Ayble Health

What Ayble Health does

Ayble Health is a digital health platform that delivers personalized nutrition and behavioral health care for people with gastrointestinal conditions such as Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD). The platform combines an AI-assisted recommendation engine — built on what the company describes as the largest GI data ecosystem, enabling personalization from 200 quadrillion possible combinations — with a Mind-Gut behavioral program using cognitive behavior therapy, gut-directed hypnosis, and acceptance and commitment therapy. A Food Discovery Engine with item scanner and 2.3 million recipes supports trigger-food identification, while a physician-facing remote monitoring module integrates the program into clinical workflows for gastroenterologists and health systems.

The core product is offered as a tiered subscription ($39.99 to $49.99 per month for 4 to 12-month programs) and is reimbursed by health insurance, with most members paying $0 out of pocket and copays typically under $60 per month. Ayble operates a hybrid go-to-market model: direct-to-consumer self-serve onboarding through a mobile app combined with enterprise B2B sales to employers, health plans, and benefits brokers. Flagship commercial relationships include Cleveland Clinic, Mayo Clinic, Priority Health (1.3M members), and Apex Benefits, alongside a United Healthcare Marketplace listing. The company is venture-backed with approximately $4.6 million raised from M13, Upfront Ventures, Founder Collective, and Inflect Health, and is based in Boston.

Founded by Sam Jactel in 2020 based on his personal experience with Ulcerative Colitis, Ayble has assembled a clinical advisory board spanning Cleveland Clinic, Harvard Medical School / Brigham & Women's Hospital, Massachusetts General Hospital, Northwestern, and the IMAGINE network, and has published outcomes research in Gastroenterology, Inflammatory Bowel Diseases, and Clinical & Translational Gastroenterology showing 80%+ symptom improvement. The company is the first and only gastroenterology firm independently validated by the Validation Institute.

Name

Ayble Health

Legal name

Ayble Health, Inc.

Website

https://ayblehealth.com

Company type

Private

Founded year

2020

Operating status

Operating

Headcount range

11–50 employees

Short description

Ayble Health is a digital health platform delivering AI-personalized nutrition and behavioral health programs for patients with gastrointestinal conditions such as IBS and IBD. It sells tiered consumer subscriptions reimbursed by insurance and licenses its platform to health systems, employers, and health plans including Cleveland Clinic, Mayo Clinic, and Priority Health.

Ownership category

akta.pro rank

Product category

Digital Gastrointestinal Care Platform

NAICS

Software Publishers (5132), Social Assistance (624)

SIC

Services-Health Services (8000), Services-Prepackaged Software (7372)

akta.pro primary industry

Gastroenterology Telemedicine Platforms (HLALAGAE)

akta.pro secondary industries

Medical Nutrition Therapy (Registered Dietitian) (HSADAFAE), Patient Education, Content & Personalized Journey Orchestration (HLACAEAE), Healthcare & Wellness Personalization (HDAAAGAI)

Keywords

• Digital GI care
• Digestive health platform
• Gut health programs
• Personalized nutrition plans
• GI behavior therapy

Headquarters

HQ city

Boston

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B and B2C

Offering type

Software

Cost components

Technology or R&D, Personnel, Marketing or Sales, Operations, Infrastructure

Revenue model

1. Subscription - Consumer Direct: Direct-to-consumer subscription model with tiered membership options ranging from Essentials ($49.99/mo) to comprehensive bundles ($39.99/mo with annual commitment). Most members pay $0 through health insurance coverage.
2. Enterprise B2B - Employer Health Plans: B2B enterprise licensing agreements with employers and health plans to provide digestive health benefits as part of employee benefits packages. Organizations bear the burden of unmanaged gut health symptoms driving demand for employer-sponsored coverage.
3. Health Insurance Reimbursement: Ayble Health submits claims to health insurers for eligible and covered Medical Services. Most Ayble members pay $0 for their care through health insurance, with copays typically less than $60/month when applicable.

