Amalgam Rx
Amalgam Rx operates a modular, AI-powered SaMD platform delivering EHR-integrated clinical decision support, digital therapeutics, and conversational AI to life sciences, payer, and provider customers across four continents.
- Company typePrivate
- Founded2009
- HeadquartersWilmington, United States
- Headcount51–100
- GTM typeB2B
- OfferingSoftware
What Amalgam Rx does
Amalgam Rx is a US-based, private digital health company that operates a modular, AI-powered Software as a Medical Device (SaMD) platform delivering EHR-integrated clinical decision support, digital therapeutics, and conversational AI applications to life sciences companies, health plans, and provider organizations. The platform is anchored by a proprietary Medical-Grade AI™ layer (40+ clinical guardrails for MLR compliance, trained on 100B+ real-world healthcare knowledge points) and, more recently, the Chiron foundation model—an autoregressive transformer trained on millions of longitudinal patient records that predicts next medical events across therapeutic areas simultaneously. Core product lines include EHR Solutions (patient identification, clinical trial recruitment, care guidelines, financial assistance, medication safety, prior authorization), Digital Products (companion apps such as DoseCheck/iSage Rx for insulin titration and Elevmi for Alzheimer's caregiver support), and Enterprise Platform deployments for global life sciences and payer customers.
The company monetizes primarily through SaaS and platform licensing, per-provider EHR-integrated clinical decision support deployments, and co-development / commercialization agreements with life sciences partners (Novo Nordisk, Otsuka, Biolinq, Exact Sciences) under which it earns platform fees, development milestones, and royalties while acting as Manufacturer of Record for regulated SaMD across multiple geographies. Amalgam's solutions are embedded directly into the native UI/UX of every major US EHR (Epic, Cerner/Oracle Health, athenahealth, Veradigm, DrChrono, NextGen, Modernizing Medicine), with a stated 53-minute implementation window from contract to live. Named enterprise customers include Novo Nordisk, Otsuka Precision Health, Biolinq, Privia Health, Exact Sciences, Aetna (CVS Health), and Summit Medical Group-City MD, while the platform underpins products reaching nearly 10 million patients and 70M+ clinical decisions evaluated across four continents with FDA, CE Mark, and SFDA regulatory clearances.
The company is headquartered in Wilmington, Delaware, employs 51-100 people, and was founded by the former WellDoc founding team. Capital sources include a Series B led by CVS Health Ventures (Oct 2023), a strategic equity investment from Novo Nordisk, and a $20M senior secured term loan from Catalio Capital Management (Aug 2025). The Avhana Health and Geetha acquisitions expanded the EHR-anchored clinical decision support footprint and conversational AI / psychosocial engine capabilities, respectively. Compliance posture includes FDA 21 CFR Part 820, ISO 13485:2016, ISO 27001:2022, SOC 2 Type 2, HIPAA, and GDPR, with AWS as the underlying cloud infrastructure partner.
Amalgam Rx firmographics
Firmographics- Name
- Amalgam Rx
- Legal name
- Amalgam Rx, Inc.
- Website
- https://amalgamrx.com
- Company type
- Private
- Founded year
- 2009
- Operating status
- Operating
- Headcount range
- 51–100 employees
- Short description
- Amalgam Rx operates a modular, AI-powered SaMD platform delivering EHR-integrated clinical decision support, digital therapeutics, and conversational AI to life sciences, payer, and provider customers across four continents.
- Ownership category
- akta.pro rank
Amalgam Rx industry classification
Industry- Product category
- Digital Health Software / Healthcare AI SaMD Platform
- NAICS
- Software Publishers (5132), Navigational, Measuring, Electromedical, and Control Instruments Manufacturing (33451)
- SIC
- Surgical & Medical Instruments & Apparatus (3841), Services-Prepackaged Software (7372)
- akta.pro primary industry
- DTx/SaMD Deployment, Integration & Reimbursement Enablement (HLACANAO)
- akta.pro secondary industries
- EHR Extensions, APIs, App Marketplaces & SMART-on-FHIR Apps (HLACAAAN), DTx/SaMD Regulatory, Quality & Compliance Software (QMS/ISO/FDA) (HLACANAN), DTx/SaMD Evidence, Outcomes & Real-World Data (RWE) Platforms (HLACANAM)
Keywords
Where Amalgam Rx is headquartered
LocationHeadquarters
- HQ city
- Wilmington
- HQ country
- United States
- HQ region
- North America
Offices1 record
Markets served
Amalgam Rx business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Marketing or Sales, Infrastructure, Operations
Revenue model
- SaaS Platform Licensing: Amalgam Rx operates a SaaS-enabled digital marketplace and product platform that generates recurring licensing fees from life sciences companies, health plans, and provider organizations. The modular platform enables rapid solution creation and is licensed across brands, business units, geographies, and therapeutic areas.
