Actial Nutrition

What Actial Nutrition does

Actial Nutrition, Inc. is a privately-held Colorado corporation that distributes VSL® Probiotics in the United States under two product lines. VSL#3® is a refrigerated, ultra-high-potency probiotic medical food (112.5B-900B CFU, 8 complementary strains across Bifidobacterium, Lactobacillus, and Streptococcus) marketed for the dietary management of IBS, ulcerative colitis, and pouchitis, supported by 40+ peer-reviewed publications and recognized as the #1 gastroenterologist-recommended multi-strain probiotic brand by ProVoice Surveys. VSL4® is a shelf-stable consumer supplement line — VSL4® Gut (30B CFU) for daily digestive wellness and VSL4® Vaginal Health (10B CFU, 4-in-1 formula with prebiotics, vitamins, and cranberry extract) for women's intimate wellness — built on the same strain science heritage. Core technology centers on multi-genus probiotic combinations, a cold-chain refrigerated supply chain for VSL#3® potency preservation, and acid-resistant capsule technology for VSL4® shelf-stability, with CFU potency guaranteed through expiration.

Name

Actial Nutrition

Legal name

Actial Nutrition, Inc.

Website

https://vsl3.com

Company type

Private

Founded year

2022

Operating status

Operating

Headcount range

11–50 employees

Short description

Actial Nutrition distributes VSL® Probiotics in the US, selling medical-food (VSL#3®) and daily wellness (VSL4®) multi-strain probiotic products to chronic GI patients, health-conscious consumers, and women seeking intimate wellness via DTC, Walmart, Amazon, pharmacy, and HCP channels.

Ownership category

akta.pro rank

Product category

Probiotic Supplements and Medical Foods

NAICS

Food (Health) Supplement Retailers (456191)

SIC

Miscellaneous Food Preparations & Kindred Products (2090)

akta.pro primary industry

Probiotics & Digestive Health Supplements (CRADAGAF)

akta.pro secondary industries

Probiotic, Prebiotic & Gut-Health Foods Manufacturing (Fermented Functional Foods, Synbiotics) (AFAKAJAH), Probiotics (Strains, Spore-Formers, Synbiotic Components) (AFAJAKAE), Digestive Health OTC (Antacids, Laxatives, Anti-diarrheals, Probiotics OTC) (CRADAMAE)

Keywords

• Probiotic supplements
• Medical foods
• Multi-strain probiotics
• Gut health supplements
• Women's wellness supplements

Headquarters

HQ city

Covington

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Marketing or Sales, Personnel, Technology or R&D

Revenue model

1. Direct-to-Consumer E-commerce: Sales through vsl3.com website with subscription model (Subscribe & Save 10%), one-time purchases, and multi-pack bundles (save up to 15%). Products shipped directly to consumers within continental US, Alaska, and Hawaii.
2. Retail Distribution (Walmart): VSL4® products distributed through Walmart's mass retail channel, with VSL4® Gut and VSL4® Vaginal Health available in over 1,500 Walmart locations nationwide at $28.97 per SKU.
3. Marketplace Sales (Amazon.com): VSL4® products available through Amazon.com marketplace, extending reach to Prime customers seeking probiotic supplements for gut and vaginal health.
4. Pharmacy Distribution: VSL#3® products distributed through pharmacies nationwide via special order with supplier codes (Cardinal, Cencora, McKesson). Products stored in pharmacy refrigerator to maintain potency.
5. Healthcare Professional Channel (Fullscript): Healthcare providers can order VSL#3® and VSL4® products through Fullscript platform for patient recommendations and professional dispensing.

Pricing tiers

Go-to-market motion2 records

Distribution channels5 records

Marketing channels6 records

Core offering

Actial Nutrition develops, markets, and distributes science-backed probiotic products under the VSL® Probiotics brand, offering two product lines: VSL#3® medical-food probiotics (refrigerated capsules, powder, and double-strength powder with 112.5B–900B CFU from 8 complementary strains) intended for the dietary management of IBS, ulcerative colitis, and pouchitis, and VSL4® shelf-stable daily supplements (VSL4® Gut for digestive health and VSL4® Vaginal Health, a 4-in-1 women's intimate wellness formula) for everyday consumer use. Products are sold direct-to-consumer via vsl3.com and through retail (Walmart, Amazon), pharmacy wholesale, and healthcare professional dispensing channels.

