Zynx Health

What Zynx Health does

Zynx Health is a privately-held clinical decision support (CDS) software company founded in 1996 by clinicians at Cedars-Sinai Medical Center in Los Angeles. Operating as a wholly-owned subsidiary of Hearst Health (the healthcare information division of Hearst Corporation), Zynx develops evidence-based content and software platforms that enable hospitals and health systems to standardize care delivery through order sets, care plans, and gap analysis tools. The company has grown to serve 1,500+ hospitals across the United States and Canada with a fully remote workforce of 51-100 employees.

The product portfolio centers on three core assets: ZynxOrder (a library of 500+ evidence-based order sets covering 3,300+ referential pages drawn from 60,000+ practice-influencing articles and 100,000+ published studies), ZynxCare (care plans spanning 600+ quality measures), and Knowledge Analyzer (a patented gap analysis solution). These are delivered through proprietary content management platforms—AuthorSpace (used for nearly 20 years) and ViewSpace—plus a FHIR-based REST API and embedded OEM integrations with Epic, MEDITECH (ZynxInside), Oracle Health, and athenahealth. Specialized offerings include Zynx for Primary Care (launched March 2024), Zynx for Chronic Care Management, ZynxCare Modules for post-acute settings, and Informatics Services. The Zynx Informatics Team has completed more than 10,000 content builds across all major EHRs.

Zynx operates on a quote-based subscription licensing model with annual or multi-year contracts, with pricing negotiated per organization based on hospital size and facilities. Go-to-market combines direct enterprise field sales targeting CMIOs/CNIOs/CMOs with channel distribution via EHR vendor partnerships (athenahealth, MEDITECH, Oracle Health, Epic), technology partnerships (Innovaccer, First Databank), an FHIR Developer Program, and presence at industry conferences. The company is recognized as the category leader, having earned Best in KLAS for Clinical Decision Support – Care Plans and Order Sets for four consecutive years (2021-2024), with 9 KLAS awards total.

Name

Zynx Health

Legal name

Zynx Health, Incorporated

Website

https://zynxhealth.com

Company type

Private

Founded year

1996

Operating status

Operating

Headcount range

51–100 employees

Short description

Zynx Health, a Hearst Health subsidiary, develops evidence-based clinical decision support software—order sets, care plans, and gap analysis tools—for 1,500+ hospitals and health systems across North America, earning Best in KLAS recognition four consecutive years.

Ownership category

akta.pro rank

Product category

Clinical Decision Support Software

NAICS

Software Publishers (5132), Custom Computer Programming Services (541511)

SIC

Services-Computer Programming, Data Processing, Etc. (7370)

akta.pro primary industry

Quality Measurement, Reporting & Benchmarking (HEDIS/Stars/CQM) (HLACAHAC)

akta.pro secondary industries

Cost of Care, Spend Analytics & Financial Performance Management (HLACAHAJ), Patient Education, Content & Personalized Journey Orchestration (HLACAEAE)

Keywords

• Clinical decision support
• Evidence-based order sets
• Nursing care plans
• Healthcare analytics software
• Care plan content

Headquarters

HQ city

Los Angeles

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2B

Offering type

Software

Cost components

Personnel, Technology or R&D, Operations, Marketing or Sales, Infrastructure

Revenue model

1. Subscription / Software Licensing: Zynx Health operates on a subscription licensing model, providing healthcare organizations access to its evidence-based clinical decision support content libraries (order sets, care plans) and software platforms (AuthorSpace, ViewSpace, Knowledge Analyzer). Subscriptions are typically sold on an annual or multi-year contract basis to hospitals and healthcare systems.

