Applied Neuroscience

What Applied Neuroscience does

Applied Neuroscience, Inc. is a privately held St. Petersburg, Florida-based software company founded in 1994 by Robert W. Thatcher, Ph.D. that develops and sells NeuroGuide, a comprehensive EEG and quantitative EEG (QEEG) analysis platform used by clinicians and researchers. NeuroGuide integrates conventional EEG with quantitative EEG on a single screen and adds proprietary swLORETA neuroimaging, 3D brain visualization via NeuroNavigator and BrainSurfer, automatic artifact rejection, an Automatic Clinical Report Writer that generates Microsoft Word reports locally, and Z-score neurofeedback modules for surface, sLORETA, swLORETA, and cross-frequency protocols. The platform supports 45+ EEG amplifier formats, runs on Windows, and is paired with iOS and Android companion apps (NeuroLink Pro) for patient symptom self-assessment.

The company serves two primary customer segments: mental health and neurofeedback clinicians (psychiatrists, psychologists, neuropsychologists, neurologists, neurotherapists, TBI specialists) and academic/government researchers (Stanford, UCSD, Columbia, Georgetown, University of Tennessee, Walter Reed, and 50+ US VA Medical Centers, among 100+ institutions across more than 20 countries). The product portfolio is monetized through perpetual software licenses for NeuroGuide and a wide catalog of add-on modules (NeuroStat, NeuroBatch, NeuroNavigator databases, BrainSurfer, Concussion Index, Brain Optimization Index, swLORETA Neurofeedback, Automatic Clinical Report Writer, etc.), annual update subscriptions, per-use pricing for certain products, and ancillary services including expert clinical reports, medical-legal consulting, mentoring, workshops, and the Handbook of QEEG and EEG Biofeedback textbook.

Applied Neuroscience distributes primarily through its own online store at appliedneuroscience.com, supplemented by free demo downloads, 10-month financing plans, and a content-driven marketing program (webinars, workshop videos, scientific articles, Vimeo/YouTube video library, SBMT Congress presentations). The company is bootstrapped and founder-controlled with no disclosed outside funding, parent company, or acquisition activity, and it maintains an ongoing product release cadence with NeuroGuide version 4.0.0 shipped in July 2026.

Name

Applied Neuroscience

Legal name

Applied Neuroscience, Inc.

Website

https://appliedneuroscience.com

Company type

Private

Founded year

1994

Operating status

Operating

Headcount range

51–100 employees

Short description

Applied Neuroscience, Inc. develops NeuroGuide, a Windows-based EEG and QEEG analysis and neurofeedback software platform. It sells perpetual licenses and add-on modules to clinicians, academic researchers, VA Medical Centers, and military hospitals across 20+ countries, founded in 1994 by Robert W. Thatcher, Ph.D.

Ownership category

akta.pro rank

Product category

Clinical EEG / QEEG Analysis Software

NAICS

Custom Computer Programming Services (541511), Electromedical and Electrotherapeutic Apparatus Manufacturing (334510)

SIC

Electromedical & Electrotherapeutic Apparatus (3845), Surgical & Medical Instruments & Apparatus (3841)

akta.pro primary industry

Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables) (HLAHACAE)

akta.pro secondary industries

Neurodiagnostic Centers (EEG/EMG/NCS) (HLAFAKAK), Cognitive & Behavioral Neurology (Dementia/Memory Disorders) (HLAKAIAH), Neurodevelopmental & Behavioral Therapy Platforms (ADHD/Autism/Behavioral Coaching) (HLALAEAJ)

Keywords

• EEG analysis software
• QEEG neurofeedback
• LORETA neuroimaging
• Brain-computer interface
• Clinical neuroscience tools

Headquarters

HQ city

Largo

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Software

Cost components

Technology or R&D, Personnel, Operations, Marketing or Sales, Infrastructure, Supply Chain, Others

