NeurOptics

What NeurOptics does

NeurOptics is a privately held US medical device company, incorporated in California and headquartered in Irvine, that develops automated quantitative pupillometry systems used to objectively measure pupillary size and reactivity in critically ill patients. The company's core technology combines an infrared camera and proprietary Vertex Invariant Pupillometry (VIP) signal processing with the Neurological Pupil index (NPi) algorithm — a 0-4.9 numeric scale that compares a patient's pupillary light reflex measurements against a proprietary normative database built over 20+ years. Flagship products include the NPi-300 and NPi-200 handheld pupillometers for clinical use, the single-patient-use SmartGuard disposable for data capture and EMR upload, and the NPi-Connect connectivity hub introduced commercially in early 2025 to streamline EMR integration. The company also sells research-grade instruments (VIP-400 and PLR-4000) to pharmaceutical companies, contract research organizations, and academic institutions.

NeurOptics' primary customers are hospitals and academic medical centers using NPi pupillometry in neuro-ICUs, emergency departments, and other critical care settings, with named adopters including Vanderbilt University Medical Center, Inova Health System, UPMC, CHOP, and UC Irvine Health. Revenue is generated through capital equipment sales of the pupillometers, recurring consumable revenue from the SmartGuard disposable used per patient encounter, and applied research instrument sales. The company sells via a direct sales force and RN Clinical Specialists in North America and through an appointed distributor network covering 50+ countries. NPi pupillometry is supported by 100+ peer-reviewed publications and is referenced in major clinical guidelines including the American Heart Association, Neurocritical Care Society, American College of Surgeons 2024 TBI Best Practices, and ELSO 2025 ECMO Consensus Guidelines.

Name

NeurOptics

Legal name

NeurOptics, Inc.

Website

https://neuroptics.com

Company type

Private

Founded year

1995

Operating status

Operating

Headcount range

1–10 employees

Short description

NeurOptics manufactures automated infrared pupillometers and the proprietary Neurological Pupil index (NPi) algorithm, selling the NPi-300 device, SmartGuard disposable, and NPi-Connect EMR hub to neuro-ICUs, emergency departments, and applied research customers across 50+ countries.

Ownership category

akta.pro rank

Product category

Medical Pupillometry Devices

NAICS

Electromedical and Electrotherapeutic Apparatus Manufacturing (334510), Surgical and Medical Instrument Manufacturing (339112), Navigational, Measuring, Electromedical, and Control Instruments Manufacturing (33451)

SIC

Electromedical & Electrotherapeutic Apparatus (3845), Surgical & Medical Instruments & Apparatus (3841), Optical Instruments & Lenses (3827)

akta.pro primary industry

Neurological Monitoring (EEG, Seizure/Sleep/Neuro Wearables) (HLAHACAE)

akta.pro secondary industries

Visual Field & Functional Vision Testing (Perimetry, ERG/VEP, Contrast Sensitivity) (HLAHAJAC), Neuro-Ophthalmology (HLAKAKAH)

Keywords

• Automated pupillometry devices
• Neurological pupil monitoring
• Infrared medical pupillometers
• Critical care neuro assessment
• EMR-integrated pupil measurement

Headquarters

HQ city

Laguna Hills

HQ country

United States

HQ region

North America

Offices1 record

Markets served

GTM type

B2B

Offering type

Hardware or Manufacturing

Cost components

Supply Chain, Technology or R&D, Personnel, Marketing or Sales, Operations

Revenue model

1. Hardware Sales (Pupillometers): Sale of NPi pupillometer devices (NPi-300, NPi-200) to hospitals and healthcare facilities. These are capital equipment purchases typically managed through procurement processes.
2. Disposable SmartGuard: Single-patient-use disposable SmartGuard devices that attach to pupillometers for patient data storage. This creates recurring consumable revenue as each patient requires a new SmartGuard.
3. Applied Research Products: Sale of research-grade pupillometers (VIP-400, PLR-4000) to pharmaceutical companies, contract research organizations, and academic institutions for clinical research applications.

