Rion Aesthetics

What Rion Aesthetics does

Rion Aesthetics is a privately held regenerative aesthetics company founded in 2022 in Rochester, Minnesota, that develops and commercializes platelet-derived exosome technology for skincare and investigational clinical applications. Its proprietary Renewosome® platform is derived from human platelet extract and underpins the (plated)™ Skin Science consumer product line, which includes INTENSE, DAILY, EYE, and HAIR serums. The company also offers CALM Serum, a provider-exclusive post-procedure SKU, and is developing PEP™ (Purified Exosome Product™), a shelf-stable lyophilized injectable currently in an FDA-allowed Phase 1 investigator-initiated trial.

The company operates a hybrid go-to-market model combining direct-to-consumer e-commerce (platedskinscience.com) with a B2B2C provider network of aesthetic practices and med spas that purchase wholesale and resell through branded microsites with revenue share. CALM Serum is sold exclusively through participating providers, reinforcing channel segmentation. The company has formal partnerships with Mayo Clinic for clinical research, the Clinical Testing Center of Beverly Hills for the PEP™ trial, and a flagship channel relationship with VIO Med Spa (65 locations, ranked #1 med spa franchise).

Commercially, Rion Aesthetics positions itself as a science-led professional-grade skincare brand, with clinical validation from the Mayo Clinic POSH study (published in Aesthetic Surgery Journal, statistically significant results at 6 weeks across 55 participants) and a recognition footprint spanning TIME Best Inventions 2024, multiple NewBeauty Awards, and Guidepoint Qsight's #1 dermatologist-recommended exosome skincare ranking. The company expanded its physical footprint in June 2025 with a 14,000-square-foot manufacturing facility in Rochester, Minnesota, and continues to pursue investigational indications in hair restoration and facial wrinkles.

Name

Rion Aesthetics

Legal name

Rion Aesthetics, Inc.

Website

https://rionaesthetics.com

Company type

Private

Founded year

2022

Operating status

Operating

Headcount range

51–100 employees

Short description

Rion Aesthetics is a regenerative aesthetics company developing platelet-derived exosome (Renewosome®) technology, selling (plated) Skin Science serums to consumers directly and through aesthetic providers and med spas.

Ownership category

akta.pro rank

Product category

Regenerative Aesthetics Skincare

NAICS

Cosmetics, Beauty Supplies, and Perfume Retailers (456120), Health and Personal Care Retailers (456)

SIC

Perfumes, Cosmetics & Other Toilet Preparations (2844)

akta.pro primary industry

Treatment Skincare (Serums, Actives, Acne & Anti-aging) (CRABAAAB)

akta.pro secondary industries

Dermocosmetics & Medical-Grade Skincare (CRABAAAF), Professional Skincare & Facial Treatments (CRABALAF)

Keywords

• Platelet-derived exosomes
• Regenerative skincare
• Anti-aging serums
• Post-procedure skincare
• Exosome technology

Headquarters

HQ city

Rochester

HQ country

United States

HQ region

North America

Offices3 records

Markets served

GTM type

B2B and B2C

Offering type

Hardware or Manufacturing

Cost components

Personnel, Operations, Supply Chain, Marketing or Sales, Technology or R&D, Infrastructure

Revenue model

1. Consumer Skincare Product Sales: Direct-to-consumer sales of ( plated ) Skin Science skincare products through e-commerce. Products include INTENSE Serum, DAILY Serum, EYE Serum, and HAIR Serum. Revenue is generated through one-time and subscription-style purchases by consumers. The company offers free standard shipping on all US orders.
2. Provider/Med Spa Channel Sales: B2B2C model where aesthetic practices and med spas purchase products wholesale and resell to patients. Providers receive branded microsites for online sales with revenue share. CALM Serum is exclusively available through participating providers. The company provides white-glove support including training, clinical insights, and marketing materials.

