What Symbiome does

Symbiome is a regenerative skincare company founded in 2017 and headquartered in San Francisco that develops microbiome-focused skincare products targeting skin barrier restoration, anti-aging, and microbiome replenishment. The product platform is built on two proprietary technologies: Postbiomic™ Fermentation, which uses ancestral native microbes to unlock bioavailability of botanical nutrients without heat degradation, and BioIntact™ Emulsion, a cold-emulsion process that preserves biological integrity in formulations with as few as three ingredients. Key SKUs include The Answer Reparative Serum (containing 50% Stem Cell Conditioned Media with peptides, growth factors, exosomes and cytokines), The One Restorative Cream, The Essence Rejuvenating Mist, The Renewal Daily Cleanser, The Luminary Eye Cream, and a numbered Postbiomic face-oil line (Rewind003, Respond004, Recharge002, Rebalance001), alongside curated sets such as Kate's Kit and The Treatment Trio.

The business operates a direct-to-consumer e-commerce model through symbiome.com with individual products priced $45-$350 and a Subscribe & Save subscription option offering a 15% discount on 30/60/90-day cadences. A secondary B2B channel runs through a partnership with MeyerSPA, a national U.S. distributor serving med-spa professionals, providing professional pricing for clinical skincare protocols. Ingredient sourcing is conducted via a biotech partnership with Plantus in Natal, Brazil, using controlled fermentation with whole plant microbiomes rather than isolated compounds. The company sells across the USA, UK, Canada, and the Netherlands, has no physical retail, and relies on content marketing, social media, email, and earned media (including Vogue, The Zoe Report, and The Hollywood Reporter) for customer acquisition.

Symbiome has raised approximately $22.2M across disclosed rounds, including a $7.17M round led by Mission BioCapital in June 2020 and a $15M round led by True Ventures in September 2020, with an additional unspecified event from Robust in October 2022. The company is led by founder and CSO Larry Weiss, alongside a research team (Julia Durack, Yvette Piceno, Hoang Vuong) representing 80+ years of collective microbial-science experience. A manuscript developed by the in-house R&D team was accepted for publication in Nature, validating the company's microbiome research program, and celebrity investor Kate Hudson has collaborated on limited-edition products including Kate's Kit and The Ceremony Matcha Mask (launched March 2026).

Name

Symbiome

Legal name

Symbiome

Website

https://www.symbiome.com

Company type

Private

Founded year

2017

Operating status

Operating

Headcount range

1–10 employees

Short description

Symbiome is a San Francisco-based regenerative skincare brand founded in 2017 that develops microbiome-restoring skincare using proprietary Postbiomic fermentation and BioIntact cold-emulsion technologies, selling premium DTC products priced $45-$350 to affluent consumers and med-spa professionals via symbiome.com and the MeyerSPA channel.

Ownership category

akta.pro rank

Product category

Premium Skincare

NAICS

Cosmetics, Beauty Supplies, and Perfume Retailers (456120)

SIC

Perfumes, Cosmetics & Other Toilet Preparations (2844)

akta.pro primary industry

Dermocosmetics & Medical-Grade Skincare (CRABAAAF)

Keywords

• Regenerative skincare
• Microbiome skincare
• Fermented skincare
• Anti-aging serums
• Natural facial oils

Headquarters

HQ city

San Francisco

HQ country

United States

HQ region

North America

Offices2 records

Markets served

GTM type

B2C

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Operations, Marketing or Sales, Technology or R&D, Personnel

Revenue model

1. Direct-to-Consumer E-commerce: Primary revenue stream through the brand's e-commerce website selling individual products and curated sets at premium price points ($45-$350). Subscription model offering 15% discount drives recurring revenue.
2. Professional/B2B Sales: Wholesale to med spa professionals through MeyerSPA partnership, providing exclusive professional pricing for treatment providers.

Pricing tiers

Go-to-market motion1 record

Distribution channels2 records

Marketing channels6 records

Core offering

Symbiome manufactures and sells a direct-to-consumer line of premium regenerative skincare products — serums, creams, cleansers, mists, eye creams, masks, and face oils — built on proprietary Postbiomic™ fermentation and BioIntact™ cold-emulsion technologies designed to restore the skin's microbiome. The company sells primarily through its own e-commerce website (with subscription pricing) and secondarily to med spa professionals through distributor MeyerSPA, at price points ranging from $45 to $350 per SKU.

Product overview

Symbiome is a regenerative skincare brand offering a comprehensive portfolio of science-backed skincare products centered on microbiome restoration. The product line is built on proprietary Postbiomic™ fermentation and BioIntact™ emulsion technologies, utilizing Amazonian botanical ingredients sourced through biotech partner Plantus in Natal, Brazil. The core offerings include The Answer Reparative Serum (stem cell-based anti-aging treatment), The One Restorative Cream (BioIntact moisturizing barrier cream), The Essence Rejuvenating Mist (antioxidant facial mist), The Renewal Daily Cleanser (gentle hydrating cleanser), The Luminary Eye Cream (fermented eye treatment), and various Postbiomic face oils (Rewind003, Respond004, Recharge002, Rebalance001). The brand also offers curated bundled product sets including Kate's Kit, The Treatment Trio, and targeted regimen sets for concerns like slow-aging, supple skin, and sun recovery. All products emphasize minimal ingredient lists, fermented botanical actives, and restoration of the skin's natural microbiome.

