Instinct Bio

What Instinct Bio does

INSTINCT BIO TECHNICAL COMPANY HOLDINGS INC. (NASDAQ: BIOT) is a Cayman Islands-incorporated holding company that completed a de-SPAC business combination with Relativity Acquisition Corp. and began trading on NASDAQ on July 24, 2026. The group was founded in Japan in 2011 and operates through four wholly-owned operating subsidiaries organized around a Five Elements framework: Instinct Brothers (Wood — regenerative stem-cell cosmetics and brands), Instinct RAS (Fire — R&D, branding and marketing), HIROKI GLOBAL (Water — sourcing and trading), and Artisans Production (Metal — manufacturing and OEM/ODM). This structure delivers a vertically integrated value chain from raw-material sourcing through proprietary R&D, in-house manufacturing at the Kakegawa (Shizuoka) plant, and brand-building via the proprietary direct-to-consumer platform Value Village (valuevillage.jp).

The commercial product surface spans five in-house consumer brands — premium skincare GENRêVER, daily-care VIVÉA, inner-care and supplements MANOROL, and Japanese-minimal skincare HAKUA — plus OEM brands Brosky and bebe. Core technology rests on proprietary stem cell culture supernatant used as a cosmetic ingredient across the in-house lineup and on the inbound-licensed Crystal Sponge Method molecular analysis technology from a leading Japanese university, which underpins ongoing regenerative-medicine R&D. A B2B professional line supplies exclusive formulations to partner clinics and salons in Japan and Asian markets, and Artisans Production performs OEM/ODM contract manufacturing for external brand clients.

Revenue is generated through a mix of one-time sales (DTC e-commerce, retail, B2B professional line, OEM/ODM contracts) and, beginning with the planned GENRêVER CLINIC rollout across Indonesia's five major metropolitan areas (with transparent flat-fee cancel-anytime membership and ~US$1 million initial investment), an emerging subscription-based recurring revenue stream positioned as a strategic gateway to the regenerative-medicine business. The customer base comprises beauty and wellness consumers in Japan and Southeast Asia (Singapore and Indonesia), B2B clinics and salons, and OEM/ODM clients; pricing is not publicly disclosed and gross margin is described in IR materials as maintained at a high level, with the company explicitly in a growth-investment phase. Founder, Chairman and CEO Tomoki Nagano controls 36.21% of the 28,794,472 ordinary shares outstanding.

Name

Instinct Bio

Legal name

INSTINCT BIO TECHNICAL COMPANY HOLDINGS INC.

Website

https://instinct-biot.com

Company type

Public

Founded year

2011

Operating status

Ipo

Short description

Instinct Bio (NASDAQ: BIOT) is a Cayman-incorporated holding company that operates a vertically integrated Japanese biotech group spanning stem-cell-derived cosmetics brands (GENRêVER, VIVÉA, MANOROL, HAKUA), in-house manufacturing, OEM/ODM services, and regenerative medicine R&D, sold via its DTC platform Value Village and partner clinics across Japan, Singapore and Indonesia.

Ownership category

akta.pro rank

Product category

Stem-cell-derived cosmetics and regenerative skincare

NAICS

Soap and Cleaning Compound Manufacturing (32561), Research and Development in Biotechnology (except Nanobiotechnology) (541714), Health and Personal Care Retailers (456)

SIC

Medicinal Chemicals & Botanical Products (2833)

akta.pro primary industry

Hand & Body Care (Lotions, Creams, Body Oils) (CRADANAC)

akta.pro secondary industries

Hair Care (Shampoo, Conditioner, Styling, Treatments) (CRADANAE), Health & Wellness (Vitamins, Supplements, OTC) DTC (CRAFACAC), Private Label & Contract/White-Label Beauty Distribution (CRAOAEAO)

Keywords

• Stem cell skincare
• Japanese cosmetics OEM
• Regenerative medicine cosmetics
• Vertically integrated beauty
• DTC skincare brands

Headquarters

HQ city

Grand Cayman

HQ country

Cayman Islands

Offices4 records

Markets served

GTM type

B2B and B2C

Offering type

Hardware or Manufacturing

Cost components

Technology or R&D, Supply Chain, Operations, Marketing or Sales, Personnel, Infrastructure

