Metabolize

What Metabolize does

Metabolize is a US-based, founder-led wellness company that has developed NatLean, a precision metabolite dietary supplement positioned to support satiety signaling in individuals discontinuing GLP-1 weight-loss medications. The product is built around two research-validated endogenous metabolites — BHB Phenylalanine, identified in a Cell paper as a signal of fat and energy sufficiency, and N-acetyltaurine, identified in Nature research as a signal of protein and energy sufficiency under metabolic stress. The company frames NatLean as a precision alternative to broad, high-dose supplements, delivering specific biological signals the body naturally produces to communicate fullness rather than relying on blunt nutritional inputs.

The business operates a direct-to-consumer e-commerce model through a Shopify-powered storefront, currently in a pre-launch state with a waitlist capturing early-access email signups. Marketing is built around top-of-funnel digital content — website storytelling, email list acquisition, and a single-narrative product page — targeting a narrowly defined persona of post-GLP-1 users who need help maintaining fullness cues and weight-loss progress after medication ends. No pricing has been disclosed publicly, and the product is not yet listed for sale on the storefront at the time of the snapshot.

Metabolize was founded in 2024 by Morris Laster, MD, who serves as Founder & CEO. The firm is privately held, appears to be founder-owned with no disclosed institutional investors beyond a first funding round led by SOSV (SOSV SF & NY, fka IndieBio) in August 2025, and operates with a 1–10 employee footprint. There are no disclosed patents, regulatory clearances, certifications, clinical trial results, or named customers; the company's differentiation rests entirely on its scientific narrative and the post-GLP-1 market thesis.

Name

Metabolize

Legal name

Metabolize

Website

https://metabolize.life

Company type

Private

Founded year

2024

Operating status

Operating

Headcount range

1–10 employees

Short description

Metabolize is a US-based wellness company developing NatLean, a precision metabolite supplement intended to support satiety signaling in individuals discontinuing GLP-1 weight-loss medications, sold direct-to-consumer through a Shopify storefront currently in pre-launch waitlist stage.

Ownership category

akta.pro rank

Product category

Metabolic Health Supplements

NAICS

Medicinal and Botanical Manufacturing (325411)

SIC

Medicinal Chemicals & Botanical Products (2833)

akta.pro industry

PRIMARYCRADAGAG

Weight Management & Metabolic Supplements

Consumer Products & Retail/Consumer Packaged Goods (CPG) Manufacturing & Brands/Vitamins, Supplements & Sports Nutrition

Keywords

• Precision metabolite supplements
• Metabolic health products
• Post-GLP-1 satiety support
• Weight management supplements
• Direct-to-consumer wellness

Headquarters

HQ city

St. Petersburg

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Marketing or Sales, Technology or R&D, Personnel, Operations

Revenue model

1. E-commerce product sales: Direct-to-consumer online sales of NatLean precision metabolite supplement through the company's Shopify-powered e-commerce store. Product is currently in pre-launch/waitlist stage with early access sign-ups being collected.

Go-to-market motion1 record

Distribution channels1 record

Marketing channels3 records

Core offering

Metabolize develops and sells NatLean, a precision metabolite dietary supplement designed to support the body's natural satiety signaling after users stop taking GLP-1 weight-loss medications. The product delivers specific endogenous molecules (BHB Phenylalanine and N-acetyltaurine) that communicate fullness and energy sufficiency, and is sold direct-to-consumer through a Shopify e-commerce storefront, currently in waitlist/early access stage ahead of launch.

Product overview

Metabolize offers NatLean as its core precision metabolite product. NatLean is designed to support satiety signaling specifically for individuals transitioning off GLP-1 medications, helping them maintain the fullness cues and weight management progress achieved during medication use. The company positions NatLean as a more precise form of nutrition that works with biology rather than using broad, high-dose nutrient supplements.

Differentiator

Problem solved

Functional benefit

Brands

• NatLean: A precision metabolite product designed to support satiety signaling after GLP-1 medication use. NatLean is a waitlisted product preparing for launch.

Products and services

• NatLean NatLean is a precision metabolite dietary supplement designed to deliver the same biological signals the body naturally uses to indicate fullness and energy sufficiency, supporting satiety signaling for individuals who have discontinued GLP-1 weight-loss medications and want to maintain the fullness cues they had while on treatment.

Quantifiable outcome

• Reduction in weight gain in animal models with BHB Phenylalanine treatment (research published in Cell)

Segments1 record

Ideal customer profiles1 record

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Partnerships

One partnership is on record.

• ShopifycoreTechnology or IntegrationShopify powers the Metabolize e-commerce store, enabling product sales, payment processing, and order fulfillment. The company uses Shopify to provide its Services, including personalized advertising with third-party services based on customer online activity. Shopify collects and processes personal information about store visitors and transactions.

Recent moves5 records

Expansion highlights4 records

Broad incumbents

• Life Extension: Established longevity- and metabolic-supplement brand selling to a science-conversant 50+ consumer. Comparable as a broad incumbent in clinically positioned dietary supplements targeting metabolic and weight-management outcomes.
• Thorne: Broad incumbent premium-supplement brand with an established DTC infrastructure, practitioner channel, and a metabolic/weight-management SKU set. Thorne is the most likely "fast follower" competitor with the resources to launch a post-GLP-1 satiety-support product.
• Designs for Health: Clinician-channel supplement brand with a metabolic-health product line. Comparable as a professional-grade, science-positioned incumbent that could expand into the post-GLP-1 white space and compete for the practitioner endorsement channel Metabolize's MD founder may pursue.
• Ro (GLP-1 / Body program): Large telehealth platform that has built a substantial GLP-1 weight management program including companion coaching and supplements. A potential channel partner, acquirer, or competitive incumbent in the same post-GLP-1 category.

Others

• Noom: Behavior-change weight management platform with a strong GLP-1 user base and adjacent metabolic-care offerings (Noom Med). Relevant as a downstream channel/partner and as competition for the same post-GLP-1 engagement budget.

Emerging players

• ZOE: Metabolic health company selling personalized nutrition based on gut microbiome and blood biomarkers. ZOE competes in the same consumer mindshare for "biological, evidence-based metabolic optimization" without directly selling a satiety metabolite product.
• Levels: Emerging metabolic-health DTC brand using continuous glucose monitoring and food/supplement recommendations to drive metabolic outcomes. Overlaps with Metabolize on the precision-metabolic, science-led positioning and the same consumer persona interested in satiety and energy signaling.

Direct peers

• Found: Direct peer in post-GLP-1 weight management. Found combines clinician-prescribed medication programs with behavior and nutrition support for the same target persona as Metabolize (post-GLP-1 patients maintaining weight loss), competing for the same wallet share.
• Calibrate: Direct competitor focused on the metabolic-health continuum around GLP-1 medications. Calibrate pairs medical treatment with coaching and supplements, addressing the same post-medication sustainability gap that NatLean targets.
• Pendulum: Direct peer: Pendulum sells precision probiotics and metabolite-targeting supplements (e.g., Akkermansia) for metabolic health. Both companies monetize precision-metabolite science via DTC supplements targeting blood sugar, satiety, and metabolic function, and compete for the same evidence-driven metabolic-health consumer.

Market position

Strengths4 records

Weaknesses5 records

Competitive moat2 records

Key risks6 records

Key highlights6 records

Customer concentration

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds1 record

Investors2 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Metabolize