ZETA SURGICAL
ZETA SURGICAL is a Boston-based medical technology company that develops AI-powered, frameless neuronavigation systems for neurosurgery and transcranial magnetic stimulation, sold to hospitals, outpatient clinics, and ambulatory surgical centers.
- Company typePrivate
- Founded2018
- HeadquartersBoston, United States
- Headcount11–50
- GTM typeB2B
- OfferingHardware or Manufacturing
ZETA SURGICAL firmographics
Firmographics- Name
- ZETA SURGICAL
- Legal name
- Zeta Surgical, Inc.
- Website
- https://zetasurgical.com
- Company type
- Private
- Founded year
- 2018
- Operating status
- Operating
- Headcount range
- 11–50 employees
- Short description
- ZETA SURGICAL is a Boston-based medical technology company that develops AI-powered, frameless neuronavigation systems for neurosurgery and transcranial magnetic stimulation, sold to hospitals, outpatient clinics, and ambulatory surgical centers.
- Ownership category
- akta.pro rank
ZETA SURGICAL industry classification
Industry- Product category
- Neurosurgical Navigation Systems
- NAICS
- Navigational, Measuring, Electromedical, and Control Instruments Manufacturing (33451), Surgical and Medical Instrument Manufacturing (339112), Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)
- SIC
- Surgical & Medical Instruments & Apparatus (3841), Electromedical & Electrotherapeutic Apparatus (3845), Orthopedic, Prosthetic & Surgical Appliances & Supplies (3842)
- akta.pro primary industry
- Surgical Navigation, Tracking & Intraoperative Guidance (Ortho/Neuro/ENT) (HLAHADAG)
Keywords
Where ZETA SURGICAL is headquartered
LocationHeadquarters
- HQ city
- Boston
- HQ country
- United States
- HQ region
- North America
Offices2 records
Markets served
ZETA SURGICAL business model
Business model- GTM type
- B2B
- Offering type
- Hardware or Manufacturing
- Cost components
- Technology or R&D, Personnel, Supply Chain, Operations, Marketing or Sales
Revenue model
- Navigation System Hardware Sales: Sale of Zeta Cranial Navigation System and Zeta TMS Navigation System as capital medical equipment to hospitals, surgical centers, and outpatient clinics. The systems are FDA-cleared and commercially available in the United States.
- Navigation System Service and Support: Ongoing maintenance, support, and potentially software updates for deployed navigation systems in clinical settings.
Pricing tiers
| Model | Billing | Price |
|---|---|---|
| Other | Multi-year contract | Enterprise medical device pricing - quote-based |
Go-to-market motion1 record
Distribution channels3 records
Marketing channels5 records
ZETA SURGICAL product offering
Product offeringCore offering
ZETA SURGICAL develops and sells FDA-cleared, AI-powered neuronavigation systems for neurosurgical procedures and transcranial magnetic stimulation (TMS). Its flagship products are the Zeta Cranial Navigation System and the Zeta TMS Navigation System, both powered by the proprietary RealTrack computer-vision platform that delivers sub-millimetric, markerless, frameless image guidance deployable in operating rooms, emergency settings, and outpatient clinics.
Product overview
ZETA SURGICAL offers a platform of AI-powered neuronavigation products for neurosurgery and neuromodulation. The core offerings include the Zeta Navigation System (for neurosurgical procedures) and the Zeta TMS Navigation System (for transcranial magnetic stimulation), both using the proprietary RealTrack™ computer vision technology for frameless, real-time guidance. These are complemented by navigated instruments Zeta Stylet and Zeta Bolt. The platform enables sub-millimetric accuracy without skull fixation or general anesthesia, deployable across operating rooms, emergency settings, and outpatient clinics.
Differentiator
Problem solved
Functional benefit
Products and services
- Zeta Navigation System FDA-cleared computer-assisted, real-time image guidance system for spatial positioning and orientation of neurosurgical instruments. Uses computer vision and AI to align preoperative CT or MRI scans with patient anatomy, providing sub-millimeter navigation at virtually any point-of-care for external ventricular drain placement, brain biopsy, tumor resection, and trigeminal rhizotomies.