Revenue model

1. NeuroGuide Software Licenses: Core EEG analysis software sold as perpetual licenses with annual update subscriptions. Includes base NeuroGuide package with optional add-on modules.
2. Add-on Modules and Extensions: Additional products including NeuroNavigator, BrainSurfer, Discriminant Functions, NeuroStat, NeuroBatch, LORETA Source Correlation Database, Bi-Spectrum Normative Database, Brain Performance Index, and others.
3. Update Subscriptions: Annual subscription for software updates, security key renewals, and access to new features.
4. Per-Use Products: Pay-per-use pricing options for certain products and services.
5. Professional Services: Expert Clinical Report Services, Medical Legal Services, Mentoring and Consultation, and Editing of EEG files offered as add-on professional services.
6. Education and Training: Workshop attendance, webinar access, and the Handbook of QEEG and EEG Biofeedback textbook (e-book and hardcopy).

Pricing tiers

Go-to-market motion1 record

Distribution channels4 records

Marketing channels8 records

Core offering

Applied Neuroscience develops and sells NeuroGuide, a desktop software platform that performs clinical and quantitative EEG (QEEG) analysis combined with real-time Z-score neurofeedback, LORETA source localization, and 3D neuroimaging (swLORETA). The platform integrates conventional EEG with QEEG on a single screen, supports 45+ EEG amplifier formats with microvolt calibration, and ships with normative databases spanning ages 2 months to 82 years. The company sells NeuroGuide and its add-on modules (NeuroNavigator, BrainSurfer, NeuroLink, NeuroStat, NeuroBatch, Concussion Index, etc.) as perpetual licenses with annual update subscriptions, complemented by per-use products and professional services such as expert clinical report writing, medical-legal work, and mentoring.

Product overview

Applied Neuroscience offers NeuroGuide as the core platform for EEG and QEEG analysis, which integrates conventional EEG with quantitative EEG on the same screen. The product portfolio consists of multiple add-on modules organized into categories: (1) Analysis Modules including NeuroStat for statistics, NeuroBatch for batch processing, and Discriminant Functions for predictive analysis; (2) Neuroimaging Add-ons including NeuroNavigator with swLORETA databases (Current Source Density, Functional Connectivity, Effective Connectivity, Phase Reset), BrainSurfer and swBrainSurfer for 3D BCI visualization; (3) Neurofeedback Modules including Surface Z Score Neurofeedback (1-19 channels), sLORETA and swLORETA Z Score Neurofeedback, plus Surface and swLORETA Cross-Frequency Neurofeedback for cross-frequency coupling training; (4) Symptom Assessment Tools including NeuroLink, NeuroLink Pro, and NeuroLinkQ smartphone app for patient self-assessment linked to protocol generation; (5) Specialized Indices including Concussion Index, Brain Optimization Index (BOI), Brain Performance Index; (6) Connectivity Add-ons including LORETA Effective Connectivity, Surface Effective Connectivity, LORETA Source Correlation; (7) Clinical Tools including Automatic Clinical Report Writer, NaviStat 3D statistics, and the eHandbook of QEEG; (8) Hardware including CGX/Cognionics Dry EEG Headsets. Services include expert clinical reports, medical-legal services, and professional workshops.

Differentiator

Problem solved

Functional benefit

Brands

• NeuroGuide: Primary EEG and QEEG analysis software product that integrates conventional EEG with quantitative EEG on the same screen, featuring z-score neurofeedback, LORETA imaging, and automatic clinical report generation.
• NeuroNavigator
• BrainSurfer
• NeuroLink
• NeuroStat
• NeuroBatch

