Holistic Health International

What Holistic Health International does

Holistic Health International (HHI), operating as HolisticHeal.com, is a privately held nutraceutical and at-home diagnostics company founded in 2002 and headquartered in Bethel, Maine. The company sells nutritional supplements, at-home health tests, and educational resources built around Dr. Amy Yasko's proprietary "Yasko Protocol" — a data-driven framework that combines genetic and biochemical testing with personalized supplement recommendations targeted at methylation cycle function, neurotransmitter balance, and related metabolic pathways. The founder-formulator brand and 25+ years of methylation-focused R&D are central to its positioning.

The core technology is a custom 30-SNP DNA nutrigenomic panel (covering COMT, MTHFR, VDR, SUOX, MTR/MTRR, CBS, BHMT, AHCY, and related methylation genes) priced at $530, paired with mutation-specific nucleotide blends and bioavailable supplement formulations (methylated B12, resveratrol, phosphatidyl serine, GABA, SAMe, and others). At-home diagnostics include the CardioMetabolic Profile ($180), Hair Elements ($125), and CytoDX Cytokine Analysis ($305) tests, processed through partner laboratories such as ZRT Laboratory. Manufacturing occurs in an NSF cGMP-certified Maine facility with double-testing of raw materials and finished products, and orders are hand-packed on-site.

HHI operates a direct-to-consumer e-commerce model via holisticheal.com, with a secondary Amazon Marketplace presence. Products are HSA/FSA eligible (offering roughly 30% pre-tax savings) and are sold through one-time purchases, curated bundles (Foundational Wellness, Longevity, Calm Focus, etc.), and subscription options. Marketing is content-led: blog articles, free seminars and e-books, an at-home testing quiz, organic social (Facebook, Instagram, LinkedIn), and on-site testimonials. Primary customer segments include individuals with identified methylation-related SNPs, parents of children with autism/ADHD, chemically sensitive consumers, and adults seeking functional-medicine interventions for anxiety, mood, and cognitive performance. The company has cumulatively fulfilled more than 500,000 orders since inception.

Name

Holistic Health International

Legal name

Holistic Health International, LLC

Website

https://holisticheal.com

Company type

Private

Founded year

2002

Operating status

Operating

Headcount range

11–50 employees

Short description

Holistic Health International (HolisticHeal.com) is a privately held Maine-based nutraceutical and at-home diagnostics company that sells personalized supplements, genetic and biochemical tests, and educational content based on Dr. Amy Yasko's methylation-focused Yasko Protocol, serving health-conscious consumers and individuals with identified genetic SNPs.

Ownership category

akta.pro rank

Product category

Nutrigenomics and Personalized Wellness

NAICS

Food (Health) Supplement Retailers (456191), Medical and Diagnostic Laboratories (62151)

SIC

Medicinal Chemicals & Botanical Products (2833)

akta.pro primary industry

Specialty Condition Supplements (Sleep, Stress, Heart, Joint, Gut, Immunity) (CRADAGAE)

akta.pro secondary industry

Clinical Biomarker Testing Services (central labs, trial enrollment/monitoring assays) (HLAAAMAC)

Keywords

• Nutritional supplements
• Nutrigenomics testing
• Methylation support
• At-home health tests
• Personalized wellness

Headquarters

HQ city

Bethel

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2C

Offering type

Services

Cost components

Personnel, Operations, Supply Chain, Marketing or Sales, Technology or R&D

Revenue model

1. Direct Product Sales: Sale of nucleotide products, supplements, vitamins, and health test kits through e-commerce website and Amazon marketplace. Products include capsules, sprays, liquids, and gummies with various formulations targeting methylation support, cognitive health, anxiety, sleep, and general wellness.
2. Genetic Testing Services: DNA Nutrigenomic Test with Methylation Pathway Analysis sold for $530, along with various biochemical tests (Hair Elements Test $125, CardioMetabolic Profile Test $180, CytoDX Cytokine Analysis Test $305). Results accessed through Health Companion client portal.
3. Subscription/Recurring Revenue: Subscribe to back-in-stock notifications, subscription options for regular product purchases, and ongoing client portal access for health tracking and test result management.

Pricing tiers

Go-to-market motion3 records

Distribution channels3 records

Marketing channels6 records

Core offering

Holistic Health International formulates and sells Dr. Amy Yasko's branded nutritional supplements (nucleotides, multivitamins, B12 products, cognitive and methylation support formulations) along with at-home diagnostic test kits, most notably the DNA Nutrigenomic Test with Methylation Pathway Analysis. Customers purchase these through the company's own e-commerce site holisticheal.com and on Amazon, and access personalized results and protocols through the Dr. Amy Yasko Client Portal.