Pricing tiers

Go-to-market motion3 records

Distribution channels4 records

Marketing channels9 records

Core offering

Zynx Health develops and licenses evidence-based clinical decision support content and analytics software for hospitals, health systems, and ambulatory providers. Its core offerings include physician order sets (ZynxOrder), nursing and allied health plans of care (ZynxCare), a knowledge gap-analysis tool (Knowledge Analyzer), EHR-embedded content for MEDITECH (ZynxInside), and ambulatory content bundles for primary care and chronic care management. Revenue is generated through enterprise software subscriptions and content-licensing agreements, supplemented by paid professional services such as informatics consulting, EHR (Epic) migration support, and performance improvement engagements.

Product overview

Zynx Health offers an integrated suite of evidence-based clinical decision support solutions purpose-built to improve the quality, safety, and efficiency of patient care. The core portfolio includes ZynxOrder (evidence-based order sets with 500+ order sets), ZynxCare (evidence-based care plans covering 600+ quality measures), Knowledge Analyzer (gap analysis and content assessment), ZynxInside (embedded content for MEDITECH Expanse), and Zynx for Primary Care (ambulatory clinical decision support with 100+ topics). Specialized solutions include Zynx for Chronic Care Management and ZynxCare Modules for home health, long-term acute care, rehabilitation, skilled nursing, and patient education settings. Supporting services include Informatics Services for content builds, Epic Migration support, and Performance Improvement programs. All solutions are cloud-based and built on a patented content management methodology with over 25 years of evidence synthesis.

Differentiator

Problem solved

Functional benefit

Brands

• ZynxOrder: Leading evidence-based order set solution for hospitals to reduce clinical variation, improve patient outcomes, and maximize financial performance featuring a comprehensive order set library with over 500 evidence-based medical, surgical, and nonsurgical order sets.
• ZynxCare
• Knowledge Analyzer
• ZynxInside
• Zynx for Primary Care
• Zynx for Chronic Care Management
• Zynx Health API

Quantifiable outcome

• North York General Hospital achieved a 56% reduction in mortality after implementing ZynxOrder with 350 evidence-based order sets
• +8 more outcomes

Named customers17 records

Segments6 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

Yes

API docs

API detail

Core technology

AI maturity

App detail

Integration4 records

AI capability2 records

Feature8 records

Partnerships

Seven partnerships are on record, tiered core and minor.

• InnovaccercoreStrategic or Co-development Partner · 18 September 2024Zynx Health partnered with Innovaccer in September 2024 to advance population health. This strategic partnership integrates Zynx's award-winning clinical decision support with Innovaccer's cutting-edge care management solution to reduce clinical variation, enhance operational efficiency, and improve patient outcomes. The partnership aims to set a new standard for care by combining Zynx's evidence-based content with Innovaccer's data platform capabilities.
• Hendrich Fall Program (Hendrich II Fall Risk Model)coreStrategic or Co-development PartnerZynx Health formed a strategic partnership with the Hendrich Fall Program to provide the most comprehensive and holistic fall prevention care guidance available. Through this partnership, mutual clients can license The Hendrich Care Plans in addition to accessing ZynxCare fall risk content. The Hendrich II Fall Risk Model features eight valid and reliable risk factors assessed during patient encounters. Combined content is routinely updated to ensure caregivers have access to the latest best practice recommendations.
• Epic SystemscoreTechnology or IntegrationZynx Health supports Epic EHR migrations and deployments. Zynx Knowledge Analyzer helps organizations migrating to Epic to quickly identify gaps in starter sets, deploy evidence-based order sets, and leverage Consensus Builder for virtual stakeholder review. Zynx content is available within the Epic ecosystem.
• MEDITECHcoreTechnology or IntegrationZynxInside was developed exclusively for MEDITECH Expanse users. The solution embeds Zynx Health's industry-leading clinical decision support content directly into MEDITECH Expanse. The partnership includes a full-service project team for implementation and maintenance, and integration with First Databank for drug database functionality.
• Hearst HealthcoreOthersZynx Health is part of the Hearst Health network of companies. Hearst Health provides strategic oversight and resources to Zynx Health as part of a portfolio of healthcare information companies. Hearst Health also sponsors the Hearst Health Prize ($100,000 award for excellence in data science in healthcare) in partnership with UCLA.
• Annenberg Center for Health Sciences at EisenhowerminorStrategic or Co-development PartnerZynx Health partnered with the Annenberg Center for Health Sciences at Eisenhower to bring CME credit opportunities directly to physicians using Zynx order sets and checklists. The entire process is electronic with no forms to complete or mail in, enabling clinicians to earn CME credits through daily patient care.
• UCLA Center for SMART HealthminorStrategic or Co-development PartnerZynx Health's parent company Hearst Health co-sponsors the Hearst Health Prize ($100,000) with the UCLA Center for SMART Health, recognizing excellence in data science in healthcare. This partnership highlights Zynx's commitment to healthcare innovation and data-driven care.