Pricing tiers

Go-to-market motion3 records

Distribution channels6 records

Marketing channels6 records

Core offering

Ayble Health operates a clinically-backed digital health platform that delivers personalized nutrition planning, GI psychology programs (CBT, gut-directed hypnosis, ACT), and access to licensed GI dietitians and health coaches for individuals with gastrointestinal conditions such as IBS and IBD. The platform combines AI-powered personalization from a proprietary GI data ecosystem with a food discovery engine, barcode item scanner, and 2.3 million recipes, and is offered directly to consumers via subscription as well as through employer health benefits, health plan coverage, and health system clinical integrations.

Product overview

Ayble Health is a unified digital health platform offering personalized GI nutrition and mental health care. The core Ayble Health Platform serves as the central hub, supplemented by the Mind-Gut Program for psychological interventions and the Food Discovery Engine for dietary management. The platform is offered through tiered subscription programs (Essentials, Essentials + Exploration, and Essentials + Exploration + Deep Dive) ranging from 4 to 12 months of access. For clinical partners and health systems, Ayble offers a physician-facing remote monitoring platform. For employers and health plans, enterprise benefits packages are available. The Learning Hub provides supplementary educational content, and all offerings are covered by insurance with most members paying $0 through their health insurance.

Differentiator

Problem solved

Functional benefit

Products and services

• Ayble Health Platform A personalized GI nutrition and mental health care platform that combines behavior science and clinical protocols to help patients manage digestive conditions through AI-powered symptom tracking, trigger food identification, and virtual care team access. Targeted at individuals with IBS, IBD, and other GI conditions.
• Physician-Facing Remote Monitoring Platform A clinical partner platform that integrates at the point of care, allowing clinicians to remotely recommend and track patients' progress through GI behavioral programs and creating a comprehensive at-home and in-clinic experience. Targeted at health systems, gastroenterologists, and clinical providers.
• Enterprise Health Benefits An employer and health plan offering providing science-backed digital gut health care to organizations, addressing GI conditions that impact 70M Americans and generate $140B in direct medical spend annually. Targeted at employers, health insurers, and benefits brokers/consultants.

Quantifiable outcome

• 81%+ of users report improved digestive symptoms (vs 24-70% for other tools)
• +4 more outcomes

Named customers4 records

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration1 record

AI capability6 records

Feature5 records

Partnerships

Eleven partnerships are on record, tiered flagship, core and supporting.

• Cleveland ClinicflagshipStrategic or Co-development PartnerCleveland Clinic is collaborating with Ayble Health to provide virtual behavioral health and nutrition counseling to GI patients. The model, co-developed by both organizations, is described as the first of its kind in the GI space. It aims to keep patients engaged between visits while addressing a projected shortage of 1,600+ GI specialists by 2025. Both organizations are working to integrate their systems and expand insurance coverage to increase patient accessibility. Cleveland Clinic's Dr. Stephen Lupe, Director of Behavioral Medicine, serves as a clinical advisor to Ayble.
• Mayo ClinicflagshipStrategic or Co-development PartnerMayo Clinic and Ayble Health collaborated to make GI care less complicated and to treat high-acuity patients in person. The partnership integrates Ayble's digital care platform with Mayo Clinic's clinical expertise for comprehensive GI care delivery.
• Priority HealthcoreGTM or Marketing PartnerPriority Health, a nonprofit health plan serving over 1.3 million members, partnered with Ayble Health for digestive health as part of a shift from treating isolated health conditions to a whole-person care model encompassing physical, mental, emotional health and social determinants of health.
• Apex BenefitscoreGTM or Marketing PartnerAyble Health and Apex Benefits partnered to expand access to digestive healthcare. Apex Benefits provides workplace health benefits consulting and will offer Ayble Health as part of their digestive health solution for employer clients.
• Commure EngagesupportingTechnology or IntegrationAyble partnered with Commure Engage to connect GI patients with personalized care through integration with Commure's patient engagement platform, enhancing connectivity and care coordination.
• Brigham and Women's HospitalsupportingStrategic or Co-development PartnerResearch collaboration with Brigham and Women's Hospital for GI clinical studies. Dr. Joshua Korzenik, Director of the Crohn's & Colitis Center at Brigham & Women's Hospital and Associate Professor of Medicine at Harvard Medical School, serves as a clinical advisor.
• Massachusetts General HospitalsupportingStrategic or Co-development PartnerResearch collaboration with Massachusetts General Hospital for GI clinical studies. Dr. Mythili Pathipati, Gastroenterologist at MGH and Stanford School of Medicine, serves as a clinical advisor. MGH is listed as a research partner on the website.
• Northwestern UniversitysupportingStrategic or Co-development PartnerResearch collaboration with Northwestern University for GI clinical studies. Dr. Tiffany Taft, Associate Professor of Medicine at Northwestern Feinberg School of Medicine and Founding Member of Rome Foundation Psycho-Gastroenterology Section, serves as a clinical advisor.
• University of WashingtonsupportingStrategic or Co-development PartnerResearch collaboration with University of Washington for GI clinical studies, contributing to the evidence base supporting Ayble Health's approach.
• Mayo ClinicsupportingStrategic or Co-development PartnerResearch and clinical collaboration with Mayo Clinic. Mayo Clinic logo appears alongside other academic research institutions on the Ayble Health website, indicating a formal research partnership.
• IMAGINE NetworksupportingStrategic or Co-development PartnerDr. Paul Moayyedi, Principal Investigator of the IMAGINE network, serves as a clinical advisor. IMAGINE is a clinical research network focused on GI conditions.