Revenue model

1. Cosmetics Manufacturing & Sales: Core revenue pillar: develops, manufactures, and sells skincare, body/hair care, inner care supplements, and professional line products under own brands (GENRÊVER, VIVÉA, MANOROL, HAKUA) and OEM/ODM B2B contracts. High gross margin maintained through high-value stem-cell-related cosmetics and beauty ingredients. Revenue streams include OEM, ODM, direct-to-consumer, e-commerce, and retail across Japan and Asian markets.
2. Regenerative Medicine R&D: Activities related to regenerative medicine field, including R&D and supply of stem-cell-derived cosmetic ingredients. Partly commercialized (ingredient supply) and partly at R&D stage. Complements cosmetics business as second revenue pillar.
3. Subscription-Based Clinic Model (Indonesia): Planned membership beauty clinics under GENRÊVER CLINIC brand across Indonesia's five major metropolitan areas, with transparent flat-fee cancel-anytime membership. Designed to build predictable recurring revenue as a strategic gateway to regenerative medicine business. Initial investment approximately US$1 million.
4. Professional / Clinic B2B (OEM/ODM): Exclusive products for partner clinics and salons, plus OEM/ODM contract development and manufacturing for external brand clients. B2B professional line revenue through direct sales relationships with clinical and salon partners.

Go-to-market motion4 records

Distribution channels5 records

Marketing channels5 records

Core offering

The group develops, manufactures, and sells stem-cell-derived skincare, body/hair care, and inner-care supplement products under proprietary in-house brands (GENRÊVER, VIVÉA, MANOROL, HAKUA) and OEM brands (Brosky, bebe), distributed through its proprietary Value Village DTC e-commerce platform and partner clinics/salons. It also offers OEM/ODM contract manufacturing services through Artisans Production and runs a regenerative medicine R&D program built on stem cell culture technology and the licensed Crystal Sponge Method, with a planned GENRÊVER CLINIC subscription clinic rollout in Indonesia.

Product overview

INSTINCT BIO TECHNICAL COMPANY HOLDINGS INC. (BIOT) is a vertically integrated biotech holding company organized around two core pillars: a cosmetics business and regenerative medicine R&D. The cosmetics business operates through multiple in-house brands—GENRÊVER (premium skincare), VIVÉA (daily beauty), MANOROL (inner care/supplements), and HAKUA (Japanese minimal skincare)—sold via the proprietary DTC platform Value Village. The Group also operates OEM/ODM services (Brosky, bebe brands) and a Professional Line for partner clinics. A planned GENRÊVER CLINIC membership beauty clinic service is being rolled out in Southeast Asia. All brands feature stem-cell-derived ingredients and proprietary formulations developed through the Group's vertically integrated value chain spanning R&D, manufacturing, sourcing, and distribution.

Differentiator

Problem solved

Functional benefit

Brands

• Value Village: The group's proprietary direct-to-consumer retail platform and in-house brand covering skincare, body care, inner care, and professional line products.
• GENRÊVER
• VIVÉA
• MANOROL
• HAKUA
• Brosky
• bebe
• INSTINCT BROTHERS CUP
• MottainaE:CO

Products and services

• GENRÊVER Flagship premium skincare brand bringing together advanced materials research in a high-end line designed for mature skin, featuring stem-cell-derived beauty ingredients and proprietary formulations. Sold through the Value Village DTC platform.
• VIVÉA Accessible, everyday care skincare brand designed around consistency and ease of daily use, including face masks and daily beauty products. Sold through the Value Village DTC platform.
• MANOROL Supplement and inner-care brand focused on conditioning the body from within using functional ingredients that support beauty and wellness. Sold through the Value Village DTC platform.
• HAKUA Minimal skincare brand rooted in Japanese material sensibility and an aesthetic of restraint. Sold through the Value Village DTC platform.
• Value Village Proprietary direct-to-consumer retail platform (valuevillage.jp) through which all in-house brand products (GENRÊVER, VIVÉA, MANOROL, HAKUA) are sold to consumers in Japan and Asian markets; serves as the group's primary retail channel and hosts the SDGs initiative 'MottainaE:CO'.
• Professional Line Exclusive B2B professional line products for partner clinics and salons across Japan and Asian markets, including Singapore and Indonesia, sold through direct sales relationships with clinical and salon partners.
• OEM/ODM Services B2B contract development and manufacturing services for external skincare and beauty brands (including the in-house OEM brands Brosky and bebe), leveraging the group's vertically integrated manufacturing capabilities through Artisans Production in Kakegawa.
• GENRÊVER CLINIC Planned subscription-based membership beauty clinic service under the GENRÊVER CLINIC brand, planned for rollout across Indonesia's five major metropolitan areas. Features transparent flat-fee, cancel-anytime membership pricing designed to build predictable recurring revenue as a strategic gateway to the regenerative medicine business.