- EHR-Integrated Clinical Decision Support: Clinical decision support solutions integrated into EHR workflows are provided to provider organizations, health plans, and life sciences companies, typically structured as per-provider or per-implementation licensing arrangements.
- Digital Therapeutics (DTx) and Companion Products: Amalgam develops and commercializes DTx and companion products with life sciences partners (e.g., DoseCheck with Novo Nordisk, Elevmi with Otsuka, Biolinq Shine app with Biolinq). Revenue flows through co-development agreements, commercialization milestones, and platform fees.
- Enterprise Platform Deployment: Enterprise customers deploy Amalgam's platform across their organizations to unify patient, caregiver, and provider engagement on a single global foundation. Revenue is generated through platform fees, customization, and ongoing support.
Go-to-market motion3 records
Distribution channels4 records
Marketing channels6 records
Amalgam Rx product offering
Product offeringCore offering
Amalgam Rx develops and licenses a modular, AI-powered Software as a Medical Device (SaMD) platform that delivers EHR-integrated clinical decision support, digital therapeutics, and conversational Medical-Grade AI applications for life sciences companies, health plans, and provider organizations. Named offerings include Elevmi (Alzheimer's caregiver support), DoseCheck and iSage Rx (insulin titration), and Avhana Health (point-of-care clinical decision support), all powered by the proprietary Chiron foundation model and embedded directly into provider EHR workflows.
Product overview
Amalgam Rx operates a modular, AI-powered Software as a Medical Device (SaMD) platform with three core solution pillars: Medical-Grade AI™ (conversational AI with healthcare-specific guardrails), EHR Solutions (integrated clinical decision support), and Digital Products (patient support applications). The Enterprise Platform serves as the unified foundation enabling deployment and scaling across brands, markets, and therapeutic areas. Individual products include Chiron (foundation model for predictive patient intelligence), Elevmi (Alzheimer's caregiver support), DoseCheck/iSage Rx (insulin titration), and Avhana Health (clinical decision support - acquired). The company also offers PDURS (Prescription Drug Use-Related Software) services. Solutions are integrated into leading EHRs including Epic, athenahealth, Cerner, and Veradigm, supporting nearly 10 million patients across four continents.
Differentiator
Problem solved
Functional benefit
Brands
- DoseCheck: Digital insulin initiation and titration app for people with type 2 diabetes using basal insulin
- iSage Rx
- Elevmi
- Chiron
- Medical-Grade AI
- Biolinq Shine
Products and services
- Medical-Grade AI Clinically tested conversational AI platform with built-in guardrails for healthcare applications, powering HCP, Patient, and Caregiver Assistants for life sciences companies, health plans, and providers.
- EHR Solutions EHR-integrated point-of-care solutions enabling patient identification, clinical trial recruitment, care guidelines, financial assistance, medication safety, prior authorization, and quality measure improvement for provider organizations.
- Digital Products Patient support applications and Software as a Medical Device (SaMD) products co-developed with global life sciences companies to drive outcomes across diabetes, Alzheimer's, oncology, and other therapeutic areas.
- Enterprise Platform Modular, AI-powered SaMD platform that enables enterprise customers to deploy and scale patient, caregiver, and provider engagement solutions across brands, business units, geographies, and therapeutic areas on a single global foundation.
- PDURS (Prescription Drug Use-Related Software) Prescription Drug Use-Related Software solutions that support, improve, or supplement use of prescription medications, enabling FDA labeling differentiation for life sciences brand franchises.
- Elevmi AI digital support application for caregivers of patients with Alzheimer's Disease, co-developed with Otsuka Precision Health and powered by Amalgam's Medical-Grade AI platform.
- DoseCheck Digital insulin initiation and titration app for people with type 2 diabetes on basal insulin, white-labeled from iSage Rx and integrated with Novo Nordisk's connected insulin delivery, CGM, and EHRs.
- iSage Rx Insulin titration application supporting titration of all basal insulins with connectivity to leading Bluetooth-enabled blood glucose meters, CE Marked for European market launch.
- Avhana Health CDS Clinical decision support SaaS tool acquired by Amalgam Rx with deep EHR integrations, enabling providers to support real-time adoption of clinical quality guidelines and identify cost savings.
- Chiron Foundation Model Proprietary foundation model for predictive patient intelligence that predicts medical events across multiple therapeutic areas simultaneously from a unified longitudinal patient journey, embedded within Amalgam's Medical-Grade AI platform.
- Biolinq Shine App Mobile app developed by Amalgam as the digital backbone for the Biolinq Shine needle-free, wearable glucose sensor integrating glucose, activity, and sleep data in a single device.