Differentiator

Problem solved

Functional benefit

Brands

• BioIntact Emulsion: Proprietary cold emulsion technology that creates sustainable, supercharged biointact creams with minimal ingredients that deliver nutrients, exosomes, enzymes and peptides.
• Postbiomic Technology

Products and services

• The Answer Reparative Serum Anti-aging serum containing 50% Stem Cell Conditioned Media with peptides, growth factors, exosomes, and cytokines; designed to maintain collagen, improve elasticity, reduce dark spots, and smooth fine lines and wrinkles for premium anti-aging skincare consumers.
• The One Restorative Cream BioIntact™-powered restorative cream with fermented botanicals and Sanoma Leaf Oil; combats signs of accelerated aging, maintains a healthy skin barrier, and delivers deep hydration for all skin types.
• The Essence Rejuvenating Mist Ultra-fine facial mist with Postbiomic microbial lysates and enzymes, hyaluronic acid, and aloe vera to refresh, rejuvenate, and provide antioxidant defense against free radicals and UV damage.
• The Renewal Daily Cleanser Hybrid gel-to-milk daily cleanser with fermented oils that gently removes makeup and impurities while maintaining the skin's moisture barrier and microbiome.
• The Luminary Replenishing Eye Cream Ultra-hydrating BioIntact™ eye cream with fermented Green Coffee Oil and Sanoma Flower Oil to smooth, brighten, and rejuvenate the delicate under-eye area while diminishing dark circles.
• Rewind003 Age-Defying Face Oil Postbiomic™ face oil blend that brightens and evens skin tone, improves skin resilience, and provides anti-aging benefits through fermented Amazonian botanical oils.
• The Ceremony Matcha Mask

Quantifiable outcome

• 90% agree skin appears more radiant
• +7 more outcomes

Segments3 records

Ideal customer profiles2 records

Technology focussed No

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Feature4 records

Partnerships

Three partnerships are on record, tiered minor and core.

• APC PackagingminorOthersAPC Packaging is a U.S. primary packaging provider for the beauty and skincare industries. Symbiome participates in educational panels with APC at industry events like Luxe Pack Los Angeles, discussing environmentally responsible packaging solutions.
• MeyerSPAcoreChannel Partner/ Reseller/ DistributorMeyerSPA is a family-owned, national distributor serving the professional spa market. Symbiome partners with MeyerSPA to provide exclusive professional pricing on products for med spa professionals, including dermaplaning, injection supplies, and treatment room essentials.
• PlantuscoreStrategic or Co-development PartnerPlantus is a biotech partner based in Natal, Brazil. The partnership enables ingredient sourcing using controlled fermentation that works with whole plant microbiomes rather than isolating single compounds, a core differentiator for Symbiome's regenerative beauty approach.

Scale indicators2 records

Recent moves6 records

Expansion highlights5 records

Emerging players

• Codex Beauty: Codex Beauty is a science-led, microbiome-friendly skincare brand with plant-based, clinically tested formulations — a smaller but directly comparable indie in the same niche.
• Gallinée: Gallinée is a microbiome-focused skincare and body care brand targeting similar skin-barrier and probiotic-beauty claims, with a European footprint overlapping Symbiome's UK/NL coverage.

Broad incumbents

• La Mer: La Mer is the ultra-luxury science-skincare incumbent with a fermentation-broth heritage story; Symbiome's microbiome narrative competes for the same prestige, science-led anti-aging wallet share.
• Estée Lauder Companies: Estée Lauder is a global prestige beauty conglomerate with overlapping science-skincare brands (Clinique, La Mer) and is the natural acquirer/partner Symbiome would court for microbiome IP.

Direct peers

• Biossance: Biossance is a clean, biotech-derived premium skincare brand using squalane and fermentation-derived ingredients — overlapping with Symbiome in the fermentation/biotech-active prestige skincare category.
• Mother Dirt: Mother Dirt is a microbiome-focused skincare brand built around restoring skin's native bacteria, with a similar biotech-led, science-first narrative and D2C distribution.
• Drunk Elephant: Drunk Elephant is a science-backed, "clean biocompatible" premium skincare brand that pioneered ingredient-focused positioning in prestige retail and D2C — Symbiome competes for the same prestige-active shopper.
• Tula Skincare: Tula is a probiotic/microbiome-focused skincare brand with a similar D2C-led, science-storytelling positioning and overlapping customer base of premium, wellness-oriented women.
• Augustinus Bader: Augustinus Bader is a luxury, science-led skincare brand built on a proprietary cellular technology platform (TFC8) — directly comparable to Symbiome's Postbiomic/BioIntact claims of differentiated, patent-grade process technology.
• Tata Harper: Tata Harper is a prestige clean-beauty brand with a science-forward, botanical-ingredient story and similar D2C-led premium pricing model.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat4 records

Key risks5 records

Key highlights7 records

Customer concentration

• Facebookfacebook.com/symbiomeskin
• Instagraminstagram.com/symbiomeskin
• TikToktiktok.com/@symbiome
• Xx.com/symbiomeskin

Compliance7 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles4 records

Funding overview

Funding rounds3 records

Investors6 records

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about Symbiome