What UNMC Regional Pathology Services does

UNMC Regional Pathology Services (RPS/RegLab) is the clinical laboratory services division of the University of Nebraska Medical Center, operating a regional reference laboratory founded in 1974 in Omaha, Nebraska. The organization delivers anatomic and clinical pathology testing across more than 30 subspecialties, including molecular diagnostics, next-generation sequencing, immunohistochemistry (exceeding 56,000 stains annually), digital pathology/telepathology, forensic DNA testing, and human genetics with over 130 diagnostic tests. Its customers span hospitals, physicians, academic medical centers, public health agencies, and research clients across the Midwest, supported by a regional courier network, seven patient service centers, and more than 200 EMR/LIS interfaces.

RPS monetizes testing through fee-for-service billing to providers, payers, and institutional clients, supplemented by Nebraska Public Health Laboratory state contracts and forensic casework. Its 24/7 operations, board-certified UNMC pathology faculty across subspecialties, and stack of accreditations (CAP, CLIA in Nebraska and California, ANAB/ISO 17025:2017, AABB, FACT, ASHI) define its service tier. The organization also functions as an academic teaching laboratory with active residency and fellowship programs, and is modernizing its core platform with the June 2026 Epic Beaker LIS implementation and RPSLink client portal launch.

Name

UNMC Regional Pathology Services

Legal name

Regional Pathology Services

Website

https://reglab.org

Company type

Private

Founded year

1974

Operating status

Operating

Headcount range

51–100 employees

Short description

UNMC Regional Pathology Services is the University of Nebraska Medical Center's clinical reference laboratory, providing anatomic and clinical pathology testing across 30+ subspecialties to hospitals, physicians, and public health agencies across the Midwest through 200+ EMR/LIS integrations.

Ownership category

akta.pro rank

Product category

Clinical Pathology Laboratory Services

NAICS

Medical and Diagnostic Laboratories (6215)

SIC

Services-Medical Laboratories (8071), Services-Health Services (8000), Services-Specialty Outpatient Facilities, Nec (8093)

akta.pro primary industry

Anatomic Pathology (Histopathology & Cytopathology) (HLAFAMAA)

akta.pro secondary industry

Independent Diagnostic Testing Facilities (IDTFs) & Multi-Specialty Diagnostic Centers (HLAFAKAN)

Keywords

• Clinical pathology laboratory services
• Anatomic pathology testing
• Molecular diagnostics
• Genetic testing services
• Pathology consultation services

Headquarters

HQ city

Omaha

HQ country

United States

HQ region

North America

Offices7 records

Markets served

GTM type

B2B

Offering type

Services

Cost components

Personnel, Technology or R&D, Operations, Supply Chain, Infrastructure

Revenue model

1. Clinical Laboratory Testing Services: Provides both technical and professional components of clinical and anatomic pathology testing. Services include clinical chemistry, hematopathology, molecular diagnostics, microbiology, virology, immunology, and over 30 subspecialty pathology services. Billing includes client/institutional billing for healthcare providers and direct patient billing, with participation in Medicare, Medicaid, and major commercial insurance plans.
2. Insurance-Reimbursed Testing: Participates with most major commercial insurance plans, Medicare and Medicaid. Prior authorization assistance is offered for molecular, genetic, and some pathology testing. Client and insurance billing services are provided directly.
3. Client/Institutional Billing: Direct institutional billing for healthcare clients, including academic medical centers, hospital laboratories, and physician offices, separate from patient insurance billing.
4. Specialized Molecular and Genetic Testing: Precision oncology panels (POP300 with 337 genes, STPP with 49 genes), HLA tissue typing, prenatal/postnatal genetic testing, oncology FISH and microarray testing, generating revenue through specialized assay fees.
5. Professional Consultation Services: Consultations and second opinions from board-certified specialists across all pathology subspecialties, including urologic pathology, neuropathology, renal pathology, and transplant pathology.

Pricing tiers

Go-to-market motion1 record

Distribution channels5 records

Marketing channels5 records

Core offering

UNMC Regional Pathology Services is the clinical and anatomic pathology laboratory division of the University of Nebraska Medical Center, providing comprehensive diagnostic testing, molecular diagnostics, next-generation sequencing, digital pathology/telepathology, forensic DNA testing, and board-certified specialist consultations across 30+ pathology subspecialties. Services are delivered 24/7 to healthcare providers across the Midwest through an extensive ground courier network, electronic ordering portals, and seven patient service centers in Nebraska.