Product overview

Holistic Health International (HHI) offers a comprehensive health and wellness platform centered on The Yasko Protocol, which combines genetic testing and personalized supplementation. The core offerings include: (1) DNA Nutrigenomic Test with Methylation Pathway Analysis identifying 30 SNPs; (2) Health Tests including CardioMetabolic Profile and CytoDX Cytokine Analysis; (3) A broad supplement portfolio spanning nucleotides (Bestsellers and Mutation-Specific for MTHFR, COMT, VDR, SUOX), multivitamins (All In One), B12 products (MegaDrops in Methyl, Hydroxy, and Adenosyl forms), cognitive support (Phosphatidyl Serine Complex, GABA, Zen), antioxidant/sleep support (Resveratrol Spray, BeCalm Spray), and specialized formulas (Liver Well, Glucose Support, Inflammatory Pathway Support); (4) Product bundles (Foundational Wellness, Unwind & Restore, Longevity, Calm Focus, Daily Digestive). All HHI-formulated supplements are Dr. Amy Yasko-formulated, NSF cGMP certified, and lab tested twice. Products are designed for methylation cycle support, with many formulations addressing specific genetic mutations.

Differentiator

Problem solved

Functional benefit

Brands

• The Yasko Protocol: A comprehensive health protocol developed by Dr. Amy Yasko, incorporating genetic testing, biochemical testing, and personalized supplementation based on methylation cycle support.

Products and services

• DNA Nutrigenomic Test with Methylation Pathway Analysis At-home DNA test panel of 30 SNPs in the methylation cycle, designed by Dr. Amy Yasko, with personalized supplement suggestions based on results. Sold for $530 with results accessed via the Dr. Amy Yasko Client Portal.
• CardioMetabolic Profile Test Blood spot at-home test assessing cardiometabolic risk factors including insulin, hsCRP, HbA1c, triglycerides, HDL, LDL, and VLDL. Priced at $180 (compare at $229) with optional Dr. Amy client file review add-on. Not available in New York and requires a healthcare practitioner in Maryland.
• CytoDX Cytokine Analysis Test Blood draw test measuring pro-inflammatory and anti-inflammatory cytokine levels to assess immune response and chronic inflammation. Priced at $305 (compare at $345).
• Hair Elements Test At-home hair test for toxic and essential elements. Priced at $125.
• Mutation-Specific Nucleotides Liquid nucleotide blends designed for individuals carrying MTHFR 1298C+, COMT V158M +/-, VDR Fok+, or SUOX +/- mutations, providing personalized support based on individual genetic profiles.
• Nucleotides (Bestsellers) Core nucleotide supplements including Bowel Support, Nerve Calm, General Support, and Language + Cognition I, formulated as building blocks for DNA and RNA.
• All In One Multi-Vitamin/Mineral Comprehensive 120-capsule multivitamin formulated with bioavailable forms of B vitamins and essential antioxidants to support methylation cycle health and general wellness. Priced at $34.95 per bottle.
• Methyl B12 MegaDrops Liquid methylcobalamin B12 supplement supporting energy, attention, focus, neurological function, balanced mood, and red blood cell health.
• Resveratrol Antioxidant and Glutamate Balance Spray Antioxidant spray containing resveratrol to support anti-aging, pain management, cognition, and glutamate balance for those with nerve overstimulation.
• Phosphatidyl Serine Complex Phospholipid supplement supporting memory, attention, learning, mental acuity, concentration, mood, and healthy cortisol levels.
• BeCalm Spray Proprietary blend spray combining GABA, L-Theanine, and herbs to promote relaxation, target anxiety and stress, and support B12 transport.
• GABA 90 Capsules 90-capsule supplement promoting calmness, restful sleep, balanced glutamate levels, and limiting nerve overexcitation such as repetitive behavior and OCD.
• Lithium Drops by New Beginnings Ultra-concentrated ionic liquid lithium supplement supporting healthy mood, behavior, dopamine and serotonin activity, and brain receptor function.
• Phosphatidylserine (Soy Free) Plant-based phosphatidylserine supplement (Sharp-PS GREEN from non-GMO sunflower) supporting cognitive function, memory, attention, and mood.
• SAMe S-Adenosyl-Methionine Enteric-coated SAMe supplement supporting mood, liver health, joint function, and neurotransmitter synthesis including dopamine, serotonin, and norepinephrine.
• Zen 60 Capsules 60-capsule hypoallergenic calmness supplement combining L-theanine and GABA for day or night use.
• Pycnogenol 60 Vegetarian Capsules French Maritime Pine Bark extract supplement supporting healthy circulation, blood glucose levels, and providing antioxidant and anti-inflammatory properties.
• Inflammatory Pathway Support 60-capsule multi-pathway inflammation support supplement combining stinging nettle, Indian frankincense, curcumin, Chinese skullcap, and slippery elm.
• Liver Well MTHFR A1298C+ Support 60-capsule supplement (formerly MTHFR A1298C+ Liver Support) promoting healthy liver function, natural BH4 production, and neurotransmitter balance.
• Glucose Support 60 Capsules 60-capsule comprehensive blend of minerals and herbs including alpha-lipoic acid, gymnema sylvestre, and milk thistle supporting normal blood glucose levels.
• MTR/MTRR+ Nucleotide Blend Liquid nucleotide blend supporting individuals with MTR gene mutations, providing an alternative to capsule supplements.
• Pancreas Health 60 Capsules 60-capsule supplement (formerly VDR/FOK Pancreatic Support) with gymnema sylvestre, chromium, and vanadium for healthy glucose levels and pancreatic health.
• European Grape Seed Extract 30-capsule Lecoselect brand grape seed extract with OPCs providing antioxidant protection, circulatory health support, and anti-inflammatory benefits.
• Longevity and Whole-Body Support Bundle Bundle containing Cellular Energy, Coenzyme Q10 Spray, and Resveratrol Spray to support cellular energy, metabolic balance, and whole-body resilience. Priced at $66.11-$73.45 depending on options.
• Wellness Bundles Curated multi-product bundles including Foundational Wellness Bundle (foundational nutrition and energy), Unwind and Restore Bundle (sleep and relaxation), Calm Focus Bundle (calmness and focus), and Daily Digestive and Immune Health Bundle (digestive comfort and immune balance).
• The Yasko Protocol Personalized health protocol developed by Dr. Amy Yasko that integrates DNA Nutrigenomic testing, biochemical test results, and customized supplement recommendations to guide individuals through a data-driven health journey, with results and protocols delivered through the Dr. Amy Yasko Client Portal.