- Zeta TMS Navigation System FDA-cleared AI-powered navigation system for transcranial magnetic stimulation providing real-time, markerless image guidance with sub-millimetric accuracy. Uses RealTrack technology to align patient MRI or CT imaging with facial anatomy and continuously track TMS coil positioning across treatment sessions for major depressive disorder and other neurological conditions.
- Zeta Stylet FDA-cleared navigated instrument that integrates with the Zeta Navigation System for neurosurgical procedures including external ventricular drain placement, brain biopsy, and shunt procedures.
- Zeta Bolt FDA-cleared navigated instrument that integrates with the Zeta Navigation System providing navigated guidance for catheter placements, brain biopsies, and trigeminal rhizotomies.
Quantifiable outcome
- 100% ideal catheter placement vs 32% freehand for EVD procedures
- +5 more outcomes
Companies that use ZETA SURGICAL
Customer profileNamed customers4 records
Segments4 records
Ideal customer profiles4 records
ZETA SURGICAL technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
AI capability5 records
Feature5 records
ZETA SURGICAL partnerships and signals
Strategic signalPartnerships
Eight partnerships are on record, tiered flagship, core and minor.
- HOPE Therapeutics (NRx Pharmaceuticals subsidiary)flagshipFirst commercial deployment of Zeta TMS Navigation System at HOPE Therapeutics clinics in West Palm Beach and Sarasota, Florida. The partnership supports outpatient TMS therapy for major depressive disorder and represents ZETA's transition from R&D to commercial operations.
- Big 10 Neurosurgical ConsortiumcoreLarge-scale commercial pilot program planned for 2026 with the Big 10 Neurosurgical Consortium for Zeta Navigation System deployment across member institutions.
- NRx Defense SystemscorePartnership to develop robotic-enabled Transcranial Magnetic Stimulation combined with neuroplastic therapy for military and first responder applications. ZETA provides AI-powered neuronavigation platform; NRx Defense Systems focuses on D-Cycloserine (NRX-101) combined with TMS. Prototype unveiling planned for June 2026 at Clinical TMS Society meeting.
- University of CambridgeminorCollaborative study with University of Cambridge and Harvard Medical School demonstrating sub-millimeter translational and sub-degree angular precision for navigated TMS.
- Imperial College LondonminorResearch collaboration on SCOUT (Skull-Corrected Optimization for Ultrasound Transducers) project for skull-corrected ultrasound imaging.
- Singapore General Hospital and Tan Tock Seng HospitalcoreMulti-center clinical trial sites for first multicenter clinical trial using Zeta Cranial Navigation System. Fifteen patients successfully cannulated in single attempt with no adverse events.
- National Neuroscience Institute, SingaporecoreFirst-in-human clinical trial site for EVD procedures using ZETA navigation system. Successful trial demonstrated 100% ideal catheter placement and 0% adverse events across all cases.
- Harvard Medical School (Brigham and Women's Hospital, Massachusetts General Hospital)corePrimary research and clinical development partnership. Dr. William Gormley serves as Co-Founder and Director of Neurosurgical Innovation at Harvard Medical School's Brigham and Women's Hospital. Multiple joint publications and clinical studies.
Scale indicators9 records
Recent moves7 records
Expansion highlights7 records
ZETA SURGICAL competitors and assessment
Company assessmentDirect peers
- 7D Surgical: 7D Surgical (now part of Proprio Vision) develops machine-vision surgical navigation systems for spine and cranial procedures. It is a direct competitor with a comparable value proposition of markerless, fast-setup image guidance in neurosurgery and spine.
- Brainlab: Brainlab is a direct competitor in image-guided surgical navigation for neurosurgery and other specialties. Its Curve and Kick navigation platforms compete directly with the Zeta Navigation System in hospital neurosurgery departments and address overlapping use cases including cranial and spine procedures.
- Synaptive Medical: Synaptive Medical sells image-guided neurosurgical platforms (e.g., Modus V, BrightMatter) directly competing with ZETA's navigation system in cranial procedures. Both companies target academic and community neurosurgery departments with AI/computer-vision-enabled navigation.