Pricing tiers

Go-to-market motion4 records

Distribution channels4 records

Marketing channels6 records

Core offering

Rion Aesthetics develops, manufactures, and sells professional-grade skincare serums powered by its proprietary Renewosome® platelet-derived exosome technology. The ( plated ) Skin Science product line includes INTENSE, DAILY, EYE, HAIR, and CALM serums targeting anti-aging and post-procedure care. The company sells directly to consumers via its own e-commerce storefront and to aesthetic providers/med spas through a wholesale B2B2C model with branded microsites.

Product overview

Rion Aesthetics offers the ( plated )® Skin Science product line, a professional-grade skincare brand powered by proprietary Renewosome® technology derived from human platelet extract. The portfolio consists of five distinct serums: INTENSE (flagship anti-aging formula with 1+ trillion exosomes), DAILY (daily maintenance and hydration), EYE (specialized eye area treatment), and HAIR (scalp and hair renewal) for consumer use, plus CALM serum for provider-exclusive post-procedure applications. The company is also developing PEP™ (Purified Exosome Product™) as an investigational injectable for future FDA-regulated clinical applications in aesthetics medicine.

Differentiator

Problem solved

Functional benefit

Brands

• ( plated )® Skin Science: Professional-grade skincare brand developed by Rion Aesthetics, powered by proprietary Renewosome® platelet-derived exosome technology. Products include INTENSE Serum, DAILY Serum, EYE Serum, HAIR Serum, and CALM Serum.

Products and services

• INTENSE Serum The most concentrated exosome serum powered by 1+ trillion platelet-derived exosomes. Clinically proven to deliver 2x younger-looking skin, reduce fine lines and wrinkles, fight dark spots and uneven tone, and boost luminosity. Sold to consumers directly and through providers.
• DAILY Serum Daily defense serum powered by platelet-derived exosomes that replenishes hydration and supports continuous renewal. Promotes more resilient, healthy, and radiant-looking skin in as little as 6 weeks. For consumer use.
• EYE Serum The first and only eye serum to harness platelet-derived exosomes, optimized to address aging and fatigue in the delicate eye area in as little as 4 weeks. Clinically proven to improve dark circles, crow's feet, texture, and puffiness. For consumer use.
• HAIR Serum Scalp and hair serum with 2+ trillion platelet-derived exosomes per bottle. Designed to increase hair thickness, fullness, and strength while improving hair density and scalp coverage. For consumer use.
• CALM Serum Provider-exclusive post-procedure serum powered by Renewosome® platelet-derived exosome technology. Designed to calm and support sensitive skin during pre- and post-procedure care. Integrates into protocols for laser procedures, microneedling, RF treatments, and chemical peels. Sold exclusively through participating providers and med spas.
• PEP™ (Purified Exosome Product™) Shelf-stable lyophilized powder derived from human platelets for intradermal injection applications. Currently under FDA-regulated Phase 1 clinical investigation for safety, tolerability, and regenerative potential on collagen and elastin markers. Investigational product targeting future FDA-regulated clinical applications in aesthetics medicine.

Quantifiable outcome

• 98% of 55 participants said they would continue using ( plated ) after clinical trial
• +3 more outcomes

Named customers4 records

Segments3 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

Feature4 records

Partnerships

Six partnerships are on record, tiered core, flagship and minor.