Product overview

Actial Nutrition offers VSL® Probiotics, a portfolio of science-backed probiotic products consisting of two main product lines: VSL#3® (medical food probiotics for clinical dietary management) and VSL4® (daily wellness supplements). VSL#3® products are ultra-high-potency, refrigerated medical foods containing 8 complementary probiotic strains at 112.5 to 900 billion CFU, formulated for the dietary management of IBS, ulcerative colitis (UC), and pouchitis. VSL4® products are precision-formulated, shelf-stable probiotic supplements containing clinically studied strains designed for everyday wellness—VSL4® Gut supports digestive balance and regularity, while VSL4® Vaginal Health is a 4-in-1 women's health formula combining probiotics, prebiotics, vitamins, and cranberry extract. Both lines share scientific heritage and strain selection principles but differ in potency, formulation purpose, and storage requirements.

Differentiator

Problem solved

Functional benefit

Brands

• VSL#3: Ultra-high-potency probiotic medical food for dietary management of IBS, ulcerative colitis, and pouchitis; available in capsules, powder, and double-strength (DS) formulations with up to 900 billion CFU
• VSL4

Products and services

• VSL#3® Capsules Refrigerated ultra-high-potency probiotic medical food for the dietary management of IBS and ulcerative colitis. Each capsule delivers 112.5 billion CFU from 8 complementary probiotic strains across 3 genera (Bifidobacterium, Lactobacillus, Streptococcus). Requires refrigeration; potency guaranteed through expiration. Priced $65.95–$224.95 depending on capsule count (60–240). FODMAP Friendly, vegan, dairy-free, gluten-free, soy-free, nut-free, non-GMO.
• VSL#3® Powder Refrigerated ultra-high-potency probiotic medical food powder for the dietary management of IBS, ulcerative colitis, and pouchitis. Each packet delivers 450 billion CFU from the same 8-strain multi-genus blend. Requires refrigeration; potency guaranteed through expiration. Priced $112.95–$213.95 for 30–60 packets. Available via vsl3.com subscription and pharmacy distribution.
• VSL#3® DS (Double Strength) Powder Refrigerated double-strength ultra-high-potency probiotic medical food powder for the dietary management of ulcerative colitis and pouchitis. Each packet delivers 900 billion CFU from the 8-strain multi-genus blend — the highest potency in the VSL#3® portfolio. Requires refrigeration; priced at $157.95 regular / $142.16 sale for 20 packets. FODMAP Friendly, Halal, Kosher, vegan, and free from dairy, gluten, soy, nuts, and GMOs.
• VSL4® Gut Capsules Shelf-stable daily probiotic supplement designed for digestive comfort, regularity, and overall gut wellness. Delivers 30 billion CFU from the same 8 complementary probiotic strains as VSL#3®, in acid-resistant capsules that do not require refrigeration. FODMAP Friendly and HSA/FSA eligible. Priced $57.94 regular / $26.07 sale for 30 capsules. Intended for health-conscious adult consumers without a clinical prescription.
• VSL4® Vaginal Health Shelf-stable 4-in-1 daily probiotic supplement for women's intimate wellness, vaginal microbiota balance, normal yeast and pH levels, and urinary tract support. Combines 10 billion CFU from 5 scientifically studied probiotic strains (including licensed L. plantarum ROSELLA, L. rhamnosus Rosell®-11, B. bifidum HA-132, L. crispatus Rosell®-470, L. gasseri HA-275) with prebiotic acacia fiber, vitamins D3/folate/riboflavin, and whole-fruit cranberry extract. Priced $28.97 (30 ct) and $55.04 (60 ct); sold via vsl3.com, Amazon.com, Walmart, and Fullscript.