Segments3 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Partnerships

Three partnerships are on record, tiered core and moderate.

• Leading Japanese University (Crystal Sponge Method)coreTechnology or IntegrationCrystal Sponge Method, a molecular analysis technology, was licensed from academic research originating at a leading Japanese university. This technology forms the foundation for the company's regenerative medicine research and development activities. The company discloses partnerships and licenses only as confirmed, publicly announced facts within the limits of relevant agreements.
• Specialist Clinics and Research InstitutionsmoderateStrategic or Co-development PartnerJoint research relationships with universities and research institutions established since 2019. Expanded collaboration with specialist clinics and research institutions as part of regenerative medicine R&D activities. Also deepened specialist partnerships and expanded scope of business operations in 2021.
• Overseas Ingredient SuppliersmoderateStrategic or Co-development PartnerPartnerships with overseas ingredient suppliers established in 2018, building distribution framework for Japanese market. Strengthened development and manufacturing capabilities with overseas partners in 2024 as part of Southeast Asia expansion activities.

Scale indicators7 records

Recent moves7 records

Expansion highlights6 records

Emerging players

• Calecim Cosmeceuticals: Stem-cell-derived (cord lining) cosmetic-ingredient brand sold through professional/clinic channels — directly comparable to BIOT's stem-cell-derived ingredient offering and professional-clinic distribution, though smaller and clinic-focused.
• Allies of Skin: Smaller but rapidly growing premium skincare brand built around biotech-inspired active ingredients and DTC-led global distribution — comparable as a science-led emerging premium DTC beauty peer.

Direct peers

• FANCL Corporation: Japanese cosmetics and supplements company selling science-led, additive-conscious skincare and inner-care products via DTC and direct stores — directly comparable to BIOT's HAKUA skincare and MANOROL inner-care positioning.
• Dr. Ci:Labo Holdings: Japanese dermatology-led skincare brand sold via DTC and clinic channels, anchored by science-driven and stem-cell-adjacent formulations — comparable to BIOT across Japanese origin, science positioning, premium pricing, and partner-clinic distribution.
• Augustinus Bader: Premium skincare brand built on stem-cell and biotech-inspired proprietary technology with a science-led storytelling approach and DTC-led global distribution — highly comparable to BIOT's GENRĆVER premium stem-cell positioning and Value Village DTC engine.

Others

• Intercos S.p.A. Global OEM/ODM cosmetics manufacturer supplying indie and major beauty brands — relevant as a directly comparable OEM/ODM peer to Artisans Production.
• Cosmax Inc. Large Asia-headquartered OEM/ODM cosmetics manufacturer — comparable to BIOT's Artisans Production business as a peer in the contract cosmetics-manufacturing value chain serving indie and global beauty brands.

Broad incumbents

• Shiseido Company, Limited: Global Japanese beauty leader with significant regenerative and bio-ingredient R&D and premium skincare brands — comparable as the most established Japanese incumbent that BIOT competes with across STEM-cell-led formulations and premium DTC distribution.
• KOSÉ Corporation: Major Japanese cosmetics company with premium skincare lines, biotech R&D, and broad Asia-Pacific distribution — comparable as another incumbent competitor in the same science-led Japanese beauty category.
• POLA Orbis Holdings: Large Japanese beauty holding group with multi-brand portfolio, biotech R&D (including stem-cell research at POLA Chemical), and significant domestic and Asian retail — comparable as a broader incumbent competing with BIOT's Japanese premium beauty brands.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks7 records

Key highlights7 records

Customer concentration

• Instagraminstagram.com/value_athlete_isb

Revenue estimate

Valuation estimate

Number of profiles

Profiles12 records

Subsidiaries4 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Instinct Bio