Products and services

• NeuroGuide Comprehensive desktop EEG and QEEG analysis software that combines conventional EEG and quantitative EEG on the same screen with real-time Z-score neurofeedback, automated artifact rejection, JTFA, discriminant functions, and LORETA source localization; supports 45+ EEG amplifier formats. Sold as a perpetual license with annual update subscription for clinicians and neuroscience researchers.
• NeuroNavigator 3D neuroimaging add-on module for NeuroGuide that navigates swLORETA Current Source Density, Functional Connectivity, Effective Connectivity, and Phase Reset normative databases across Brodmann areas and deep brain structures (cerebellum, thalamus, sub-thalamus, habenula, nucleus accumbens, red nucleus). Sold separately as an add-on license for clinical and research users.
• BrainSurfer Real-time 3D rendered MRI brain-computer interface add-on for NeuroGuide that displays 88 Brodmann areas as nodes with Coherence, Phase, and Phase Reset connections for assessment and neurofeedback visualization.
• swBrainSurfer Enhanced BrainSurfer add-on using swLORETA with 12,400 MRI voxels for real-time BCI-based neurofeedback, including session scores and score-per-minute tracking.
• NeuroLink Standalone symptom self-assessment software for PC and Mac that links to Surface Z Score Neurofeedback, LORETA Z Score Neurofeedback, and BrainSurfer for protocol generation based on patient symptom severity.
• NeuroLink Pro Enhanced version of NeuroLink with platform-independent symptom assessment integrated with swLORETA NeuroNavigator for symptom-to-network protocol generation on PC, iOS, tablets, and Android.
• NeuroStat Statistical comparison program for NeuroGuide enabling paired t-tests, ANOVA, independent t-tests, and group statistics on EEG data with color topographic maps. Sold as a separate add-on module.
• NeuroBatch Automatic batch processing program for NeuroGuide that analyzes large numbers of edited EEG files and outputs color topographic maps and tab-delimited files importable into NeuroStat.
• Discriminant Functions Statistical add-on module for NeuroGuide that detects EEG patterns statistically similar to individuals with traumatic brain injury or learning disabilities, with cross-validation accuracy of approximately 85%.
• Automatic Clinical Report Writer Add-on module for NeuroGuide that generates QEEG clinical reports locally in Microsoft Office Word format, including swLORETA plots, radar maps, Brain Function Index, and Concussion Index displays.
• Brain Performance Index (BPI) NeuroGuide add-on module that uses discriminant functions and spectral measures to provide predicted neuropsychological test scores with histogram of predicted scaled scores.
• Concussion Index NeuroGuide add-on metric that tracks brain network changes over time and following treatment for concussion and traumatic brain injury. Sold with per-use capacity and unlimited access options.
• Brain Optimization Index (BOI) NeuroGuide add-on index using functional and effective connectivity Z-score metrics to track changes in brain networks in the direction of optimal functioning.
• Surface Z Score Neurofeedback (NF1) NeuroGuide add-on module providing 1 to 19 channel surface EEG Z-score neurofeedback with real-time autospectral and cross-spectral Z-scores, symptom checklist protocol generation, phase shift, and phase lock duration measures.
• sLORETA Z Score Neurofeedback NeuroGuide add-on module providing LORETA Z-score neurofeedback using Low Resolution Electromagnetic Tomography for 3D source localization across 98 Brodmann areas and 66 Regions of Interest.
• swLORETA Z Score Neurofeedback NeuroGuide add-on module providing standardized weighted LORETA Z-score neurofeedback using the ICBM MRI database with 12,270–12,700 voxels for improved source localization accuracy.
• Surface Cross-Frequency Z Score Neurofeedback NeuroGuide add-on module providing surface EEG Z-score neurofeedback using cross-frequency coupling metrics including Cross-Frequency Coherence, Cross-Frequency Phase-Amplitude Coupling, and Cross-Frequency Power Correlation.
• swLORETA Cross-Frequency Z Score Neurofeedback NeuroGuide add-on module providing swLORETA Z-score neurofeedback using cross-frequency coupling metrics for deep brain structures.
• LORETA Source Correlation Normative Database NeuroGuide add-on normative database for LORETA 3D source correlations measuring coupling between 46 different regions of interest and the rest of the brain.
• Dynamic Bi-Spectral Analyses NeuroGuide add-on module for cross-frequency power correlation and phase synchrony analyses from 1 to 50 Hz.
• eHandbook of QEEG and EEG Biofeedback Over 200-page e-book (and hardcopy edition) providing tutorials on EEG/QEEG analysis and neurofeedback techniques; e-book priced at $39.95 with free updates. Sold as a standalone educational product.
• CGX / Cognionics Dry EEG Headset Dry and wet EEG headset hardware products sold through the NeuroGuide store, including Cognionics 6-channel dry headset and 19-channel wet headset compatible with NeuroGuide.
• Expert Clinical Report Services Professional service in which ANI experts produce QEEG clinical reports on behalf of clinicians using customer EEG data.
• Medical Legal Services Expert witness and legal documentation services for medical-legal cases involving EEG/QEEG findings.
• Mentoring and Consultation Professional mentorship and consultation services for clinicians learning to use NeuroGuide and QEEG analysis.
• NeuroGuide Workshop Training workshops (in-person and online) led by Robert W. Thatcher, Ph.D., on NeuroGuide tools, QEEG analysis, and neurofeedback protocols. Sold as a paid workshop offering.