Quantifiable outcome

• VSL#3® demonstrated outcomes comparable to Low FODMAP diet in randomized clinical trial for IBS symptom management (Ankersen et al., 2021, J Med Internet Res)
• +3 more outcomes

Named customers4 records

Segments4 records

Ideal customer profiles4 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature5 records

Partnerships

Five partnerships are on record, tiered core and minor.

• WalmartcoreChannel Partner/ Reseller/ Distributor · 19 May 2026Walmart serves as the first major retail distribution partner for VSL4® products, making VSL4® Gut and VSL4® Vaginal Health available in over 1,500 Walmart locations nationwide and online at Walmart.com. This retail expansion brings science-backed microbiome solutions to a broader consumer audience at accessible price points.
• Amazon.comcoreChannel Partner/ Reseller/ Distributor · 20 January 2026Amazon.com serves as an online marketplace channel for VSL4® products, including VSL4® Vaginal Health launch and VSL4® Gut, providing Prime customers with convenient access to probiotic supplements.
• FullscriptcoreChannel Partner/ Reseller/ DistributorFullscript provides an ordering platform for healthcare professionals to prescribe and order VSL#3® and VSL4® products for their patients, enabling professional dispensing and ensuring patient access to clinically-backed probiotics.
• Cardinal Health, Cencora, McKessoncoreChannel Partner/ Reseller/ DistributorMajor pharmaceutical distributors enabling pharmacy availability of VSL#3® products nationwide. Each distributor has assigned supplier codes for easy pharmacy ordering: Cardinal CIN#, Cencora SAP#, and McKesson Econo#.
• TruemedminorGTM or Marketing PartnerTruemed integration enables HSA/FSA payment options for qualified customers, allowing pre-tax medical spending account usage for VSL® Probiotics purchases with average 30-40% savings for eligible customers.

Scale indicators6 records

Recent moves7 records

Expansion highlights6 records

Broad incumbents

• Jarrow Formulas: Science-driven supplement brand offering multiple multi-strain probiotic formulations sold through natural products and pharmacy channels; overlaps with Actial across both customer base and evidence-based positioning.
• Garden of Life: Nestlé Health Science-owned whole-food supplement brand offering a broad probiotic SKU lineup including Dr. Perlmutter-branded formulations; competes in the same natural/grocery and pharmacy channels as Actial.
• Align (Procter & Gamble): Bifidobacterium 35624 probiotic brand from P&G, sold through major US retailers and pharmacy; a top gastroenterologist-recommended brand competing head-to-head with VSL#3® for GI symptom patients.

Emerging players

• Seed Health: Microbiome-focused DTC subscription brand with multi-strain formulations backed by clinical trials; targets similar premium-positioned, science-led health-conscious consumers as VSL4®.
• HUM Nutrition: DTC women's wellness and beauty supplements brand with a private-label-shaped probiotic SKU, targeting the same women's health and gut wellness consumer that VSL4® Vaginal Health is pursuing.
• Ritual: DTC subscription supplement brand offering clinically backed, traceable ingredient formulations including women's health and gut products, with overlapping positioning to VSL4® lifestyle consumers.
• Love Wellness: Women's intimate wellness brand with feminine probiotic and boric acid products; one of the most direct competitive overlaps with VSL4® Vaginal Health for vaginally-oriented consumers.

Direct peers

• BioGaia: Swedish probiotic company with proprietary Lactobacillus reuteri strains, licensed into consumer brands like Florastor and Gerber Good Start; competes in the same evidence-backed, multi-strain probiotic space as VSL Probiotics.
• Renew Life: Probiotic, cleanse, and digestive health brand owned by Clorox; provides gut-health-focused multi-strain probiotics competing directly with VSL4® Gut at mass retail.
• Culturelle (iHealth): Lactobacillus rhamnosus GG-based probiotic brand owned by DSM/iHealth; one of the most prescribed and retail-distributed probiotic brands in the US, competing directly with VSL#3® for gastroenterologist recommendation and shelf space.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat4 records

Key risks6 records

Key highlights7 records

Customer concentration

• Instagraminstagram.com/vslprobiotics
• Facebookfacebook.com/vsl3probiotic

Compliance5 records

Revenue estimate

Valuation estimate

Number of profiles

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Actial Nutrition