What Renue By Science does

Renue By Science is a Jacksonville, Florida-based direct-to-consumer longevity supplement company founded in 2016 that develops, manufactures, and sells NAD+ precursor and related longevity formulations under its own brand. Its product architecture is organized around a four-pathway NAD+ restoration framework: Boost (NMN, NR, Trigonelline precursors), Protect (CD38 inhibitors such as Quercetin, Apigenin, Fisetin), Optimize (mitochondrial efficiency compounds including Resveratrol, Berberine, CoQ10, EGCG), and Regenerate (autophagy support such as Spermidine). The company's principal technology claim is a proprietary powder-based liposomal delivery system said to protect active ingredients from digestive degradation and deliver ~90% of payload to the bloodstream; a 15-subject double-blind placebo-controlled trial reported an 84% increase in blood NAD+ (28.6 µM to 52.5 µM) over four weeks of Liposomal NMN use. The catalog spans ~40 SKUs delivered as capsules, powders, sublingual tablets, nasal sprays, gels, and topical skincare, priced from $22.95 to $84.95 per unit with bundled protocols at $207.

The company sells primarily through its own Shopify storefront (renuebyscience.com) and Amazon Marketplace, with global shipping to over 100 countries. Revenue mechanics combine one-time purchases with a subscription program offering 10% off recurring orders (the company reports 80%+ customer reorder rates) and a Truemed partnership that enables HSA/FSA pre-tax qualification (average 30% effective savings). Customer segments include health-conscious adults seeking longevity benefits, skincare consumers served through the Renue Blue sub-brand, and pet owners served through the Renue Pets sub-brand. The company operates as a privately held, founder-controlled business (Bryan Nettles, Founder/CEO; Dr. Rebecca Crews, Research Director) with 11–50 employees, no disclosed institutional funding, and cumulative sales exceeding one million bottles across its operating history.

Name

Renue By Science

Legal name

Renue By Science

Website

https://renuebyscience.com

Company type

Private

Founded year

2016

Operating status

Operating

Headcount range

11–50 employees

Short description

Renue By Science is a Jacksonville-based direct-to-consumer longevity supplement brand founded in 2016, selling NAD+ precursors and related formulations using a proprietary liposomal delivery system to health-conscious adults, with sub-brands for skincare (Renue Blue) and pets (Renue Pets).

Ownership category

akta.pro rank

Product category

Longevity and NAD+ Restoration Dietary Supplements

NAICS

Food (Health) Supplement Retailers (456191), Animal Food Manufacturing (3111), Cosmetics, Beauty Supplies, and Perfume Retailers (456120)

SIC

Food And Kindred Products (2000), Perfumes, Cosmetics & Other Toilet Preparations (2844)

akta.pro primary industry

Healthy Aging & Cognitive Support Supplements (CRADAGAM)

akta.pro secondary industry

Species-Specific Supplements (Dog/Cat/Other Companion Species) (HLAMALAN)

Keywords

• NAD+ supplements
• Longevity supplements
• Liposomal delivery
• Anti-aging skincare
• Cellular health

Headquarters

HQ city

Jacksonville

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Operations, Marketing or Sales, Supply Chain, Personnel, Technology or R&D, Infrastructure

Revenue model

1. Direct Supplement Sales: Direct-to-consumer sales of NAD+ precursor supplements, skincare products, and pet supplements through e-commerce storefront. Individual product purchases and bundled protocol packages. Subscription model with recurring orders offering 10% savings.
2. HSA/FSA Qualified Purchases: Partnership with Truemed enabling customers to use HSA/FSA pre-tax dollars for purchases, with potential reimbursement through Letters of Medical Necessity.

Pricing tiers

Go-to-market motion2 records

Distribution channels2 records

Marketing channels7 records

Core offering

Renue By Science manufactures and sells a portfolio of liposomal NAD+ precursor supplements (NMN, NR, Trigonelline), senolytic and mitochondrial-optimization blends (Quercetin, Resveratrol, Berberine, CoQ10, Spermidine, Fisetin), NAD+ Complex skincare products under the Renue Blue sub-brand, and liposomal NMN longevity chews for dogs and cats. The company sells direct-to-consumer through its own e-commerce storefront (renuebyscience.com) and Amazon, with subscriptions and HSA/FSA eligibility via Truemed.