Go-to-market motion1 record

Distribution channels3 records

Marketing channels7 records

Core offering

NeurOptics manufactures and sells automated infrared pupillometers that objectively measure pupil size and reactivity in critical care and emergency settings, scoring results on its proprietary Neurological Pupil index (NPi) scale. Its core commercial offering centers on the NPi-300 and NPi-200 handheld pupillometers, supported by single-patient-use SmartGuard disposables and the NPi-Connect EMR connectivity hub, with separate research-grade devices (VIP-400, PLR-4000) sold for ophthalmic and pharmaceutical research applications.

Product overview

NeurOptics offers a portfolio of pupillometry products centered on automated quantitative pupillary assessment. The core clinical products are the NPi-300 and NPi-200 Pupillometers, which measure pupil size and reactivity using infrared technology and report results as the Neurological Pupil index (NPi). The SmartGuard is a single-patient-use disposable that stores patient data and enables EMR integration. NPi-Connect is a connectivity hub that facilitates seamless data transfer of NPi measurements into electronic medical records. For applied research, NeurOptics offers the VIP-400 (using Vertex Invariant Pupillometry for refractive surgery and research) and PLR-4000 (for pharmaceutical and academic research). All clinical products use the proprietary NPi scale for objective neurological assessment.

Differentiator

Problem solved

Functional benefit

Products and services

• NPi-300 Pupillometer Flagship handheld automated infrared pupillometer that objectively measures pupil size and reactivity, reporting results on the proprietary Neurological Pupil index (NPi) 0–4.9 scale; Class 1 FDA 510(k)-exempt, CE-marked for adults and children, with a 2-year warranty. Sold to hospitals and ICUs for neurological assessment of critically ill patients.
• NPi-200 Pupillometer Previous-generation handheld automated pupillometer providing objective pupillary assessment and NPi measurement, with Bluetooth connectivity, a customizable trending screen, and EMR compatibility; still sold and supported by NeurOptics.
• SmartGuard Disposable Single-patient-use disposable smart-card device with Mifare 4K RFID that stores 168 paired pupil measurements and a unique patient identifier, enabling HIPAA-compliant data storage and EMR upload when used with the NPi pupillometers.
• NPi-Connect Connectivity Hub SmartGuard connectivity hub that enables seamless data transfer of NPi and pupillary measurements into the hospital EMR, with Light Ring upload status indicators (white/blue/green) and wired ethernet or wireless connectivity options.
• VIP-400 Pupillometer Research-grade pupillometer using proprietary Vertex Invariant Pupillometry (VIP) technology that compensates for vertex distance variance and accounts for pupillary noise; targeted at refractive surgery/LASIK pre-operative evaluation, autonomic neuroscience, and clinical research applications.
• PLR-4000 Pupillometer Research pupillometer used by universities, pharmaceutical companies, and contract research organizations worldwide; offers adjustable light stimulus intensity, duration, and onset with 0.03mm accuracy for high-precision pupillometry research.

Quantifiable outcome

• Nurses save average 19.8 minutes per patient per day using automated pupillometry with direct EMR upload
• +4 more outcomes

Named customers5 records

Segments3 records

Ideal customer profiles2 records

Technology focussed Yes

API detail

Has API

No

API docs

API detail

Core technology

AI maturity

App detail

Integration4 records

AI capability3 records

Feature5 records

Partnerships

Eleven partnerships are on record, tiered standard and core.