Quantifiable outcome

• 500,000+ orders fulfilled
• +2 more outcomes

Named customers5 records

Segments5 records

Ideal customer profiles5 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature3 records

Partnerships

One partnership is on record.

• ZRT LaboratorycoreTechnology or IntegrationZRT Laboratory is the certified diagnostic lab used for processing CardioMetabolic Profile Test samples. Located in Beaverton, OR (8605 SW Creekside Place). Ships samples within 30 days of collection; samples remain stable in extreme temperatures.

Scale indicators3 records

Recent moves1 record

Expansion highlights6 records

Broad incumbents

• 23andMe: Largest direct-to-consumer DNA testing brand with health + ancestry reports. Comparable in DTC genetic testing model, though operates at much larger scale and broader consumer brand awareness than HHI.
• Life Extension: Established science-based supplement brand offering broad condition-specific formulations including cognitive, cardiovascular, and methylation support. Comparable in longevity/wellness positioning; HHI already resells Life Extension SAMe.

Direct peers

• SelfDecode: DNA and lab-based testing platform that generates personalized health reports including supplement and diet recommendations. Comparable to HHI's DNA Nutrigenomic Test in delivering gene-based wellness guidance.
• Thorne: Premium personalized supplement and at-home testing brand offering practitioner-grade products plus health test kits. Comparable in DTC motion, premium pricing, NSF cGMP manufacturing, and integration of testing with supplement recommendations.
• Viome: At-home microbiome and biomarker testing company that converts results into personalized nutrition recommendations and custom supplement blends. Comparable in integrating at-home test results with proprietary supplement formulations.
• Pure Encapsulations: Hypoallergenic, practitioner-grade supplement brand with strict purity standards (free from fillers/excipients). Comparable to HHI's chemically-sensitive customer segment and hypoallergenic product positioning.
• Seeking Health: Direct-to-consumer supplement brand specializing in methylation support, MTHFR-friendly formulations, and B12/folate variants for genetically predisposed consumers. Highly comparable to HHI's methylation-focused positioning and chemically-sensitive customer base.
• Designs for Health: Practitioner-channel supplements brand emphasizing science-backed formulations and targeted condition support. Comparable to HHI in functional-medicine orientation and condition-specific product lines.

Emerging players

• XCode Life: Nutrigenomics and DNA health testing company focused on genetic insights for diet, fitness, and wellness. Comparable as a focused DNA-based personalized nutrition provider, though smaller and less supplement-integrated than HHI.

Others

• AncestryDNA: Largest DTC DNA testing brand primarily focused on ancestry. Adjacent rather than directly comparable — relevant only as a benchmark for DNA testing consumer market dynamics, not as a direct competitor for HHI's health/supplement focus.

Market position

Strengths5 records

Weaknesses4 records

Competitive moat4 records

Key risks6 records

Key highlights6 records

Customer concentration

• Facebookfacebook.com/DrAmyYasko
• LinkedInlinkedin.com/company/holistic-health-international
• Instagraminstagram.com/holistic_heal

Revenue estimate

Valuation estimate

Number of profiles

Profiles1 record

Funding overview

Funding rounds

Investors

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Holistic Health International