Quantifiable outcome

• Test-retest reliability > 0.95 for EEG measurements
• +3 more outcomes

Named customers8 records

Segments4 records

Ideal customer profiles3 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration55 records

AI capability10 records

Feature9 records

Partnerships

25 partnerships are on record, tiered core and minor.

• Society for Brain Mapping and Therapeutics (SBMT)coreStrategic or Co-development Partner · 1 January 2021NeuroNavigator presented at SBMT Congress 2021-2023. Dr. Thatcher received Pioneer in Medicine Award 2021. Multiple presentations by ANI team and users on clinical applications.
• g.tec (g.Nautilus)coreTechnology or IntegrationIntegration of g.Nautilus 19 or 21/32 channel EEG strands with gel or hybrid electrodes. Added to NeuroGuide 4.0.0 (July 2026) as calibrated and compatible amplifier.
• ANT NeurocoreTechnology or IntegrationIntegration of ANT EEG caps including EE-2xx (64 channel), EE-511 (24 channel variants) with various amplifier configurations (CA-208, CA-505, CY-245, NA-245, CA-546, NA-246, NA-265, CA-209).
• CognionicscoreTechnology or IntegrationCognionics dry and wet EEG amplifiers integrated for EEG collection and neurofeedback. Supports Cognionics 19 channel wet amplifier (CAMP) and Cognionics Dry headset.
• BrainMaster TechnologiescoreTechnology or IntegrationBrainMaster EEG amplifiers (Standard, Mini-Q, Discovery) integrated with microvolt calibration for EEG collection and neurofeedback control.
• MitsarcoreTechnology or IntegrationMitsar EEG amplifiers integrated with updated acquisition modules for EEG collection and neurofeedback.
• NeXus (Mind Media)coreTechnology or IntegrationNeXus Q32 and 32/32F amplifiers integrated with calibration and equilibration factors.
• NeuroScan (Compumedics)coreTechnology or IntegrationNeuroScan amplifiers supported through standard import formats with microvolt calibration.
• Neuron-SpectrumcoreTechnology or IntegrationNeuron-Spectrum amplifiers (including NeuronSpectrum 5, 65) integrated with impedance checking and acquisition modules.
• NeuroFieldcoreTechnology or IntegrationNeuroField Q20 and Q21 amplifiers integrated for EEG collection and neurofeedback control.
• BrainVision (Brain Products)coreTechnology or IntegrationBrainAmp series amplifiers integrated with calibration support.
• BioSemicoreTechnology or IntegrationBioSemi amplifiers supported with flexible reference configuration and microvolt calibration.
• DeyMed ( Deymed Diagnostic)coreTechnology or IntegrationDeyMed amplifiers and TrueScan integration with NC module updates, plus DeyMed games integration for neurofeedback.
• Wearable Sensing (DSI)coreTechnology or IntegrationWearable Sensing DSI-24 dry electrode headset integrated for EEG collection and neurofeedback.
• Neuroelectrics (Enobio/StarStim)coreTechnology or IntegrationNeuroelectrics Enobio and StarStim-20 amplifiers integrated for EEG collection and neurofeedback.
• Advanced Brain MonitoringcoreTechnology or IntegrationB-Algebra and other Advanced Brain Monitoring products integrated for EEG analysis.
• Grass-Telefactor (Compumedics)coreTechnology or IntegrationGrass-Telefactor Aura and Comet amplifiers supported with calibrated imports.
• Cadwell LaboratoriescoreTechnology or IntegrationCadwell Easy II and Spectrum 32 amplifiers supported with microvolt calibration and equilibration.
• XLTEK (Natus)coreTechnology or IntegrationXLTEK amplifiers supported through native file imports and extended format support.
• MedicomcoreTechnology or IntegrationMedicom EEG amplifiers integrated in EDF format with collection and neurofeedback support.
• ZetocoreTechnology or IntegrationZeto WR19 wireless EEG headset integrated for EEG collection.
• BrainBitcoreTechnology or IntegrationBrainBit Dragon EEG amplifier added as calibrated and compatible amplifier in NeuroGuide 3.3.8 (February 2025).
• IQeegcoreTechnology or IntegrationIQeeg added to list of calibrated and compatible amplifiers in NeuroGuide 3.3.9 (August 2025).
• KT88-2400 ConteccoreTechnology or IntegrationContec KT88-2400 amplifier with updated Collection Module in NeuroGuide 3.4.0 (December 2025).
• International QEEG Certification BoardminorStrategic or Co-development PartnerDr. Thatcher interviewed for the International QEEG Certification Board, establishing professional standards and recognition for QEEG practitioners.