Scale indicators19 records

Recent moves6 records

Expansion highlights5 records

Others

• Premier Inc. Premier provides performance improvement services and group purchasing for US health systems, with overlapping content in clinical quality improvement and care standardization. Complementary rather than direct — Premier partners with content providers including Zynx — but addresses the same quality/cost imperative.

Emerging players

• Health Catalyst: Health Catalyst provides healthcare analytics and population health management platforms. Its growing focus on evidence-based care improvement and quality outcomes overlaps with Zynx for Chronic Care Management, particularly via Zynx's Innovaccer partnership for population health.

Direct peers

• Elsevier (ClinicalPathways, ClinicalKey): Elsevier's ClinicalPathways and ClinicalKey offer evidence-based clinical content and care pathway solutions to hospitals, directly competing with ZynxOrder's order sets and ZynxCare's care plans. Targets the same hospital decision-makers (CMIOs, CNIOs) with comparable subscription licensing model.
• Wolters Kluwer Health: Wolters Kluwer offers UpToDate, Lexicomp, and Medi-Span — direct evidence-based clinical decision support and drug information content for hospitals and clinicians. Closest direct competitor to ZynxOrder and ZynxCare, competing for the same hospital budget and EHR integration slots.
• EBSCO Information Services (DynaMed): EBSCO's DynaMed and Nursing Reference Center provide evidence-based clinical decision support content to hospitals and health systems, directly overlapping with ZynxCare's evidence-based care plans and ZynxOrder's order set content for nursing and clinical teams.

Broad incumbents

• Oracle Health (formerly Cerner): Oracle Health offers embedded clinical decision support within its Millennium/Cerner EHR, including order sets and care plans. Zynx for Primary Care integrates with Oracle Health, but Oracle Health also offers its own CDS content, creating overlap and channel conflict.
• Merative (formerly IBM Watson Health): Merative's products (Merge, Micromedex, clinical decision support solutions) target hospital and health system buyers with evidence-based content and analytics. As a broader healthcare data and analytics incumbent, it overlaps with Zynx in clinical content and value-based care analytics.
• First Databank (FDB): FDB provides drug knowledge and medication decision support databases integrated into major EHRs, including ZynxInside via its MEDITECH integration. As a Hearst Health sister company, FDB is partly aligned and partly adjacent to Zynx's clinical decision support content.
• Philips HealthSuite: Philips offers clinical decision support and care management solutions as part of its broader healthcare technology portfolio (including patient monitoring, imaging, and population health), competing for hospital IT budget and overlapping with Zynx in clinical workflows and care standardization.
• Epic Systems: Epic is both a key distribution partner (Epic Toolbox, embedded order sets) and a competitive incumbent through its native Best Practice Advisories and Foundation System content. As the dominant hospital EHR, Epic's evolving native CDS capabilities directly compete with Zynx content inside Epic environments.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/zynxhealth
• YouTubeyoutube.com/channel/UCYtEU8J4asAXBOtnwbSYySQ
• LinkedInlinkedin.com/company/zynx-health

Revenue estimate

Valuation estimate

Number of profiles

Profiles9 records

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A1 record

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Zynx Health