Quantifiable outcome
- Nearly 2x improvement in diagnostic efficiency for sleep apnea compared to traditional tools, reducing unnecessary diagnostic follow-ups by nearly half (Chiron foundation model)
- +6 more outcomes
Companies that use Amalgam Rx
Customer profileNamed customers7 records
Segments4 records
Ideal customer profiles3 records
Amalgam Rx technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration14 records
AI capability9 records
Feature6 records
Amalgam Rx partnerships and signals
Strategic signalPartnerships
Ten partnerships are on record, tiered core.
- Privia HealthcorePrivia Health, a national physician enablement company (NASDAQ: PRVA), partnered with Amalgam Rx for EHR-integrated clinical decision support and population health workflows. The collaboration achieved an 84% colorectal cancer screening rate in 2024, exceeding the National Colorectal Cancer Roundtable's 80% goal. The program engaged over 100,000 patients nationally, processed approximately 23,000 screening orders within 48 hours, and identified 550+ patients requiring diagnostic follow-up.
- Exact Sciences Corp.coreExact Sciences Corp. (NASDAQ: EXAS) partnered with Amalgam Rx and Privia Health to integrate the Cologuard colorectal cancer screening test into EHR workflows for automated patient identification, engagement, and follow-up at population scale. The nationwide EHR-enabled outreach program achieved colorectal cancer screening rates outperforming national benchmarks while reducing staff workload.
- BiolinqcoreAmalgam Rx partnered with Biolinq to develop the digital infrastructure for Biolinq Shine™, the first FDA De Novo-cleared, needle-free glucose sensor. Amalgam's scalable software platform enabled rapid software development supporting Biolinq's regulatory timelines. The same architecture supports Biolinq's multi-analyte ambitions beyond glucose.
- Otsuka Precision Health, Inc. (OPH)coreAmalgam Rx partnered with Otsuka Precision Health to launch Elevmi™, an AI-powered digital application helping caregivers support loved ones with Alzheimer's Disease. Amalgam provided its Medical-Grade AI platform and regulatory expertise; OPH provided brand and therapeutic area expertise. Elevmi is available on iOS and Android stores.
- Novo NordiskcoreAmalgam Rx expanded its global agreement with Novo Nordisk for commercialization of DoseCheck (insulin titration app). Novo Nordisk also made an equity investment in Amalgam. The new agreement incorporated integration with connected insulin delivery devices, continuous glucose monitors, and EHRs. Global expansion followed, with launches in Europe, Asia, and South America.
- Amazon Web Services (AWS)coreAmalgam Rx collaborates with AWS for Health initiative to accelerate development and global commercialization of regulated digital solutions. Amalgam's platform runs on AWS using container-based serverless technologies, service control policies for security/regulatory compliance, and Infrastructure as Code with CI/CD practices. AWS supports GxP-compliant workloads and HIPAA requirements.
- EpiccoreEpic is one of the major EHR systems with which Amalgam Rx has deep integration. Amalgam's solutions are embedded directly into the Epic EHR workflow for clinical decision support, patient identification, and other point-of-care tools.
- Cerner (Oracle Health)coreCerner (now Oracle Health) is a major EHR system with deep Amalgam Rx integration. Solutions are embedded into the Cerner EHR workflow for clinical decision support and population health management.
- athenahealthcoreathenahealth is a major EHR platform integrated with Amalgam Rx's solutions. The Privia Health colorectal cancer screening program used athenaClinicals EHR for ordering, results delivery, and follow-up integration.
- VeradigmcoreVeradigm (formerly Allscripts) is a major EHR system with Amalgam Rx integration for clinical decision support and point-of-care solutions.
Scale indicators12 records
Recent moves6 records
Expansion highlights7 records
Amalgam Rx competitors and assessment
Company assessmentDirect peers
- WellDoc: WellDoc pioneered the FDA-cleared, clinically validated mobile prescription therapy space (BlueStar for type 2 diabetes) and was co-founded by Amalgam's founders, Ryan Sysko and Dr. Suzanne Clough. It directly overlaps Amalgam's insulin-titration DTx business (DoseCheck/iSage Rx) and provider-EHR-integrated chronic care.
- Click Therapeutics: Click Therapeutics develops prescription digital therapeutics with FDA clearance and pharma commercialization partnerships, most directly comparable to Amalgam's pharma-co-developed DTx and SaMD pipeline. Overlap is strongest in regulated software-as-medicine, pharma co-development, and life-sciences commercialization.
- Akili Interactive: Akili develops FDA-cleared prescription digital therapeutics (EndeavorRx) and partners with pharma and providers on cognitive and behavioral interventions, making it a directly comparable DTx peer in regulatory pathway, evidence generation, and pharma commercialization model.
