount range

1–10 employees

Short description

Laboratoire Labrha is a Lyon-based French private company, founded in 2005, that develops and sells natural dietary supplements, topical gels, and CE-marked viscosupplements for osteoarthritis and joint pain, primarily through direct-to-consumer e-commerce in France.

Ownership category

akta.pro rank

Product category

Rheumatology dietary supplements and viscosupplements

NAICS

Food (Health) Supplement Retailers (456191), Pharmaceutical and Medicine Manufacturing (3254), Biological Product (except Diagnostic) Manufacturing (325414)

SIC

Medicinal Chemicals & Botanical Products (2833), Perfumes, Cosmetics & Other Toilet Preparations (2844), Orthopedic, Prosthetic & Surgical Appliances & Supplies (3842)

akta.pro industry

PRIMARYCRADAGAE

Specialty Condition Supplements (Sleep, Stress, Heart, Joint, Gut, Immunity)

Consumer Products & Retail/Consumer Packaged Goods (CPG) Manufacturing & Brands/Vitamins, Supplements & Sports Nutrition

SECONDARYCRADAGAD

Herbal & Botanical Supplements

Consumer Products & Retail/Consumer Packaged Goods (CPG) Manufacturing & Brands/Vitamins, Supplements & Sports Nutrition

SECONDARYCRADAGAI

Functional Foods & Supplement Formats (Gummies, Chews, Powders, Shots)

Consumer Products & Retail/Consumer Packaged Goods (CPG) Manufacturing & Brands/Vitamins, Supplements & Sports Nutrition

SECONDARYEUAAAIAK

Bio-based Pharmaceuticals, Nutraceuticals & Specialty Bioactives

Energy, Utilities & Environment/Bioenergy, Natural Gas & Biomass/Biorefining & Bio-based Chemicals (Co-products, Bioproducts)

Keywords

• Rheumatology supplements
• Joint health products
• Viscosupplement injections
• Topical pain gels
• Osteoarthritis treatments

Headquarters

HQ city

Lyon

HQ country

France

HQ region

Europe

Offices2 records

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Personnel, Marketing or Sales, Technology or R&D, Others

Revenue model

1. Dietary Supplements Sales: Direct-to-consumer sales of oral supplements (Cuivramine, Cuivragène, Ainat, Chondrofon, Fibro Classique, Fibro Forte, Nutros, Tenofort capsules) through e-commerce website with subscription and one-time purchase options
2. Topical Gels Sales: Direct sales of topical pain relief gels (Gel Capsaïne, Tenofort Gel) for localized joint and muscle pain treatment
3. Viscosupplements (Medical Devices) Sales: Sales of hyaluronic acid injection products (HAppycross, HAppyMini, HAppyvisc) for osteoarthritis treatment, delivered via physician prescription and administration
4. Subscription/Recurring Revenue: Loyalty program and subscription model encouraging repeat purchases with benefits such as free shipping and accumulated acerola points

Pricing tiers

Go-to-market motion2 records

Distribution channels3 records

Marketing channels8 records

Core offering

Laboratoire Labrha develops, manufactures and markets a rheumatology-focused product range consisting of natural dietary supplements for joint, tendon and bone health, topical capsaicin-based pain relief gels, and prescription-only hyaluronic acid viscosupplement injections for osteoarthritis. Products are sold direct-to-consumers via its own French/English e-commerce website and through a physician-administered channel for viscosupplements, with free shipping in France and a subscription/loyalty program. The portfolio is supported by clinical studies (INSTINCT, REPAR, ARTEMIS), referenced in VIDAL, and certified 'fabricant de qualité' by ASFA since 2005.

Product overview

Laboratoire Labrha is a French pharmaceutical/healthcare company specializing in applied rheumatology, founded in 2005 and based in Lyon. The company offers a three-tier product portfolio: (1) Dietary supplements (Cuivramine®, Cuivragène®, Ainat®, Tenofort® capsules/gel/pack, Chondrofon®, Fibro® Classique/Forte, Nutros®) for oral joint care, energy/vitality, and bone health; (2) Topical gels (Gel Capsaïne®, Tenofort Gel®) for localized pain relief; and (3) Prescription-only viscosupplements (HAppyMini®, HAppycross®, HAppyvisc®) delivered via intra-articular injection for osteoarthritis treatment. Products are listed in VIDAL, manufactured in France, and certified as 'quality manufacturer' by ASFA since 2005. The company also offers bundled packs combining supplements with viscosupplements for comprehensive joint management programs.