• Mayo CliniccoreStrategic or Co-development PartnerClinical research partnership with Mayo Clinic in Rochester, MN for the Platelets On Skin Health (POSH) study. Dr. Saranya Wyles, MD, Ph.D., Assistant Professor of Dermatology at Mayo Clinic, served as principal investigator and published findings in Aesthetic Surgery Journal June 2022 edition. Study validated Rion's platelet-derived exosome technology for skin rejuvenation with 55 participants.
• Clinical Testing Center of Beverly HillscoreStrategic or Co-development PartnerSponsor and independent conduct of Phase 1 FDA investigator-initiated trial evaluating PEP™ (Purified Exosome Product) for intradermal injection safety and tolerability. Up to nine participants enrolled, evaluating regenerative potential on collagen and elastin markers.
• VIO Med SpaflagshipChannel Partner/ Reseller/ DistributorVIO Med Spa franchise network with 65 locations nationwide (ranks #1 among med spa franchises) incorporates Rion products in treatments. Rion Aesthetics speakers featured at VIO University training event in Fort Lauderdale, FL. Company seeks to support continued expansion with experienced operators and multi-unit partners.
• AIA Aesthetic Industry AssociationminorChannel Partner/ Reseller/ DistributorListed as a valued partner organization on Rion Aesthetics' Become a Provider page, indicating industry association relationship for professional credibility and network access.
• ASDS (American Society for Dermatologic Surgery)minorChannel Partner/ Reseller/ DistributorListed as a valued partner organization on Rion Aesthetics' Become a Provider page, indicating professional association relationship for dermatologic surgery community engagement.
• FDAcoreStrategic or Co-development PartnerFDA allowed Investigational New Drug (IND) application to proceed for Phase 1 trial evaluating PEP™ exosome product for dermal injection applications. Rion Aesthetics provides investigational product and research support for the trial.

Scale indicators7 records

Recent moves7 records

Expansion highlights5 records

Emerging players

• Elevai Labs: Exosome-based skincare company targeting the professional aesthetics market with proprietary exosome technology. Most direct emerging competitor to Rion's exosome-aesthetics positioning.
• CALECIM Professional: Stem-cell-derived post-procedure skincare sold through aesthetic providers. Comparable regenerative-biologic positioning and professional-channel distribution, though focused specifically on post-procedure recovery rather than daily anti-aging.
• DefenAge: Skincare brand built around proprietary defensin-molecule technology marketed through physician channels for anti-aging. Comparable as an emerging science-driven, physician-channel skincare company with proprietary biotech IP.

Direct peers

• Revision Skincare: Physician-dispensed professional skincare brand with peptide and growth factor-based anti-aging products sold through med spas and dermatology offices. Directly comparable premium professional skincare business model and channel.
• Alastin Skincare: Physician-dispensed skincare brand owned by Galderma focused on procedure-enhancing and anti-aging products. Closely comparable business model: professional channel (med spas/aesthetic practices), post-procedure SKUs, and regenerative/biotech positioning.
• iS Clinical: Innovative Skincare's physician-dispensed brand offering active-ingredient serums for anti-aging and post-procedure care. Comparable as a professional-channel, clinically-positioned skincare line with serums as hero SKUs.
• SkinMedica: Professional-grade skincare brand owned by AbbVie/Allergan Aesthetics, sold primarily through physician offices and med spas. Directly comparable as a clinical/medical-grade skincare line targeting anti-aging and rejuvenation with provider-driven distribution.

Broad incumbents

• Obagi Medical: Established medical-grade skincare brand sold through physicians and med spas with a focus on anti-aging and skin health. Comparable in professional-channel distribution and clinical positioning, though at significantly larger scale.
• SkinCeuticals: L'Oréal-owned clinical skincare brand with broad physician and retail distribution. Comparable as a science-led, antioxidant- and active-ingredient-focused skincare line marketed to dermatologists and aesthetic providers, but at much larger scale and broader portfolio.
• Galderma: Global dermatology-focused aesthetics company with major skincare (Alastin, Cetaphil) and injectable (Restylane, Sculptra) portfolios. Comparable as the broader dermatology/aesthetics incumbent that employs multiple Rion senior leaders and represents both a competitive threat and potential acquirer.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• LinkedInlinkedin.com/company/rion-aesthetics
• Instagraminstagram.com/rionaesthetics

Compliance1 record

Revenue estimate

Valuation estimate

Number of profiles

Profiles5 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Rion Aesthetics