- Voluntis: Voluntis (acquired by Otsuka in 2020) developed insulin titration and oncology DTx products including Oleena, directly competing with Amalgam's DoseCheck/iSage Rx franchise. As Otsuka now owns Voluntis, Amalgam's Elevmi partnership with Otsuka sits alongside a vertically integrated competing asset, sharpening the comparison.
Broad incumbents
- Omada Health: Omada Health delivers digital chronic care (diabetes, hypertension, MSK) through payer and employer channels, comparable to Amalgam's life-sciences chronic-disease focus. Although broader in employer/ payer distribution, Omada overlaps heavily in diabetes and behavior-change digital therapeutics.
- Health Catalyst: Health Catalyst provides data-and-analytics infrastructure for health systems, including clinical decision support, quality-measure improvement, and value-based care enablement — directly comparable to Amalgam's Avhana-acquired CDS workflow and EHR-integrated quality/savings tooling.
- Doximity: Doximity's workflow tools and physician-facing applications overlap with Amalgam's HCP Assistant and EHR-embedded point-of-care decision support, particularly in connecting clinical content and decision support to providers inside daily workflows.
Emerging players
- Phreesia: Phreesia provides patient intake, eligibility, and clinical workflow tools integrated into major EHRs. The category overlap is around EHR-embedded patient identification, automated outreach, and quality-measure workflows (e.g., Phreesia's preventive screening modules), aligned with Amalgam's colorectal cancer screening execution.
- Innovaccer: Innovaccer offers EHR-integrated population health management, clinical decision support, and value-based care enabler tools across health systems and payers, comparable to Amalgam's EHR Solutions suite and Avhana CDS footprint at 150+ provider groups.
Others
- Babylon Health: Babylon Health represented the AI-driven clinical decision/chatbot category that overlaps thematically with Amalgam's Medical-Grade AI conversational engine and Chiron's predictive intelligence, although its geographic and payer-partnership profile differs; useful as an adjacent AI-clinical benchmark.
Market position
Strengths5 records
Weaknesses5 records
Competitive moat6 records
Key risks7 records
Key highlights7 records
Customer concentration
Amalgam Rx social profiles
Digital presenceAmalgam Rx compliance and trust
Trust signalCompliance9 records
Amalgam Rx financial estimates
Financial estimateRevenue estimate
Valuation estimate
Amalgam Rx leadership team
Management profileNumber of profiles
Profiles10 records
Amalgam Rx subsidiaries and ownership
Company hierarchySubsidiaries2 records
Amalgam Rx funding detail
Funding detailFunding overview
Funding rounds6 records
Investors5 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Amalgam Rx M&A and investment
M&A and investmentM&A1 record
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Amalgam Rx
What does Amalgam Rx do?
Amalgam Rx develops and licenses a modular, AI-powered Software as a Medical Device (SaMD) platform that delivers EHR-integrated clinical decision support, digital therapeutics, and conversational Medical-Grade AI applications for life sciences companies, health plans, and provider organizations. Named offerings include Elevmi (Alzheimer's caregiver support), DoseCheck and iSage Rx (insulin titration), and Avhana Health (point-of-care clinical decision support), all powered by the proprietary Chiron foundation model and embedded directly into provider EHR workflows.
Is Amalgam Rx a public or private company?
Amalgam Rx is a private company. It is classified as venture growth investor backed and is currently operating.
When was Amalgam Rx founded?
Amalgam Rx was founded in 2009. It employs 51 to 100 people.
Where is Amalgam Rx based?
Amalgam Rx is headquartered in Wilmington, United States, in the North America region.
How does Amalgam Rx make money?
Four revenue lines are on record. SaaS Platform Licensing is the primary driver. The others are EHR-Integrated Clinical Decision Support, digital Therapeutics (DTx) and Companion Products and enterprise Platform Deployment.
Who are Amalgam Rx's main competitors?
Direct peers on record are WellDoc, Click Therapeutics, Akili Interactive and Voluntis. Broad incumbents are Omada Health, Health Catalyst and Doximity. Emerging players are Phreesia and Innovaccer. Babylon Health is listed as an others.
Does Amalgam Rx have an API?
No public API is recorded for Amalgam Rx.
What industry is Amalgam Rx in?
Amalgam Rx's product category is Digital Health Software / Healthcare AI SaMD Platform. Its primary akta.pro industry code is HLACANAO, DTx/SaMD Deployment, Integration & Reimbursement Enablement, with a secondary code of HLACAAAN, EHR Extensions, APIs, App Marketplaces & SMART-on-FHIR Apps. Its NAICS code is 5132 and its SIC code is 3841.