Product overview

Renue By Science is a Jacksonville-based NAD+ restoration and longevity supplementation company offering a comprehensive portfolio of dietary supplements organized around a four-pathway NAD+ restoration system: Boost (NAD+ precursors including NMN, NR, Trigonelline), Protect (CD38 inhibitors and anti-inflammatory compounds), Optimize (mitochondrial efficiency support including resveratrol, berberine, CoQ10, EGCG, CaAKG), and Regenerate (cellular cleanup during sleep including spermidine, glutathione, sleep support). The company pioneered liposomal delivery technology for supplement absorption, with products available in multiple delivery formats including powders, capsules, sublingual tablets, nasal sprays, gels, and topical skincare. The product line includes core NAD+ precursors (NMN Pure Powder, NAD+ Complete, NMN Liposomal Capsules, NR variants, Trigonelline), combination longevity blends (Senolytique, Trans-Resveratrol, CardioMAX, Berberine), specialty supplements (CoQ10, EGCG Green Tea, CaAKG, Spermidine, Fisetin, Quercetin, Apigenin, TMG), health-specific formulations (Shield, HLA Hyaluronic Acid, P.E.A., Hesperidin, Vitamin C, D3 & K2, Glutathione, GABA, Melatonin, Restore PM), pet supplements (PET NMN Longevity Chews for Dogs and Cats), and Renue Blue skincare line (Face Serum, Face Cream, Body Moisturizing Cream, Chocolate Drink Mix). The company previously operated under the brand Alive by Nature before rebranding.

Differentiator

Problem solved

Functional benefit

Brands

• Renue Blue: Skincare sub-brand focused on NAD+ complex and Methylene Blue infused topical products including face serum, face cream, and body moisturizing cream for skin resilience and longevity
• Renue Pets

Products and services

• NMN Pure Powder Ultra-pure (>99%) nicotinamide mononucleotide (NMN) powder for maintaining healthy NAD+ levels, supporting energy, metabolism, and cellular renewal in adults focused on longevity.
• NAD+ Complete (LIPO NAD+ Complete) Complete 4-in-1 NAD+ formula supporting energy, recovery, and healthy aging, designed for optimal absorption across multiple NAD+ pathways through liposomal delivery.
• NMN Liposomal Capsules Powder-based liposomal NMN capsules using proprietary liposomal encapsulation to deliver approximately 90% of the payload intact to the bloodstream for sustained energy and cellular NAD+ restoration.
• NMNs Fast Dissolve Sublingual Tablets Portable sublingual NMN tablets for cellular energy and repair support with fast-dissolution delivery bypassing digestive breakdown.
• NR (Liposomal Nicotinamide Riboside) Liposomal nicotinamide riboside (NR) capsules supporting NAD+ restoration through the Preiss-Handler pathway.
• NR Powder Smooth Taste Blend Nicotinamide riboside powder supplement with a smooth taste profile for NAD+ restoration support.
• Trigonelline Methylated niacin NAD+ precursor with exceptional bloodstream stability and direct muscle-tissue NAD+ increase support, complementing NMN and NR via a separate biosynthetic pathway.
• Trans-Resveratrol Longevity-enzyme activation formula supporting sirtuin activity and mitochondrial function through liposomal trans-resveratrol delivery.
• Quercetin Liposomal quercetin supporting immune resilience and CD38 enzyme inhibition to preserve NAD+ levels.
• Apigenin Liposomal apigenin for protecting NAD+ levels through documented CD38 enzyme inhibition.
• Fisetin Liposomal fisetin providing senotherapeutic action for clearing senescent cells and supporting longevity.
• Spermidine Liposomal spermidine supporting cellular renewal through autophagy and mitophagy activation.
• Berberine Liposomal berberine supporting healthy heart and metabolism through AMPK activation.
• CoQ10 Liposomal CoQ10 providing essential cellular fuel and supporting mitochondrial electron transport chain efficiency.
• EGCG Green Tea Liposomal green tea extract supporting DNA protection through EGCG-triggered mitophagy.
• CaAKG Liposomal calcium alpha-ketoglutarate for mitochondrial activation and Krebs cycle support.
• Energizer AM Morning energy activation formula combining H2S and nitric oxide stimulation for NAD+ energizing support.
• Restore PM Nighttime recovery formula supporting restorative sleep and cellular cleanup during sleep phases.
• NAD+ Complete Nasal Spray Nasal spray delivery of NAD+ for rapid cognitive clarity and direct brain-pathway access.
• Total NAD+ Restoration Protocol Comprehensive 4-product protocol combining Boost, Protect, Optimize, and Regenerate formulas through coordinated liposomal products for systems-level NAD+ restoration.
• Renue Blue Face Serum Age-defying face serum with liposomal NAD+ complex and Methylene Blue for deep skin rejuvenation, improved firmness, and visible reduction in signs of aging.
• Renue Blue Face Cream Hydration and protection face cream with Methylene Blue and liposomal NAD+ complex for skin barrier strengthening.
• Renue Blue Body Moisturizing Cream Moisturizing body cream infused with liposomal NAD+ complex and Methylene Blue supporting skin hydration, elasticity, and cellular health.
• PET NMN Longevity Chews for Dogs Liposomal NMN chews supporting energy and vitality for aging dogs under the Renue Pets sub-brand.
• PET NMN Longevity Chews for Cats Liposomal NMN chews with fish oil supporting vibrant and active years for aging cats under the Renue Pets sub-brand.