- Neuronetics: Neuronetics sells NeuroStar TMS systems for treatment-resistant depression and adjacent indications. As ZETA's TMS Navigation System is sold alongside TMS treatment delivery to psychiatric and neurology clinics, Neuronetics is a directly adjacent peer with overlapping customers and complementary (rather than competing) positioning.
- BrainsWay: BrainsWay develops deep TMS systems for depression, OCD, and other psychiatric conditions, competing in the same outpatient psychiatric clinic channel as ZETA's TMS navigation deployments. Its clinical evidence base and reimbursement infrastructure shape the same customer conversations ZETA enters.
Broad incumbents
- Medtronic (StealthStation): Medtronic's StealthStation is the entrenched leader in surgical navigation with a large installed base across neurosurgery and spine ORs. It competes with ZETA across the same neurosurgical use cases but as part of a much broader neuromodulation and cranial portfolio.
- Stryker (Navigation): Stryker offers surgical navigation systems (acquired with MAKO and other platforms) used in neurosurgery and other OR settings. It is a broad incumbent competing with ZETA in the same hospital neurosurgery procurement cycles but with a much larger capital equipment portfolio.
Emerging players
- Surgical Theater: Surgical Theater provides VR-based surgical planning and visualization tools for neurosurgery that complement or compete with image-guidance workflows. It is an emerging player with overlapping neurosurgical customers and adjacent positioning in pre-operative planning.
- Soterix Medical: Soterix Medical develops non-invasive brain stimulation and neuromodulation devices (including TMS and tDCS systems) for research and clinical use. It is an emerging peer competing in the same brain-circuit therapeutics market served by ZETA's TMS navigation.
- Viz.ai: Viz.ai applies AI imaging triage to acute neurological care (stroke, etc.), operating adjacent to ZETA in AI-enabled neuro workflows. While not a navigation competitor, it is led by a former Viz.AI Global VP (Dr. Aimee Degaetano) who now advises ZETA, signaling ecosystem overlap.
Market position
Strengths5 records
Weaknesses4 records
Competitive moat5 records
Key risks5 records
Key highlights6 records
Customer concentration
ZETA SURGICAL compliance and trust
Trust signalCompliance2 records
ZETA SURGICAL financial estimates
Financial estimateRevenue estimate
Valuation estimate
ZETA SURGICAL leadership team
Management profileNumber of profiles
Profiles16 records
ZETA SURGICAL funding detail
Funding detailFunding overview
Funding rounds3 records
Investors9 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
ZETA SURGICAL M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about ZETA SURGICAL
What does ZETA SURGICAL do?
ZETA SURGICAL develops and sells FDA-cleared, AI-powered neuronavigation systems for neurosurgical procedures and transcranial magnetic stimulation (TMS). Its flagship products are the Zeta Cranial Navigation System and the Zeta TMS Navigation System, both powered by the proprietary RealTrack computer-vision platform that delivers sub-millimetric, markerless, frameless image guidance deployable in operating rooms, emergency settings, and outpatient clinics.
Is ZETA SURGICAL a public or private company?
ZETA SURGICAL is a private company. It is classified as venture growth investor backed and is currently operating.
When was ZETA SURGICAL founded?
ZETA SURGICAL was founded in 2018. It employs 11 to 50 people.
Where is ZETA SURGICAL based?
ZETA SURGICAL is headquartered in Boston, United States, in the North America region.
How does ZETA SURGICAL make money?
Two revenue lines are on record. Navigation System Hardware Sales are the primary driver. The others are navigation System Service and Support.
Who are ZETA SURGICAL's main competitors?
Direct peers on record are 7D Surgical, Brainlab, Synaptive Medical, Neuronetics and BrainsWay. Broad incumbents are Medtronic (StealthStation) and Stryker (Navigation). Emerging players are Surgical Theater, Soterix Medical and Viz.ai.
Does ZETA SURGICAL have an API?
No public API is recorded for ZETA SURGICAL.
What industry is ZETA SURGICAL in?
ZETA SURGICAL's product category is Neurosurgical Navigation Systems. Its primary akta.pro industry code is HLAHADAG, Surgical Navigation, Tracking & Intraoperative Guidance (Ortho/Neuro/ENT). Its NAICS code is 33451 and its SIC code is 3841.