Lirio
Lirio is a Knoxville-based healthcare AI company that uses its proprietary Large Behavior Model and behavioral science methodology (Precision Nudging) to deliver n-of-1 personalized patient engagement to health systems, payers, life sciences firms, and retail pharmacies.
- Company typePrivate
- Founded2017
- HeadquartersKnoxville, United States
- Headcount51–100
- GTM typeB2B
- OfferingSoftware
What Lirio does
Lirio is a Knoxville, Tennessee-based behavioral science and AI company that delivers personalized patient and member engagement solutions to healthcare organizations. The company's core product, Precision Nudging, combines proprietary behavioral science methodology with a Large Behavior Model (LBM) — a reinforcement-learning-based AI — to identify psychological, emotional, and contextual barriers preventing health actions and to deliver timely, tailored messages that drive individual behavior change. The platform processes 400M+ nudges per year and supports n-of-1 personalization across the patient journey. Lirio sells primarily through enterprise contracts to four healthcare verticals: health systems, payers, life sciences, and retail pharmacy, with named customers including Covenant Health, Cone Health, Rochester Regional Health, Kroger, Truth Initiative, and Ayin Health Solutions. Distribution is a hybrid of direct enterprise field sales and, since October 2025, the Microsoft Marketplace with Azure and Dynamics 365 integrations; the company is also a member of the AWS Health Equity Initiative.
Lirio's commercial model is a quote-based enterprise SaaS subscription, with pricing not publicly disclosed. The company holds HITRUST CSF, SOC 2 Type II, and NIST certifications, which are prerequisites for selling into large integrated delivery networks, payers, and federal health buyers. The platform integrates with customers' existing CRM, data warehouse, and marketing automation stacks rather than replacing them, positioning Lirio as a behavioral intelligence layer that sits above incumbent healthcare IT infrastructure. The company was founded in 2016-2017, originally operating in financial and energy sectors before pivoting exclusively to healthcare via the launch of Lirio Health in January 2019. Leadership includes CEO Marten den Haring (formerly CPO, prior SVP of Platform at Element AI and CPO at Digital Reasoning), Chief Behavioral Officer Amy Bucher, Ph.D. (formerly VP at One Drop and faculty at Vanderbilt), and Chief AI Scientist Christopher Symons, Ph.D. (formerly at Oak Ridge National Laboratory).
Capital structure: privately held, with approximately $65M raised across nine funding events between 2016 and 2022. Strategic investors have included Bon Secours Mercy Health (two rounds), HDHGV Fund 1, and WR Hambrecht. The company is headquartered in Knoxville with a secondary office in Franklin, Tennessee, and reports a headcount of 51-100 employees. No revenue or ARR has been publicly disclosed, and there have been no disclosed funding rounds since mid-2022, suggesting either capital efficiency or a gap in growth-stage fundraising that would warrant diligence.
Lirio firmographics
Firmographics- Name
- Lirio
- Legal name
- Lirio, Inc.
- Website
- https://lirio.com
- Company type
- Private
- Founded year
- 2017
- Operating status
- Operating
- Headcount range
- 51–100 employees
- Short description
- Lirio is a Knoxville-based healthcare AI company that uses its proprietary Large Behavior Model and behavioral science methodology (Precision Nudging) to deliver n-of-1 personalized patient engagement to health systems, payers, life sciences firms, and retail pharmacies.
- Ownership category
- akta.pro rank
Lirio industry classification
Industry- Product category
- Healthcare Patient Engagement Software
- NAICS
- Software Publishers (5132)
- SIC
- Services-Prepackaged Software (7372)
- akta.pro primary industry
- Medication Adherence, Digital Therapeutics & Remote Coaching (condition-specific programs) (HLALAFAF)
- akta.pro secondary industry
- Behavioral Health-Integrated Chronic Care (SUD comorbidity, collaborative care) (HLALAFAK)
Keywords
Where Lirio is headquartered
LocationHeadquarters
- HQ city
- Knoxville
- HQ country
- United States
- HQ region
- North America
Offices3 records
Markets served
Lirio business model
Business model- GTM type
- B2B
- Offering type
- Software
- Cost components
- Personnel, Technology or R&D, Marketing or Sales, Operations, Infrastructure
Revenue model
- Software Platform Subscription: Lirio provides its Precision Nudging platform as a software solution to healthcare organizations. The platform is sold as a subscription to health systems, life sciences companies, health plans, and retail pharmacy organizations for patient engagement and behavior change campaigns.