Differentiator

Problem solved

Functional benefit

Products and services

• Clinical and Anatomic Pathology Laboratory Services Comprehensive clinical and anatomic pathology testing services including clinical chemistry, hematopathology, molecular diagnostics, microbiology, virology, immunology, and over 30 subspecialty pathology services for healthcare providers in Nebraska and surrounding regions.
• Pathology Consultant Services Board-certified medical experts offering pathology consultations and second opinions across multiple subspecialties including molecular genetics, dermatopathology, hematopathology, neuropathology, surgical pathology, urologic pathology, renal pathology, and transplantation pathology.
• Specialty Testing Services Over 28 specialty testing services including Biologics Production, Blood/Transfusion/Tissue, Bone and Soft Tissue Pathology, Breast Pathology, Cardiovascular Pathology, Chemistry, Coagulation, Cytology, Dermatopathology, Digital Pathology/Telepathology, Electron Microscopy, Flow Cytometry, GI/Liver Pathology, Gynecologic Pathology, Hematopathology, Histocompatibility, HLA Tissue Typing, Human Genetics, Immunohistochemistry, Lung/Thoracic Pathology, Microbiology/Virology, Molecular Diagnostics, Molecular Forensics, Neuropathology, Public Health Testing, Renal Pathology, Transplantation Pathology, and Urologic Pathology.
• Molecular Diagnostics Molecular oncology testing for solid tumors and hematologic malignancies including next-generation sequencing assays such as the Precision Oncology Profile 300 (337-gene panel) and Solid Tumor Precision Panel (49-gene panel) for personalized medicine, precision oncology profiling, and targeted therapy selection.
• 50 Gene Cancer Panel First-in-Nebraska 50-gene cancer panel enabling physicians to identify genetic mutations to personalize and tailor cancer therapies for patients.
• Human DNA Identification Laboratory Forensic STR DNA-based testing offered since 1995 with next-generation sequencing capabilities for Forensic Investigative Genetic Genealogy (FIGG), ancestry and phenotype analysis; compliant with ANAB ISO/IEC 17025:2017 and FBI Quality Assurance Standards.
• RPSLink Web Portal Secure web-based portal providing healthcare providers access to test orders and result information; integrates with Epic Beaker LIS to replace the legacy RPS Pathways portal.
• New Chemistry Analyzer with NT-proBNP New clinical chemistry analyzer platform with updated reference ranges and introduction of the NT-proBNP assay replacing the CHFP Assay for heart failure biomarker testing.
• Patient Service Centers Seven phlebotomy and specimen collection locations in Omaha, Bellevue, and Lincoln providing convenient patient access to blood draws and laboratory specimen collection.
• Nebraska Public Health Laboratory Services Public health testing services provided in coordination with Nebraska Public Health Laboratory including outbreak investigation, sexually transmitted disease testing, and bioterrorism/chemical terrorism testing for the State of Nebraska.
• Courier and Specimen Transport Services Extensive ground courier network across the Midwest and surrounding states with same-day specimen delivery to the main campus laboratory, plus prepaid overnight mail service available for distant clients.

Quantifiable outcome

• Seven patient service center locations in Omaha, Bellevue, and Lincoln for patient blood draws
• +5 more outcomes

Named customers7 records

Segments5 records

Ideal customer profiles5 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration2 records

Feature8 records

Partnerships

Six partnerships are on record, tiered notable, core and supporting.