• eServices Medical SASstandardChannel Partner/ Reseller/ DistributorInternational distributor for Critical Care products covering Argentina, Chile, Colombia, Ecuador, Paraguay, Peru, Uruguay, and Latin American markets.
• JR Medical SuppliesstandardChannel Partner/ Reseller/ DistributorInternational distributor for Critical Care products in Australia.
• Surgi-One Medical TechnologiesstandardChannel Partner/ Reseller/ DistributorInternational distributor for Critical Care products in Canada.
• Unidas MedicalstandardChannel Partner/ Reseller/ DistributorInternational distributor for Critical Care products in Brazil.
• Unimedtec GmbHstandardChannel Partner/ Reseller/ DistributorInternational distributor for Critical Care products in Germany and Switzerland.
• IMI Co.standardChannel Partner/ Reseller/ DistributorInternational distributor for Critical Care products in Japan.
• Palex Medical, S.A.standardChannel Partner/ Reseller/ DistributorInternational distributor for Critical Care products in Spain.
• TriLas Medical GmbHstandardChannel Partner/ Reseller/ DistributorInternational distributor for Applied Research products covering Germany and European markets.
• Capsule TechnologiescoreTechnology or IntegrationEMR middleware partner providing device driver interface to enable SmartGuard pupillometry data upload into hospital EMR systems.
• iSirona/NanthealthcoreTechnology or IntegrationEMR middleware partner providing device driver interface to enable SmartGuard pupillometry data upload into hospital EMR systems.
• CernercoreTechnology or IntegrationEMR middleware partner providing device driver interface to enable SmartGuard pupillometry data upload into hospital EMR systems.

Scale indicators1 record

Recent moves7 records

Expansion highlights6 records

Direct peers

• Natus Medical: Natus is a long-standing neurological and neurocritical care monitoring company whose product range (EEG, ICU brain monitoring, neurodiagnostics) overlaps directly with NeurOptics' neurological assessment focus and shares the same hospital neurology customer base.
• Compumedics: Compumedics specializes in neurological diagnostic equipment (EEG, sleep, long-term monitoring) and overlaps with NeurOptics in hospitals and research institutions performing quantitative neurological assessments.
• iCare (Revenio Group): iCare manufactures handheld ophthalmic diagnostic devices (tonometers, retinal imaging) used in ophthalmology and optometry practices — comparable to NeurOptics' VIP-400 and PLR-4000 research/clinical devices in target customers and handheld optical form factor.

Broad incumbents

• Masimo: Masimo is a leading patient-monitoring company with growing neurological monitoring offerings and deep ICU/hospital relationships; its broader portfolio and R&D scale make it both a partner and a potential competitive threat to NeurOptics in quantitative neuro assessment.
• Integra LifeSciences: Integra has a significant neurosurgery and neurocritical care portfolio (including ICP monitoring and tissue oxygenation), serving the same neuro ICU customers as NeurOptics and providing an adjacent platform for pupillometry bundling or competition.
• Nihon Kohden: Nihon Kohden is a global patient-monitoring and neurology company (EEG, polysomnography, ICU monitors) that sells into the same neurocritical care and emergency department purchasing channels as NeurOptics.
• Welch Allyn (Baxter International): Welch Allyn (now part of Baxter) manufactures handheld physical-assessment and ophthalmic instruments used by frontline clinicians; it competes with NeurOptics' handheld point-of-care design philosophy and shares many clinical decision-making customers.

Emerging players

• Nonin Medical: Nonin is a specialty patient-monitoring company (pulse oximetry, regional oximetry) selling into hospital and critical-care channels; it represents an adjacent neurological/physiological monitoring peer that could expand into pupillometry.
• Topcon Healthcare: Topcon offers ophthalmic diagnostic and refractive-surgery devices, including pupil measurement tools for LASIK/IOL planning — directly comparable to NeurOptics' VIP-400 product line in ophthalmic applied research.

Others

• Capsule Technologies (Mindray): Capsule Technologies is an EMR medical-device integration platform and current NeurOptics partner for SmartGuard data upload; it is a key enabling technology vendor rather than a competitor, but its broader ICU integration footprint is strategically relevant.

Market position

Strengths5 records

Weaknesses5 records

Competitive moat6 records

Key risks6 records

Key highlights7 records

Customer concentration

• Xx.com/NeurOpticsInc
• Facebookfacebook.com/NeurOptics

Compliance3 records

Revenue estimate

Valuation estimate

Number of profiles

Profiles2 records

Funding overview

Funding rounds3 records

Investors1 record

Funding detail is available on the Subscription and Enterprise plan.Contact sales →

M&A

Investments

M&A and investment is available on the Subscription and Enterprise plan.Contact sales →

Frequently asked questions about NeurOptics