- Securities Offering: SEC Form D filings indicate the company has conducted securities offerings in the United States, including a $27.5 million offering (2022) and a $3 million convertible notes offering (2022).
Go-to-market motion2 records
Distribution channels2 records
Marketing channels5 records
Lirio product offering
Product offeringCore offering
Lirio provides a behavioral science and agentic AI platform branded as Precision Nudging that identifies psychological, emotional, and contextual barriers preventing health actions and delivers personalized, n-of-1 outreach messages to patients and members. The platform is sold as a subscription to enterprise healthcare organizations across health systems, payers, life sciences, and retail pharmacy segments, with vertical-specific solution configurations tailored to each segment's engagement challenges.
Product overview
Lirio is a behavioral science and agentic AI platform that offers a unified product architecture centered on its Precision Nudging solution. The core platform combines behavioral science with agentic AI to deliver hyper-personalized patient and consumer engagement across healthcare. The product portfolio includes specialized solutions for Health Systems, Life Sciences (including Precision Nudging for Life Sciences), Payers, and Retail Pharmacy, each tailored to address specific engagement challenges including medication adherence, vaccine uptake, care gap closure, and chronic condition management. The platform delivers over 400 million nudges per year, personalizing messages, channels, and timing for each individual.
Differentiator
Problem solved
Functional benefit
Products and services
- Precision Nudging
Quantifiable outcome
- 4x more effective than standard health messages
- +6 more outcomes
Companies that use Lirio
Customer profileNamed customers6 records
Segments4 records
Ideal customer profiles4 records
Lirio technology and API
TechnologyTechnology focussed Yes
API detail
- Has API
- No
- API docs
- API detail
Core technology
AI maturity
App detail
Integration2 records
AI capability5 records
Feature5 records
Lirio partnerships and signals
Strategic signalPartnerships
Eight partnerships are on record, tiered core, strategic and minor.
- MicrosoftcoreLirio's Precision Nudging solution is now available in Microsoft Marketplace, enabling healthcare organizations worldwide to discover and deploy the solution with seamless integration across Microsoft Azure and Microsoft Dynamics 365.
- Truth InitiativestrategicPartnership to expand Truth Initiative's EX Program tobacco cessation outreach using AI and Precision Nudging to drive greater reach to employees and members.
- Ayin Health SolutionsminorValue-based care partnership for population health management services and community-based healthcare delivery solutions.
- Cone HealthstrategicPartnership aims to improve the patient experience, close gaps in care, and advance health equity. Co-created patient nudges resulting in clinically meaningful outcomes.
- Amazon Web Services (AWS)strategicSelected as part of the AWS Health Equity Initiative, a $40 million three-year commitment supporting organizations developing solutions to advance health equity. Lirio receives AWS credits and customized technical expertise.
- NTT DATAstrategicStrategic alliance focused on enabling healthcare providers to deliver more personalized care through Lirio's behavior change AI platform.
- Rochester Regional HealthstrategicStrategic alliance to optimize communication between healthcare organizations and patients they serve. Lirio Health leverages machine learning and AI to help empower people to be full partners in their healthcare.
- KrogerminorKroger's in-store pharmacies partner with Lirio to offer high-touch, personalized patient engagement experiences through Kroger's retail pharmacy network.
Scale indicators17 records
Recent moves7 records
Expansion highlights5 records
Lirio competitors and assessment
Company assessmentDirect peers
- mPulse Mobile: mPulse Mobile delivers mobile-first healthcare engagement and behavior change programs to payers, providers, and pharmacies. It competes most directly with Lirio in personalized outreach for medication adherence, care gap closure, and member activation.