Scale indicators13 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Oshi Health: Oshi Health is a virtual-first gastroenterology clinic providing integrated care (dietitians, behavioral health, GI specialists) for IBS, IBD, and related conditions. It is the closest direct competitor to Ayble, sharing the same hybrid D2C + employer/payer + health-system GTM model and recently featured alongside Ayble in IBD management research.
• Vivante Health: Vivante Health offers GIThrive, a digital gut-health platform combining nutrition, behavioral, and clinical care for digestive conditions, sold primarily through employers and health plans. It competes head-to-head with Ayble in the employer/payer benefits channel for GI care.
• Trellus Health: Trellus Health provides a digital therapeutic program for IBD and IBS built on gut-directed hypnosis and resilience training. It overlaps with Ayble's Mind-Gut Program (CBT, GDH, ACT) and shares the same specialty digital therapeutics category for chronic GI conditions.
• metaMe Health: metaMe Health developed Regulora, an FDA-cleared digital therapeutic using gut-directed hypnosis for IBS abdominal pain. It directly competes with Ayble's Mind-Gut program on the digital therapeutics side of GI behavioral care.
• Mahana Therapeutics: Mahana Therapeutics is a digital therapeutics company focused on gut-brain conditions including IBS, with evidence-based behavioral programs. It is a direct competitor in the digital therapeutic category for GI conditions and shares Ayble's gut-directed hypnosis and CBT methodologies.
• Bold Health: Bold Health (formerly Bold Health and later Mahana-branded operations) developed evidence-based digital therapeutic programs for IBS and other GI conditions using CBT and gut-directed hypnotherapy. It competes with Ayble in the digital GI therapeutics category, especially in Europe.

Regional players

• Cara Care: Cara Care is a digital digestive health platform offering personalized nutrition, symptom tracking, and content for conditions like IBS and IBD, primarily in Europe. It is comparable to Ayble in product scope (nutrition + symptom tracking) but does not directly compete in the U.S. enterprise/payer market.

Emerging players

• ModifyHealth: ModifyHealth provides medically tailored meals and nutrition support for GI and other chronic conditions, often sold through employer benefits and providers. It is comparable to Ayble's nutrition-focused offering and shares the employer-channel GTM motion, though its core product is food delivery rather than a digital platform.

Broad incumbents

• GI Alliance: GI Alliance is the largest gastroenterology services network in the U.S., operating hundreds of GI providers and clinics. It is comparable to Ayble as the incumbent clinical GI delivery layer against which Ayble's health system integration and remote patient monitoring platform competes.

Others

• Headspace Health: Headspace Health combines the Headspace mental health app with Ginger's on-demand coaching/therapy. It is adjacent to Ayble's Mind-Gut Program (which uses CBT, ACT, and mindfulness for GI patients) and represents a broader mental health incumbent that could expand into GI-specific behavioral care.

Market position

Strengths4 records

Weaknesses4 records

Competitive moat6 records

Key risks5 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/ayblehealth
• LinkedInlinkedin.com/company/ayble-health
• Instagraminstagram.com/be_ayble
• Xx.com/be_ayble

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds3 records

Investors10 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Ayble Health