Differentiator

Problem solved

Functional benefit

Brands

• Cuivragène®: Marine collagen dietary supplement
• Cuivramine®
• Ainat®
• Tenofort®
• Chondrofon®
• Fibro®
• Nutros®
• HAppycross®
• HAppyMini®
• HAppyvisc®
• Gel Capsaïne®

Products and services

• Cuivragène® Marine collagen supplement combined with copper, designed for joint health support; priced at €31.00 and listed in the Labrha dietary supplements range.
• Cuivramine® Joint supplement containing glucosamine sulfate (1500 mg/day), ginger, copper and vitamin C to support cartilage preservation and joint flexibility; priced at €31.00 and referenced in VIDAL.
• Ainat® Dietary supplement combining bromelain, turmeric and harpagophytum to reduce inflammation and discomfort in joint pain; priced at €30.00.
• Pack Tenofort® (1 month) Monthly subscription pack pairing Tenofort capsules and Tenofort Gel with spirulina, ginseng, harpagophytum and other natural ingredients for stronger tendons; priced at €35.00 per month (1-month pack).
• Tenofort® Gélules Tendon capsules with glucosamine sulfate, white ginseng root and spirulina; priced at €24.50.
• Chondrofon® Joint flexibility supplement with glucosamine sulfate and vitamin C; priced at €11.80.
• Fibro® Classique Energy and vitality supplement for fibromyalgia and chronic fatigue, combining royal jelly, meadowsweet, ginger, vitamin C, acerola, griffonia simplicifolia, chamomile, passionflower and L-tyrosine; priced at €59.00.
• Fibro® Forte Dual-formula fibromyalgia supplement with morning formula (white willow, acerola, ginseng, sage, L-tyrosine, magnesium) and evening formula (valerian, eschscholzia, passionflower, L-tryptophan); priced at €64.00 (2 months), €115.00 (4 months) and €155.00 (6 months).
• Nutros® Bone health supplement enriched with calcium (258 mg), vitamin D3 (10 µg), inulin (500 mg) and silicon (10 mg) to support bone capital; priced at €23.00 (2 months), €69.00 (6 months) and €120.00 (12 months).
• Gel Capsaïne® Pain relief gel with capsaicin, chondroitin, glucosamine sulfate, camphor, clove and menthol for localized joint and muscle pain; applied 2-4 times daily; priced at €17.00.
• Tenofort Gel® Tendon gel combining camphor, capsaicin and chondroitin for targeted pain relief; priced at €17.00.
• HAppyMini® Second-generation viscosupplement for localized joint osteoarthritis, supplied as a single 1 ml intra-articular injection with cross-linked hyaluronic acid and mannitol (antioxidant); prescription required; priced at €66.00 per syringe.
• HAppycross® Second-generation knee viscosupplement delivered as a single 2.2 ml intra-articular injection of hyaluronic acid and mannitol for knee osteoarthritis; CE-marked, VIDAL-listed, prescription required; priced at €169.00 (1 syringe) and €299.00 (2-pack).
• HAppyvisc® Second-generation viscosupplement for larger joints, supplied as a 3-injection course with 15.5 mg/g sodium hyaluronate and mannitol; priced at €120.00 (3 syringes) and €199.00 promotional (3 syringes).
• Pack HappyMini® & Cuivramine® Combined pack pairing the HAppyMini viscosupplement with the Cuivramine dietary supplement for comprehensive joint support; priced at €189.00.
• Pack HAppycross® & Cuivramine® Combined pack pairing the HAppycross knee viscosupplement with the Cuivramine dietary supplement; priced from €276.00 to €382.00 depending on pack size.

Quantifiable outcome

• Fibro Classique: 75% of patients report improved quality of life
• +4 more outcomes

Segments4 records

Ideal customer profiles3 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature6 records

Partnerships

Five partnerships are on record, tiered core and minor.

