Surescripts

What Surescripts does

Surescripts operates the largest health intelligence network in the United States, connecting virtually all pharmacies, prescribers, payers, PBMs, EHR vendors, and health systems to facilitate electronic health data exchange. Founded in 2001 and headquartered in Arlington, Virginia, the company processed 30.5 billion health data interoperability transactions in 2025, connecting 2.32 million healthcare professionals and routing 2.64 billion e-prescriptions. The platform supports a portfolio of services spanning e-prescribing (EPCS, RxTransfer), medication history, real-time prescription benefit, prior authorization automation, specialty medication workflows, and clinical direct messaging, all built on NCPDP SCRIPT and HL7 FHIR standards. Surescripts was designated as a Qualified Health Information Network (QHIN) under TEFCA in April 2025, establishing a regulatory role in nationwide health data exchange infrastructure, and operates with 99.998% average network uptime.

Name

Surescripts

Legal name

Surescripts, LLC

Website

https://surescripts.com

Company type

Private

Founded year

2001

Operating status

Operating

Headcount range

501–1,000 employees

Short description

Surescripts operates the largest U.S. health intelligence network, connecting 2.32 million healthcare professionals, virtually every pharmacy, prescriber, and payer to process 30.5 billion annual data interoperability transactions and route 2.64 billion e-prescriptions. The platform monetizes via network transaction fees and value-added services (prior authorization automation, real-time prescription benefit, specialty pharmacy solutions) sold to health systems, health plans, PBMs, pharmacies, and EHR vendors.

Ownership category

akta.pro rank

Product category

Healthcare Interoperability / Health Information Network

NAICS

Pharmacy Benefit Management and Other Third Party Administration of Insurance and Pension Funds (524292)

SIC

Services-Computer Programming, Data Processing, Etc. (7370)

akta.pro primary industry

PBM Technology Platforms (ePA/eRx/Real-Time Benefit Tools) (HLAEAKAL)

akta.pro secondary industries

Pharmacy Benefit Management (PBM) & Formulary Management IT (HLACAKAD), Pharmacy Benefit Management (PBM) & Pharmacy Network Administration (HLAFALAI), Specialty Pharmacy Benefit Management (Specialty PBM) (HLAEAKAE)

Keywords

• Health data interoperability
• Electronic prescribing network
• Healthcare information exchange
• Prior authorization automation
• Medication history services

Headquarters

HQ city

Arlington

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Technology or R&D, Personnel, Infrastructure, Operations, Marketing or Sales

Revenue model

1. Network Transaction Fees: Surescripts charges network participation and transaction fees to healthcare stakeholders (pharmacies, health plans, PBMs, EHR vendors) for access to its interoperability network and health intelligence services. The network processes 30.5 billion transactions annually.
2. Value-Added Services: Premium services including prior authorization automation, specialty medication solutions, medication history, and real-time prescription benefit tools. These are sold to health plans, pharmacies, and health systems as add-on capabilities to core network access.

Go-to-market motion2 records

Distribution channels5 records

Marketing channels6 records

Core offering

Surescripts operates a nationwide health intelligence network that electronically connects pharmacies, payers, PBMs, physicians, hospitals, HIEs, and EHRs for secure health information sharing. The platform processes over 30.5 billion transactions annually and offers e-prescribing, prior authorization automation, medication history, real-time prescription benefit, and clinical interoperability services across the U.S. healthcare system.

Product overview

Surescripts operates as a health intelligence network platform connecting healthcare professionals across the entire U.S. healthcare system. The core Surescripts Health Information Network processes over 30.5 billion health data interoperability transactions annually, connecting 2.32 million healthcare professionals. The product portfolio centers on e-prescribing capabilities (E-Prescribing, EPCS, RxTransfer) that route prescriptions electronically to pharmacies nationwide. Medication management solutions include Medication History for Ambulatory, Populations, and Reconciliation; Formulary; Eligibility; and Real-Time Prescription Benefit. Prior authorization solutions range from Electronic Prior Authorization to the advanced Prior Authorization Automation system and a dedicated Prior Authorization Portal. Specialty medication solutions include Specialty Medications Gateway, Specialty Patient Enrollment, and First-Fill Abandonment insights. Interoperability is enabled through Clinical Direct Messaging, National Record Locator Service, and QHIN connectivity via Interconnect for TEFCA participation. Patient-facing solutions include Script Corner for price transparency.

Differentiator

Problem solved

Functional benefit

Products and services

• E-Prescribing Electronic prescription routing capabilities enabling prescribers to send prescriptions directly to pharmacies nationwide, with 2.64 billion e-prescriptions filled in 2025.
• Electronic Prescribing for Controlled Substances (EPCS)

Quantifiable outcome

• 40% lower out-of-pocket cost for high-cost drug classes using Real-Time Prescription Benefit recommendations
• +7 more outcomes

Named customers10 records

Segments7 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration3 records

AI capability2 records

Feature12 records

Partnerships

13 partnerships are on record, tiered secondary and core.