• Kearney Regional Medical CenternotableStrategic or Co-development Partner · 1 October 2019Collaboration using digital pathology and telecytology to provide faster thyroid cancer diagnosis for patients in central Nebraska. Kearney Regional Medical Center is the first hospital in Nebraska to use telecytology technology from UNMC, connecting histologists to UNMC pathologists via Skype for real-time adequacy assessment of thyroid specimens. This partnership has enabled earlier cancer diagnosis and faster treatment decisions for patients in central Nebraska, completing over 20 cases.
• Nebraska Public Health Laboratory (NPHL)coreStrategic or Co-development PartnerRPS serves as the Nebraska Public Health Laboratory Client Services Department, working collaboratively with NPHL to coordinate public health testing across the State of Nebraska for disease outbreaks, sexually transmitted diseases, and bioterrorism/chemical terrorism testing. The organizations share a supply portal and courier network.
• University of Nebraska Medical Center (UNMC)coreStrategic or Co-development PartnerRegional Pathology Services is the clinical laboratory services division of the UNMC Department of Pathology. All medical experts hold appointments at UNMC and are board-certified specialists. The partnership leverages UNMC's academic medical center infrastructure, research capabilities (Eppley Cancer Center), and faculty expertise across all pathology subspecialties.
• Nebraska Medical Center (The)coreStrategic or Co-development PartnerThe Nebraska Medical Center is the primary clinical care facility co-located with UNMC. RPS provides pathology and laboratory services for The Nebraska Medical Center, which hosts CAP, CLIA, AABB, and FACT accredited laboratory operations. The relationship provides access to a major hospital system patient base.
• Epic Systems (Epic Beaker LIS)coreTechnology or IntegrationImplementation of Epic Beaker as the Laboratory Information System (LIS), replacing ATLAS/RPS Pathways. Effective June 6, 2026. RPSLink is being developed as the web portal to integrate with Epic Beaker for order entry and result delivery. The transition involves over 200 unique interface connections with client EMR/LIS systems.
• ARUP LaboratoriessupportingTechnology or IntegrationARUP Laboratories provides the web platform (testmenu.com/nebraska) for RPS's clinical test directory. ARUP is also used as a reference laboratory for certain send-out tests, including during temporary disruptions (e.g., mycobacteriology testing temporarily sent to ARUP in October 2025, COVID-19 testing send-outs).

Scale indicators8 records

Recent moves6 records

Expansion highlights5 records

Direct peers

• PathGroup: Large physician-led anatomic and clinical pathology practice providing hospital-based and reference pathology services across multiple states. Comparable subspecialty pathology consultation model and hospital reference lab relationships to UNMC Regional Pathology Services.
• PreventionGenetics: Clinical DNA testing laboratory offering an extensive menu of genetic and genomic tests for inherited disorders, similar to RPS's Warren G. Sanger Human Genetics Laboratory (130+ diagnostic tests). Comparable specialty genetic testing services for hospitals and reference lab clients across the Midwest.
• ARUP Laboratories: National academic reference laboratory operated by the University of Utah, offering the same comprehensive menu of esoteric clinical and anatomic pathology testing, molecular diagnostics, and consultative specialist reads. RPS already uses ARUP as a backup reference lab and ARUP powers RPS's test menu platform (testmenu.com/nebraska), making it the most direct operational peer.
• NeoGenomics: Specialty oncology-focused reference laboratory providing molecular and genetic testing, NGS panels, and hematopathology services to community oncologists and hospitals. Directly comparable in the precision oncology and molecular diagnostics segment where RPS's POP300 and STPP panels compete.
• Mayo Clinic Laboratories: Academic medical-center-affiliated reference laboratory serving hospitals and health systems with esoteric testing, subspecialty pathology consultation, and a national courier footprint. Closely comparable in operating model to UNMC Regional Pathology Services as an academic reference lab leveraging faculty expertise across pathology subspecialties.
• Hospital Pathology Associates: Private pathology group providing hospital-based anatomic and clinical pathology services with subspecialty expertise. Comparable in delivering board-certified specialist reads and consultative services to hospital clients in a regional model.

Broad incumbents

• Quest Diagnostics: Large national clinical laboratory network with a broad routine and specialty testing menu, hospital reference services, and nationwide logistics. Competes with RPS for hospital send-out and outpatient reference work, though its portfolio extends well beyond academic pathology into routine clinical lab testing, employer screening, and direct-to-consumer offerings.
• Sonic Healthcare USA: Network of regional reference and anatomic pathology laboratories across the United States (including affiliated academic-style practices). Comparable full-service clinical and anatomic pathology menu and hospital/client outreach model, with multiple regional brands serving similar customer profiles.
• Laboratory Corporation of America (Labcorp): National clinical and anatomic pathology reference laboratory with extensive esoteric and routine testing capabilities, courier network, and integrated diagnostics offerings. Direct competitor to RPS in reference lab services with much broader geographic reach.

Emerging players

• Athena Diagnostics: Specialized reference laboratory focused on neurology, oncology, and rare disease genetic and molecular testing. Partial overlap with RPS's neuropathology, molecular diagnostics, and human genetics testing categories, particularly for complex send-out cases.

Market position

Strengths4 records

Weaknesses5 records

Competitive moat5 records

Key risks7 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/RegionalPathologyServices
• LinkedInlinkedin.com/company/regionalpathologyservices

Compliance7 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles9 records

Subsidiaries1 record

Funding overview

Funding rounds

Investors

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M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about UNMC Regional Pathology Services