• VIDAL GroupcoreOthersProducts are referenced in VIDAL, the authoritative French pharmaceutical reference. This listing provides medical-professional credibility and ensures visibility to healthcare professionals prescribing joint health treatments.
• CiteominorOthersLabrha fulfills Extended Producer Responsibility (EPR) obligations as a member of Citeo, the French packaging recycling organization. EPR identifiers: FR285158_01MUNT (Packaging) and FR285158_03XKTL (Graphic Papers).
• SAS Médiation SolutionminorOthersDesignated consumer mediation entity for dispute resolution, registered under number 80195/MJ/2212, in accordance with French Consumer Code Article L. 612-1.
• Memory AgencyminorImplementation/ SI/ Consulting PartnerDigital agency responsible for website design and development, located at 13 Av. Albert Einstein, 69100 Villeurbanne, France.
• AdememinorOthersFrench Environment and Energy Management Agency issuing unique EPR identifiers for packaging and graphic papers compliance (FR285158_01MUNT and FR285158_03XKTL).

Scale indicators5 records

Recent moves6 records

Expansion highlights4 records

Broad incumbents

• Anika Therapeutics: US-based specialty company focused exclusively on hyaluronic acid viscosupplements (Monovisc, Orthovisc, Cingal). Comparable to Labrha as a viscosupplement pure-play with similar single-injection cross-linked HA technology competing in the same physician channel.
• IBSA Pharma: Swiss pharmaceutical company with a leading hyaluronic acid viscosupplement franchise (Sinovial, Gelsyn-3). Comparable to Labrha in viscosupplement category, with broader portfolio and global distribution versus Labrha's physician-channel focus in France.
• Bioiberica: Spanish life-science company supplying bioactive ingredients (including native and hydrolyzed collagen, hyaluronic acid) used in joint-health supplements globally. Comparable to Labrha as a science-based joint-health specialist operating in both ingredient and finished-product categories.
• Sanofi (viscosupplement franchise - Synvisc/Synvisc-One): Global pharmaceutical company whose Genzyme division markets the Synvisc/Synvisc-One viscosupplement franchise. Comparable to Labrha's viscosupplement line as the dominant incumbent competitor in intra-articular hyaluronic acid injections for osteoarthritis.

Direct peers

• Aptissen: Swiss company developing and marketing viscosupplements (hyaluronic acid injections) for osteoarthritis. Directly comparable to Labrha's HAppycross®/HAppyMini®/HAppyvisc® range as a focused viscosupplement specialist competing in the same physician-administered intra-articular injection category.
• Forté Pharma: French laboratory developing and marketing dietary supplements and health products across categories including joint care. Comparable to Labrha in DTC supplement positioning, French consumer base, and multi-category joint/vitality product range.
• Arkopharma: Leading French laboratory specializing in natural health products, dietary supplements and phytotherapy. Comparable to Labrha through its French DTC supplement portfolio, natural ingredient positioning, and pharmacy/retail distribution model.
• Nutergia: French family-owned micronutrition laboratory selling dietary supplements through pharmacy and DTC channels. Comparable to Labrha in French specialty supplement positioning, natural-formulation philosophy, and chronic-condition product targeting.
• Expanscience: French independent pharmaceutical company that develops and markets Piascledine, a leading prescription osteoarthritis product, alongside joint-health dermo-cosmetic and supplement ranges. Directly comparable to Labrha as a French specialty player operating across joint-health supplements and prescription osteoarthritis products.
• Pileje: French micronutrition laboratory selling dietary supplements and probiotics direct to consumers and via healthcare professionals. Comparable to Labrha in French-language DTC supplement distribution, health professional channel, and chronic-condition positioning (fatigue, joint health).

Market position

Strengths5 records

Weaknesses5 records

Competitive moat3 records

Key risks6 records

Key highlights6 records

Customer concentration

• Facebookfacebook.com/LabrhaLaboratoire
• LinkedInlinkedin.com/company/laboratoire-labrha
• Instagraminstagram.com/labrha_laboratoire

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Laboratoire De Rhumatologie Appliquee