Quantifiable outcome

• 84% increase in blood NAD+ levels in clinical trial (from 28.6 µM baseline to 52.5 µM after 4 weeks of Liposomal NMN)
• +5 more outcomes

Named customers2 records

Segments6 records

Ideal customer profiles4 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

One partnership is on record.

• TruemedcoreGTM or Marketing PartnerTruemed provides HSA/FSA qualification services enabling customers to use pre-tax health savings for Renue By Science supplement purchases. Truemed offers health assessments reviewed by independent licensed clinicians to determine medical expense eligibility. Partnership allows Letter of Medical Necessity issuance for reimbursement claims to HSA/FSA administrators.

Scale indicators7 records

Recent moves6 records

Expansion highlights6 records

Direct peers

• Elysium Health: Direct peer in NAD+ precursor and longevity supplements (Basis with NR and pterostilbene). Targets the same health-conscious adults seeking cellular aging support and competes on clinical evidence and premium DTC positioning.
• ChromaDex (Tru Niagen): Direct peer in NAD+ precursor supplementation via branded Tru Niagen (nicotinamide riboside). Operates a substantially larger ingredient IP and consumer brand business in the same NAD+ category as Renue's NMN/NR products.
• NOVOS: Direct peer in longevity nutraceuticals combining multiple anti-aging ingredients into a single protocol. Targets similar biohacker and longevity-focused consumers with science-backed bundles positioned around aging biomarkers.
• Double Wood Supplements: Direct peer in NMN and longevity supplements sold via DTC e-commerce and Amazon. Competes on price and product breadth across NAD+ precursors and related longevity ingredients.
• Jarrow Formulas: Direct peer in NMN, NR, resveratrol, and longevity supplement SKUs sold through both DTC and third-party retailers. Targets a similar health-conscious buyer with broad product line overlap.
• NMN Bio: Direct peer focused narrowly on NMN supplements (capsules and powder) sold DTC. Competes directly with Renue's flagship NMN Pure Powder and NMN Liposomal Capsules on formulation, dosage, and price.
• Cymbiotika: Direct peer in liposomal delivery supplements including NAD+ precursors, glutathione, CoQ10, and longevity blends. Competes on liposomal bioavailability claims similar to Renue's core technology differentiator.
• Quicksilver Scientific: Direct peer in liposomal nutraceuticals with a practitioner and DTC channel mix. Overlaps with Renue's liposomal glutathione, CoQ10, vitamin C, and detox/regeneration products.

Broad incumbents

• Life Extension: Broad incumbent in the longevity supplement space offering NMN, NAD+, resveratrol, and dozens of related ingredients. Competes across Renue's full product portfolio and operates at much larger scale with longer brand history.

Emerging players

• Allies of Skin: Emerging player in science-backed longevity and anti-aging skincare, comparable to the Renue Blue sub-brand. Both target consumers seeking clinically validated, ingredient-forward skincare addressing visible aging.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/alivebyscience
• LinkedInlinkedin.com/company/renue-by-science

Compliance2 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Renue By Science