Scale indicators4 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• ANT Neuro: ANT Neuro manufactures EEG caps, amplifiers (EE-2xx, EE-511, eego), and provides the ASA/WaveGuard analysis ecosystem. It is a direct peer through its EEG hardware integration with NeuroGuide and competes in the EEG research and clinical analysis market.
• BESA (BESA GmbH / BESA Research): BESA develops BESA Research and BESA EEG/MEG analysis software for clinical and research EEG/MEG source imaging, directly competing with NeuroGuide in QEEG analysis, source localization, and connectivity workflows used by neurologists and clinical researchers.
• BrainMaster Technologies: BrainMaster develops EEG amplifiers (Discovery, Atlantis, Mini-Q) and clinical neurofeedback software. It is a direct peer in the clinical neurofeedback and QEEG market whose hardware integrates with NeuroGuide.
• Brain Products (BrainVision): Brain Products sells EEG hardware (BrainAmp) and Analyzer software for EEG/ERP analysis. It is a direct peer through its BrainAmp integration with NeuroGuide and competes in the clinical-research EEG analysis software category.
• Wave Neuroscience (Brain Performance Center): Wave Neuroscience offers EEG-guided neurofeedback and personalized neuromodulation services for TBI, PTSD, and cognitive conditions, directly overlapping with NeuroGuide's clinical neurofeedback and Concussion Index use cases.
• Mitsar Co. Ltd. Mitsar manufactures EEG amplifiers and the WinEEG/EEG Studio analysis platform, directly competing with NeuroGuide in QEEG and clinical EEG analysis, particularly in Eastern European and Russian markets.

Broad incumbents

• Cadwell Industries: Cadwell manufactures clinical neurodiagnostic equipment (Easy II, Spectrum 32 EEG amplifiers) and software. Its amplifier products integrate with NeuroGuide, and it competes as a broader incumbent in clinical EEG/EMG/PSG markets.
• Electrical Geodesics / Magstim EGI: Magstim EGI (formerly EGI/Philips) provides high-density EEG systems (Geodesic Sensor Net) and analysis software (Net Station) for research and clinical applications, competing as a broader incumbent in clinical-research EEG.
• Natus Medical (now part of Natus / Archimed): Natus offers the XLTEK EEG/neurophysiology product line and broader neurodiagnostic solutions. It is a broader incumbent serving the same clinical EEG customer base that NeuroGuide addresses, with integrated hardware-software offerings.
• Compumedics / Neuroscan: Compumedics owns Neuroscan and offers integrated EEG hardware-software systems (CURRY, Scan) for clinical and research applications. It is a broader incumbent in EEG/PSG that competes with NeuroGuide in clinical QEEG and neurology research software.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat5 records

Key risks6 records

Key highlights7 records

Customer concentration

• YouTubeyoutube.com/user/appliedneuro
• Xx.com/applied_neuro
• Facebookfacebook.com/Neuronavigator
• LinkedInlinkedin.com/company/applied-neuroscience-inc

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Applied Neuroscience