- Upfront Healthcare: Upfront Healthcare provides a patient activation platform using personalized outreach and microsurveys to drive visit completion and care gap closure, serving many of the same health system customers as Lirio.
- Conversa Health: Conversa Health offers automated, AI-driven patient conversations for chronic care management, discharge follow-up, and care gap closure — overlapping directly with Lirio's Precision Nudging use cases across health systems.
- Welltok: Welltok's consumer activation platform drives personalized health and wellbeing outreach for payers and providers. It competes with Lirio in member engagement, care gap closure, and behavior change campaigns.
- OptimizeRx: OptimizeRx delivers AI-driven patient and provider engagement at the point of care for life sciences organizations, directly overlapping with Lirio's newly launched Precision Nudging for Life Sciences offering.
- Xealth: Xealth enables clinicians to digitally prescribe content, apps, and services to patients within the EHR workflow. It is a peer in the digital health engagement layer for health systems, though focused more on prescription of programs than behavioral messaging.
Broad incumbents
- Salesforce Health Cloud: Salesforce Health Cloud is a major CRM platform used by health systems and payers for patient/member engagement. As a broad incumbent, it competes with Lirio via native personalization and journey orchestration features.
- Microsoft Cloud for Healthcare: Microsoft Cloud for Healthcare bundles patient engagement, care management, and analytics capabilities. Although Lirio is also a Microsoft Marketplace partner, the underlying Microsoft stack represents the most consequential incumbent competitive threat.
Emerging players
- Twill: Twill (formerly Happify Health) delivers digital therapeutics and care programs for mental health, MS, and psoriasis. It overlaps with Lirio in digital behavior change and condition-specific coaching, though focused more on self-directed programs.
- Memora Health: Memora Health uses AI to automate patient follow-up and care navigation across text and chat, competing with Lirio in patient outreach for health systems but with less of a behavioral science foundation.
Market position
Strengths4 records
Weaknesses4 records
Competitive moat6 records
Key risks5 records
Key highlights6 records
Customer concentration
Lirio social profiles
Digital presenceLirio compliance and trust
Trust signalCompliance3 records
Lirio financial estimates
Financial estimateRevenue estimate
Valuation estimate
Lirio leadership team
Management profileNumber of profiles
Profiles5 records
Lirio funding detail
Funding detailFunding overview
Funding rounds9 records
Investors3 records
Funding detail is available on the Subscription and Enterprise plan.Contact sales →
Lirio M&A and investment
M&A and investmentM&A
Investments
M&A and investment is available on the Subscription and Enterprise plan.Contact sales →
Frequently asked questions about Lirio
What does Lirio do?
Lirio provides a behavioral science and agentic AI platform branded as Precision Nudging that identifies psychological, emotional, and contextual barriers preventing health actions and delivers personalized, n-of-1 outreach messages to patients and members. The platform is sold as a subscription to enterprise healthcare organizations across health systems, payers, life sciences, and retail pharmacy segments, with vertical-specific solution configurations tailored to each segment's engagement challenges.
Is Lirio a public or private company?
Lirio is a private company. It is classified as venture growth investor backed and is currently operating.
When was Lirio founded?
Lirio was founded in 2017. It employs 51 to 100 people.
Where is Lirio based?
Lirio is headquartered in Knoxville, United States, in the North America region.
How does Lirio make money?
Two revenue lines are on record. Software Platform Subscription is the primary driver. The others are securities Offering.
Who are Lirio's main competitors?
Direct peers on record are mPulse Mobile, Upfront Healthcare, Conversa Health, Welltok, OptimizeRx and Xealth. Broad incumbents are Salesforce Health Cloud and Microsoft Cloud for Healthcare. Emerging players are Twill and Memora Health.
Does Lirio have an API?
No public API is recorded for Lirio.
What industry is Lirio in?
Lirio's product category is Healthcare Patient Engagement Software. Its primary akta.pro industry code is HLALAFAF, Medication Adherence, Digital Therapeutics & Remote Coaching (condition-specific programs), with a secondary code of HLALAFAK, Behavioral Health-Integrated Chronic Care (SUD comorbidity, collaborative care). Its NAICS code is 5132 and its SIC code is 7372.