• eNavvisecondaryTechnology or Integration · 29 June 2026eNavvi achieved Surescripts E-Prescribing certification, enabling clinicians to access Surescripts' nationwide pharmacy routing capabilities within the eNavvi digital prescribing platform.
• TEFCA/CMS Health Tech EcosystemcoreTechnology or Integration · 15 June 2026Surescripts, designated as a QHIN under TEFCA, is among 21 networks and companies that have pledged to become CMS Aligned Networks, committing to provide data access via FHIR APIs.
• SapphireHealthsecondaryTechnology or Integration · 25 March 2026SapphireHealth achieved Surescripts Medication History for Reconciliation certification for its v2026 prescriber software serving correctional facilities. Enables integration of patient medication history into workflow.
• LogiCoysecondaryTechnology or Integration · 24 March 2026LogiCoy achieved Surescripts Real-Time Prescription Benefit certification for its LogiCoy eRx platform, enabling prescribers to access patient-specific prescription coverage and cost information within their clinical workflow.
• ArcadiasecondaryTechnology or Integration · 18 February 2026Partnership to integrate Surescripts' First-Fill Abandonment insights into Arcadia's healthcare data platform for their provider customers, enabling faster interventions for patients who don't pick up prescriptions.
• GoodRxcoreGTM or Marketing Partner · 14 January 2026Exclusive partnership to incorporate GoodRx discounted cash prices alongside insurance-based pricing in Script Corner solution. Expands patient visibility into medication costs at point of prescribing through an exclusive arrangement.
• Milliman CareFlowIQsecondaryTechnology or Integration · 20 November 2025Milliman CareFlowIQ expanded its clinical intelligence platform by integrating broader medication history sourced from Surescripts, enhancing real-time insights for healthcare providers.
• WalgreenscoreTechnology or Integration · 21 January 2025Walgreens and Surescripts presented jointly on Specialty Medications Gateway at NASP Conference. Solution has achieved 85% adoption across Walgreens specialty pharmacies with 63% of users reporting it helped avoid calls to prescribers.
• CLEARcoreTechnology or Integration · 15 January 2025Partnership with CLEAR's secure identity platform to enhance identity verification technology infrastructure for the Surescripts Network Alliance. CLEAR's identity proofing technology supports providers, pharmacies, and payers in streamlining identity validation.
• NACDS, APhA Foundation, NCPA FoundationcoreStrategic or Co-development Partner · 13 January 2025Pharmacy Workgroup sponsors along with Surescripts working to address interoperability gaps that prevent pharmacists from sharing data with other healthcare providers and payers.
• The Sequoia ProjectcoreStrategic or Co-development Partner · 29 July 2024Launched joint Pharmacy Workgroup under Interoperability Matters program, funded and collaboratively developed with Surescripts. Surescripts co-chairs the workgroup with Point-of-Care Partners to address pharmacy interoperability gaps.
• ActiveRADAR (Acquired)coreOthers · 6 November 2023Acquisition of ActiveRADAR, a clinical intelligence company, to enhance solutions for medication management and prescription pricing. Aims to improve medication adherence, reduce drug spend, and increase provider access to comprehensive clinical and cost data.
• Major EHR Vendors (Epic, eClinicalWorks, Cerner, Allscripts, etc.)coreTechnology or IntegrationExtensive partnerships with EHR vendors enabling integration of Surescripts e-prescribing, medication history, prior authorization, and interoperability services into their platforms. Over 480,000 healthcare providers have access through these integrations.

Scale indicators13 records

Recent moves6 records

Expansion highlights3 records

Emerging players

• Avaneer Health: Avaneer Health is an emerging blockchain-based healthcare network launched by major payers and providers that targets provider-to-payer data exchange — an emerging peer in the same interoperability/QHIN-adjacent category as Surescripts.

Direct peers

• DrFirst: DrFirst is a direct competitor in e-prescribing, medication management, and clinical interoperability, providing EHR-integrated prescribing, medication history, and prior-authorization workflows for ambulatory providers and hospitals.
• Health Gorilla: Health Gorilla is a Qualified Health Information Network (QHIN) under TEFCA providing clinical data exchange, record retrieval, and interoperability — a direct peer in the federal QHIN framework alongside Surescripts.
• NaviNet (Zelis): NaviNet, owned by Zelis, operates a healthcare information network connecting payers, providers, and pharmacies for eligibility, claims status, and care coordination — directly comparable to the Surescripts Network Alliance model.
• CoverMyMeds: CoverMyMeds (acquired by McKesson) is the most direct competitor to Surescripts in electronic prior authorization, also serving prescribers, pharmacies, and payers with workflow-integrated PA services across the U.S. healthcare market.
• RelayHealth (McKesson): RelayHealth, part of McKesson, operates a competing pharmacy network and clinical messaging platform that routes e-prescriptions and eligibility transactions — overlapping core Surescripts rails including e-prescribing and pharmacy messaging.

Broad incumbents

• eClinicalWorks: eClinicalWorks is a major ambulatory EHR vendor integrated with the Surescripts network via National Record Locator Service and e-prescribing, but its expanding native interoperability features create competitive overlap for smaller providers.
• Change Healthcare (Optum): Change Healthcare, now part of Optum, is a broad incumbent in healthcare data exchange covering eligibility, claims, payments, and clinical interoperability — overlapping with Surescripts across eligibility, coordination of benefits, and pharmacy messaging.
• Veradigm (formerly Allscripts): Veradigm provides EHR and practice management software with integrated e-prescribing and interoperability services for ambulatory providers — a broad incumbent that competes for EHR-embedded prescribing and medication history workflows.
• Epic Systems: Epic is both a deep integration partner and a potential competitive incumbent through its Cosmos data platform, Carequality interop framework, and growing native ePA/prescribing capabilities reaching large U.S. health systems.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks5 records

Key highlights6 records

Customer concentration

• Xx.com/Surescripts
• YouTubeyoutube.com/user/SurescriptsTV
• Facebookfacebook.com/Surescripts
• LinkedInlinkedin.com/company/395901

Compliance4 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A1 record

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Surescripts